Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription

Dilworth, F Jeffrey; Chambon, Pierre

doi:10.1038/sj.onc.1204329

Cited by 272Genomics and Chromatin DynamicsChromatin Remodeling and CancerEstrogen and related hormone effects

Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription

Dilworth, F Jeffrey, Chambon, Pierre·2001·Oncogene

DOI 10.1038/sj.onc.1204329

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Abstract

Recent advances in the field of in vitro chromatin assembly have led to in vitro transcription systems which reproduce in the test tube, in vivo characteristics of ligand-dependent transcriptional activation by nuclear receptors. Dissection of these systems has begun to provide us with information concerning the underlying molecular mechanisms. Through recruitment of coactivator proteins, nuclear receptors act first to remodel chromatin within the promoter region and then to recruit the transcriptional machinery to the promoter region in order to initiate transcription. Here we present a possible sequential mechanism for ligand-dependent transcriptional activation by nuclear receptors and discuss the in vitro and in vivo data that support this model.

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In the absence of ligand, transcription is turned off by RXR/RAR heterodimers bound to DNA and associated to corepressor complexes.
“In the absence of ligand, transcription is turned “off” by RXR/RAR heterodimers bound to DNA and associated to corepressor complexes”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
In the absence of ligand, the DNA-bound RARα subtype is associated with corepressors, which serve as adaptors recruiting high molecular weight complexes endowed with histone deacetylase (HDAC) activity.
“According to the current model of gene regulation by RARs ( 89 ), in the absence of ligand, the DNA-bound RAR ␣ subtype is associated with corepressors, which serve as adaptors recruiting high molecular weight complexes endowed with histone deacetylase (HDAC) activity ( 90 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
These complexes deacetylate lysine residues in the N-terminal tails of histones and maintain chromatin in a condensed, repressed state over the target promoter.
“These complexes deacetylate lysine residues in the N-terminal tails of histones and maintain chromatin in a condensed, repressed state over the target promoter ( 35, 89 ) ( Fig. 4A ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]
Activated RARs recruit the transcription machinery, including the multisubunit Mediator complex, RNA polymerase II, and the general transcription factors.
“Then, activated RARs recruit the transcription machinery, including the multisubunit Mediator complex, RNA polymerase II, and the general transcription factors ( 35, 89 ) ( Fig. 4B ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [89]

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Nuclear retinoid receptors and the transcription of retinoid-target genes
Bastien, J., & Rochette-Egly, C. (2004) · Gene · doi:10.1016/j.gene.2003.12.005 · Cited by 773 · see citing works
ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation
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The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1
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Transcriptional Enhancers in Animal Development and Evolution
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Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
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A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation
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Retracted
Retinoic acid receptors: From molecular mechanisms to cancer therapy
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Vitamin A and retinoid signaling: genomic and nongenomic effects
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Vitamin D Signaling, Infectious Diseases, and Regulation of Innate Immunity
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Rapid Actions of Steroid Receptors in Cellular Signaling Pathways
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Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse
Bourdeau, V., Deschênes, J., Métivier, R., Nagai, Y., Nguyen, D., Bretschneider, N., Gannon, F., White, J. H., & Mader, S. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0441 · Cited by 361 · see citing works
Nuclear receptors: integration of multiple signalling pathways through phosphorylation
Rochette-Egly, C. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00115-8 · Cited by 291 · see citing works
Cooperative interaction between retinoic acid receptor-α and estrogen receptor in breast cancerPreprint
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Vitamin D metabolism and signaling in the immune system
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ACTR/AIB1 Functions as an E2F1 Coactivator To Promote Breast Cancer Cell Proliferation and Antiestrogen Resistance
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Ligand-Dependent Nuclear Receptor Corepressor LCoR Functions by Histone Deacetylase-Dependent and -Independent Mechanisms
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Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs)
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Targeting of SWI/SNF chromatin remodelling complexes to estrogen‐responsive genes
Belandia, B., Orford, R. L., Hurst, H. C., & Parker, M. G. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf412 · Cited by 242 · see citing works
Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway in Cancer Prevention and Treatment
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DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex
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The nuclear receptor superfamily: a personal retrospect on the first two decades
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Self-citation
XPD Mutations Prevent TFIIH-Dependent Transactivation by Nuclear Receptors and Phosphorylation of RARα
Keriel, A., Stary, A., Sarasin, A., Rochette-Egly, C., & Egly, J.-M. (2002) · Cell · doi:10.1016/s0092-8674(02)00692-x · Cited by 192 · see citing works
A Ligand-Activated Nuclear Localization Signal in Cellular Retinoic Acid Binding Protein-II
Sessler, R. J., & Noy, N. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.026 · Cited by 192 · see citing works
Aberrant HOXC expression accompanies the malignant phenotype in human prostate.
Miller, G. J., Miller, H. L., van Bokhoven, A., Lambert, J. R., Werahera, P. N., Schirripa, O., Lucia, M. S., & Nordeen, S. K. (2003) · PubMed · Cited by 171 · see citing works
Role of Vitamin D in the Hygiene Hypothesis: The Interplay between Vitamin D, Vitamin D Receptors, Gut Microbiota, and Immune Response
Clark, A. P., & Mach, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00627 · Cited by 168 · see citing works
Steroid receptor coactivators 1, 2, and 3: Critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy
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Control of mammalian germ cell entry into meiosis
Feng, C.-W. A., Bowles, J., & Koopman, P. A. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.026 · Cited by 161 · see citing works
Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo
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DNA binding and protein interactions of the AHR/ARNT heterodimer that facilitate gene activation.
Swanson, H. I. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00066-2 · Cited by 158 · see citing works
Phosphorylation by p38MAPK and recruitment of SUG‐1 are required for RA‐induced RARγ degradation and transactivation
Giannì, M., Bauer, A., Garattini, E., Chambon, P., & Rochette‐Egly, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf374 · Cited by 151 · see citing works
Self-citation
Additional Sex Comb-like 1 (ASXL1), in Cooperation with SRC-1, Acts as a Ligand-dependent Coactivator for Retinoic Acid Receptor
Cho, Y.-S., Kim, E., Park, U., Sin, H., & Um, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512616200 · Cited by 145 · see citing works
Molecular switching of osteoblastogenesis versus adipogenesis: implications for targeted therapies
Takada, I., Kouzmenko, A., & Kato, S. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902915310 · Cited by 146 · see citing works
A methylation-mediator complex in hormone signalingPreprint
Xu, W., Cho, H. K., Kadam, S., Banayo, E., Anderson, S., Yates, J. R., Emerson, B. M., & Evans, R. M. (2004) · Genes & Development · doi:10.1101/gad.1141704 · Cited by 145 · see citing works
Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells
Bourdeau, V., Deschênes, J., Laperrière, D., Aid, M., White, J. H., & Mader, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm945 · Cited by 143 · see citing works
Glycogen Synthase Kinase-3 Interacts with and Phosphorylates Estrogen Receptor α and Is Involved in the Regulation of Receptor Activity
Medunjanin, S., Hermani, A., Servi, B. D., Grisouard, J., Rincke, G., & Mayer, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506758200 · Cited by 140 · see citing works
Suppression of PPAR Transactivation Switches Cell Fate of Bone Marrow Stem Cells from Adipocytes into Osteoblasts
Takada, I., Suzawa, M., Matsumoto, K., & Kato, S. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.034 · Cited by 139 · see citing works
Expression and function of androgen receptor coactivators in prostate cancer
Čulig, Z., Comuzzi, B., Steiner, H., Bartsch, G. H., & Hobisch, A. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.003 · Cited by 133 · see citing works
A Global View of Transcriptional Regulation by Nuclear Receptors: Gene Expression, Factor Localization, and DNA Sequence Analysis
Kininis, M., & Kraus, W. L. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06005 · Cited by 133 · see citing works
Ligand-Specific Dynamics of the Androgen Receptor at Its Response Element in Living Cells
Klokk, T. I., Kurys, P., Elbi, C., Nagaich, A. K., Hendarwanto, A., Slagsvold, T., Chang, C., Hager, G. L., & Saatcioglu, F. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01297-06 · Cited by 128 · see citing works
Transcriptional co-operativity between distant retinoic acid response elements in regulation ofCyp26A1inducibility
Loudig, O. D., MacLean, G. A., Dore, N. L., Luu, L., & Petkovich, M. P. (2005) · Biochemical Journal · doi:10.1042/bj20050874 · Cited by 127 · see citing works
Vitamin D deficiency in girls from South Brazil: a cross-sectional study on prevalence and association with vitamin D receptor gene variants
dos Santos, B. R., Mascarenhas, L. P. G., Satler, F., Boguszewski, M. C. D. S., & Spritzer, P. M. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-62 · Cited by 126 · see citing works
Retinoid Regulated Association of Transcriptional Co-regulators and the Polycomb Group Protein SUZ12 with the Retinoic Acid Response Elements of Hoxa1, RARβ2, and Cyp26A1 in F9 Embryonal Carcinoma Cells
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Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor
Dubbink, H. J., Hersmus, R., Verma, C. S., van der Korput, H. A. G. M., Berrevoets, C. A., van Tol, J., Ziel-van der Made, A. C. J., Brinkmann, A. O., Pike, A. C. W., & Trapman, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0375 · Cited by 118 · see citing works
Vitamin A regulation of gene expression: molecular mechanism of a prototype gene
McGrane, M. M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.10.006 · Cited by 115 · see citing works
The Biology of Acute Promyelocytic Leukemia and Its Impact on Diagnosis and Treatment
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Retinoid Receptors and Their Coregulators
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Nuclear receptors in cancer — uncovering new and evolving roles through genomic analysis
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Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development
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A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-κB-regulated promotersPreprint
Kassel, O., Schneider, S., Heilbock, C., Litfin, M., Göttlicher, M., & Herrlich, P. A. (2004) · Genes & Development · doi:10.1101/gad.322404 · Cited by 112 · see citing works
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Ligand-Specific Dynamics of the Progesterone Receptor in Living Cells and during Chromatin Remodeling In Vitro
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Navigating Steroid Hormone Receptors through the Nuclear Compartment
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A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARα to target promoters
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Vitamin A and the epigenome
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TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4
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Epigenomic Reorganization of the Clustered Hox Genes in Embryonic Stem Cells Induced by Retinoic Acid
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Retinoic acid signaling and mouse embryonic stem cell differentiation: Cross talk between genomic and non-genomic effects of RA
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TSG101 Interacts with Apoptosis-antagonizing Transcription Factor and Enhances Androgen Receptor-mediated Transcription by Promoting Its Monoubiquitination
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Retinoid treatment of skin diseases
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Polymeric Nanoparticles to Control the Differentiation of Neural Stem Cells in the Subventricular Zone of the Brain
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Chromatin Remodeling Complexes Interact Dynamically with a Glucocorticoid Receptor–regulated Promoter
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Dynamic Combinatorial Networks in Nuclear Receptor-mediated Transcription
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A Subset of Nuclear Receptor Coregulators Act as Coupling Proteins during Synthesis and Maturation of RNA Transcripts
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Coactivators in transcription initiation: here are your orders
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The Nuclear Transcription Factor RARα Associates with Neuronal RNA Granules and Suppresses Translation
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Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia
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Jumonji Represses Atrial Natriuretic Factor Gene Expression by Inhibiting Transcriptional Activities of Cardiac Transcription Factors
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Epigenetic Regulatory Mechanisms Distinguish Retinoic Acid-mediated Transcriptional Responses in Stem Cells and Fibroblasts
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Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy
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Selective Regulation of Vitamin D Receptor-Responsive Genes by TFIIH
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CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells
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Trifarotene: A Current Review and Perspectives in Dermatology
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PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues
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Transcription factors and neoplasia: vistas in novel drug design.
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Sequential Histone Modifications at Hoxd4 Regulatory Regions Distinguish Anterior from Posterior Embryonic Compartments
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Retinoic Acid Receptor Isotype Specificity in F9 Teratocarcinoma Stem Cells Results from the Differential Recruitment of Coregulators to Retinoic Acid Response Elements
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Swapping Function of Two Chromatin Remodeling Complexes
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Protein kinases and the proteasome join in the combinatorial control of transcription by nuclear retinoic acid receptors
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Crosstalk between Vitamin D Metabolism, VDR Signalling, and Innate Immunity
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Authors: Dilworth, F. J., & Chambon, P.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Dilworth, F Jeffrey
Chambon, Pierre
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2001-05-28
Volume: 20
Issue: 24
Pages: 3047-3054
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1204329
OpenAlex: W2315037039
Cited by: 269
References: 83
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 9 · 2013: 9 · 2012: 10
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: nuclear receptors, chromatin remodeling, transcriptional coactivator, transcription initiation, in vitro transcription system, chromatin assembly
MeSH terms: Animals, Chromatin, Humans, Models, Biological, Transcription, Genetic, Trans-Activators, Receptors, Cytoplasmic and Nuclear

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Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription

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