An immune origin of type 2 diabetes?

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Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes

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Interleukin-6-deficient mice develop mature-onset obesity

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High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells

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Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

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Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1

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Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation

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Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes

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The clearance of apoptotic cells: implications for autoimmunity

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Gamma Globulin Levels Predict Type 2 Diabetes in the Pima Indian Population

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Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA region.

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[General Articles] Intracellular Thiol Concentration Modulating Inflammatory Response: Influence on the Regulation of Cell Functions Through Cysteine Prodrug Approach

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Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice.

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Understanding adipose tissue development from transgenic animal models

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Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men—report from 27 years of follow-up study

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Effect of Metformin and Sulfonylurea on C-Reactive Protein Level in Well-Controlled Type 2 Diabetics with Metabolic Syndrome

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Acute-phase response and immunological markers in morbid obese patients and patients following adjustable gastric banding

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Variations in plasma soluble tumour necrosis factor receptors after diet‐induced weight loss in obesity

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Glucose Regulates Interleukin-8 Production in Aortic Endothelial Cells through Activation of the p38 Mitogen-activated Protein Kinase Pathway in Diabetes

Srinivasan, S. R., Bolick, D. T., Hatley, M. E., Natarajan, R. D., Reilly, K. B., Yeh, M. W., Chrestensen, C. A., Sturgill, T. W., & Hedrick, C. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400753200 · Cited by 58 · see citing works

Glycotoxins: A Missing Link in the “Relationship of Dietary Fat and Meat Intake in Relation to Risk of Type 2 Diabetes in Men”

Peppa, Μ., Goldberg, T., Cai, W., Rayfield, E. J., & Vlassara, H. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1898 · Cited by 57 · see citing works

SERUM CONCENTRATION OF α2-MACROGLOBULIN, HAPTOGLOBIN AND α1-ANTITRYPSIN IN DIABETES MELLITUS

Ganrot, P. O., Gydell, K., & Ekelund, H. (1967) · European Journal of Endocrinology · doi:10.1530/acta.0.0550537 · Cited by 56 · see citing works

Insulin resistance: from benign to type 2 diabetes mellitus.

Goldstein, B. J. (2003) · PubMed · Cited by 54 · see citing works

Causation of Type 2 Diabetes — The Gordian Knot Unravels

Taylor, R. (2004) · New England Journal of Medicine · doi:10.1056/nejmp038239 · Cited by 53 · see citing works

Addition of glucose to an oral fat load reduces postprandial free fatty acids and prevents the postprandial increase in complement component 3

van Oostrom, A. J., van Dijk, H., Verseyden, C., Sniderman, A. D., Cianflone, K., Rabelink, T. J., & Castro Cabezas, M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.3.510 · Cited by 53 · see citing works

Increased Abdominal Obesity, Insulin and Glucose Levels in Nondiabetic Subjects with a T29C Polymorphism of the Transforming Growth Factor-β1 Gene

Rosmond, R., Chagnon, M., Bouchard, C., & Björntorp, P. A. (2003) · Hormone Research in Paediatrics · doi:10.1159/000069323 · Cited by 52 · see citing works

Inflammation and emerging risk factors in diabetes mellitus and atherosclerosis

Theuma, P., & Fonseca, V. A. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0072-3 · Cited by 50 · see citing works

Lowered Tumor Necrosis Factor Receptors, but Not Increased Insulin Sensitivity, with Infliximab

Rocco, P. D., Manco, M., Rosa, G., Greco, A. V., & Mingrone, G. (2004) · Obesity Research · doi:10.1038/oby.2004.86 · Cited by 49 · see citing works

High glucose and hyperosmolarity increase secretion of interleukin-1 β in cultured human aortic endothelial cells

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Beta-cell failure in the pathogenesis of type 2 diabetes mellitus

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Potential Role of Statins in Inflammation and Atherosclerosis

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Inhibition of tumor necrosis factor-α with anti-diabetic agents

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Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus.

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Troglitazone reduces plasma levels of tumour necrosis factor‐α in obese patients with type 2 diabetes

Katsuki, A., Sumida, Y., Murata, K., Furuta, M., Araki-Sasaki, R., Tsuchihashi, K., Hori, Y., Yano, Y., Gabazza, E. C., & Adachi, Y. (2000) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2000.00072.x · Cited by 43 · see citing works

Inflammation and insulin resistance

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Dietary factors and low-grade inflammation in relation to overweight and obesity

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A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works

Muscles and their myokines

Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

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GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective

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Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes

Larsen, C. M., Faulenbach, M., Vaag, A., Ehses, J. A., Donath, M. Y., & Mandrup-Poulsen, T. (2009) · Diabetes Care · doi:10.2337/dc09-0533 · Cited by 401 · see citing works

Targeting innate immune mediators in type 1 and type 2 diabetes

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Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial

Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28548 · Cited by 364 · see citing works

Inflammatory Process in Type 2 Diabetes: The Role of Cytokines

ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309 · see citing works

Adapted dietary inflammatory index and its association with a summary score for low-grade inflammation and markers of glucose metabolism: The Cohort study on Diabetes and Atherosclerosis Maastricht (CODAM) and the Hoorn study

van Woudenbergh, G. J., Theofylaktopoulou, D., Kuijsten, A., Ferreira, I., van Greevenbroek, M. M., van der Kallen, C. J., Schalkwijk, C. G., Stehouwer, C. D., Ocké, M. C., Nijpels, G., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.056333 · Cited by 190 · see citing works

Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes

Carstensen, M., Herder, C., Kivimäki, M., Jokela, M., Roden, M., Shipley, M. J., Witte, D. R., Brunner, E. J., & Tabák, A. G. (2010) · Diabetes · doi:10.2337/db09-1199 · Cited by 137 · see citing works

Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle

Bouzakri, K., Plomgaard, P., Berney, T., Donath, M. Y., Pedersen, B. K., & Halban, P. A. (2011) · Diabetes · doi:10.2337/db10-1178 · Cited by 122 · see citing works

Inflammation and Type 2 Diabetes: Results from KORA Augsburg

Herder, C., Illig, T., Rathmann, W., Martin, S., Haastert, B., Müller-Scholze, S., Holle, R., Thorand, B., Koenig, W., Wichmann, H., et al. (2005) · Das Gesundheitswesen · doi:10.1055/s-2005-858252 · Cited by 97 · see citing works

The Clinical Efficacy and Safety of Stem Cell Therapy for Diabetes Mellitus: A Systematic Review and Meta-Analysis

Yazhen, Z., Wenyi, C., Bing, F., & Hongcui, C. (2020) · Aging and disease · doi:10.14336/ad.2019.0421 · Cited by 82 · see citing works

The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes

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Inflammation in Metabolic Syndrome and Type 2 Diabetes: Impact of Dietary Glucose

KEMPF, K., ROSE, B., HERDER, C., KLEOPHAS, U., MARTIN, S., & KOLB, H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.012 · Cited by 48 · see citing works

Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial

Kempf, K., Röhling, M., Banzer, W., Braumann, K. M., Halle, M., Schaller, N., McCarthy, D., Predel, H. G., Schenkenberger, I., Tan, S., et al. (2022) · Nutrients · doi:10.3390/nu14122537 · Cited by 14 · see citing works

MicroRNA-345-3p is a potential biomarker and ameliorates rheumatoid arthritis by reducing the release of proinflammatory cytokines

Ma, J., Zhao, W., Pei, X., et al. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03797-3 · Cited by 3 · see citing works

Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner

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Effects of Proinflammatory Cytokines in the Heart

Zhang, C. (2004) · Life Science Research

Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p′-DDT in macrophages

Kim, J. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.001 · Cited by 45 · see citing works

Proinflammatory Cytokines Mediate GPCR Dysfunction

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