Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908

The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21

Kharitonenkov, A., Wroblewski, V. J., Koester, A., Chen, Y.-F., Clutinger, C. K., Tigno, X. T., Hansen, B. C., Shanafelt, A. B., & Etgen, G. J. (2007) · Endocrinology · doi:10.1210/en.2006-1168 · Cited by 738

βKlotho is required for metabolic activity of fibroblast growth factor 21

Ogawa, Y., Kurosu, H., Yamamoto, M., Nandi, A., Rosenblatt, K. P., Goetz, R., Eliseenkova, A. V., Mohammadi, M., & Kuro-o, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701600104 · Cited by 617

Activation of AMP‐activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders

Viollet, B., Foretz, M., Guigas, B., Horman, S., Dentin, R., Bertrand, L., Hue, L., & Andréelli, F. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108506 · Cited by 543

Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

Wente, W., Efanov, A. M., Brenner, M. B., Kharitonenkov, A., Koster, A. M., Sandusky, G. E., Sewing, S., Treinies, I., Zitzer, H., & Gromada, J. (2006) · Diabetes · doi:10.2337/db05-1435 · Cited by 497

FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway

Dai, H., Hu, W., Zhang, L., Jiang, F., Mao, X., Yang, G., & Li, L. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03588-w · Cited by 65

Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho

Aaldijk, A. S., Verzijl, C. R. C., Jonker, J. W., & Struik, D. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150222 · Cited by 63

Metabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues

Lin, X., Liu, Y. B., & Hu, H. (2017) · Biomedical Reports · doi:10.3892/br.2017.890 · Cited by 61

Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction

Tang, T., Li, Y.-Y., Li, J.-J., Wang, K., Han, Y., Dong, W.-Y., Zhu, Z.-F., Xia, N., Nie, S.-F., Zhang, M., et al. (2018) · Theranostics · doi:10.7150/thno.24723 · Cited by 63

A link between hepatic glucose production and peripheral energy metabolism via hepatokines

Abdul-Wahed, A., Gautier‐Stein, A., Casteras, S., Soty, M., Roussel, D., Romestaing, C., Guillou, H., Tourette, J.-A., Plèche, N., Zitoun, C., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.005 · Cited by 75

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

Smith, R. J., Duguay, A. N., Bakker, A., Li, P., Weiszmann, J., Thomas, M. R., Alba, B. M., Wu, X., Gupte, J., Li, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061432 · Cited by 59

The 2009 Stock Conference Report: Inflammation, Obesity and Metabolic Disease

Hevener, A. L., Febbraio, M. A., & the Stock Conference Working Group (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00691.x · Cited by 60

Dynamic Change of Serum FGF21 Levels in Response to Glucose Challenge in Human

Lin, Z., Gong, Q., Wu, C., Yu, J., Lü, T., Pan, X., Lin, S., & Li, X. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1132 · Cited by 58

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis

Mottillo, E. P., Desjardins, E. M., Fritzen, A. M., Zou, V. Z., Crane, J. D., Yabut, J. M., Kiens, B., Erion, D. M., Lanba, A., Granneman, J. G., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.001 · Cited by 57

Association between serum fibroblast growth factor 21 and diabetic nephropathy

Jian, W., Peng, W., Jin, J., Chen, X., Fang, W., Wang, W., Li, Q., Dong, Y., & Su, Q. (2011) · Metabolism · doi:10.1016/j.metabol.2011.10.012 · Cited by 57

The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines

Sherrier, M. C., & Li, H. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz145 · Cited by 56

The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates

Cui, A., Li, J., Ji, S., Ma, F., Wang, G., Xue, Y., Liu, Z., Gao, J., Han, J. S., Tai, P., et al. (2020) · Diabetes · doi:10.2337/db20-0209 · Cited by 55

Hormone-like fibroblast growth factors and metabolic regulation

Long, Y. C., & Kharitonenkov, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.04.002 · Cited by 55

Role of exercise-induced hepatokines in metabolic disorders

Ennequin, G., Sirvent, P., & Whitham, M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00433.2018 · Cited by 54

The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases

Yan, J., Nie, Y., Cao, J., Luo, M., Yan, M., Chen, Z., & He, B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.655575 · Cited by 53

Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats

Wang, W., Li, S., Ren, G., Zheng, W., Lu, Y., Yu, Y.-H., Xu, W.-J., Li, T.-H., Zhou, L., Liu, Y., et al. (2014) · Endocrine · doi:10.1007/s12020-014-0433-5 · Cited by 52

Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism

Kim, K. H., & Lee, M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9272-6 · Cited by 50

Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin‐induced insulin‐deficient diabetic mice by restoring brown adipose tissue function

Kim, J. H., Bae, K., Choi, Y. ‐., Go, Y., Choe, M., Jeon, Y. ‐., Lee, H.-M., Koo, S., Perfield, J. W., Harris, R. A., et al. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12408 · Cited by 51

Liraglutide Suppresses Obesity and Hyperglycemia Associated with Increases in Hepatic Fibroblast Growth Factor 21 Production in KKA y Mice

Nonogaki, K., Hazama, M., & Satoh, N. (2014) · BioMed Research International · doi:10.1155/2014/751930 · Cited by 48

Effects of fibroblast growth factor 21 on cell damage in vitro and atherosclerosis in vivo

Zhu, W., Wang, C., Liu, L., Li, Y., Li, X., Cai, J., & Wang, H. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0227 · Cited by 48

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

Kim, T. H., Hong, D.-G., & Yang, Y. M. (2021) · Biomedicines · doi:10.3390/biomedicines9121903 · Cited by 57

Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice

Kodo, K., Sugimoto, S., Nakajima, H., Mori, J., Itoh, I., Fukuhara, S., Shigehara, K., Nishikawa, T., Kosaka, K., & Hosoi, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173661 · Cited by 48

Growth Hormone Stimulates Transcription of the Fibroblast Growth Factor 21 Gene in the Liver through the Signal Transducer and Activator of Transcription 5

Yu, J., Zhao, L., Wang, A., Eleswarapu, S., Ge, X., Chen, D., & Jiang, H. (2011) · Endocrinology · doi:10.1210/en.2011-1591 · Cited by 45

Short Term Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome Via B-hydroxybutyrate and Fibroblast Growth Factor 21

Kim, E. R., Kim, S. R., Cho, W., Lee, S., Kim, S. H., Kim, J. H., Choi, E., Kim, J., Yu, J., Lee, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843520 · Cited by 44

Serum fibroblast growth factor 21 is predictive of combined cardiovascular morbidity and mortality in patients with type 2 diabetes at a relatively short-term follow-up

Lenart-Lipińska, M., Matyjaszek‐Matuszek, B., Gernand, W., Nowakowski, A. M., & Solski, J. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.04.010 · Cited by 44

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21

Camporez, J. P., Asrih, M., Zhang, D., Kahn, M., Samuel, V. T., Jurczak, M. J., & Jornayvaz, F. R. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0136 · Cited by 44

Effects of a novel selective peroxisome proliferator‐activated receptor‐α modulator, pemafibrate, on hepatic and peripheral glucose uptake in patients with hypertriglyceridemia and insulin resistance

Matsuba, I., Matsuba, R., Ishibashi, S., Yamashita, S., Arai, H., Yokote, K., Suganami, H., & Araki, E. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12845 · Cited by 43

Implications of Mitochondrial Unfolded Protein Response and Mitokines: A Perspective on Fatty Liver Diseases

Yi, H. (2019) · Endocrinology and Metabolism · doi:10.3803/enm.2019.34.1.39 · Cited by 43

Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis

Watanabe, M., Singhal, G., Fisher, F. M., Beck, T. C., Morgan, D. A., Socciarelli, F., Mather, M. L., Risi, R., Bourke, J., Rahmouni, K., et al. (2019) · Endocrine · doi:10.1007/s12020-019-02124-3 · Cited by 44

YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity

Wang, L., Mazagova, M., Pan, C., Yang, S. T., Brandl, K., Liu, J., Reilly, S. M., Wang, Y., Miao, Z., Loomba, R. S., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904360116 · Cited by 43

Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)

Cheng, X., Vispute, S. G., Liu, J., Cheng, C., Kharitonenkov, A., & Klaassen, C. D. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.04.013 · Cited by 42

Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention

Figarska, S. M., Rigdon, J., Ganna, A., Elmståhl, S., Lind, L., Gardner, C. D., & Ingelsson, E. (2020) · Scientific Reports · doi:10.1038/s41598-020-64636-7 · Cited by 41

Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression

Girer, N. G., Murray, I. A., Omiecinski, C. J., & Perdew, G. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.715151 · Cited by 40

Targeting Neurovascular Interaction in Retinal Disorders

Fu, Z., Sun, Y., Cakir, B., Tomita, Y., Huang, S., Wang, Z., Liu, C., Cho, S. S., Britton, W. R., Kern, T. S., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041503 · Cited by 43

Protective Effects of Fibroblast Growth Factor 21 Against Amyloid-Beta1–42-Induced Toxicity in SH-SY5Y Cells

Amiri, M., Braidy, N., & Aminzadeh, M. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9914-2 · Cited by 38

Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

Camacho, R. C., Zafian, P., Achanfuo-Yeboah, J., Manibusan, A., & Berger, J. P. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.06.023 · Cited by 38

Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats

Charoenphandhu, N., Suntornsaratoon, P., Krishnamra, N., Sa‐nguanmoo, P., Tanajak, P., Wang, X., Liang, G., Li, X., Jiang, C., Chattipakorn, N., et al. (2016) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-016-0745-z · Cited by 38

Transcription Regulators and Hormones Involved in the Development of Brown Fat and White Fat Browning: Transcriptional and Hormonal Control of Brown/Beige Fat Development

Zhang, J., Wu, H., MA, S., Jing, F., Yu, C., Gao, L., & Zhao, J. (2018) · Physiological Research · doi:10.33549/physiolres.933650 · Cited by 38

The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes

Izaguirre, M., Gil, M. J., Monreal, I., Montecucco, F., Frühbeck, G., & Catalán, V. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0866-3 · Cited by 41

Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network

Li, S., Zou, T., Chen, J., Li, J., & You, J. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.06.033 · Cited by 37

Targeting fibroblast growth factor 19 in liver disease: a potential biomarker and therapeutic target

Liu, W., Xie, D.-M., Zhu, G., Huang, G., Lin, Y.-Q., Wang, L., Shi, K., Hu, B., Braddock, M., Chen, Y., et al. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.997711 · Cited by 38

The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling

Jager, J., Wang, F., Fang, B., Lim, H., Peed, L. C., Steger, D. J., Won, K., Kharitonenkov, A., Adams, A. C., & Lazar, M. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719120 · Cited by 35

Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes

Hong, E. S., Lim, C., Choi, H. Y., Lee, Y. K., Ku, E. J., Moon, J. H., Park, K. S., Jang, H. C., & Choi, S. H. (2019) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000776 · Cited by 35

Visceral adipose tissue-directed FGF21 gene therapy improves metabolic and immune health in BTBR mice

Queen, N. J., Bates, R., Huang, W., Xiao, R., Appana, B., & Cao, L. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.12.011 · Cited by 38

Hepatokines as a Molecular Transducer of Exercise

Seo, D. Y., Park, S.-H., Marquez, J. C., Kwak, H., Kim, T. N., Bae, J. H., Koh, J., & Han, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030385 · Cited by 37

Recently Discovered Adipokines and Cardio-Metabolic Comorbidities in Childhood Obesity

Barraco, G. M., Luciano, R., Semeraro, M., Prieto-Hontoria, P. L., & Manco, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151119760 · Cited by 33

Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21

Girer, N. G., Carter, D., Bhattarai, N., Mustafa, M. G., Denner, L. A., Porter, C. C., & Elferink, C. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040950 · Cited by 31

Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases

Cheung, B. M. Y., & Deng, H. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.904745 · Cited by 32

Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis

Wu, X., & Li, Y. (2009) · Aging · doi:10.18632/aging.100108 · Cited by 30

Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review

Drabsch, T., Gatzemeier, J., Pfadenhauer, L. M., Hauner, H., & Holzapfel, C. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy024 · Cited by 32

High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components

Li, D., Fu, G., Tu, R., Jin, Z., & Zhang, D. (2019) · Microbial Cell Factories · doi:10.1186/s12934-019-1066-4 · Cited by 31

FGF21 as a Therapeutic Reagent

Zhao, Y., Dunbar, J. D., & Kharitonenkov, A. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0887-1_14 · Cited by 30

Berberine stimulates fibroblast growth factor 21 by modulating the molecular clock component brain and muscle Arnt-like 1 in brown adipose tissue

Hirai, T., Mitani, Y., Kurumisawa, K., Nomura, K., Wang, W., Nakashima, K., & Inoue, M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.04.017 · Cited by 31

Potential roles of bone morphogenetic protein-9 in glucose and lipid homeostasis

Wang, Y., Ma, C., Sun, T., & Ren, L. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00763-z · Cited by 29

Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARMα) in the Metabolic Syndrome: Is Pemafibrate Light at the End of the Tunnel?

Fruchart, J., Hermans, M. P., Fruchart‐Najib, J., & Kodama, T. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00897-x · Cited by 30

Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver

Zhang, A., Sieglaff, D. H., York, J. P., Suh, J. H., Ayers, S. D., Winnier, G. E., Kharitonenkov, A., Pin, C. L., Zhang, P., Webb, P., et al. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0440 · Cited by 29

Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations

Fletcher, J. A., Linden, M. A., Sheldon, R. D., Meers, G. M.-E., Morris, E. M., Butterfield, A. M., Perfield, J. W., Thyfault, J. P., & Rector, R. S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00355.2015 · Cited by 28

Hepatic glucose production pathways after three days of a high-fat diet

Jin, E. S., Beddow, S. A., Malloy, C. R., & Samuel, V. T. (2012) · Metabolism · doi:10.1016/j.metabol.2012.07.012 · Cited by 29

Reversal of obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) rats

Yi, X., Pashaj, A., Xia, M., & Moreau, R. F. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.063 · Cited by 27

FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish

Blanco, A. M., Bertucci, J. I., & Unniappan, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-63726-w · Cited by 26

FGF21 ameliorates hepatic fibrosis by multiple mechanisms

Meng, F., Khoso, M. H., Kang, K., He, Q., Cao, Y., Jiang, X., Xiao, W. L., & Li, D. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06707-0 · Cited by 26

Prenatal dexamethasone exposure induced pancreatic β-cell dysfunction and glucose intolerance of male offspring rats: Role of the epigenetic repression of ACE2

Dai, Y., Kou, H., Gui, S., Guo, X.-L., Liu, H., Gong, Z., Sun, X., Wang, H., & Guo, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154095 · Cited by 25

FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ

Kong, L.-J., Feng, W., Wright, M., Chen, Y., Dallas-Yang, Q., Zhou, Y., & Berger, J. P. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.065 · Cited by 25

Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis

Zein, M. A., Zein, O., Diab, R., Dimachkie, L., Sahebkar, A., Al‐Asmakh, M., Kobeissy, F. H., & Eid, A. H. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115876 · Cited by 28

Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary‐induced obesity

Shen, H., Alex, R., Bellner, L., Raffaele, M., Licari, M., Vanella, L., Stec, D. E., & Abraham, N. G. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13522 · Cited by 23

Metabolic Effects of FGF-21: Thermoregulation and Beyond

Ni, B., Farrar, J. S., Vaitkus, J. A., & Celi, F. S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00148 · Cited by 23

Fibroblast growth factor 21: A “rheostat” for metabolic regulation?

She, Q.-Y., Bao, J., Wang, H.-Z., Liang, H., Huang, W., Wu, J., Zhong, Y.-W., Ling, H., Li, A., & Qin, S.-L. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155166 · Cited by 22

Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH

Bae, K.-H., Min, A.-K., Kim, J., Lee, I., & Park, K. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.10.147 · Cited by 22

BMP-9 enhances fibroblast growth factor 21 expression and suppresses obesity

Kim, S., Choe, S., & Lee, D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.04.006 · Cited by 22

MECHANISMS IN ENDOCRINOLOGY: Brown adipose tissue in humans: regulation and metabolic significance

Thuzar, M., & Ho, K. K. Y. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-1217 · Cited by 22

Efruxifermin, a long‐acting Fc‐fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats

Tillman, E. J., Brock, W. J., & Rolph, T. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15725 · Cited by 22

Association between dietary intake of branched-chain amino acids and sarcopenia and its components: a cross-sectional study

Ebrahimi-Mousavi, S., Hashemi, R., Bagheri, A., Heshmat, R., Motlagh, A. D., & Esmaillzadeh, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-07605-6 · Cited by 21

Fibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice

Yan, X., Chen, J., Zhang, C., Zeng, J., Zhou, S., Zhang, Z., Lu, X., Chen, J., Feng, W., Li, X., et al. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0241-0 · Cited by 21

Fibroblast growth factor 21 reverses suppression of adiponectin expression via inhibiting endoplasmic reticulum stress in adipose tissue of obese mice

Guo, Q., Xu, L., Liu, J., Li, H., Sun, H., Wu, S., & Zhou, B. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216677354 · Cited by 20

Long-lasting anti-diabetic efficacy of PEGylated FGF-21 and liraglutide in treatment of type 2 diabetic mice

Ye, X., Qi, J., Ren, G., Xu, P., Wu, Y., Zhu, S., Yu, D., Li, S., Wu, Q., Muhi, R. L., et al. (2015) · Endocrine · doi:10.1007/s12020-014-0503-8 · Cited by 19

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From bench to bedside: novel mechanisms and therapeutic advances through the development of selective peroxisome proliferator-activated receptor γ modulators

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Dual effects of fibroblast growth factor 21 on hepatic energy metabolism

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Fibroblast Growth Factor 21 Is Not Required for the Reductions in Circulating Insulin-Like Growth Factor-1 or Global Cell Proliferation Rates in Response to Moderate Calorie Restriction in Adult Mice

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Fibroblast Growth Factor 21-Null Mice Do Not Exhibit an Impaired Response to Fasting

Antonellis, P. J., Hayes, M. P., & Adams, A. C. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00077 · Cited by 17

Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator‐activated receptor γ coactivator‐1α‐deficient mice

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Efficient Labeling Of Mesenchymal Stem Cells For High Sensitivity Long-Term MRI Monitoring In Live Mice Brains

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Maternal exposure to phenanthrene during gestation disturbs glucose homeostasis in adult mouse offspring

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Fibroblast Growth Factor 21 Is Associated With Bone Mineral Density, but not With Bone Turnover Markers and Fractures in Chinese Postmenopausal Women

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FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgery

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Mirtazapine Reduces Adipocyte Hypertrophy and Increases Glucose Transporter Expression in Obese Mice

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Fibroblast Growth Factors in Cardiovascular Disease

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Beraprost sodium, a prostacyclin analogue, reduces fructose-induced hepatocellular steatosis in mice and in vitro via the microRNA-200a and SIRT1 signaling pathway

Zhang, P., Xu, L., Guan, H., Liu, L., Liu, J., Huang, Z., Cao, X., Liao, Z., Xiao, H., & Li, Y. (2017) · Metabolism · doi:10.1016/j.metabol.2017.05.003 · Cited by 15

Long-term high-fat diet links the regulation of the insulin-sensitizing fibroblast growth factor-21 and visfatin

Sun, B., Yang, G., Yang, M., Liu, H., Boden, G. H., & Li, L. (2012) · Cytokine · doi:10.1016/j.cyto.2012.03.030 · Cited by 15

Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism

Hron, B. M., Ebbeling, C. B., Feldman, H. A., & Ludwig, D. S. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0198-y · Cited by 15

Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly

Stone, S., Wegner, D., Wambach, J., Cole, F. S., Urano, F., & Ornitz, D. M. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa138 · Cited by 12

Effect of vanillic acid and exercise training on fatty liver and insulin resistance in rats: Possible role of fibroblast growth factor 21 and autophagy

Obydah, W., Shaker, G. A., Samir, S. M., El-Basiony, S. F., & Abd-Elmoniem, H. A. (2021) · Physiology International · doi:10.1556/2060.2021.00188 · Cited by 13

Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk

Berthou, F., Sobolewski, C., Abegg, D., Fournier, M., Maeder, C., Dolicka, D., de Sousa, M. C., Adibekian, A., & Foti, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073959 · Cited by 14

Long-term effects of a fat-directed FGF21 gene therapy in aged female mice

Anderson, J. M., Arnold, W. D., Huang, W., Ray, A., Owendoff, G., & Cao, L. (2023) · Gene Therapy · doi:10.1038/s41434-023-00422-0 · Cited by 13

Association between Impaired Ketogenesis and Metabolic-Associated Fatty Liver Disease

Bae, J., & Lee, B. (2023) · Biomolecules · doi:10.3390/biom13101506 · Cited by 12

Advances in FGFs for diabetes care applications

Liu, Y., Chen, Q., Li, Y., Bi, L., He, Z., Shao, C., Jin, L., Peng, R., & Zhang, X. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121015 · Cited by 12

Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling

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The endocrine FGFs axis: A systemic anti-fibrotic response that could prevent pulmonary fibrogenesis?

Ghanem, M., Archer, G., Crestani, B., & Mailleux, A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108669 · Cited by 12

Fibroblast growth factor 21 is associated with increased serum total antioxidant capacity and oxidized lipoproteins in humans with different stages of chronic kidney disease

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Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

Xu, J., Stanislaus, S., Chinookoswong, N., Lau, Y. Y., Hager, T., Patel, J., Ge, H., Weiszmann, J., Lu, S.-C., Graham, M., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00348.2009 · Cited by 340

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

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Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

Camporez, J. P., Jornayvaz, F. R., Petersen, M. C., Pesta, D. H., Guigni, B. A., Serr, J., Zhang, D., Kahn, M., Samuel, V. T., Jurczak, M. J., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1191 · Cited by 232

MECHANISMS IN ENDOCRINOLOGY: Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21

Iglesias, P., Selgas, R., Romero, S., & Díez, J. J. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0357 · Cited by 113

[The synergistic effect of FGF-21 and insulin on regulating glucose metabolism and its mechanism].

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