The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Evidence that Intestinal Glucagon-Like Peptide-1 Plays a Physiological Role in Satiety
Open accessAbstract
A physiological role in satiety is proposed for glucagon-like peptide-1 (GLP-1), secreted by the distal intestine in response to ingested nutrients. Here we report that in rats, ip injection of the GLP-1 receptor (GLP-1-R) antagonist exendin 9-39 (Ex9) elicited hyperphagia, but only at times of day when intake is otherwise low. Furthermore, ip administration of Ex9 attenuated satiety induced by either a voluntarily consumed sucrose meal (by 100%) or an intragastric glucose load (by 40%). To determine whether these effects involve blockade of GLP-1-R in brain or at a peripheral site, we injected Ex9 either centrally (into the third ventricle) or peripherally (ip) prior to GLP-1 injected either centrally or peripherally. Anorexia induced by peripheral GLP-1 was fully blocked by peripheral, but not central, pretreatment with Ex9, whereas the opposite was true for anorexic effect of central GLP-1. Thus, ip Ex9 appears to attenuate satiety via peripheral GLP-1-R blockade. Finally, anorexia induced by ip injection of exendin-4 (a GLP-1-R agonist) was due to both reduced meal size and increased duration between meals. We conclude that GLP-1 released from the intestine in response to ingested nutrients is a physiologically active satiety signal.
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“One mechanism proposed to explain how leptin reduces food intake is by enhancing the CNS response to gut-derived satiety peptides, such as cholecystokinin (CCK) and glucagon-like-peptide-1 (GLP-1) (196)”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [196]
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Metadata
- Authors
- Williams, D. L., Baskin, D. G., & Schwartz, M. W.
- Affiliations
- Florida State University (US)
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- Corresponding author
- Williams, Diana L.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2008-12-12
- Volume
- 150
- Issue
- 4
- Pages
- 1680-1687
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC2659282
- OpenAlex
- W2082052031
- Cited by
- 300
- References
- 31
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 7 · 2022: 8 · 2021: 21 · 2020: 11 · 2019: 9 · 2018: 17 · 2017: 16 · 2016: 27 · 2015: 22 · 2014: 27 · 2013: 28 · 2012: 22
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-083042, P30-DK 17047, R01DK052989, DK-52989, K99DK078779, P01DK068384, DK-68384, P30DK035816, P30DK017047, R01DK083042)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- glucagon-like peptide-1, satiety, GLP-1 receptor, exendin-9-39, exendin-4, hyperphagia, anorexia, intestinal hormone secretion, meal size
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Exenatide, Animals, Anorexia, Eating, Injections, Male, Peptides, Satiety Response, Venoms, Receptors, Glucagon, Rats
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