Acquisition of Sexual Receptivity: Roles of Chromatin Acetylation, Estrogen Receptor-α, and Ovarian Hormones
Open accessAbstract
Sexually naïve, hormone-primed, C57BL/6J female mice are not receptive to mating attempts by conspecific males. Repeated experience with sexually active males and concurrent treatment with estradiol and progesterone gradually increases female receptivity over the course of five trials to maximal levels. Ovarian hormones activate their cognate nuclear steroid receptors estrogen receptor-α and progesterone receptor to induce female sexual receptivity. Nuclear receptors recruit coactivators of transcription that include histone acetyltransferases to hormone responsive genes. In this set of studies, we found that the histone deacetylase inhibitor sodium butyrate enhances the experiential acquisition of receptivity. Evidence is provided that the actions of sodium butyrate on receptivity require activated estrogen receptor-α and progesterone.
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Butyrate supplementation in drinking water increased brain histone acetylation.
“This is in line with previous reports showing that butyrate supplementation in drinking water increased brain histone acetylation (Bonthuis et al., 2011;Minamiyama et al., 2004)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Bonthuis et al., 2011
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Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
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Epigenetic regulation in psychiatric disorders
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Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.
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“It is possible that blocking the dynamic removal of acetyl groups from histones with SB treatment could increase the expression of estradiol- and P-responsive genes important for experience acquired receptivity by increasing transcription or delaying silencing by corepressors (59, 60) (Fig.”
BackgroundDilworth, F. J., & Chambon, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204329 · Cited by 269 · see citing works
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Monoaminergic and Neuropeptidergic Neurons Have Distinct Expression Profiles of Histone Deacetylases
Takase, K., Oda, S., Kuroda, M., & Funato, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058473 · Cited by 47 · see citing works
- Authors
- Bonthuis, P. J., Patteson, J. K., & Rissman, E. F.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Rissman, Emilie F.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2011-06-07
- Volume
- 152
- Issue
- 8
- Pages
- 3172-3181
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC3138229
- OpenAlex
- W2032627906
- Cited by
- 37
- References
- 5
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Endocrinology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH057759)
- National Institute of General Medical Sciences (T32GM008715)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- female receptivity, mating behavior, estrogen receptor alpha, progesterone receptor, histone acetylation, histone deacetylase inhibition, sodium butyrate, estradiol, ovarian hormones, transcriptional coactivator, nuclear steroid receptors, sexual experience, female mice
- MeSH terms
- Acetylation, Animals, Butyrates, Chromatin, Female, Histones, Mice, Inbred C57BL, Progesterone, Sexual Behavior, Animal, Maze Learning, Estrogen Receptor alpha, Mice, Histone Deacetylase Inhibitors
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