Cited by 2,217Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismCholesterol and Lipid Metabolism

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Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

Braissant, O, Foufelle, F, Scotto, C, Dauça, M, Wahli, W·1996·Endocrinology

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Abstract

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily that can be activated by various xenobiotics and natural fatty acids. These transcription factors primarily regulate genes involved in lipid metabolism and also play a role in adipocyte differentiation. We present the expression patterns of the PPAR subtypes in the adult rat, determined by in situ hybridization using specific probes for PPAR-alpha, -beta and -gamma, and by immunohistochemistry using a polyclonal antibody that recognizes the three rat PPAR subtypes. In numerous cell types from either ectodermal, mesodermal, or endodermal origin, PPARs are coexpressed, with relative levels varying between them from one cell type to the other. PPAR-alpha is highly expressed in hepatocytes, cardiomyocytes, enterocytes, and the proximal tubule cells of kidney. PPAR-beta is expressed ubiquitously and often at higher levels than PPAR-alpha and -gamma. PPAR-gamma is expressed predominantly in adipose tissue and the immune system. Our results suggest new potential directions to investigate the functions of the different PPAR subtypes.

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Authors: Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W.
Affiliations: University of Lausanne (CH)
ORCID: Braissant, O
Foufelle, F
Wahli, W
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1996-01
Volume: 137
Issue: 1
Pages: 354-366
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.137.1.8536636
OpenAlex: W2047982128
Cited by: 2,217
References: 0
Citations by year: 2026: 14 · 2025: 34 · 2024: 31 · 2023: 32 · 2022: 56 · 2021: 53 · 2020: 50 · 2019: 42 · 2018: 74 · 2017: 64 · 2016: 76 · 2015: 65 · 2014: 75 · 2013: 95 · 2012: 71
FWCI: 23.68
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: peroxisome proliferator-activated receptors, PPARα, PPAR-beta, PPARγ, tissue distribution, nuclear receptors, lipid metabolism, adipogenesis, hepatocytes, cardiomyocytes, enterocytes, proximal tubular epithelial cells, adipose tissue, immune system, rats
MeSH terms: Animals, Base Sequence, Female, Male, Molecular Sequence Data, Tissue Distribution, Transcription Factors, Molecular Probes, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Cytoplasmic and Nuclear, Rats

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Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

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