The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human Platelet-Derived Transforming Growth Factor-β Stimulates Parameters of Bone Growth in Fetal Rat Calvariae*
Abstract
Human platelet-derived transforming growth factor type beta (TGF beta) is mitogenic for fetal rat calvariae in serum-free organ culture. It enhances DNA synthesis in short (24-h) and long (48- to 96-h) term cultures, but produces no significant stimulatory effects on bone collagen synthesis or alkaline phosphatase activity (two parameters of differentiated osteoblastic cell-type function) when present continuously in culture. Transitory treatment with TGF beta, however, induces a subsequent stimulation of collagen and noncollagen protein synthesis that depends on prior cell replication, suggesting an increase in the number of newly differentiated bone cells. In addition, TGF beta increases prostaglandin release, but this effect is probably unrelated to its mitogenic function. TGF beta activity is also found in culture medium conditioned by fetal rat calvariae, and the bone-derived factor produces effects similar to those of the human platelet factor. This polypeptide, therefore, may have an important function in early stages of bone development as well as bone repair after trauma-induced platelet degranulation.
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Citations
Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Self-citationRole of osteoblasts in hormonal control of bone resorption—A hypothesis
Rodan, G. A., & Martin, T. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409454 · Cited by 982
Cited by
Joyce, M. E., Roberts, A. B., Sporn, M. B., & Bolander, M. E. (1990) · The Journal of cell biology · doi:10.1083/jcb.110.6.2195 · Cited by 733
Transforming Growth Factor-β1 to the Bone
Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710
In Vivo Stimulation of Bone Formation by Transforming Growth Factor-β
NODA, M., & CAMILLIERE, J. J. (1989) · Endocrinology · doi:10.1210/endo-124-6-2991 · Cited by 578
The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro
Canalis, E. (1996) · Bone · doi:10.1016/8756-3282(96)00080-4 · Cited by 498
Self-citationBone cell biology: The regulation of development, structure, and function in the skeleton
Marks, S. C., & Popoff, S. N. (1988) · American Journal of Anatomy · doi:10.1002/aja.1001830102 · Cited by 477
Metadata
- Authors
- CENTRELLA, M., MASSAGUÉ, J., & CANALIS, E.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1986-11
- Volume
- 119
- Issue
- 5
- Pages
- 2306-2312
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1974142861
- Cited by
- 197
- References
- 2
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- CENTRELLA, M., MASSAGUÉ, J., & CANALIS, E. (1986). Human Platelet-Derived Transforming Growth Factor-β Stimulates Parameters of Bone Growth in Fetal Rat Calvariae*. Endocrinology. https://doi.org/10.1210/endo-119-5-2306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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