Cited by 48Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological ResponsesAdipose Tissue and Metabolism

Inflammation in Metabolic Syndrome and Type 2 Diabetes: Impact of Dietary Glucose

KEMPF, KERSTIN, ROSE, BETTINA, HERDER, CHRISTIAN, KLEOPHAS, URSULA, MARTIN, STEPHAN, KOLB, HUBERT·2006·Annals of the New York Academy of Sciences

Abstract

Chronic overnutrition combined with a lack of exercise is the main cause for the rapidly increasing prevalence of overweight and obesity. It seems accepted that adipositis (macrophage infiltration and inflammation of adipose tissue in obesity) and systemic low grade inflammation affect the pathogenesis of the metabolic syndrome or type 2 diabetes mellitus (T2DM). Therefore, modern weight reduction programs additionally focus on strategies to attenuate the inflammation state. Exercise is one major factor, which contributes to the reduction of both the incidence of T2DM and inflammation, and the immunomodulatory effects of exercise are supported by similarly beneficial effects of dietary changes. In this context, glucose is the most extensively studied nutrient and current investigations focus on postprandial glucose-induced inflammation, one possible reason why hyperglycemia is detrimental. Indeed, glucose may modulate the mRNA expression and serum concentrations of immune parameters but these alterations rapidly normalize in normoglycemic subjects. In case of an impaired metabolic state, however, postprandial hyperglycemia increases magnitude and duration of systemic inflammatory responses, which probably promotes the development of T2DM and of cardiovascular disease.

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Crossref · 10.1196/annals.1372.012

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  • These indirect effects include up- or down-regulation of resistin, leptin, adiponectin, lipocalin 2, osteopontin and insulin itself.

    “These effects include the up-or down-regulation of the synthesis of resistin (138) , leptin, adiponectin (139) , lipocalin 2 (140) , osteopontin (141) , and of insulin itself.”

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Authors
KEMPF, K., ROSE, B., HERDER, C., KLEOPHAS, U., MARTIN, S., & KOLB, H.
Affiliations
Deutsches Diabetes-Zentrum e.V. (DE)
Corresponding author
KEMPF, KERSTIN
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2006-11
Volume
1084
Issue
1
Pages
30-48
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1563001226
Cited by
48
References
97
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 3 · 2019: 2 · 2014: 2 · 2013: 5 · 2012: 8
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
inflammation, metabolic syndrome, type 2 diabetes, adipose tissue inflammation, obesity, physical activity, dietary intervention, postprandial hyperglycemia, immunological parameters, weight loss, cardiovascular disease
MeSH terms
Insulin Secretion, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Glucose, Humans, Inflammation, Insulin, RNA, Messenger, Transcription, Genetic, Cytokines, Metabolic Syndrome

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