Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1

Majdalawieh, A. F., & Ro, H.-S. (2010) · Nuclear Receptor Signaling · doi:10.1621/nrs.08004 · Cited by 94

Loss of PPARγ in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue

Guri, A. J., Hontecillas, R., Ferrer, G., Casagran, O., Wankhade, U. D., Noble, A. M., Eizirik, D. L., Ortis, F., Cnop, M., Liu, D., et al. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.02.010 · Cited by 92

A gut feeling of the PXR, PPAR and NF‐κB connection

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Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor α by AMP-activated protein kinase

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Peroxisome Proliferator-Activated Receptor γ Inhibits the Migration of Dendritic Cells: Consequences for the Immune Response

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Iron restriction improves type 2 diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats

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Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease

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Multiple variants of the peroxisome proliferator-activated receptor (PPAR) γ are expressed in the liver of Atlantic salmon (Salmo salar)

Andersen, Ø., Eijsink, V. G. H., & Thomassen, M. S. (2000) · Gene · doi:10.1016/s0378-1119(00)00350-4 · Cited by 89

Peroxisome Proliferators‐Activated Receptor (PPAR) Modulators and Metabolic Disorders

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Th1 cytokine–induced downregulation of PPARγ in human biliary cells relates to cholangitis in primary biliary cirrhosis†

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Peroxisome proliferator activated receptor agonists

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PPAR‐γ agonists as therapy for diseases involving airway neutrophilia

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Peroxisome proliferator-activated receptor-γ ligands for the treatment of breast cancer

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Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

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Peroxisome Proliferator‐Activated Receptors as Mediators of Phthalate‐Induced Effects in the Male and Female Reproductive Tract: Epidemiological and Experimental Evidence

Latini, G., Scoditti, E., Verrotti, A., Felice, C. D., & Massaro, M. (2007) · PPAR Research · doi:10.1155/2008/359267 · Cited by 93

Lemon Polyphenols Suppress Diet-induced Obesity by Up-Regulation of mRNA Levels of the Enzymes Involved in β-Oxidation in Mouse White Adipose Tissue

Fukuchi, Y., Hiramitsu, M., Okada, M., Hayashi, S., Nabeno, Y., Osawa, T., & Naito, M. (2008) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2008066 · Cited by 90

Do PPARGC1A and PPARα polymorphisms influence sprint or endurance phenotypes?

Eynon, N., Meckel, Y., Sagiv, M. S., Yamin, C., Amir, R. E., Sagiv, M. S., Goldhammer, E., Duarte, J. A., & de Oliveira, J. J. F. (2010) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.00930.x · Cited by 93

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

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Overlapping Transcriptional Programs Regulated by the Nuclear Receptors Peroxisome Proliferator-Activated Receptor α, Retinoid X Receptor, and Liver X Receptor in Mouse Liver

Anderson, S. P., Dunn, C. S., Laughter, A., Yoon, L., Swanson, C. L., Stulnig, T. M., Steffensen, K. R., Chandraratna, R. A. S., Gustafsson, J.-Å., & Corton, J. C. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.005496 · Cited by 87

Correlation between expression of peroxisome proliferator-activated receptor β and squamous differentiation in epidermal and tracheobronchial epithelial cells

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PFAS and Potential Adverse Effects on Bone and Adipose Tissue through Interactions with PPARγ

Kirk, A. B., Michelsen-Correa, S., Rosen, C., Martin, C. F., & Blumberg, B. (2021) · Endocrinology · doi:10.1210/endocr/bqab194 · Cited by 90

Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach

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Regulation of Intestinal Inflammation by Dietary Fats

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Connexins 43 and 26 Are Differentially Increased after Rat Bladder Outlet Obstruction

Haefliger, J. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5465 · Cited by 87

Bezafibrate is a dual ligand for PPARα and PPARβ: studies using null mice

Peters, J. M., Aoyama, T., Burns, A., & Gonzalez, F. J. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(03)00065-9 · Cited by 92

Diverse regulation of NF-κB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver

Romics, L., Kodys, K., Dolganiuc, A., Graham, L. S., Velayudham, A., Mandrekar, P., & Szabó, G. (2004) · Hepatology · doi:10.1002/hep.20304 · Cited by 87

Mechanisms of Peroxisome Proliferator Activated Receptor γ Regulation by Non-steroidal Anti-inflammatory Drugs

Puhl, A. C., Milton, F. A., Čvoro, A., Sieglaff, D. H., Campos, J. C. L. D. O., Bernardes, A., Filgueira, C. S., Lindemann, J. A. L., Deng, T., Neves, F. D. A. R., et al. (2015) · Nuclear Receptor Signaling · doi:10.1621/nrs.13004 · Cited by 88

Molecular Mechanisms and Signaling Pathways Involved in the Nutritional Support of Spermatogenesis by Sertoli Cells

Crisóstomo, L., Alves, M. G., Gorga, A., Sousa, M., Riera, M. F., Galardo, M. N., Meroni, S. B., & Oliveira, P. F. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7698-0_11 · Cited by 90

Lipid sensing and lipid sensors

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Deficiency of PPARβ/δ in the Epidermis Results in Defective Cutaneous Permeability Barrier Homeostasis and Increased Inflammation

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Review: PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury

Collino, M., Patel, N. S. A., & Thiemermann, C. (2008) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944708090924 · Cited by 87

Clofibric acid, a peroxisome proliferator–activated receptor α ligand, inhibits growth of human ovarian cancer

Yokoyama, Y., Xin, B., Shigeto, T., Umemoto, M., Kasai-Sakamoto, A., Futagami, M., Tsuchida, S., Al‐Mulla, F., & Mizunuma, H. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0722 · Cited by 86

The impact of PPARα activation on whole genome gene expression in human precision cut liver slices

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Impact of environmental exposures on ovarian function and role of xenobiotic metabolism during ovotoxicity

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Differential Expression of Peroxisome Proliferator-activated Receptors (PPARs) in the Developing Human Fetal Digestive Tract

Huin‐Schohn, C., Corriveau, L., Bianchi, A., Keller, J. M., Collet, P., Krémarik, P., Domenjoud, L., Bécuwe, P., Schohn, H., Ménard, D., et al. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800504 · Cited by 85

Expression of Peroxisome Proliferator-Activated Receptor γ (PPARγ) in Rat Aortic Smooth Muscle Cells

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IUGR decreases PPARγ and SETD8 Expression in neonatal rat lung and these effects are ameliorated by maternal DHA supplementation

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Integrative and Systemic Approaches for Evaluating PPARβ/δ (PPARD) Function

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Interactions Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma on Neuroinflammation, Demyelination, and Remyelination in Multiple Sclerosis

Vallée, A., Vallée, J.-N., Guillevin, R., & Lecarpentier, Y. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0550-9 · Cited by 88

Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARα and SREBP-1c signaling

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Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes

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Role of Peroxisome Proliferator-Activated Receptor γ and Its Ligands in Non-Neoplastic and Neoplastic Human Urothelial Cells

Nakashiro, K., Hayashi, Y., Kita, A., Tamatani, T., Chlenski, A., Usuda, N., Hattori, K., Reddy, J. K., & Oyasu, R. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61730-0 · Cited by 84

The role of peroxisome proliferator‐activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus

Gupta, D., Kono, T., & Evans‐Molina, C. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01299.x · Cited by 83

The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling

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Nuclear Control of the Inflammatory Response in Mammals by Peroxisome Proliferator-Activated Receptors

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Immunohistochemistry in Investigative and Toxicologic Pathology

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Neuroprotective effects of pioglitazone in a rat model of permanent focal cerebral ischemia are associated with peroxisome proliferator-activated receptor gamma-mediated suppression of nuclear factor-κB signaling pathway

Zhang, H.-L., Xu, M., Wei, C., Qin, A.-P., Liu, C.-F., Hong, L.-Z., Zhao, X., Liu, J., & Qin, Z. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.029 · Cited by 83

Expression of peroxisome proliferator-activated receptors in zebrafish (Danio rerio) depending on gender and developmental stage

Ibabe, A., Bilbao, E., & Cajaraville, M. P. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0737-2 · Cited by 83

Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE

Kostiuk, M. A., Keller, B. O., & Berthiaume, L. G. (2010) · The FASEB Journal · doi:10.1096/fj.09-149765 · Cited by 85

Peroxisome Proliferator-Activated Receptor α Gene Variation Influences Age of Onset and Progression of Type 2 Diabetes

Flavell, D. M., Ireland, H., Stephens, J. W., Hawe, E., Acharya, J., Mather, H. M., Hurel, S. J., & Humphries, S. E. (2005) · Diabetes · doi:10.2337/diabetes.54.2.582 · Cited by 83

Identification of differentially expressed genes and pathways for intramuscular fat metabolism between breast and thigh tissues of chickens

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Endocannabinoid System in Hepatic Glucose Metabolism, Fatty Liver Disease, and Cirrhosis

Bazwinsky‐Wutschke, I., Zipprich, A., & Dehghani, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102516 · Cited by 85

O-GlcNAc modification of PPARγ reduces its transcriptional activity

Ji, S., Park, S., Roth, J., Kim, H. S., & Cho, J. W. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.12.086 · Cited by 84

Modulating the transcriptional control of adipogenesis

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Response of Experimental Retinal Neovascularization to Thiazolidinediones

Murata, T. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.5.709 · Cited by 82

PPARα agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity

Hou, X., Shen, Y. H., Li, C., Wang, F., Zhang, C., Bu, P., & Zhang, Y. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.043 · Cited by 81

Thiazolidinediones Inhibit Growth and Invasiveness of the Human Adrenocortical Cancer Cell Line H295R

Ferruzzi, P., Ceni, E., Tarocchi, M., Grappone, C., Milani, S., Galli, A., Fiorelli, G., Serio, M., & Mannelli, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0978 · Cited by 81

The Peroxisome Proliferator-activated Receptor-γ Regulates Murine Pyruvate Carboxylase Gene Expression in Vivo and in Vitro

Jitrapakdee, S., Slawik, M., Medina‐Gómez, G., Campbell, M., Wallace, J. C., Sethi, J. K., O’Rahilly, S., & Vidal‐Puig, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503836200 · Cited by 82

Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity

Duszka, K., Gregor, A., Guillou, H., König, J. S., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071708 · Cited by 86

PPAR-Targeted Therapies in the Treatment of Non-Alcoholic Fatty Liver Disease in Diabetic Patients

Lange, N. F., Graf, V., Caussy, C., & Dufour, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084305 · Cited by 84

Peroxisome proliferator-activated receptors (PPARs) and peroxisomes in rat cortical and cerebellar astrocytes

Cristiano, L., Bernardo, A., & Ceru`, M. P. (2001) · Journal of Neurocytology · doi:10.1023/a:1016525716209 · Cited by 81

Hematopoietic recovery following chemotherapy is improved by BADGE-induced inhibition of adipogenesis

Zhu, R., Wu, M.-Q., Li, Z., Zhang, Y., & Liu, K. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1233-4 · Cited by 80

PPARγ and metabolism: insights from the study of human genetic variants

Gurnell, M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01767.x · Cited by 80

Cross-talk between Peroxisome Proliferator-Activated Receptor δ and Cytosolic Phospholipase A2α/Cyclooxygenase-2/Prostaglandin E2 Signaling Pathways in Human Hepatocellular Carcinoma Cells

Xu, L., Han, C. L., Lim, K., & Wu, T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1445 · Cited by 84

Metabolomics of the interaction between PPAR‐α and age in the PPAR‐α‐null mouse

Atherton, H. J., Gulston, M. K., Bailey, N. J. C., Cheng, K., Zhang, W., Clarke, K., & Griffin, J. L. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.18 · Cited by 80

A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARα-dependent and -independent pathways

Gloerich, J., van Vlies, N., Jansen, G. A., Denis, S. W., Ruiter, J. P. N., van Werkhoven, M. A., Durán, M., Vaz, F. M., Wanders, R. J. A., & Ferdinandusse, S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400337-jlr200 · Cited by 80

The potential interactions between polyunsaturated fatty acids and colonic inflammatory processes

Mills, S., Windsor, A. C. J., & Knight, S. C. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02851.x · Cited by 81

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis

Brusotti, G., Montanari, R., Capelli, D., Cattaneo, G., Laghezza, A., Tortorella, P., Loiodice, F., Peiretti, F., Bonardo, B., Paiardini, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05666-6 · Cited by 84

In vitro and in vivo antidiabetic activity, isolation of flavonoids, and in silico molecular docking of stem extract of Merremia tridentata (L.)

Van, L. V., Pham, E. C., Nguyen, C. V., Duong, N. T. N., Thi, T. V. L., & Truong, T. N. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112611 · Cited by 87

The Roles of Peroxisome Proliferator-Activated Receptors in the Metabolic Syndrome

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Perfluorooctanoic acid-induced hepatic toxicity following 21-day oral exposure in mice

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A Mutant Thyroid Hormone Receptor α Antagonizes Peroxisome Proliferator-Activated Receptor α Signaling in Vivo and Impairs Fatty Acid Oxidation

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Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN

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Regulation of the peroxisomal β-oxidation-dependent pathway by peroxisome proliferator-activated receptor α and kinases

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Peroxisome Proliferator‐Activated Receptor β/δ in the Brain: Facts and Hypothesis

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The Transcriptional Response to a Peroxisome Proliferator-activated Receptor α Agonist Includes Increased Expression of Proteome Maintenance Genes

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Hepatic protein expression of lean mice and obese diabetic mice treated with peroxisome proliferator‐activated receptor activators

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Peroxisome proliferator-activated receptor γ1 (PPARγ1) expresses in rat mesangial cells and PPARγ agonists modulate its differentiation

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Peroxisome proliferator‐activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages

Gbaguidi, F. G., Chinetti, G., Milosavljevic, D., Morier-teissier, E., Chapman, J., Olivecrona, G., Fruchart, J., Griglio, S., Fruchart, J., & Staels, B. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02223-8 · Cited by 79

TRANSCRIPTIONAL ACTIVATION OF CYTOCHROME P450 GENES BY DIFFERENT CLASSES OF CHEMICAL INDUCERS

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Hanging Drop, A Best Three-Dimensional (3D) Culture Method for Primary Buffalo and Sheep Hepatocytes

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Mechanisms of carbon nanotube‐induced pulmonary fibrosis: a physicochemical characteristic perspective

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Molecular characterization of three peroxisome proliferator‐activated receptors from the sea bass (Dicentrarchus labrax)

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Fenofibric Acid, an Active Form of Fenofibrate, Increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by Enhancing Transcription of ATP-Binding Cassette Transporter A1 Gene in a Liver X Receptor–Dependent Manner

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PPARs in Alzheimer′s Disease

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Peroxisome Proliferator Activated Receptor

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Printed in U.S.A. Copyright © 1998 by The Endocrine Society Differential Expression of Peroxisome Proliferator- Activated Receptor-�,-�, and- � during Rat

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Differential Expression of Peroxisome Proliferator-Activated Receptor- , - , and - during Rat Embryonic Development

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