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Inhibition of Hypothalamic Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid during Food Deprivation*
Abstract
Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta, PRL, and pro-TRH mRNA were measured using in situ hybridization histochemistry. Peripheral total T3 was greatly reduced in food-deprived rats. Hypothalamic portal blood TRH levels declined significantly with time in control animals. The initial level of TRH in the portal blood of food-deprived rats was significantly reduced compared to that in controls, but did not fall further with time. In situ hybridization histochemistry revealed significantly lower pro-TRH mRNA in the paraventricular nucleus of food-deprived animals, while pro-TRH mRNA in the reticular nucleus remained unaltered. Furthermore, in the anterior pituitary, TSH beta mRNA decreased significantly in food-deprived animals, while PRL mRNA was unaltered. We conclude that the reduction in circulating T3 after food deprivation appears to be due primarily to decreased hypothalamic TRH synthesis and release.
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“Indeed, reduced hypothalamic TRH expression, portal serum TRH and pituitary TSH content have been observed both in NTIS patients [65] and NTIS animal models [12, 19, 66, 67].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [66]
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Cites
Mechanisms of Osteoporosis in Adult and Adolescent Women with Anorexia Nervosa*
Biller, B. M. K., SAXE, V. C., Herzog, D. B., Rosenthal, D. I., HOLZMAN, S., & Klibanski, A. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-3-548 · Cited by 417
Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus
Segerson, T. P., Kauer, J., Wolfe, H. C., Mobtaker, H., Wu, P., Jackson, I. M. D., & Lechan, R. M. (1987) · Science · doi:10.1126/science.3116669 · Cited by 327
Young, W. S., Mezey, É., & Siegel, R. E. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90029-x · Cited by 244
Campbell, G. A., Kurcz, M., Marshall, S., & Meites, J. (1977) · Endocrinology · doi:10.1210/endo-100-2-580 · Cited by 211
Koller, K. J., Wolff, R. S., Warden, M. K., & Zoeller, R. T. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.7329 · Cited by 173
Effect of dietary composition on fasting-induced changes in serum thyroid hormones and thyrotropin
Azizi, F. (1978) · Metabolism · doi:10.1016/0026-0495(78)90137-3 · Cited by 156
SUDA, A. K., Pittman, C. S., SHIMIZU, T., & Chambers, J. B. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-6-1311 · Cited by 153
Vagenakis, A. G., Portnay, G. I., O’Brian, J. T., RUDOLPH, M., Arky, R. A., Ingbar, S. H., & Braverman, L. E. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-6-1305 · Cited by 131
DYESS, E. M., SEGERSON, T. P., LIPOSITS, Z., PAULL, W. K., KAPLAN, M. M., WU, P., JACKSON, I. M. D., & LECHAN, R. M. (1988) · Endocrinology · doi:10.1210/endo-123-5-2291 · Cited by 127
Kinlaw, W. B., Schwartz, H. L., & Oppenheimer, J. H. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111821 · Cited by 87
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Yoshimura, M., Hagimoto, M., Matsuura, T., Ohkubo, J., Ohno, M., Maruyama, T., Ishikura, T., Hashimoto, H., Kakuma, T., Yoshimatsu, H., et al. (2013) · The Journal of Physiological Sciences · doi:10.1007/s12576-013-0296-1 · Cited by 20
Effects of Metoclopramide on Fasting-Induced TSH Suppression
Samuels, M. H., & Kramer, P. F. (1996) · Thyroid · doi:10.1089/thy.1996.6.85 · Cited by 20
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Karydis, I., & Tolis, G. (1998) · Thyroid · doi:10.1089/thy.1998.8.947 · Cited by 20
Ding, L., Chen, J. Q., Degen, A. A., Qiu, Q., Liu, P. P., Dong, Q., Shang, Z., Zhang, J. J., & Liu, S. J. (2016) · Small Ruminant Research · doi:10.1016/j.smallrumres.2016.09.018 · Cited by 18
Alvarez-Salas, E., Aceves, C., Anguiano, B., Uribe, R. M., García-Luna, C., Sánchez, E., & de Gortari, P. (2012) · Endocrinology · doi:10.1210/en.2011-2011 · Cited by 17
Pro-TRH and pro-CRF expression in paraventricular nucleus of small litter-reared fasted adult rats
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Valdés-Moreno, M. I., Alcántara‐Alonso, V., Estrada-Camarena, E. M., Mengod, G., Amaya, M. I., Matamoros‐Trejo, G., & de Gortari, P. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.027 · Cited by 17
Thyroid hormones homeostasis in rats refed after short-term and prolonged fasting
Kmieć, Z., Kotlarz, G., Smiechowska, B., & Myśliwski, A. (1996) · Journal of Endocrinological Investigation · doi:10.1007/bf03347867 · Cited by 17
Regulation of Somatostatin Receptor mRNA Expression
Berelowitz, M., Xu, Y. F., Song, J., & Bruno, J. F. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514733.ch7 · Cited by 16
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Lechan, R. M., & Toni, R. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50022-6 · Cited by 15
Nonthyroidal illness syndrome in patients with subarachnoid hemorrhage due to intracranial aneurysm
Casulari, L. A., Mangieri, P., Naves, L. A., Suzuki, K., Ferreira, M., & Domingues, L. (2004) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2004000100005 · Cited by 14
Keech, A. L., Rosen, D. A. S., Booth, R. K., Trites, A. W., & Wasser, S. K. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.11.014 · Cited by 15
Deschner, T., Hohmann, G., Ortmann, S., Schaebs, F. S., & Behringer, V. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113290 · Cited by 16
Magalhães, A. P. A., Gus, M., Neto, L. B. D. S., & Schaan, B. D. (2006) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006000700015 · Cited by 14
Uribe, R. M., Cisneros, M., Vargas, M. Á., Lezama, L., Cote-Vélez, A., Joseph‐Bravo, P., & Charli, J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.10.011 · Cited by 13
Molecular biology of the regulation of hypothalamic hormones
Rondeel, J. M. M., & JACKSON, I. M. D. (1993) · Journal of Endocrinological Investigation · doi:10.1007/bf03344952 · Cited by 13
de Gortari, P., González-Alzati, M. E., Cisneros, M., & Joseph‐Bravo, P. (2000) · Nutritional Neuroscience · doi:10.1080/1028415x.2000.11747323 · Cited by 12
Knight, W. D., Swoap, S. J., Parsons, A. D., & Overton, J. M. (2006) · Neuroendocrinology · doi:10.1159/000094004 · Cited by 12
Hyder, I., Ramesh, K., Sharma, S., Uniyal, S., Yadav, V. P., Panda, R. P., Maurya, V. P., Singh, G., & Sarkar, M. (2013) · Livestock Science · doi:10.1016/j.livsci.2012.12.005 · Cited by 11
Costa-e-Sousa, R. H., Souza, L. L., Calviño, C., Cabanelas, A., Almeida, N. A. S., Oliveira, K. J., & Pazos-Moura, C. C. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.07.001 · Cited by 11
Cocaine Regulation of Brain Preprothyrotropin‐Releasing Hormone mRNA
Sevarino, K. A., & Primus, R. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03267.x · Cited by 11
Thyrotropin dysregulation during a non-thyroidal illness: Transient hypothalamic hypothyroidism?
Kabadi, U. M. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343839 · Cited by 11
Barnhoorn, S., Meima, M. E., Peeters, R. P., Darras, V., Leeuwenburgh, S., Hoeijmakers, J. H. J., Vermeij, W. P., & Visser, W. E. (2023) · European Thyroid Journal · doi:10.1530/etj-22-0231 · Cited by 8
Anorexigenic neuropeptides as anti-obesity and neuroprotective agents
Strnadová, V., Pačesová, A., Charvát, V., Šmotková, Z., Železná, B., Kuneš, J., & Maletı́nská, L. (2024) · Bioscience Reports · doi:10.1042/bsr20231385 · Cited by 8
Alvarez‐Salas, E., Mengod, G., García-Luna, C., Soberanes-Chávez, P., Matamoros‐Trejo, G., & de Gortari, P. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.11.001 · Cited by 8
de Gortari, P., Cisneros, M., Medellín, M. A., & Joseph‐Bravo, P. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00017-7 · Cited by 8
McCarty, M. F. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90068-3 · Cited by 10
de Gortari, P., Alcántara‐Alonso, V., Matamoros‐Trejo, G., Amaya, M. I., & Alvarez‐Salas, E. (2020) · Peptides · doi:10.1016/j.peptides.2020.170285 · Cited by 8
Low, M. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00007-1 · Cited by 8
Coiro, V., Volpi, R., Capretti, L., Caffarri, G., Colla, R., & Chiodera, P. (1999) · Journal of Investigative Medicine · doi:10.1177/108155899904700509 · Cited by 7
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Mayerl, S. E., Liebsch, C., Visser, T. J., & Heuer, H. (2014) · Endocrinology · doi:10.1210/en.2014-1395 · Cited by 6
Physiology of the Hypothalamic-Pituitary Thyroidal System.
Mariotti, S. (2011) · UNICA IRIS Institutional Research Information System (University of Cagliari) · Cited by 6
Low, M. J. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00007-9 · Cited by 6
Alcántara‐Alonso, V., Alvarez‐Salas, E., Matamoros‐Trejo, G., & de Gortari, P. (2017) · Nutrients · doi:10.3390/nu9101139 · Cited by 5
Neuroendocrinology of the Hypothalamus and Pituitary Axes
Tran, T. N., Sosa-Pagan, M., & Uwaifo, G. I. (2020) · Contemporary Endocrinology · doi:10.1007/978-3-030-62187-2_5 · Cited by 5
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Watts, A. G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10014-9 · Cited by 6
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Chávez, J., Alcántara‐Alonso, V., García-Luna, C., Soberanes-Chávez, P., Grammatopoulos, D. K., & de Gortari, P. (2022) · eNeuro · doi:10.1523/eneuro.0077-22.2022 · Cited by 4
Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity
Oudmaijer, C. A. J., van den Boogaard, W. M. C., Komninos, D. S. J., Verwaaijen, E. J., van Santen, H. M., Liliën, M. R., Hoeijmakers, J. H. J., Wijnen, M. H. W. A., van den Heuvel‐Eibrink, M. M., & Vermeij, W. P. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.828615 · Cited by 4
Dissociation of Thyrotropin and Leptin Secretion in Acute Surgical Stress in Severely Obese Patients
Michalaki, M. A., Vagenakis, A. G., Argentou, M., Mylonas, P. G., Kalfarentzos, F. E., & Kyriazopoulou, V. E. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9852-4 · Cited by 4
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Zhang, N., Zhang, H., Bi, S., Moran, T. H., & Bi, S. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.030 · Cited by 3
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Lightman, S. L. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90199-i · Cited by 3
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Scanlon, M. F. (1997) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60709-7_2 · Cited by 3
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Reed, S. M., Bayly, W. M., & Sellon, D. C. (2004) · Elsevier eBooks · doi:10.1016/b0-72-169777-1/50020-2 · Cited by 3
Leptin negatively regulates thyroid function of Wistar rats
Hecht, F., Cazarin, J., Rossetti, C. L., Rosenthal, D., Araújo, R. L., & de Carvalho, D. P. (2021) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765202120201551 · Cited by 2
Soberanes-Chávez, P., de Gortari, P., García-Luna, C., & Cruz, S. (2023) · NeuroToxicology · doi:10.1016/j.neuro.2023.11.003 · Cited by 2
Leptin and Other Endocrine Systems
Considine, R. V. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_6 · Cited by 2
Neuropeptide Regulation of Appetite and Reproduction
Small, C., & Sa, S. (2004) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 2
Role of Thyrotropin-Releasing Hormone in the Regulation of the Thyroid Axis
Hollenberg, A. N. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4745-2.00006-7 · Cited by 1
Angell, T. E., Huang, S. A., & Alexander, E. K. (2016) · Endocrinology · doi:10.1007/978-3-319-27318-1_14-1 · Cited by 2
DeGroot, L. J. (1999) · The Endocrinologist · doi:10.1097/00019616-199905000-00020 · Cited by 1
Moslemipur, F., Khazali, H., & meybodi, M. A. E. (2006) · Cited by 1
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Sarmin, S., Widiyono, I., Astutı, P., & Putro, P. P. (2017) · Pakistan Journal of Nutrition · doi:10.3923/pjn.2017.101.108 · Cited by 1
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Özçelik, F., DAŞTAN, A. İ., Pençe, H. H., & Çıracı, M. Z. (2019) · International Journal of Negative Results · doi:10.14302/issn.2641-9181.ijnr-18-2530 · Cited by 1
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LIM, V. S., & Suneja, M. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-373870-7.00028-4 · Cited by 1
Angell, T. E., Huang, S. A., & Alexander, E. K. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_14 · Cited by 1
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Jaimes-Hoy, L., Cabrera‐Wrooman, A., Vilches‐Flores, A., Guzmán, C., & Arroyo, I. (2005) · Revista de Endocrinología y Nutrición · Cited by 1
Swain, R. K. (1996) · Cited by 1
La regulación de la conducta alimentaria en un modelo experimental de anorexia
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Shapiro, L. E., & Baron, T. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4304-9_8
de Gortari, P., González-Alzati, M. E., Jaimes-Hoy, L., Estrada, A., Mancera, K. F., García-Luna, C., & Amaya, M. I. (2012) · Redalyc (Universidad Autónoma del Estado de México)
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Naggert, J. Κ., & Naggert, J. Κ. (2001) · CRC Press eBooks · doi:10.1201/9781420039108.ch9
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Vella, K. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_10
Senior Author Correspondence Information
(2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.1-v
Metadata
- Authors
- BLAKE, N. G., ECKLAND, D. J. A., FOSTER, O. J. F., & LIGHTMAN, S. L.
- Affiliations
- Charing Cross Hospital (GB)
- ORCID
- LIGHTMAN, S. L.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-11
- Volume
- 129
- Issue
- 5
- Pages
- 2714-2718
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2044918899
- Cited by
- 168
- References
- 25
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 6
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- food deprivation, thyrotropin-releasing hormone, hypothalamus, hypothalamic-pituitary-thyroid axis, paraventricular nucleus, reticular nucleus, anterior pituitary, prolactin, triiodothyronine, neuroendocrine regulation, thyroid hormone synthesis
- MeSH terms
- Animals, Food Deprivation, Hypothalamus, Male, Prolactin, Protein Precursors, Pyrrolidonecarboxylic Acid, Rats, Inbred Strains, RNA, Messenger, Thyrotropin, Thyrotropin-Releasing Hormone, Triiodothyronine, Rats
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