The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Inhibition of Hypothalamic Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid during Food Deprivation*
Abstract
Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta, PRL, and pro-TRH mRNA were measured using in situ hybridization histochemistry. Peripheral total T3 was greatly reduced in food-deprived rats. Hypothalamic portal blood TRH levels declined significantly with time in control animals. The initial level of TRH in the portal blood of food-deprived rats was significantly reduced compared to that in controls, but did not fall further with time. In situ hybridization histochemistry revealed significantly lower pro-TRH mRNA in the paraventricular nucleus of food-deprived animals, while pro-TRH mRNA in the reticular nucleus remained unaltered. Furthermore, in the anterior pituitary, TSH beta mRNA decreased significantly in food-deprived animals, while PRL mRNA was unaltered. We conclude that the reduction in circulating T3 after food deprivation appears to be due primarily to decreased hypothalamic TRH synthesis and release.
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“Indeed, reduced hypothalamic TRH expression, portal serum TRH and pituitary TSH content have been observed both in NTIS patients [65] and NTIS animal models [12, 19, 66, 67].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [66]
Citations
Cites
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Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus
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Self-citationRADIOIMMUNOASSAY OF THYROTROPHIN RELEASING HORMONE
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Thyrotropin Secretion in Starved Rats is Enhanced by Somatostatin Antiserum
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Dangerous dogmas in medicine: the nonthyroidal illness syndrome
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Minireview: From Anorexia to Obesity—The Yin and Yang of Body Weight Control
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Metadata
- Authors
- BLAKE, N. G., ECKLAND, D. J. A., FOSTER, O. J. F., & LIGHTMAN, S. L.
- Affiliations
- Charing Cross Hospital (GB)
- ORCID
- LIGHTMAN, S. L.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1991-11
- Volume
- 129
- Issue
- 5
- Pages
- 2714-2718
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2044918899
- Cited by
- 168
- References
- 25
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 6
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- food deprivation, thyrotropin-releasing hormone, hypothalamus, hypothalamic-pituitary-thyroid axis, paraventricular nucleus, reticular nucleus, anterior pituitary, prolactin, triiodothyronine, neuroendocrine regulation, thyroid hormone synthesis
- MeSH terms
- Animals, Food Deprivation, Hypothalamus, Male, Prolactin, Protein Precursors, Pyrrolidonecarboxylic Acid, Rats, Inbred Strains, RNA, Messenger, Thyrotropin, Thyrotropin-Releasing Hormone, Triiodothyronine, Rats
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