Cited by 520Hypothalamic control of reproductive hormonesReproductive Biology and FertilityNeuropeptides and Animal Physiology

Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat

Matsui, Hisanori, Takatsu, Yoshihiro, Kumano, Satoshi, Matsumoto, Hirokazu, Ohtaki, Tetsuya·2004·Biochemical and Biophysical Research Communications

Abstract

Metastin is a novel peptide that has been isolated from the human placenta as the cognate ligand of the G-protein-coupled receptor OT7T175 (or GPR54). However, its physiological functions have not yet been fully investigated. In the present study, we show that subcutaneous administration of metastin increased the plasma levels of gonadotropins (follicle-stimulating hormone and luteinizing hormone) and induced ovulation in prepubertal female rats that had been pretreated with pregnant mare serum gonadotropin to induce follicle maturation. Furthermore, metastin administration drastically increased the plasma levels of gonadotropins in male rats. This action was abolished by pretreatment with a GnRH antagonist, and was accompanied by induction of c-Fos immunoreactivity in GnRH neurons. These results suggest that s.c. administered metastin induces the release of gonadotropin via activation of the hypothalamic GnRH neurons.

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Crossref · 10.1016/j.bbrc.2004.05.185

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Authors
Matsui, H., Takatsu, Y., Kumano, S., Matsumoto, H., & Ohtaki, T.
Affiliations
Takeda (Japan) (JP)
Corresponding author
Ohtaki, Tetsuya
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2004-07
Volume
320
Issue
2
Pages
383-388
ISSN
0006-291X (ISSN-L)
OpenAlex
W2021996823
Cited by
520
References
31
Citations by year
2026: 3 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 17 · 2021: 22 · 2020: 14 · 2019: 13 · 2018: 23 · 2017: 21 · 2016: 25 · 2015: 18 · 2014: 30 · 2013: 36 · 2012: 34
FWCI
29.23
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
kisspeptin, GPR54, gonadotropin secretion, ovulation, follicle-stimulating hormone, luteinizing hormone, GnRH neurons, c-fos, hypothalamus, GnRH antagonist, peripheral administration, prepubertal female rats, male rats
MeSH terms
Animals, Gonadotropins, Male, Ovulation, Pituitary Gland, Anterior, Proto-Oncogene Proteins c-fos, Rats, Wistar, Rats

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