The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Direct Inhibitory Effect of Glucocorticoids upon Testicular Luteinizing Hormone Receptor and Steroidogenesis in Vivo and in Vitro *
Abstract
The direct effects of glucocorticoids on testicular LH receptor content and steroidogenesis were studied in vivo and in vitro. Immature hypophysectomized rats were treated with varying doses of dexamethasone, corticosterone, or a synthetic progestin, 17,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione (R5020). Some animals were also treated concomitantly with FSH to prevent the hypophysectomy-induced decrease in testis functions. At the end of 5 days of treatment, testicular LH/hCG receptor content was measured by [125I]hCG binding assay while steroidogenic responsiveness was measured by in vitro incubation of testes. Dexamethasone decreased testicular LH receptor in control and FSH-treated hypophysectomized rats in doses as low as 10 microgram/day, whereas corticosterone (10 microgram/day) decreased testicular LH receptor in the FSH-treated rats but had no effect in rats not treated with FSH. In contrast, R5020 had no effect on testicular LH receptor content. In vivo treatment of hypophysectomized rats with FSH increased both basal and hCG-stimulated production of androstanediol in vitro. In contrast, concomitant treatment with dexamethasone, but not R5020, decreased both basal and hCG-stimulated testicular androstanediol production. The direct effect of glucocorticoids on testicular steroidogenic potentials was also studied in primary culture of testicular cells obtained from adult hypophysectomized rats. Treatment of cultured testicular cells wtih hCG increased testosterone…
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“Moreover, increased corticosterone levels have been correlated to the inhibition of testosterone biosynthesis (28).”
From Puberty Blocker, Leuprolide, Reduces Sex Differences in Rough-and-Tumble Play and Anxiety-like Behavior in Juvenile Rats (2024) · cites this paper as [28]
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Cites
Enzymatic iodination of polypeptides with 125I to high specific activity
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PRODUCTION OF BOTH PROLACTIN AND GROWTH HORMONE BY CLONAL STRAINS OF RAT PITUITARY TUMOR CELLS
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General Presence of Glucocorticoid Receptors in Mammalian Tissues1
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Cortisol-Induced Suppression of Plasma Testosterone in Normal Adult Males
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Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541
Reproduction and Resistance to Stress: When and How
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Mechanisms of stress: A dynamic overview of hormonal and behavioral homeostasis
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THE IMPACT OF PREDATOR-INDUCED STRESS ON THE SNOWSHOE HARE CYCLE
Boonstra, R., Hik, D. S., Singleton, G. R., & Tinnikov, A. A. (1998) · Ecological Monographs · doi:10.1890/0012-9615(1998)068[0371:tiopis]2.0.co;2 · Cited by 587
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Metadata
- Authors
- BAMBINO, T. H., & HSUEH, A. J. W.
- Affiliations
- University of California San Diego (US)
- ORCID
- HSUEH, AARON J. W.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1981-06
- Volume
- 108
- Issue
- 6
- Pages
- 2142-2148
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2050045288
- Cited by
- 360
- References
- 36
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 2
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, luteinizing hormone receptor, testicular steroidogenesis, dexamethasone, corticosterone, R5020, progestins, hypophysectomy, follicle-stimulating hormone, androstanediol, testosterone production, testicular cells
- MeSH terms
- Androgens, Animals, Corticosterone, Dexamethasone, Follicle Stimulating Hormone, Glucocorticoids, Chorionic Gonadotropin, Humans, Hypophysectomy, Male, Promegestone, Receptors, Cell Surface, Receptors, LH, Testis, Time Factors, Rats
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