Estrogen Regulates KiSS1 Gene Expression through Estrogen Receptor α and SP Protein Complexes
Abstract
Kisspeptins are natural ligands of G protein-coupled receptor-54. Activation of KiSS1/G protein-coupled receptor-54 signaling pathways results in potent activation of the hypothalamus-pituitary-gonadal axis and initiates puberty. Recent data have shown that in female mice, KiSS1 is positively regulated by estradiol (E(2)) in the anteroventral periventricular nucleus, an important reproductive neuroendocrine brain region, but negatively regulated in the arcuate nucleus. However, little is known about the molecular mechanisms governing E(2)-modulated KiSS1 expression. Here, we demonstrate that the expression level of the KiSS1 gene was up-regulated with the administration of E(2) in estrogen receptor alpha (ERalpha)-positive hypothalamic GT1-7 cells. Using transient transfection of human KiSS1 gene promoter coupled to a luciferase reporter, E(2) increases promoter activity in the presence of ERalpha. Deletion analysis of KiSS1 promoter indicates that the E(2)-regulated increase in promoter activity depends on the Sp1 sites of the proximal promoter region. Using both EMSAs and chromatin immunoprecipitation analysis, we determined that both Sp1 and Sp3 proteins constitutively associate with the four putative Sp1 sites in vitro, whereas the association of ERalpha with the KiSS1 promoter is dependent on E(2) exposure. Sp1 and ERalpha form a complex in vivo to mediate the E(2)-induced activation of KiSS1 promoter. Interestingly, Sp1 transactivates KiSS1 promoter activity, whereas Sp3 functions as a transcriptional repressor. Together, these results demonstrate that E(2)-dependent transcriptional activation of KiSS1 gene is mediated by ERalpha through the interaction of Sp1/Sp3 proteins with the GC-rich motifs of KiSS1 promoter, providing a molecular mechanism of how steroid hormone feedback regulates KiSS1 expression.
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In animal models, the KISS1 neurons appear to mediate sex steroid feedback effects in the hypothalamus.
“In animal models, the KISS1 neurons appear to mediate sex steroid feedback effects in the hypothalamus.58,59”
From Pubertal development and regulation (2016) · cites this paper as [58]
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- Authors
- Li, D., Mitchell, D., Luo, J., Yi, Z., Cho, S.-G., Guo, J., Li, X., Ning, G., Wu, X., & Liu, M.
- Affiliations
- Texas A&M University System (US)
- Shanghai Jiao Tong University (CN)
- Hunan Normal University (CN)
- Corresponding author
- Liu, Mingyao
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2007-10-01
- Volume
- 148
- Issue
- 10
- Pages
- 4821-4828
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1965007233
- Cited by
- 90
- References
- 57
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 8
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense (W81XWH)
- National Institutes of Health (5r01ca106479-05, 5r01hl064792-04, W81XWH)
- University of California, San Diego
- National Key Research and Development Program of China
- National Heart, Lung, and Blood Institute (5 R01 HL064792)
- National Cancer Institute (1R01CA106479)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- KISS1, kisspeptin, estrogen receptor alpha, estrogen, Sp1, Sp3, transcriptional regulation, hypothalamus, anteroventral periventricular nucleus, arcuate nucleus, hypothalamic-pituitary-gonadal axis, puberty, transcriptional repressor
- MeSH terms
- Cell Line, Estradiol, Estrogens, Gene Expression Regulation, Humans, Luciferases, Promoter Regions, Genetic, RNA, Messenger, Transfection, Up-Regulation, Sp1 Transcription Factor, Tumor Suppressor Proteins, Estrogen Receptor alpha, Sp3 Transcription Factor, Kisspeptins
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