Cited by 168Thyroid Disorders and TreatmentsRegulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Inhibition of Hypothalamic Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid during Food Deprivation*

BLAKE, N. G., ECKLAND, D. J. A., FOSTER, O. J. F., LIGHTMAN, S. L.·1991·Endocrinology

DOI 10.1210/endo-129-5-2714

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Abstract

Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta, PRL, and pro-TRH mRNA were measured using in situ hybridization histochemistry. Peripheral total T3 was greatly reduced in food-deprived rats. Hypothalamic portal blood TRH levels declined significantly with time in control animals. The initial level of TRH in the portal blood of food-deprived rats was significantly reduced compared to that in controls, but did not fall further with time. In situ hybridization histochemistry revealed significantly lower pro-TRH mRNA in the paraventricular nucleus of food-deprived animals, while pro-TRH mRNA in the reticular nucleus remained unaltered. Furthermore, in the anterior pituitary, TSH beta mRNA decreased significantly in food-deprived animals, while PRL mRNA was unaltered. We conclude that the reduction in circulating T3 after food deprivation appears to be due primarily to decreased hypothalamic TRH synthesis and release.

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Authors: BLAKE, N. G., ECKLAND, D. J. A., FOSTER, O. J. F., & LIGHTMAN, S. L.
Affiliations: Charing Cross Hospital (GB)
ORCID: LIGHTMAN, S. L.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1991-11
Volume: 129
Issue: 5
Pages: 2714-2718
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo-129-5-2714
OpenAlex: W2044918899
Cited by: 168
References: 25
Citations by year: 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 6
FWCI: 2.39
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: food deprivation, thyrotropin-releasing hormone, hypothalamus, hypothalamic-pituitary-thyroid axis, paraventricular nucleus, reticular nucleus, anterior pituitary, prolactin, triiodothyronine, neuroendocrine regulation, thyroid hormone synthesis
MeSH terms: Animals, Food Deprivation, Hypothalamus, Male, Prolactin, Protein Precursors, Pyrrolidonecarboxylic Acid, Rats, Inbred Strains, RNA, Messenger, Thyrotropin, Thyrotropin-Releasing Hormone, Triiodothyronine, Rats

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Inhibition of Hypothalamic Thyrotropin-Releasing Hormone Messenger Ribonucleic Acid during Food Deprivation*

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