The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
Abstract
Interleukin-1 (IL-1) is a cytokine that mediates the acute phase reaction. Many of the actions of IL-1 involve direct effects on the central nervous system. However, IL-1 has not previously been identified as an intrinsic component within the brain, except in glial cells. An antiserum directed against human IL-1β was used to stain the human brain immunohistochemically for IL-1β-like immunoreactive neural elements. IL-1β-immunoreactive fibers were found innervating the key endocrine and autonomic cell groups that control the central components of the acute phase reaction. These results indicate that IL-1 may be an intrinsic neuromodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.
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Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
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Self-citationInterleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor
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Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1
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Interleukin 1 of the central nervous system is produced by ameboid microglia.
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Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs
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Cited by
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Biological basis of the behavior of sick animals
Hart, B. L. (1988) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(88)80004-6 · Cited by 2,223
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
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Immune-neuro-endocrine interactions: facts and hypotheses.
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Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
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Metadata
- Authors
- Breder, C. D., Dinarello, C. A., & Saper, C. B.
- Venue
- Science
- Published
- 1988-04-15
- Volume
- 240
- Issue
- 4850
- Pages
- 321-324
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047817815
- Cited by
- 758
- References
- 6
- FWCI
- 52.42
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
