Cited by 535Adipokines, Inflammation, and Metabolic DiseasesPancreatic function and diabetesAdipose Tissue and Metabolism

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

Lang, C H, Dobrescu, C, Bagby, G J·1992·Endocrinology

DOI 10.1210/endo.130.1.1727716

Open this paper in CoChat — free account

Abstract

The present study examined whether a prolonged infusion of tumor necrosis factor (TNF) into rats could sustain the increased rate of whole body glucose metabolism observed with short term exposure, and whether TNF produced hepatic or peripheral insulin resistance. Basal glucose metabolism was determined with the use of [3-3H]glucose 18 h after initiating a constant infusion of recombinant human TNF (1 microgram/kg.h). Thereafter, a two-step euglycemic hyperinsulinemic clamp was performed to determine whether TNF impaired insulin action. The overnight infusion of TNF minimally elevated plasma glucose concentrations (17%), but produced large increases in the whole body rate of glucose production and utilization (133%). Under hyperinsulinemic conditions, the glucose infusion rate necessary to maintain euglycemia was 30% lower in TNF-treated rats, indicating an insulin-resistant condition. This resulted from an impaired ability of insulin to both suppress hepatic glucose production and stimulate peripheral glucose utilization in TNF-infused animals. A second series of experiments was performed, using the in vivo tracer [U-14C]2-deoxyglucose technique, to elucidate which tissues were responsible for the TNF-induced increase in basal (no exogenous insulin) glucose disposal and peripheral insulin resistance. Under basal conditions, TNF increased glucose uptake by various muscles (gastrocnemius, heart, and diaphragm) as well as nonmuscle tissues (liver, lung, spleen, gut, skin and fat). Because of their relatively large mass and/or high rate of glucose uptake, the increased uptake by skin (25%), intestine (24%), muscle (23%), and liver (15%) accounted for the majority of the TNF-induced increment in whole body glucose disposal. Under euglycemic hyperinsulinemic conditions, the increment in glucose uptake by muscle and skin (85%) accounted for the majority of the glucose disposal in control rats. However, in TNF-infused animals, hyperinsulinemia failed to increase glucose uptake by skin and blunted the insulin-mediated increase in muscle by 73%. These results suggest that sustained elevations of TNF during chronic therapy and prolonged production of TNF by patients and experimental animals with malignancies or infectious diseases may be an important mechanism for the enhanced glucose flux as well as the insulin resistance seen in these conditions.

Integrity signals

Registry

Crossref · 10.1210/endo.130.1.1727716

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Insulin-like growth factors and their binding proteins
Sara, V. R., & Hall, K. E. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.3.591 · Cited by 923
Molecular Biology of Mammalian Glucose Transporters
Bell, G. I., Kayano, T., Buse, J. B., Burant, C. F., Takeda, J., Lin, D., Fukumoto, H., & Seino, S. (1990) · Diabetes Care · doi:10.2337/diacare.13.3.198 · Cited by 853
EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER
Balkwill, F. R., Burke, F., Talbot, D., Tavernier, J. H., Osborne, R. H., Naylor, S., Durbin, H., & Fiers, W. C. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91850-2 · Cited by 417
Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1.
Flores, E. A., Bistrian, B. R., Pomposelli, J. J., Dinarello, C. A., Blackburn, G. L., & Istfan, N. W. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114059 · Cited by 379
Mechanisms of Insulin Resistance Following Injury
Black, P. R., Brooks, D. C., Bessey, P. Q., Wolfe, R. R., & Wilmore, D. W. (1982) · Annals of Surgery · doi:10.1097/00000658-198210000-00005 · Cited by 376
Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings
MICHIE, H. R., Spriggs, D. R., Manogue, K. R., Sherman, M. L., Revhaug, A., O’Dwyer, S., Arthur, K. A., Dinarello, C. A., Cerami, A., & Wolff, S. M. (1989) · Journal of Critical Care · doi:10.1016/0883-9441(89)90142-1 · Cited by 356
Tumor necrosis factor in the pathophysiology of infection and sepsis
Fong, Y., & Lowry, S. F. (1990) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(90)90094-7 · Cited by 230
Contribution of different organs to increased glucose consumption after endotoxin administration.
Mészáros, K., Lang, C. H., Bagby, G. J., & Spitzer, J. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60912-3 · Cited by 153
Self-citation
Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.
Lee, M. D., Zentella‐Dehesa, A., Vine, W., Pekala, P. H., & Cerami, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2590 · Cited by 133

Show all 31 references

Sorted by citations

Items 201–300 of 534

Hepatoprotective Effect of Cranberry Nutraceutical Extract in Non-alcoholic Fatty Liver Model in Rats: Impact on Insulin Resistance and Nrf-2 Expression
Faheem, S. A., Saeed, N. M., El‐Naga, R. N., Ayoub, I. M., & Azab, S. S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00218 · Cited by 62
Tumor necrosis factor–induced signal transduction and left ventricular remodeling
Mann, D. L. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.129253 · Cited by 62
The biological basis of malarial disease
Clark, I. A., Al-Yaman, F. M., & Jacobson, L. S. (1997) · International Journal for Parasitology · doi:10.1016/s0020-7519(97)00121-5 · Cited by 62
A comparison of the effects of thiazolidinediones and metformin on metabolic control in patients with type 2 diabetes mellitus
Seufert, J., Lübben, G., Dietrich, K., & BATES, P. C. (2004) · Clinical Therapeutics · doi:10.1016/s0149-2918(04)90125-7 · Cited by 62
The Risk of Developing Diabetes Mellitus in Patients with Psoriatic Arthritis: A Cohort Study
Eder, L., Chandran, V., Cook, R. J., & Gladman, D. D. (2017) · The Journal of Rheumatology · doi:10.3899/jrheum.160861 · Cited by 62
Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model
Park, J.-Y., Kim, Y.-H., Im, J. A., & Lee, H. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0709-1 · Cited by 58
Nature of fatty acids in high fat diets differentially delineates obesity-linked metabolic syndrome components in male and female C57BL/6J mice
Akoum, S. E., Lamontagne, V., Cloutier, I., & Tanguay, J. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-34 · Cited by 57
Visfatin levels and intima-media thicknesses in rheumatic diseases
Özgen, M., Koca, S. S., Aksoy, K., Dağlı, N., Üstündağ, B., & Işık, A. T. (2010) · Clinical Rheumatology · doi:10.1007/s10067-010-1649-2 · Cited by 55
Diabetes as a risk factor for periodontal disease: current status and future considerations.
Tan, W., Tay, F., & Lim, L. (2006) · Annals of the Academy of Medicine, Singapore · doi:10.47102/annals-acadmedsg.v35n8p571 · Cited by 63
Diabetes of Injury: Novel Insights
Vanhorebeek, I., & den Berghe, G. V. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.09.002 · Cited by 54
Short-term exposure to tumor necrosis factor-alpha does not affect insulin-stimulated glucose uptake in skeletal muscle.
Nolte, L. A., Hansen, P. A., Chen, M. M., Schluter, J. M., Gulve, E. A., & Holloszy, J. O. (1998) · Diabetes · doi:10.2337/diabetes.47.5.721 · Cited by 52
Tumor necrosis factor‐α‐induced inflammatory responses in cattle
Kushibiki, S. (2011) · Animal Science Journal · doi:10.1111/j.1740-0929.2011.00931.x · Cited by 52
In Vitro Insulin-Like Growth Factor-I, Growth Hormone, and Insulin Resistance Occurs in Symptomatic Human Immunodeficiency Virus-1–Infected Children
Geffner, M. E., Yeh, D. Y., Landaw, E. M., Scott, M. L., Stiehm, E. R., Bryson, Y. J., & Israele, V. (1993) · Pediatric Research · doi:10.1203/00006450-199307000-00016 · Cited by 51
Stress Insulin Resistance is a Marker for Mortality in Traumatic Brain Injury
Mowery, N. T., Gunter, O. L., Guillamondegui, O. M., Dossett, L. A., Dortch, M. J., Morris, J. A., & May, A. K. (2009) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181938c5e · Cited by 50
A Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma
Kumar, D. P., Santhekadur, P. K., Seneshaw, M., Mirshahi, F., Uram–Tuculescu, C., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.30346 · Cited by 50
Metabolic alterations in muscle of thermally injured rabbits, measured by positron emission tomography
Carter, E. A., Tompkins, R. G., Hsu, H., Christian, B., Alpert, N. M., Weise, S. B., & Fischman, A. J. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00355-x · Cited by 49
Serum amyloid A is a growth factor for 3T3-L1 adipocytes, inhibits differentiation and promotes insulin resistance
Filippin-Monteiro, F. B., de Oliveira, E. M., Sandri, S., Knebel, F. H., Albuquerque, R. C., & Čampa, A. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.193 · Cited by 49
Early events involved in the development of insulin resistance in Zucker fatty rat
Liu, R., Mizuta, M., Kurose, T., & Matsukura, S. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801924 · Cited by 48
Inflammation in Metabolic Syndrome and Type 2 Diabetes: Impact of Dietary Glucose
KEMPF, K., ROSE, B., HERDER, C., KLEOPHAS, U., MARTIN, S., & KOLB, H. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.012 · Cited by 48
Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice
Gum, R. J., Gaede, L. L., Heindel, M. A., Waring, J. F., Trevillyan, J. M., Zinker, B. A., Stark, M. E., Wilcox, D. M., Jirousek, M. R., Rondinone, C. M., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0288 · Cited by 48
Insulin resistance induced in dairy steers by tumor necrosis factor alpha is partially reversed by 2,4–thiazolidinedione
Kushibiki, S., HODATE, K., Shingu, H., Ueda, Y., SHINODA, M., Mori, Y., Itoh, T., & Yokomizo, Y. (2001) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(01)00102-3 · Cited by 49
Impairment of glucose metabolism in hearts from rats treated with endotoxin
Tessier, J. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00320-1 · Cited by 48
Insulin resistance, impaired glucose tolerance and non-insulin-dependent diabetes, pathologic mechanisms and treatment: Current status and therapeutic possibilities
Turner, N. C., & Clapham, J. C. (1998) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8845-5_2 · Cited by 46
Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFα
Lang, C. H., Nystrom, G. J., & Frost, R. A. (2001) · Growth Hormone & IGF Research · doi:10.1054/ghir.2001.0233 · Cited by 45
Self-citation
Neutralization of tumor necrosis factor-α reverses insulin resistance in skeletal muscle but not adipose tissue
Borst, S. E., Lee, Y., Conover, C. F., Shek, E. W., & Bagby, G. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00054.2004 · Cited by 46
Self-citation
The Stress Axis in Obesity and Diabetes Mellitus: An Update
Gianotti, L., Belcastro, S., D’Agnano, S., & Tassone, F. (2021) · Endocrines · doi:10.3390/endocrines2030031 · Cited by 49
Insulin resistance is not related to plasma homocysteine concentration in healthy premenopausal women
Tanrıkulu-Kılıç, F., Bekpınar, S., Ünlüçerçi, Y., & Orhan, Y. (2006) · Physiological Research · doi:10.33549/physiolres.930745 · Cited by 45
KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-α production
Morimoto, Y., Nishikawa, K., & Ohashi, M. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00561-4 · Cited by 45
Effect of Tumor Necrosis Factor‐α on Insulin‐Stimulated Mitogen‐Activated Protein Kinase Cascade in Cultured Rat Skeletal Muscle Cells
Begum, N., Ragolia, L., & Srinivasan, M. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0214q.x · Cited by 45
Anabolic and anticatabolic agents in critical care
Stanojcic, M., Finnerty, C. C., & Jeschke, M. G. (2016) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000330 · Cited by 46
Consumption of Terpenoids-Rich Padina pavonia Extract Attenuates Hyperglycemia, Insulin Resistance and Oxidative Stress, and Upregulates PPARγ in a Rat Model of Type 2 Diabetes
Germoush, M. O., Elgebaly, H. A., Hassan, S. M., Kamel, E. M., Bin-Jumah, M. N., & Mahmoud, A. M. (2019) · Antioxidants · doi:10.3390/antiox9010022 · Cited by 46
Rumex dentatus L. phenolics ameliorate hyperglycemia by modulating hepatic key enzymes of carbohydrate metabolism, oxidative stress and PPARγ in diabetic rats
Elsayed, R. H., Kamel, E. M., Mahmoud, A. M., El‐Bassuony, A. A., Bin-Jumah, M. N., Lamsabhi, A. M., & Ahmed, S. A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111202 · Cited by 47
Nutrient-induced insulin resistance
Proietto, J., Filippis, A., Nakhla, C., & Clark, S. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00050-7 · Cited by 42
Effects of tumor necrosis factor alpha on leptin secretion and gene expression: relationship to changes of glucose metabolism in isolated rat adipocytes
Medina, E. A., Stanhope, K. L., Mizuno, T. M., Mobbs, C. V., Gregoire, F. M., Hubbard, N., Erickson, K., & Havel, P. J. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800970 · Cited by 43
How effective are lifestyle changes in the prevention of type 2 diabetes mellitus?
Pi-Sunyer, F. X. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00287.x · Cited by 40
TNF-α acutely upregulates amylin expression in murine pancreatic beta cells
Cai, K., Qi, D., Wang, O., Chen, J., Liu, X., Deng, B., Qian, L., Liu, X., & Le, Y. (2010) · Diabetologia · doi:10.1007/s00125-010-1972-9 · Cited by 42
Periodontal status and metabolic syndrome in middle-aged Japanese
福井, 尚. (2012) · Medical Entomology and Zoology · Cited by 42
Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases
Alnemri, E. S. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(199701)64:1 · Cited by 307
Major comorbid disease processes associated with increased incidence of acute kidney injury
Farooqi, S., & Dickhout, J. G. (2016) · World Journal of Nephrology · doi:10.5527/wjn.v5.i2.139 · Cited by 41
Insulin resistance and glucose-induced thermogenesis in critical illness
Carlson, G. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200193 · Cited by 40
PEDF-induced alteration of metabolism leading to insulin resistance
Carnagarin, R., Dharmarajan, A., & Dass, C. R. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.006 · Cited by 41
The relation between insulin resistance and cardiovascular complications of the insulin resistance syndrome
Kristian, R. E. T. T. (1999) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.1999.0010s1008.x · Cited by 40
CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)
Najjar, S. M., & Russo, L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0407-3 · Cited by 40
Yeast cell wall supplementation alters the metabolic responses of crossbred heifers to an endotoxin challenge
Sanchez, N. C. B., Young, T. R., Carroll, J. A., Corley, J. R., Rathmann, R. J., & Johnson, B. J. (2013) · Innate Immunity · doi:10.1177/1753425913482152 · Cited by 39
Increased inflammation and decreased insulin sensitivity indicate metabolic disturbances in zoo-managed compared to free-ranging black rhinoceros (Diceros bicornis)
Schook, M. W., Wildt, D. E., Raghanti, M. A., Wolfe, B. A., & Dennis, P. M. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.05.003 · Cited by 39
Rosiglitazone improves glucose metabolism in nondiabetic uremic patients on CAPD
Lin, S., Lin, Y., Kuo, S., Hsu, Y., & Hung, Y.-J. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00844-8 · Cited by 39
Profile of patients with psoriasis associated with hepatitis C virus infection
Imafuku, S., & NAKAYAMA, J. (2013) · The Journal of Dermatology · doi:10.1111/1346-8138.12112 · Cited by 38
The Emory University Perioperative Algorithm for the Management of Hyperglycemia and Diabetes in Non-cardiac Surgery Patients
Duggan, E. W., Klopman, M. A., Berry, A. J., & Umpierrez, G. E. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0720-z · Cited by 39
Glucose dysmetabolism and prognosis in critical illness
Lazzeri, C., Tarquini, R., Giunta, F., & Gensini, G. F. (2008) · Internal and Emergency Medicine · doi:10.1007/s11739-008-0206-3 · Cited by 38
The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression
Vecchione, G., Grasselli, E., Cioffi, F., Baldini, F., Oliveira, P. J., Sardão, V. A., Cortese, K., Lanni, A., Voci, A., Portincasa, P., et al. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00042 · Cited by 37
CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress
Lee, S. J., Kang, J. S., Kim, H. M., Lee, E. Y., Lee, J.-H., Chung, C. H., & Lee, E. Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222352 · Cited by 37
Hormonal and Metabolic Abnormalities in the Malnourished Cancer Patient: Effects on Host‐Tumor Interaction
Heber, D., Byerley, L. O., & Tchekmedyian, N. S. (1992) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719201600605 · Cited by 37
Role of cytokines in AIDS wasting
Chang, H. R., Dulloo, A. G., & Bistrian, B. R. (1998) · Nutrition · doi:10.1016/s0899-9007(98)00108-7 · Cited by 35
Tumor necrosis factor α −238G>A genotype alters postprandial plasma levels of free fatty acids in obese individuals with type 2 diabetes mellitus
Fontaine‐Bisson, B., Wolever, T. M. S., Chiasson, J., RABASA-LHORET, R. P. R., Maheux, P., Josse, R. G., Leiter, L. A., Rodger, N. W., Ryan, E. A., & El‐Sohemy, A. (2007) · Metabolism · doi:10.1016/j.metabol.2006.12.013 · Cited by 36
Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats
Liu, R., Kurose, T., & Matsukura, S. (2001) · Metabolism · doi:10.1053/meta.2001.19436 · Cited by 36
Relationship Between Adiposity and Cardiovascular Risk Factors in Prevalent Hemodialysis Patients
Kaysen, G. A., Kotanko, P., Zhu, F., Sarkar, S. R., Heymsfield, S. B., Kuhlmann, M. K., Dwyer, T., Usvyat, L. A., Havel, P. J., & Levin, N. W. (2009) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2009.04.002 · Cited by 36
Neutralization of tumor necrosis factor reverses age-induced impairment of insulin responsiveness in skeletal muscle of Sprague-Dawley rats
Borst, S. E., & Bagby, G. J. (2002) · Metabolism · doi:10.1053/meta.2002.34043 · Cited by 36
Self-citation
Elevated serum tumor necrosis factor alpha and ferritin may contribute to the insulin resistance found in HCV positive Egyptian patients
Elsammak, M., Refai, W., Elsawaf, A., Abdel-Fattah, I., Elatti, E. A., & Ghazal, A. A. E. R. (2005) · Current Medical Research and Opinion · doi:10.1185/030079905x38141 · Cited by 35
A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells
Li, Z., Srivastava, S., Yang, X., Mittal, S., Norton, P. R., Resau, J. H., Haab, B. B., & Chan, C. (2007) · BMC Systems Biology · doi:10.1186/1752-0509-1-21 · Cited by 35
Effects of Acanthopanax senticosus Polysaccharide Supplementation on Growth Performance, Immunity, Blood Parameters and Expression of Pro-inflammatory Cytokines Genes in Challenged Weaned Piglets
Han, J., LianQuan, B., Liu, X., Zhang, F., Zhang, Y., & Yu, N. (2014) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2013.13659 · Cited by 35
Running exercise increases tumor necrosis factor-α secreting from mesenteric fat in insulin-resistant rats
Nara, M., Kanda, T., Tsukui, S., Inukai, T., Shimomura, Y., Inoue, S., & Kobayashi, I. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00242-8 · Cited by 36
Tumor necrosis factor alpha stimulates gluconeogenesis from alanine in vivo
Blumberg, D., Hochwald, S. N., BURT, M. E., Donner, D. B., & Brennan, M. F. (1995) · Journal of Surgical Oncology · doi:10.1002/jso.2930590404 · Cited by 34
Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle
Tse, M. C. L., Herlea‐Pana, O., Brobst, D. E., Yang, X., Wood, J., Hu, X., Liu, Z., Lee, C. W., Zaw, A. M., Chow, B., et al. (2017) · Diabetes · doi:10.2337/db16-0270 · Cited by 33
Metabolic Management during Critical Illness: Glycemic Control in the ICU
Inzucchi, S. E., & Honiden, S. (2015) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0035-1565253 · Cited by 33
Interleukin‐4 Boosts Insulin‐Induced Energy Deposits by Enhancing Glucose Uptake and Lipogenesis in Hepatocytes
Yang, C., Shiau, M., Lai, Y.-R., Ho, K.-T., Hsiao, C., Chen, C., Lo, Y., & Chang, Y.-H. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6923187 · Cited by 32
Galangin Attenuates Liver Injury, Oxidative Stress and Inflammation, and Upregulates Nrf2/HO-1 Signaling in Streptozotocin-Induced Diabetic Rats
Al‐Amarat, W., Abukhalil, M. H., Althunibat, O. Y., Alfwuaires, M. A., Alnamshan, M. M., Alqosaibi, A. I., Ahmeda, A. F., Kamel, E. M., Arab, H. H., & Mahmoud, A. M. (2021) · Processes · doi:10.3390/pr9091562 · Cited by 31
REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation
Lee, D., Kim, T., Byeon, J., Park, M., Kim, S., Kim, J., Choi, S., Lee, G., Park, C., Lee, K. W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34110-1 · Cited by 35
Acute and Chronic Exposure to Tumor Necrosis Factor- Fails to Affect Insulin-Stimulated Glucose Metabolism of Isolated Rat Soleus Muscle
Fürnsinn, C., Neschen, S., Wagner, O. F., Roden, M., Bisschop, M., & Waldhäusl, W. K. (1997) · Endocrinology · doi:10.1210/endo.138.7.5219 · Cited by 31
Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells
Kim, O., Jun, W., & Lee, J. (2016) · Nutrients · doi:10.3390/nu8010060 · Cited by 31
TNF-α levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-α and insulin resistance
IJzerman, R. G., Voordouw, J. J., van Weissenbruch, M. M., Yudkin, J. S., Serné, E. H., de Waal, H. A. D., & Stehouwer, C. D. A. (2006) · Clinical Science · doi:10.1042/cs20050314 · Cited by 31
GLP-1–Based Therapies Have No Microvascular Effects in Type 2 Diabetes Mellitus
Smits, M. M., Tonneijck, L., Muskiet, M. H. A., Hoekstra, T., Kramer, M. H. H., Diamant, M., Serné, E. H., & van Raalte, D. H. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307930 · Cited by 31
Tumor necrosis factor [alpha ] -238 and -308 polymorphisms do not associate with insulin resistance in hypertensive subjects
Sheu, W. H., Lee, W., Lin, L., Chang, R., & Chen, Y.-T. (2001) · Metabolism · doi:10.1053/meta.2001.27192 · Cited by 31
Effects of long-term administration of recombinant bovine tumor necrosis factor-α on glucose metabolism and growth hormone secretion in steers
Kushibiki, S., HODATE, K., Shingu, H., Ueda, Y., Mori, Y., Itoh, T., & Yokomizo, Y. (2001) · American Journal of Veterinary Research · doi:10.2460/ajvr.2001.62.794 · Cited by 32
Abdominal obesity in BTBR male mice is associated with peripheral but not hepatic insulin resistance
Flowers, J. B., Oler, A. T., Nadler, S. T., Choi, Y., Schueler, K. L., Yandell, B. S., Kendziorski, C. M., & Attie, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00370.2006 · Cited by 33
Effect of tumor necrosis factor-α on basal and insulin-stimulated glucose transport in cultured muscle and fat cells
Ranganathan, S., & Davidson, M. B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90007-4 · Cited by 31
Modulation of the hypermetabolic response after burn injury
Gauglitz, G. G., Finnerty, C. C., Herndon, D. N., Williams, F. N., & Jeschke, M. G. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2786-9.00030-8 · Cited by 31
Insulin resistance in HIV-infected patients: relationship with pro-inflammatory cytokines released by peripheral leukocytes
Limone, P. P. (2003) · Journal of Infection · doi:10.1016/s0163-4453(03)00055-0 · Cited by 30
Tumor necrosis factor-α is induced through phorbol ester- and glycated human albumin-dependent pathway in THP-1 cells
Naitoh, T., Kitahara, M., & Tsuruzoe, N. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00152-8 · Cited by 32
Adenovirus‐mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKAy mice
Nagamatsu, S., Nakamichi, Y., Ohara‐Imaizumi, M., Ozawa, S., Katahira, H., Watanabe, T., & Ishida, H. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03146-5 · Cited by 31
Guías de práctica clínica sobre diabetes, prediabetes y enfermedades cardiovasculares: versión resumida
(ESC), G. D. T. S. D. Y. E. C. D. L. S. E. D. C., & (EASD), D. L. S. E. P. E. E. D. L. D. (2007) · Revista Española de Cardiología · doi:10.1016/s0300-8932(07)75070-4 · Cited by 28
Diet-genotype interactions in the early development of obesity and insulin resistance in mice with a genetic deficiency in tumor necrosis factor–α
Bouter, B., Geary, N., Langhans, W., & Asarian, L. (2010) · Metabolism · doi:10.1016/j.metabol.2009.11.003 · Cited by 29
Spirulina vesicolor Improves Insulin Sensitivity and Attenuates Hyperglycemia-Mediated Oxidative Stress in Fructose-Fed Rats
Hozayen, W. G., Mahmoud, A. M., Soliman, H., & Mostafa, S. (2016) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20151230055930 · Cited by 29
Modulation of insulin effects on phosphorylation of protein kinase B and glycogen synthesis by tumor necrosis factor-α in HepG2 cells
Gupta, D., & Khandelwal, R. L. (2004) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.01.003 · Cited by 29
Interleukin-4 Promotes Myogenesis and Boosts Myocyte Insulin Efficacy
Chang, Y.-H., Tsai, J., Chen, T.-L., Ho, K.-T., Cheng, H. K., Hsiao, C., & Shiau, M. (2019) · Mediators of Inflammation · doi:10.1155/2019/4182015 · Cited by 28
Arbutin ameliorates hyperglycemia, dyslipidemia and oxidative stress and modulates adipocytokines and PPARγ in high-fat diet/streptozotocin-induced diabetic rats
Abduh, M. S., Alzoghaibi, M. A., Alzoghaibi, A. M., Bin‐Ammar, A., Alotaibi, M., Kamel, E. M., & Mahmoud, A. M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121612 · Cited by 29
Lipid metabolism in tumour-bearing mice:
López‐Soriano, J., Llovera, M., Carbó, N., Garcia‐Martínez, C., López-Soriano, F. J., & Argilés, J. M. A. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00125-1 · Cited by 28
Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF‐I, IGFBP‐3 and TNFα
Grohmann, M. J., Foulstone, E. J., Welsh, G. I., Holly, J. M. P., Hamilton-Shield, J. P., Crowne, E. C., & Stewart, C. E. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093906 · Cited by 29
Angiotensin II Enhances Insulin-Stimulated Whole-Body Glucose Disposal but Impairs Insulin-Induced Capillary Recruitment in Healthy Volunteers
Jonk, A. M., Houben, A. J. H. M., Schaper, N. C., de Leeuw, P. W., Serné, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2587 · Cited by 28
Strain‐Dependent Differences for Suppression of Insulin‐Stimulated Glucose Uptake in Skeletal and Cardiac Muscle by Ethanol
Lang, C. H., Derdák, Z., & Wands, J. R. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12343 · Cited by 27
Self-citation
The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice
Takano, M., Nishihara, R., Sugano, N., Matsumoto, K., Yamada, Y., Takane, M., Fujisaki, Y., & Ito, K. (2010) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2010.03.004 · Cited by 27
Insulin‐Induced Changes in Microvascular Vasomotion and Capillary Recruitment are Associated in Humans
de Boer, M. P., Meijer, R. I., Newman, J., Stehouwer, C. D. A., Eringa, E. C., Smulders, Y. M., & Serné, E. H. (2014) · Microcirculation · doi:10.1111/micc.12114 · Cited by 27
T lymphopenia in genetically obese-diabetic wistar fatty rats: Effects of body weight reduction on T cells
Tanaka, S., Isoda, F., Kiuchi, Y., Ikeda, H., Mobbs, C. V., & Yamakawa, T. (2000) · Metabolism · doi:10.1053/meta.2000.9516 · Cited by 27
Endocrine interventions in the ICU.
Ellger, B., Debaveye, Y., & den Berghe, G. V. (2005) · European journal of internal medicine · doi:10.1016/j.ejim.2004.10.014 · Cited by 26
β-Adrenergic Blockade Exacerbates Sepsis-Induced Changes in Tumor Necrosis Factor α and Interleukin-6 in Skeletal Muscle and is Associated With Impaired Translation Initiation
Lang, C. H., Nystrom, G. J., & Frost, R. A. (2008) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000249375.43015.01 · Cited by 26
Self-citation
Leptin and the Adipocyte Endocrine System
Diamond, F., & Eichler, D. C. (2002) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360290795565 · Cited by 27
Whole-Body Insulin Sensitivity Index Is a Highly Specific Predictive Marker for Virological Response to Peginterferon Plus Ribavirin Therapy in Chronic Hepatitis C Patients with Genotype 1b and High Viral Load
Mizuta, T., Kawaguchi, Y., Eguchi, Y., Takahashi, K., Ario, K., Akiyama, T., Oza, N., Otsuka, T., Kuwashiro, T., Yoshimura, T., et al. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0691-2 · Cited by 25
Pro/con debate: Is intensive insulin therapy targeting tight blood glucose control of benefit in critically ill patients?
Merz, T. M., & Finfer, S. R. (2008) · Critical Care · doi:10.1186/cc6837 · Cited by 24
Intensive Insulin Therapy in The Intensive Care Unit: Update on Clinical Impact and Mechanisms of Action
Vanhorebeek, I., Langouche, L., & den Berghe, G. V. (2006) · Endocrine Practice · doi:10.4158/ep.12.s3.14 · Cited by 25
Malaria, blood glucose, and the role of tumour necrosis factor (TNF) in mice
Elased, K. M., Taverne, J., & Playfair, J. H. L. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.d01-781.x · Cited by 25
Understanding the peroxisome proliferator-activated receptor gamma (PPAR-γ) role in periodontitis and diabetes mellitus: A molecular perspective
Nicchio, I. G., Cirelli, T., Quil, L. C. D. C., Camilli, Â. C., Scarel‐Caminaga, R. M., & Leite, F. R. M. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116908 · Cited by 28

Authors: Lang, C. H., Dobrescu, C., & Bagby, G. J.
Affiliations: Louisiana State University (US)
ORCID: Lang, C H
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1992-01
Volume: 130
Issue: 1
Pages: 43-52
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.130.1.1727716
OpenAlex: W2067057146
Cited by: 535
References: 31
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 2 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 13 · 2016: 15 · 2015: 11 · 2014: 18 · 2013: 24 · 2012: 17
FWCI: 9.94
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01gm032654-10)
National Institute of General Medical Sciences (GM 32654, GM 38032)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: TNF-α, insulin resistance, hepatic glucose production, hyperinsulinemic-euglycemic clamp, glucose uptake, muscle glucose uptake, whole-body glucose metabolism
MeSH terms: Animals, Glucose, Insulin Antagonists, Insulin Resistance, Liver, Male, Rats, Inbred Strains, Tumor Necrosis Factor-alpha, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks