The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 MODULATES BLOOD GLUCOSE LEVELS
Abstract
We have determined the consequences of insulin-like growth factor-binding protein-1 (IGFBP-1) administration alone and in combination with insulin-like growth factor-I (IGF-I). Human recombinant IGF-I, infused as a bolus into male Wistar rats, induced a fall in plasma glucose to 72 +/- 3% of baseline 15 min after injection. Co-infusion of equimolar concentrations of human IGFBP-1 abolished the IGF-I-induced fall (P less than 0.001). Injection of IGFBP-1 alone caused a rise in plasma glucose levels (P less than 0.002). The half life of human IGFBP-1, measured using a primate-specific RIA, was 12.5 +/- 0.7 min and was not influenced by the co-infusion of IGF-I. This study demonstrates that, in the rat, human IGFBP-1 blocks the hypoglycemic response to intravenous IGF-I and increases blood glucose levels when administered alone. Since IGFBP-1 concentrations are dependent on metabolic status, we suggest that fluctuating IGFBP-1 levels might modulate the hypoglycemic activity of unbound IGFs in the circulation.
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Cites
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Self-citationMitrakou, A., Ryan, C., Veneman, T., Mokan, M., Jenssen, T., Kiss, I., Durrant, J., Cryer, P., & Gerich, J. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.260.1.e67 · Cited by 558
Short-Term Metabolic Effects of Recombinant Human Insulin-like Growth Factor I in Healthy Adults
Guler, H.-P., Zapf, J., & Froesch, E. R. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707163170303 · Cited by 554
SUIKKARI, A.-M., KOIVISTO, V. A., RUTANEN, E.-M., YKI-JÄRVINEN, H., KARONEN, S.-L., & SEPPÄLÄ, M. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-2-266 · Cited by 483
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Glucose Counterregulation in Man
Cryer, P. E. (1981) · Diabetes · doi:10.2337/diab.30.3.261 · Cited by 270
Cloning, characterization, and expression of a human insulin-like growth factor binding protein
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The Somatomedins: Insulin-Like Growth Factors
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Cited by
Frystyk, J. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.06.001 · Cited by 338
Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice
Rajkumar, K., Krsek, M., Dheen, S. T., & Murphy, L. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118982 · Cited by 97
Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice
Silha, J. V., Gui, Y., & Murphy, L. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2002 · Cited by 96
Insulin-like growth factor binding protein: a possible marker for the metabolic syndrome?
Ruan, W., & Lai, M. (2010) · Acta Diabetologica · doi:10.1007/s00592-009-0142-3 · Cited by 96
Röjdmark, S., & Brismar, K. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343879 · Cited by 44
Metadata
- Authors
- Lewitt, M. S., Denyerf, G. S., Cooney J, G., & Baxter, R. C.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-10
- Volume
- 129
- Issue
- 4
- Pages
- 2254-2256
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2038669302
- Cited by
- 261
- References
- 23
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 MODULATES BLOOD GLUCOSE LEVELS. https://app.cochat.ai/papers/10.1210/endo-129-4-2254
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- Lewitt, M. S., Denyerf, G. S., Cooney J, G., & Baxter, R. C. (1991). INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 MODULATES BLOOD GLUCOSE LEVELS. Endocrinology. https://doi.org/10.1210/endo-129-4-2254
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
