The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia
Open accessAbstract
Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines impair β-cell function and survival. A recent clinical trial shows that blocking IL-1β signaling by IL-1 receptor antagonist (IL-1Ra) improves β-cell secretory function in patients with type 2 diabetes. In the present study, we provide further mechanisms of the protective role of IL-1Ra on the β-cell. IL-1Ra prevented diabetes in vivo in C57BL/6J mice fed a high-fat/high-sucrose diet (HFD) for 12 wk; it improved glucose tolerance and insulin secretion. High-fat diet treatment increased serum levels of free fatty acids and of the adipokines resistin and leptin, which were reduced by IL-1Ra treatment. In addition, IL-1Ra counteracted adiponectin levels, which were decreased by high-fat feeding. Studies on isolated islets revealed that IL-1Ra specifically acted on the β-cell. IL-1Ra protected islets from HFD treated animals from β-cell apoptosis, induced β-cell proliferation, and improved glucose-stimulated insulin secretion. Insulin mRNA was reduced in islets from mice fed a HFD but normalized in the IL-1Ra group. Our results show that IL-1Ra improves β-cell survival and function, and support the potential role for IL-1Ra in the treatment of diabetes.
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Metadata
- Authors
- Sauter, N. S., Schulthess, F. T., Galasso, R., Castellani, L. W., & Maedler, K.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2008-01-31
- Volume
- 149
- Issue
- 5
- Pages
- 2208-2218
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2146433754
- Cited by
- 198
- References
- 8
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia. https://app.cochat.ai/papers/10.1210/en.2007-1059
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- Sauter, N. S., Schulthess, F. T., Galasso, R., Castellani, L. W., & Maedler, K. (2008). The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia. Endocrinology. https://doi.org/10.1210/en.2007-1059
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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