CoChat
Sign Up
Cited by 360Sperm and Testicular FunctionHormonal and reproductive studiesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Direct Inhibitory Effect of Glucocorticoids upon Testicular Luteinizing Hormone Receptor and Steroidogenesis in Vivo and in Vitro *

BAMBINO, THOMAS H., HSUEH, AARON J. W.·1981·Endocrinology
DOI 10.1210/endo-108-6-2142
Open this paper in CoChat — free account

Abstract

The direct effects of glucocorticoids on testicular LH receptor content and steroidogenesis were studied in vivo and in vitro. Immature hypophysectomized rats were treated with varying doses of dexamethasone, corticosterone, or a synthetic progestin, 17,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione (R5020). Some animals were also treated concomitantly with FSH to prevent the hypophysectomy-induced decrease in testis functions. At the end of 5 days of treatment, testicular LH/hCG receptor content was measured by [125I]hCG binding assay while steroidogenic responsiveness was measured by in vitro incubation of testes. Dexamethasone decreased testicular LH receptor in control and FSH-treated hypophysectomized rats in doses as low as 10 microgram/day, whereas corticosterone (10 microgram/day) decreased testicular LH receptor in the FSH-treated rats but had no effect in rats not treated with FSH. In contrast, R5020 had no effect on testicular LH receptor content. In vivo treatment of hypophysectomized rats with FSH increased both basal and hCG-stimulated production of androstanediol in vitro. In contrast, concomitant treatment with dexamethasone, but not R5020, decreased both basal and hCG-stimulated testicular androstanediol production. The direct effect of glucocorticoids on testicular steroidogenic potentials was also studied in primary culture of testicular cells obtained from adult hypophysectomized rats. Treatment of cultured testicular cells wtih hCG increased testosterone…

Overview

Integrity signals

Registry

Crossref · 10.1210/endo-108-6-2142

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 360

Related

See all

Metadata

Authors
BAMBINO, T. H., & HSUEH, A. J. W.
Affiliations
University of California San Diego (US)
ORCID
HSUEH, AARON J. W.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1981-06
Volume
108
Issue
6
Pages
2142-2148
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo-108-6-2142
OpenAlex
W2050045288
Cited by
360
References
36
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 8 · 2012: 2
FWCI
11.41
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
glucocorticoids, luteinizing hormone receptor, testicular steroidogenesis, dexamethasone, corticosterone, R5020, progestins, hypophysectomy, follicle-stimulating hormone, androstanediol, testosterone production, testicular cells
MeSH terms
Androgens, Animals, Corticosterone, Dexamethasone, Follicle Stimulating Hormone, Glucocorticoids, Chorionic Gonadotropin, Humans, Hypophysectomy, Male, Promegestone, Receptors, Cell Surface, Receptors, LH, Testis, Time Factors, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review