Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works

Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor

Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504 · see citing works

Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1

Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987) · Science · doi:10.1126/science.2443979 · Cited by 1,151 · see citing works

Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells

Bernton, E. W., Beach, J. E., Holaday, J. W., Smallridge, R. C., & Fein, H. G. (1987) · Science · doi:10.1126/science.2821620 · Cited by 671 · see citing works

The immune system as a sensory organ.

Blalock, J. E. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.3.1067 · Cited by 554 · see citing works

Catecholaminergic Modulation of Corticotropin-Releasing Factor and Adrenocorticotropin Secretion

Plotsky, P. M., Cunningham, E. T., & Widmaier, E. P. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-4-437 · Cited by 530 · see citing works

Immunoregulation mediated by the sympathetic nervous system

Besedovsky, H. O., del Rey, A., Sorkin, E., Prada, M. D., & Keller, H. H. (1979) · Cellular Immunology · doi:10.1016/0008-8749(79)90129-1 · Cited by 488 · see citing works

The Neuropsychiatric Effects of Treatment with Interleukin-2 and Lymphokine-Activated Killer Cells

Denicoff, K. D., RUBINOW, D. R., PAPA, M. Z., SIMPSON, C., SEIPP, C. A., LOTZE, M. T., Chang, A. E., ROSENSTEIN, D., & Rosenberg, S. A. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-293 · Cited by 456 · see citing works

The Immune Response Evokes Changes in Brain Noradrenergic Neurons

Besedovsky, H. O., del Rey, A., Sorkin, E., Prada, M. D., Burri, R., & Honegger, C. G. (1983) · Science · doi:10.1126/science.6867729 · Cited by 445 · see citing works

Stress and the Mesocorticolimbic Dopamine Systemsa

ROTH, R. H., TAM, S., IDA, Y., YANG, J., & DEUTCH, A. Y. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42102.x · Cited by 342 · see citing works

INTERLEUKIN-6 STIMULATES ANTERIOR PITUITARY HORMONE RELEASEIN VITRO.

Spangelo, B. L., Judd, A. M., Isakson, P. C., & MacLeod, R. M. (1989) · Endocrinology · doi:10.1210/endo-125-1-575 · Cited by 320 · see citing works

Systematic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone

Dunn, A. J. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90522-x · Cited by 297 · see citing works

In the Mouse, the Activation of the Hypothalamic Pituitary-Adrenal Axis by a Lipopolysaccharide (Endotoxin) Is Mediated through Interleukin-1*

RIVIER, C. L., Chizzonite, R., & VALE, W. W. (1989) · Endocrinology · doi:10.1210/endo-125-6-2800 · Cited by 273 · see citing works

Psychoneuroimmunology, 2nd ed.

Ader, R., Felten, D. L., & Cohen, N. (1991) · Cited by 272 · see citing works

Innervation of Lymphoid Tissue

Felten, S. Y., & Felten, D. L. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-043780-1.50006-3 · Cited by 203 · see citing works

Psychoneuroimmunology

(1991) · Elsevier eBooks · doi:10.1016/c2013-0-10269-3 · Cited by 195 · see citing works

Interleukin-1 induces changes in norepinephrine metabolism in the rat brain

Kabiersch, A., del Rey, A., Honegger, C. G., & Besedovsky, H. O. (1988) · Brain Behavior and Immunity · doi:10.1016/0889-1591(88)90028-1 · Cited by 182 · see citing works

Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system

Araujo, D. M., Lapchak, P. A., Collier, B., & Quirion, R. (1989) · Brain Research · doi:10.1016/0006-8993(89)91104-9 · Cited by 177 · see citing works

Stress‐and Endotoxin‐Induced Increases in Brain Tryptophan and Serotonin Metabolism Depend on Sympathetic Nervous System Activity

Dunn, A. J., & Welch, J. E. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb06359.x · Cited by 162 · see citing works

Interleukin 1 and interleukin 2 enhance proopiomelanocortin gene expression in pituitary cells.

Brown, S. L., Smith, L. R., & Blalock, J. E. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.10.3181 · Cited by 149 · see citing works

Effects of recombinant human interleukin-1α, -1β, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20

Fukata, J., Usui, T., Naitoh, Y., Nakai, Y., & Imura, H. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1220033 · Cited by 146 · see citing works

Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses.

Sundar, S. K., Becker, K. J., Cierpial, M. A., Carpenter, M. D., Rankin, L. A., Fleener, S. L., Ritchie, J., Simson, P. E., & Weiss, J. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6398 · Cited by 146 · see citing works

The role of interleukin-1 and tumor necrosis factor α in the neurochemical and neuroendocrine responses to endotoxin

Dunn, A. J. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90148-q · Cited by 143 · see citing works

Virus infection as a stressor: Influenza virus elevates plasma concentrations of corticosterone, and brain concentrations of MHPG and tryptophan

Dunn, A. J., Powell, M. L., Meitin, C. A., & Small, P. A. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90078-4 · Cited by 142 · see citing works

Anterior pituitary hormone control by interleukin 2.

Karanth, S., & McCann, S. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2961 · Cited by 138 · see citing works

Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus

Tancredi, V., Zona, C., Velotti, F., Eusebi, F., & Santoni, A. (1990) · Brain Research · doi:10.1016/0006-8993(90)91331-a · Cited by 121 · see citing works

Behavioural and ECoG spectrum changes induced by intracerebral infusion of interferons and interleukin 2 in rats are antagonized by naloxone

Sarro, G. D., Masuda, Y., Ascioti, C., Audino, M. G., & Nisticò, G. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90057-x · Cited by 117 · see citing works

Cytokines Stimulate the CRH but Not the Vasopressin Neuronal System: Evidence for a Median Eminence Site of Interleukin-6 Action

Spinedi, E., Hadid, R., Daneva, T., & Gaillard, R. C. (2008) · Neuroendocrinology · doi:10.1159/000126207 · Cited by 115 · see citing works

Immunoautoradiographic localization of interleukin 2-like immunoreactivity and interleukin 2 receptors (Tac antigen-like immunoreactivity) in the rat brain

Lapchak, P. A., Araujo, D. M., Quirion, R., & Beaudet, A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90259-q · Cited by 113 · see citing works

Re-investigation of the innervation of the thymus gland in mice and rats

Nance, D. M., Hopkins, D. A., & Bieger, D. (1987) · Brain Behavior and Immunity · doi:10.1016/0889-1591(87)90016-x · Cited by 105 · see citing works

Alterations of monoamines in specific central autonomic nuclei following immunization in mice

Carlson, S. L., Felten, D. L., Livnat, S., & Felten, S. Y. (1987) · Brain Behavior and Immunity · doi:10.1016/0889-1591(87)90006-7 · Cited by 90 · see citing works

Multisystem Regulation of Performance Deficits Induced by Stressors: An Animal Model of Depression

Anisman, H., Zalcman, S., Shanks, N. M., & Zacharko, R. M. (2003) · Humana Press eBooks · doi:10.1385/0-89603-177-2:1 · Cited by 86 · see citing works

Suppression of splenic macrophage interleukin-1 secretion following intracerebroventricular injection of interleukin-1β: Evidence for pituitary-adrenal and sympathetic control

Brown, R., Zuo, L., Vriend, C. Y., Nirula, R., Janz, L., Falk, J., Nance, D. M., Dyck, D. G., & Greenberg, A. H. (1991) · Cellular Immunology · doi:10.1016/0008-8749(91)90008-y · Cited by 85 · see citing works

Hypothalamic-immune interactions. II. The effect of hypothalamic lesions on the ability of adherent spleen cells to limit lymphocyte blastogenesis.

Roszman, T. L., Cross, R. J., Brooks, W. H., & Markesbery, W. R. (1982) · PubMed · Cited by 84 · see citing works

Interleukin-1β and Interleukin-6 Specifically Increase the Release of Prostaglandin E 2 from Rat Hypothalamic Explants in vitro

Navarra, P., Pozzoli, G., Brunetti, L., Ragazzoni∘, E., Besser, M., & Grossman, A. B. (2008) · Neuroendocrinology · doi:10.1159/000126209 · Cited by 83 · see citing works

Increased biogenic amine release in mouse hypothalamus following immunological challenge: antagonism by indomethacin

Mefford, I. N., & Heyes, M. P. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90136-b · Cited by 77 · see citing works

A Central Mechanism Is Involved in the Secretion of ACTH in Response to IL-6 in Rats: Comparison to and Interaction with IL-1β

Matta, S. G., Weatherbee, J., & Sharp, B. M. (2008) · Neuroendocrinology · doi:10.1159/000126269 · Cited by 71 · see citing works

Neuroendocrine regulation of immune processes: Change in circulating corticosterone levels induced by the primary antibody response in mice

Shek, P. N., & Sabiston, B. H. (1983) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(83)90068-1 · Cited by 69 · see citing works

Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus

Bindoni, M., Perciavalle, V., Berretta, S., Belluardo, N., & Diamantstein, T. (1988) · Brain Research · doi:10.1016/0006-8993(88)90578-1 · Cited by 66 · see citing works

The effects of stress on splenic immune function are mediated by the splenic nerve

Weihua, W., Vriend, C. Y., Wetmore, L., Gartner, J. G., Greenberg, A. H., & Nance, D. M. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90044-c · Cited by 66 · see citing works

Indomethacin prevents increased catecholamine turnover in rat brain following systemic endotoxin challenge

Masana, M. I., Heyes, M. P., & Mefford, I. N. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90012-6 · Cited by 57 · see citing works

Multiunit electrical activity in conscious rats during an immune response.

Saphier, D., Abramsky, O., Mor, G., & Ovadia, H. (1987) · Brain, behavior, and immunity · doi:10.1016/0889-1591(87)90005-5 · Cited by 52 · see citing works

Time-dependent variations of central norepinephrine and dopamine following antigen administration

Zalcman, S., Shanks, N. M., & Anisman, H. (1991) · Brain Research · doi:10.1016/0006-8993(91)90117-e · Cited by 39 · see citing works

The effects of lesions in the lateral septal and hippocampal areas on the humoral immune response of adult female rats

Nance, D. M., Rayson, D., & Carr, R. I. (1987) · Brain Behavior and Immunity · doi:10.1016/0889-1591(87)90032-8 · Cited by 36 · see citing works

Action of interleukin-2 and interleukin-4 on CRF mRNA in the hypothalamus and POMC mRNA in the anterior pituitary

Harbuz, M. S., Stephanou, A., Knight, R. A., Chover-Gonzalez, A. J., & Lightman, S. L. (1992) · Brain Behavior and Immunity · doi:10.1016/0889-1591(92)90044-o · Cited by 30 · see citing works

Modulation of the mitogenic response of lymphocytes from young and aged individuals by prostaglandins and indomethacin

Rao, K. M. K., Schwartz, S. A., & Good, R. A. (1979) · Cellular Immunology · doi:10.1016/0008-8749(79)90108-4 · Cited by 30 · see citing works

Cytokine interactions in the central nervous system.

Hofman, F. M., & Dr, H. (1991) · PubMed · Cited by 18 · see citing works

Neurohormonal Modulation of Natural Resistance to a Murine Lymphoma 2

Greenberg, A. H., Dyck, D. G., Sandler, L. S., Pohajdak, B., Dresel, K. M., & Grant, D. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/72.3.653 · Cited by 17 · see citing works

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297 · see citing works

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805 · see citing works

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791 · see citing works

Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.

Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637 · see citing works

Endotoxin produces a depressive-like episode in rats

Yirmiya, R. (1996) · Brain Research · doi:10.1016/0006-8993(95)01415-2 · Cited by 604 · see citing works

Effects of prenatal infection on brain development and behavior: A review of findings from animal models

Boksa, P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.03.005 · Cited by 603 · see citing works

Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection

Silverman, M. N., Pearce, B. D., Biron, C. A., & Miller, A. H. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.41 · Cited by 506 · see citing works

Depression, stress and immunological activation: The role of cytokines in depressive disorders

Connor, T. J., & Leonard, B. E. (1998) · Life Sciences · doi:10.1016/s0024-3205(97)00990-9 · Cited by 478 · see citing works

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460 · see citing works

Cytokines as mediators of depression: what can we learn from animal studies?

Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works

The effects of acute stress on episodic memory: A meta-analysis and integrative review.

Shields, G. S., Sazma, M. A., McCullough, A. M., & Yonelinas, A. P. (2017) · Psychological Bulletin · doi:10.1037/bul0000100 · Cited by 450 · see citing works

Physiological and pathological roles of interleukin-6 in the central nervous system

Gruol, D. L., & Nelson, T. E. (1997) · Molecular Neurobiology · doi:10.1007/bf02740665 · Cited by 404 · see citing works

Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events

Maes, M., Lin, A.-H., Delmeire, L., Van Gastel, A., Kenis, G., De Jongh, R., & Bosmans, E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00131-0 · Cited by 387 · see citing works

Interleukin-6 expression and regulation in astrocytes

Wagoner, N. J. V., & Benveniste, E. N. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00187-3 · Cited by 363 · see citing works

Cerebrospinal Cytokine Levels in Patients with Acute Depression

Levine, J., Barak, Y., Chengappa, K. N. R., Rapoport, A., Rebey, M., & Barak, V. (1999) · Neuropsychobiology · doi:10.1159/000026615 · Cited by 354 · see citing works

Effects of cytokines and infections on brain neurochemistry

Dunn, A. J. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.04.002 · Cited by 336 · see citing works

Dopamine, a neurotransmitter, influences the immune system

Basu, S., & Dasgupta, P. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00176-9 · Cited by 335 · see citing works

The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans

Wichers, M., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003103 · Cited by 329 · see citing works

Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: A meta-analysis

Mazza, M. G., Lucchi, S., Tringali, A. G. M., Rossetti, A., Botti, E. R., & Clerici, M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.012 · Cited by 326 · see citing works

A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities

Pace, T. W. W., & Heim, C. M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.003 · Cited by 321 · see citing works

Inflammation and Schizophrenia

Kirkpatrick, B. W., & Miller, B. J. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt141 · Cited by 318 · see citing works

Effects of Cytokines on Cerebral Neurotransmission: Comparison with the Effects of Stress

Dunn, A. J., Wang, J., & Ando, T. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_8 · Cited by 316 · see citing works

The immune system and memory consolidation: a role for the cytokine IL-1β

Pugh, C., Fleshner, M., Watkins, L. R., Maier, S. F., & Rudy, J. W. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00048-8 · Cited by 311 · see citing works

Dopamine, Immunity, and Disease

Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J. R., & Gaskill, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000618 · Cited by 319 · see citing works

Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders

Müller, N., & Ackenheil, M. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(97)00179-6 · Cited by 304 · see citing works

The influence of microglia on the pathogenesis of Parkinson's disease

Long-Smith, C. M., Sullivan, A. M., & Nolan, Y. M. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.08.001 · Cited by 296 · see citing works

Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines

Ling, Z. D., Potter, E. D., Lipton, J. W., & Carvey, P. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6715 · Cited by 292 · see citing works

Cascading effects of stressors and inflammatory immune system activation: Implications for major depressive disorder

Anisman, H. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0902 · Cited by 292 · see citing works

A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression

Miura, H., Ozaki, N., Sawada, M., Isobe, K., Ohta, T., & Nagatsu, T. (2008) · Stress · doi:10.1080/10253890701754068 · Cited by 282 · see citing works

Role of IL-6 in the regulation of neuronal development, survival and function

Kummer, K. K., Zeidler, M., Kalpachidou, T., & Kress, M. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155582 · Cited by 281 · see citing works

PTSD is associated with an excess of inflammatory immune activities

Gill, J. M., Saligan, L., Woods, S., & Page, G. (2009) · Perspectives in Psychiatric Care · doi:10.1111/j.1744-6163.2009.00229.x · Cited by 271 · see citing works

Inflammatory processes in schizophrenia: A promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond

Meyer, U., Schwarz, M., & Müller, N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.003 · Cited by 255 · see citing works

Autistic disorder and viral infections

Libbey, J., Sweeten, T., McMahon, W., & Fujinami, R. (2005) · Journal of NeuroVirology · doi:10.1080/13550280590900553 · Cited by 252 · see citing works

Developmental vitamin D deficiency causes abnormal brain development

Eyles, D. W., Feron, F. P., Cui, X., Kesby, J. P., Harms, L. R., Ko, P., McGrath, J. J., & Burne, T. H. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.015 · Cited by 248 · see citing works

Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?

Jeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247 · see citing works

The role of cytokines in modulating learning and memory and brain plasticity

Bourgognon, J.-M., & Cavanagh, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820979802 · Cited by 247 · see citing works

Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes

Sukoff Rizzo, S. J., Neal, S. J., Hughes, Z. A., Beyna, M., Rosenzweig-Lipson, S., Moss, S. J., & Brandon, N. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.120 · Cited by 241 · see citing works

Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer

Huang, A., Fuchs, D., Widner, B., Glover, C., Henderson, D. C., & Allen-Mersh, T. G. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600336 · Cited by 241 · see citing works

Synergistic Effects of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α: Central Monoamine, Corticosterone, and Behavioral Variations

Brebner, K., Hayley, S., Zacharko, R., Merali, Z., & Anisman, H. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00166-9 · Cited by 214 · see citing works

Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10

Voorhees, J. L., Tarr, A. J., Wohleb, E. S., Godbout, J. P., Mo, X., Sheridan, J. F., Eubank, T. D., & Marsh, C. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058488 · Cited by 236 · see citing works

Aggression, Social Stress, and the Immune System in Humans and Animal Models

Takahashi, A., Flanigan, M. E., McEwen, B. S., & Russo, S. J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00056 · Cited by 234 · see citing works

Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study

Linthorst, A., Flachskamm, C., Müller-Preuss, P., Holsboer, F., & Reul, J. M. H. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02920.1995 · Cited by 233 · see citing works

Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization

Steiner, J. H., Mawrin, C., Ziegeler, A., Bielau, H., Ullrich, O., Bernstein, H., & Bogerts, B. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0090-8 · Cited by 230 · see citing works

On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?

Roohi, E., Jaafari, N., & Hashemian, F. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02100-7 · Cited by 236 · see citing works

Schizophrenia, autoimmunity and immune system dysregulation: A comprehensive model updated and revisited

Strous, R. D., & Shoenfeld, Y. (2006) · Journal of Autoimmunity · doi:10.1016/j.jaut.2006.07.006 · Cited by 225 · see citing works

Attention-deficit/hyperactivity disorder and inflammation: what does current knowledge tell us? A systematic review

Anand, D., Colpo, G. D., Zeni, G., Zeni, C. P., & Teixeira, A. L. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00228 · Cited by 221 · see citing works

T-helper-1 and T-helper-2 Responses in Psychiatric Disorders

Schwarz, M., Chiang, S. S. W., Müller, N., & Ackenheil, M. (2001) · Brain Behavior and Immunity · doi:10.1006/brbi.2001.0647 · Cited by 220 · see citing works

Glial cells as key players in schizophrenia pathology: recent insights and concepts of therapy

Bernstein, H., Steiner, J. H., Guest, P. C., Dobrowolny, H., & Bogerts, B. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.035 · Cited by 203 · see citing works

Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology

Zhang, X. Y., Zhou, D. F., Zhang, P. Y., Wu, G. Y., Cao, L. Y., & Shen, Y. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00296-1 · Cited by 199 · see citing works

Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: A systematic review

Misiak, B., Stańczykiewicz, B., Kotowicz, K., RYBAKOWSKI, J. K., Samochowiec, J., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.015 · Cited by 198 · see citing works

An assessment of the effects of central interleukin-1β, -2, -6, and tumor necrosis factor-α administration on some behavioural, neurochemical, endocrine and immune parameters in the rat

Connor, T., Song, C., Leonard, B. E., Merali, Z., & Anisman, H. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00533-2 · Cited by 195 · see citing works

Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: Further evidence for disease course-related immune alterations?

Busse, S., Busse, M., Schiltz, K., Bielau, H., Gos, T., Brisch, R., Mawrin, C., Schmitt, A., Jordan, W., Müller, U., et al. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.005 · Cited by 195 · see citing works

The Immune System and Schizophrenia: An Integrative View

Müller, N., Riedel, M. J., Gruber, R., Ackenheil, M., & Schwarz, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05410.x · Cited by 189 · see citing works

The Interaction of Nuclear Factor-Kappa B and Cytokines Is Associated with Schizophrenia

Song, X., Lv, L., Li, W., Hao, Y., & Zhao, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.018 · Cited by 187 · see citing works

Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions

Miller, B. J., & Goldsmith, D. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.211 · Cited by 182 · see citing works

Anhedonic and Anxiogenic Effects of Cytokine Exposure

Anisman, H., & Merali, Z. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-0-585-37970-8_12 · Cited by 185 · see citing works

Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring

Fortier, M., Joober, R., Luheshi, G. N., & Boksa, P. (2003) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2003.10.001 · Cited by 182 · see citing works

Psychoendocrine and psychoneuroimmunological mechanisms in the comorbidity of atopic eczema and attention deficit/hyperactivity disorder

Buske-Kirschbaum, A., Schmitt, J., Plessow, F., Romanos, M., Weidinger, S., & Roessner, V. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.017 · Cited by 179 · see citing works

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

Rocha, S. M., Cristóvão, A. C., Campos, F. L., Fonseca, C. P., & Baltazar, G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.014 · Cited by 179 · see citing works

Neural circuit mechanisms of post–traumatic epilepsy

Hunt, R. F., Boychuk, J. A., & Smith, B. N. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00089 · Cited by 173 · see citing works

Immunology of Major Depression

Müller, N. (2014) · NeuroImmunoModulation · doi:10.1159/000356540 · Cited by 175 · see citing works

Understanding the Role of the Gut Microbiome in Brain Development and Its Association With Neurodevelopmental Psychiatric Disorders

Dash, S., Syed, Y. A., & Khan, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.880544 · Cited by 179 · see citing works

Variations of nucleus accumbens dopamine and serotonin following systemic interleukin-1, interleukin-2 or interleukin-6 treatment

Song, C., Merali, Z., & Anisman, H. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00271-1 · Cited by 172 · see citing works

Social isolation rearing induces mitochondrial, immunological, neurochemical and behavioural deficits in rats, and is reversed by clozapine or N-acetyl cysteine

Möller, M., du Preez, J. L., Viljoen, F. P., Berk, M., Emsley, R. A., & Harvey, B. H. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.12.011 · Cited by 168 · see citing works

Cognitive function in young and adult IL (interleukin)-6 deficient mice

Braida, D., Sacerdote, P., Panerai, A. E., Bianchi, M., Aloisi, A. M., Iosuè, S., & Sala, M. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.018 · Cited by 164 · see citing works

Affective style and in vivo immune response: Neurobehavioral mechanisms

Rosenkranz, M. A., Jackson, D. C., Dalton, K. M., Dolski, I., Ryff, C. D., Singer, B., Muller, D., Kalin, N. H., & Davidson, R. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534743100 · Cited by 164 · see citing works

Major Depression: One Brain, One Disease, One Set of Intertwined Processes

Filatova, E. V., Shadrina, M. I., & Slominsky, P. A. (2021) · Cells · doi:10.3390/cells10061283 · Cited by 167 · see citing works

Cytokines and Advanced Cancer

Dunlop, R., & Campbell, C. W. (2000) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00199-8 · Cited by 160 · see citing works

Relationships between interleukins, neurotransmitters and psychopathology in drug-free male schizophrenics

Kim, Y., Kim, L., & Lee, M. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00171-1 · Cited by 159 · see citing works

Therapeutic Strategies for Treatment of Inflammation-related Depression

Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 156 · see citing works

Sensitization to the Effects of Tumor Necrosis Factor-α: Neuroendocrine, Central Monoamine, and Behavioral Variations

Hayley, S. P., Brebner, K., Lacosta, S., Merali, Z., & Anisman, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05654.1999 · Cited by 149 · see citing works

Increased serum interleukin-1-receptor-antagonist concentrations in major depression

Maes, M. H. J., Vandoolaeghe, E., Ranjan, R., Bosmans, E., Bergmans, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00049-6 · Cited by 149 · see citing works

COX-2 inhibition as a treatment approach in schizophrenia: Immunological considerations and clinical effects of celecoxib add-on therapy

M�ller, N., Ulmschneider, M., Scheppach, C., Schwarz, M., Ackenheil, M., M�ller, H.-J., Gruber, R., & Riedel, M. J. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0478-1 · Cited by 143 · see citing works

The metabolic syndrome in schizophrenia: is inflammation a contributing cause?

Leonard, B. E., Schwarz, M., & Myint, A.-M. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111431622 · Cited by 134 · see citing works

Interleukin-6: the missing element of the neurocognitive deterioration in schizophrenia? The focus on genetic underpinnings, cognitive impairment and clinical manifestation

Frydecka, D., Misiak, B., Pawlak, E., Karabon, L., Tomkiewicz, A., Sedlaczek, P., Kiejna, A., & Beszłej, J. A. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0533-5 · Cited by 133 · see citing works

NEUROIMMUNOMODULATION VIA LIMBIC STRUCTURES — THE NEUROANATOMY OF PSYCHOIMMUNOLOGY

Haas, H. S., & Schauenstein, K. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00055-x · Cited by 133 · see citing works

Effects of interleukin-1β and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study

Merali, Z., Lacosta, S., & Anisman, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00312-0 · Cited by 130 · see citing works

The neurobiology of aggression and rage: Role of cytokines

Zalcman, S. S., & Siegel, A. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.05.002 · Cited by 129 · see citing works

Neuroleptics normalize increased release of interleukin-1β and tumor necrosis factor-α from monocytes in schizophrenia

Kowalski, J., Blada, P., Kucia, K. A., Madej, A., & Herman, Z. S. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00156-0 · Cited by 128 · see citing works

Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation

Purves-Tyson, T. D., Weber‐Stadlbauer, U., Richetto, J., Rothmond, D. A., Labouesse, M. A., Polesel, M., Robinson, K., Weickert, C. S., & Meyer, U. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0434-0 · Cited by 125 · see citing works

Neuroleptic treatment increases soluble IL-2 receptors and decreases soluble IL-6 receptors in schizophrenia

Müller, N., Empl, M., Riedel, M. J., Schwarz, M., & Ackenheil, M. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02922260 · Cited by 127 · see citing works

Prenatal inflammation and neurodevelopment in schizophrenia: A review of human studies

Miller, B. J., Culpepper, N. H., Rapaport, M. H., & Buckley, P. F. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.010 · Cited by 124 · see citing works

Neurobiology of Depression

Kim, Y. K. (2003) · Journal of the Korean Medical Association · doi:10.5124/jkma.2003.46.9.783 · Cited by 128 · see citing works

Thermogenic and corticosterone responses to intravenous cytokines (IL-1β and TNF-α) are attenuated by subdiaphragmatic vagotomy

Fleshner, M., Goehler, L. E., Schwartz, B. A., McGorry, M. M., Martin, D. A., Maier, S. F., & Watkins, L. R. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00026-5 · Cited by 124 · see citing works

Interleukin-2 and -6 induce behavioral-activating effects in mice

Zalcman, S., Murray, L., Dyck, D. G., Greenberg, A. H., & Nance, D. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00904-4 · Cited by 120 · see citing works

Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats

Kalueff, A. V., Lehtimäki, K. A., Ylinen, A., Honkaniemi, J., & Peltola, J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.061 · Cited by 119 · see citing works

Interleukin (IL)-6 and IL-1β act synergistically within the brain to induce sickness behavior and fever in rats

Harden, L. M., Plessis, I. D., Poole, S., & Laburn, H. P. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.006 · Cited by 118 · see citing works

Peptides as regulators of the immune system: emphasis on somatostatin

Krantic, S. M. (2000) · Peptides · doi:10.1016/s0196-9781(00)00347-8 · Cited by 118 · see citing works

Amitriptyline and nortriptyline inhibit interleukin-1 release by rat mixed glial and microglial cell cultures

Obuchowicz, E., Kowalski, J., Labuzek, K., Krysiak, R., Pendzich, J., & Herman, Z. S. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570500547x · Cited by 115 · see citing works

A systematic, quantitative review of blood autoantibodies in schizophrenia

Ezeoke, A., Mellor, A. L., Buckley, P. F., & Miller, B. J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.029 · Cited by 115 · see citing works

Cytokine Levels during Pregnancy Influence Immunological Profiles and Neurobehavioral Patterns of the Offspring

PONZIO, N. M., SERVATIUS, R., BECK, K., MARZOUK, A., & KREIDER, T. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.013 · Cited by 114 · see citing works

Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook

Olson, B. G., & Marks, D. L. (2019) · Cancers · doi:10.3390/cancers11050687 · Cited by 115 · see citing works

Further evidence for the depressive effects of cytokines: Anhedonia and neurochemical changes

Anisman, H., Kokkinidis, L., & Merali, Z. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00011-9 · Cited by 112 · see citing works

Serum levels of soluble IL-2 receptor α, IL-6 and IL-1 receptor antagonist in schizophrenia before and during neuroleptic administration

Akiyama, K. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00140-6 · Cited by 109 · see citing works

Long-Chain Polyunsaturated Fatty Acids Modulate Interleukin-1β–Induced Changes in Behavior, Monoaminergic Neurotransmitters, and Brain Inflammation in Rats ,

Song, C., Manku, M. S., & Horrobin, D. F. (2008) · Journal of Nutrition · doi:10.1093/jn/138.5.954 · Cited by 108 · see citing works

Modulation of behavioral and neurochemical measures of forebrain dopamine function in mice by species-specific interleukin-2

Petitto, J. M., McCarthy, D. B., Rinker, C. M., Huang, Z. L., & Getty, T. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00196-8 · Cited by 108 · see citing works

Evidence for Inflammation-Associated Depression

Liu, C. S., Adibfar, A., Herrmann, N., Gallagher, D., & Lanctôt, K. L. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_2 · Cited by 107 · see citing works

Cytokines as a stressor: implications for depressive illness

Anisman, H., Hayley, S. P., Turrin, N. P., & Merali, Z. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003097 · Cited by 106 · see citing works

Infectobesity: Obesity of Infectious Origin

Dhurandhar, N. V. (2001) · Journal of Nutrition · doi:10.1093/jn/131.10.2794s · Cited by 104 · see citing works

Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release

Guyon, A., Skrzydelski, D., Giry, I. D., Rovère, C., Conductier, G., Trocello, J., Daugé, V., Kitabgi, P., Rostène, W. H., Nahon, J., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.048 · Cited by 104 · see citing works

120. Attenuation of chronic neuroinflammation-induced depressive-like symptoms in mice by the antidepressant drug imipramine

Levy, M. Y., Kreisel, T., & Yirmiya, R. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.07.123

Influence of interleukin-1β on exploratory behaviors, plasma ACTH, corticosterone, and central biogenic amines in mice

Lacosta, S., Merali, Z., & Anisman, H. (1998) · Psychopharmacology · doi:10.1007/s002130050630 · Cited by 71 · see citing works

Interleukin-2 and -6 induce behavioral-activating effects in mice

Zalcman, S., Murray, L., Dyck, D. G., Greenberg, A. H., & Nance, D. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00904-4 · Cited by 120 · see citing works

Effects of interleukin-1β and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study

Merali, Z., Lacosta, S., & Anisman, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00312-0 · Cited by 130 · see citing works

An assessment of the effects of central interleukin-1β, -2, -6, and tumor necrosis factor-α administration on some behavioural, neurochemical, endocrine and immune parameters in the rat

Connor, T., Song, C., Leonard, B. E., Merali, Z., & Anisman, H. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00533-2 · Cited by 195 · see citing works