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Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
Abstract
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily that can be activated by various xenobiotics and natural fatty acids. These transcription factors primarily regulate genes involved in lipid metabolism and also play a role in adipocyte differentiation. We present the expression patterns of the PPAR subtypes in the adult rat, determined by in situ hybridization using specific probes for PPAR-alpha, -beta and -gamma, and by immunohistochemistry using a polyclonal antibody that recognizes the three rat PPAR subtypes. In numerous cell types from either ectodermal, mesodermal, or endodermal origin, PPARs are coexpressed, with relative levels varying between them from one cell type to the other. PPAR-alpha is highly expressed in hepatocytes, cardiomyocytes, enterocytes, and the proximal tubule cells of kidney. PPAR-beta is expressed ubiquitously and often at higher levels than PPAR-alpha and -gamma. PPAR-gamma is expressed predominantly in adipose tissue and the immune system. Our results suggest new potential directions to investigate the functions of the different PPAR subtypes.
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“Furthermore, PPAR-γ is commonly expressed in macrophages and yields anti-inflammatory effects in liver fibrosis.[105]”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [105]
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Metadata
- Authors
- Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W.
- Affiliations
- University of Lausanne (CH)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1996-01
- Volume
- 137
- Issue
- 1
- Pages
- 354-366
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2047982128
- Cited by
- 2,217
- References
- 0
- Citations by year
- 2026: 14 · 2025: 34 · 2024: 31 · 2023: 32 · 2022: 56 · 2021: 53 · 2020: 50 · 2019: 42 · 2018: 74 · 2017: 64 · 2016: 76 · 2015: 65 · 2014: 75 · 2013: 95 · 2012: 71
- FWCI
- 23.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- peroxisome proliferator-activated receptors, PPARα, PPAR-beta, PPARγ, tissue distribution, nuclear receptors, lipid metabolism, adipogenesis, hepatocytes, cardiomyocytes, enterocytes, proximal tubular epithelial cells, adipose tissue, immune system, rats
- MeSH terms
- Animals, Base Sequence, Female, Male, Molecular Sequence Data, Tissue Distribution, Transcription Factors, Molecular Probes, Rats, Sprague-Dawley, In Situ Hybridization, Receptors, Cytoplasmic and Nuclear, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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