Cited by 326Cancer-related molecular mechanisms researchRNA Research and SplicingRNA and protein synthesis mechanisms

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Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions

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Zhang, Xun, Rice, Kimberley, Wang, Yingying, Chen, Wendy, Zhong, Ying, Nakayama, Yuki, Zhou, Yunli, Klibanski, Anne·2010·Endocrinology

DOI 10.1210/en.2009-0657PMC PMC2840681

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Abstract

Maternally expressed gene 3 (MEG3) is an imprinted gene highly expressed in the human pituitary. However, MEG3 expression is lost in human gonadotroph-derived pituitary adenomas and most human tumor cell lines. Expression of MEG3 in tumor cells results in growth suppression, p53 protein increase, and activation of p53 downstream targets. The MEG3 gene encodes a noncoding RNA of approximately 1700 nucleotides. There are 12 different MEG3 gene transcripts, generated by alternative splicing. They contain the common exons 1-3 and exons 8-10, but each uses one or more exons 4-7 in a different combination in the middle. MEG3 isoform expression patterns are tissue and cell type specific. Functionally, each isoform stimulates p53-mediated transactivation and suppresses tumor cell growth. We analyzed the secondary RNA folding structure of each MEG3 isoform, using the computer program mfold. All MEG3 RNA isoforms contain three distinct secondary folding motifs M1, M2, and M3. Deletion analysis showed that motifs M2 and M3 are important for p53 activation. Furthermore, a hybrid MEG3 RNA, containing a piece of artificially synthesized sequence different from the wild type but folding into a similar secondary structure, retained the functions of both p53 activation and growth suppression. These results support the hypothesis that a proper folding structure of the MEG3 RNA molecule is critical for its biological functions. This study establishes for the first time the structure-function relationship of a large noncoding RNA and provides a first look into the molecular mechanisms of the biological functions of a large noncoding RNA.

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Mfold web server for nucleic acid folding and hybridization prediction
Zuker, M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg595 · Cited by 13,404
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure
Mathews, D. H., Sabina, J., Zuker, M., & Turner, D. H. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.2700 · Cited by 3,795
The chemical repertoire of natural ribozymes
Doudna, J. A., & Cech, T. R. (2002) · Nature · doi:10.1038/418222a · Cited by 745
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Zhou, Y., Zhong, Y., Wang, Y., Zhang, X., Batista, D. L., Gejman, R., Ansell, P. J., Zhao, J. C., Weng, C., & Klibanski, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702029200 · Cited by 665
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Zhang, X., Zhou, Y., Mehta, K. R., Danila, D. C., Scolavino, S., Johnson, S. R., & Klibanski, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030222 · Cited by 436
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Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q
Miyoshi, N., Wagatsuma, H., Wakana, S., Shiroishi, T., Nomura, M., Aisaka, K., Kohda, T., Surani, M. A., Kaneko‐Ishino, T., & Ishino, F. (2000) · Genes to Cells · doi:10.1046/j.1365-2443.2000.00320.x · Cited by 385
The Dlk1 and Gtl2 genes are linked and reciprocally imprintedPreprint
Schmidt, J. V., Matteson, P. G., Jones, B. K., Guan, X.-J., & Tilghman, S. M. (2000) · Genes & Development · doi:10.1101/gad.14.16.1997 · Cited by 310
Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes
Kagami, M., Sekita, Y., Nishimura, G., Irie, M., Kato, F., Okada, M., Yamamori, S., Kishimoto, H., Nakayama, M., Tanaka, Y., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.56 · Cited by 291
Delta-like and Gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12
Takada, S., Tevendale, M., Baker, J., Georgiades, P., Campbell, E., Freeman, T. C., Johnson, M. H., Paulsen, M., & Ferguson‐Smith, A. C. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00704-1 · Cited by 226
Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19
Takada, S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.1.77 · Cited by 219

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Shahrokhshahi, A., Salehzadeh, A., Vaziri, H., & Moradi–Shoeili, Z. (2021) · Journal of the Chinese Chemical Society · doi:10.1002/jccs.202000516 · Cited by 2
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Zhang, M.-Y., & Guo, B. (2020) · Translational Cancer Research · doi:10.21037/tcr-19-2973 · Cited by 2
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Chaudhary, M., Maity, S., Soni, N., Dongre, S., Tiwari, A., & Bissa, B. (2025) · Academia molecular biology and genomics. · doi:10.20935/acadmolbiogen7802 · Cited by 1
Maternally Expressed Gene 3 (MEG3) LncRNA: The silent guardian against solid and hematological malignancies
Elemam, N. M., Rashwan, H. H., Zakaria, Z. I., Sweillam, J. H., Khalil, L. W., Ghonim, D. A., Seada, D. A., Kiriacos, C. J., Mansour, M., Hamdy, N. Μ., et al. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105233 · Cited by 1
Unifying and unique roles of non-coding RNA biomarkers in liver and heart fibrosis
Boichenko, V., Frolova, S., Voellenkle, C., Zaccagnini, G., Ferrero, P., Bassareo, P. P., Luciani, G. B., Gorelik, J., & Martelli, F. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119607 · Cited by 2
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Ali, O. S. M., Shaker, O. G., Sroor, W., & Abdeen, M. (2023) · Azhar International Journal of Pharmaceutical and Medical Sciences/Azhar International Journal of Pharmaceutical and Medical Sciences · doi:10.21608/aijpms.2023.113761.1102 · Cited by 1
lncRNA-miRNA-mRNA Interaction Networks Regulation in Hematological Malignancies
Prado-Garcı́a, H., Santiago, A. E. G., Romero‐Garcia, S., García-Hernández, A. P., Ruiz, V., Aquino‐Gálvez, A., Cebreros-Verdin, A., & Carlos‐Reyes, Á. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00010-x · Cited by 1
Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs
abed, H. S., Oghenemaro, E. F., Kubaev, A., Jeddoa, Z. M. A., RenukaJyothi, S., Sharma, S., Vashishth, R., Jabir, M. S., Jawad, S. F., & Zwamel, A. H. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01585-2 · Cited by 1
Structural architecture of the human long non-coding RNA-PAAN as a potential target for anti-influenza drug development
Ulanowska, I., Kierzek, R., Kierzek, E., & Soszynska-Jozwiak, M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110755 · Cited by 1
Beyond miRNAs: Role of Other Noncoding RNAs in Cancer
Redis, R. S., & Călin, G. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8444-8_10 · Cited by 1
Genome‐wide feature analysis of the sequence‐specific recognition in intermolecular interaction between TGF‐β pathway DNA and MEG3 lncRNA in human cancer
Cao, L., Xie, B., Cui, B., Chen, B., Ma, Z., Chen, X., Shen, X., & Cao, F. (2018) · Journal of Chemometrics · doi:10.1002/cem.3042 · Cited by 1
AnnoLnc: A One-Stop Portal to Systematically Annotate Novel Human Long Noncoding RNAs
Yang, D.-C., Lan, K., Ding, Y., & Gao, G. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1158-6_8 · Cited by 1
OCC-1D regulates Wnt signaling pathway: potential role of long noncoding RNA in colorectal cancer
Yousefi, F., Najafi, H., Behmanesh, M., & Soltani, B. M. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07110-5 · Cited by 1
Sequence and phylogenetic analysis revealed structurally conserved domains and motifs in lincRNA-p21Preprint
Maulik, A., Bandopadhyay, D., & Singh, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.24.436769 · Cited by 1
Long Non‐Coding RNAs and Their Roles in Cancer
Sánchez, Y., & Huarte, M. (2013) · Wiley eBooks · doi:10.1002/9781118300312.ch15
Análise da expressão de RNAs não codificadores longos em adenocarcinoma de pâncreas
Tahira, A. C. (2013) · doi:10.11606/t.46.2013.tde-10062013-145054
INXS, um longo RNA não codificador de proteínas mediador da apoptose
DeOcesano-Pereira, C. (2015) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2015.tde-20072015-144251
Noncoding RNAs as Therapeutic Targets
Szymański, M., & Barciszewski, J. (2010) · RNA technologies · doi:10.1007/978-3-642-12168-5_18
Genome-wide identification and evolutionary analysis of long non-coding RNAs in cereals
Sun, Y., Rogers, W. L., Devos, K. M., Cai, L., & Malmberg, R. L. (2016) · IEEE International Conference on Computational Advances in Bio and Medical Sciences · doi:10.1109/iccabs.2016.7802791
Implications of Long Noncoding RNAs in Cancer Epigenetics
Yang, T., Shi, Y., & Yildirim, E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811022-5.00021-8
Long non-coding RNAs as potential markers for occurrence, progression, and prognosis of gastric cancer
Li, F., Chen, Z., Tan, B., & Li, Y. (2020) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v28.i13.544
DNMT1 facilitates proliferation and metastasis of breast cancer by inducing MEG3 promoter methylation in MEG3/miR-494-3p/OTUD4 regulatory axisPreprint
Zhu, X., Lv, L., Wang, M., Fan, C., Lu, X., Jin, M., Li, S., & Wang, F. (2020) · doi:10.21203/rs.3.rs-27423/v2

Authors: Zhang, X., Rice, K., Wang, Y., Chen, W., Zhong, Y., Nakayama, Y., Zhou, Y., & Klibanski, A.
Affiliations: Harvard University (US)
Corresponding author: Klibanski, Anne
ORCID: Zhang, Xun
Wang, Yingying
Chen, Wendy
Zhong, Ying
Nakayama, Yuki
Zhou, Yunli
Klibanski, Anne
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2009-12-23
Volume: 151
Issue: 3
Pages: 939-947
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2009-0657
PMC: PMC2840681
OpenAlex: W2066815559
Cited by: 325
References: 19
Citations by year: 2026: 5 · 2025: 9 · 2024: 17 · 2023: 25 · 2022: 16 · 2021: 23 · 2020: 35 · 2019: 21 · 2018: 29 · 2017: 30 · 2016: 17 · 2015: 28 · 2014: 21 · 2013: 18 · 2012: 17
FWCI: 3.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Endocrinology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK040947, R01-DK-40947)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: MEG3, imprinted genes, non-coding RNA, RNA isoforms, alternative splicing, p53 activation, structure-function relationship, pituitary adenoma, tumor growth inhibition
MeSH terms: Base Sequence, Cell Line, Humans, Molecular Sequence Data, Nucleic Acid Conformation, Pituitary Neoplasms, Proteins, Structure-Activity Relationship, Gene Expression, Tumor Suppressor Protein p53, DNA, Complementary, RNA, Untranslated, RNA, Long Noncoding

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Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions

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