Cited by 360Sperm and Testicular FunctionHormonal and reproductive studiesAdrenal Hormones and Disorders

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Direct Inhibitory Effect of Glucocorticoids upon Testicular Luteinizing Hormone Receptor and Steroidogenesis in Vivo and in Vitro *

BAMBINO, THOMAS H., HSUEH, AARON J. W.·1981·Endocrinology

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Abstract

The direct effects of glucocorticoids on testicular LH receptor content and steroidogenesis were studied in vivo and in vitro. Immature hypophysectomized rats were treated with varying doses of dexamethasone, corticosterone, or a synthetic progestin, 17,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione (R5020). Some animals were also treated concomitantly with FSH to prevent the hypophysectomy-induced decrease in testis functions. At the end of 5 days of treatment, testicular LH/hCG receptor content was measured by [125I]hCG binding assay while steroidogenic responsiveness was measured by in vitro incubation of testes. Dexamethasone decreased testicular LH receptor in control and FSH-treated hypophysectomized rats in doses as low as 10 microgram/day, whereas corticosterone (10 microgram/day) decreased testicular LH receptor in the FSH-treated rats but had no effect in rats not treated with FSH. In contrast, R5020 had no effect on testicular LH receptor content. In vivo treatment of hypophysectomized rats with FSH increased both basal and hCG-stimulated production of androstanediol in vitro. In contrast, concomitant treatment with dexamethasone, but not R5020, decreased both basal and hCG-stimulated testicular androstanediol production. The direct effect of glucocorticoids on testicular steroidogenic potentials was also studied in primary culture of testicular cells obtained from adult hypophysectomized rats. Treatment of cultured testicular cells wtih hCG increased testosterone…

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Authors: BAMBINO, T. H., & HSUEH, A. J. W.
Affiliations: University of California San Diego (US)
ORCID: HSUEH, AARON J. W.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1981-06
Volume: 108
Issue: 6
Pages: 2142-2148
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo-108-6-2142
OpenAlex: W2050045288
Cited by: 360
References: 36
Citations by year: 2026: 4 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 2
FWCI: 11.41
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, luteinizing hormone receptor, testicular steroidogenesis, dexamethasone, corticosterone, R5020, progestins, hypophysectomy, follicle-stimulating hormone, androstanediol, testosterone production, testicular cells
MeSH terms: Androgens, Animals, Corticosterone, Dexamethasone, Follicle Stimulating Hormone, Glucocorticoids, Chorionic Gonadotropin, Humans, Hypophysectomy, Male, Promegestone, Receptors, Cell Surface, Receptors, LH, Testis, Time Factors, Rats

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Direct Inhibitory Effect of Glucocorticoids upon Testicular Luteinizing Hormone Receptor and Steroidogenesis in Vivo and in Vitro *

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