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The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage.
Abstract
Both estrogens and androgens act on bone marrow stromal/osteoblastic cells to inhibit the production of local factors that promote osteoclast development. Based on this and the evidence that loss of sex steroids up-regulates not only osteoclastogenesis but also osteoblastogenesis, we have hypothesized that cells of the osteoblastic lineage are the mediators of the adverse effects of sex steroid deficiency on bone. To test this hypothesis, we used the senescence-accelerated mouse (SAMP6), a model of defective osteoblast development, and examined the effects of orchidectomy on static and dynamic histological features of bone remodeling and on bone mineral density. After orchidectomy in SAMP6 mice, the expected increases in osteoblast precursors, cancellous osteoclasts and osteoblasts, frequency of remodeling events, trabecular spacing, and rate of bone formation were absent or greatly attenuated. Moreover, whereas bone mineral density decreased in orchidectomized controls, it did not change in SAMP6. Our data indicate that when osteoblast development is defective, orchidectomy fails to result in bone loss. This evidence suggests that cells of the osteoblastic lineage are essential mediators of the changes in the rate of bone remodeling and loss of bone mass that ensue following loss of androgens.
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“Preclinical orchiectomy (ORX) models have utility in examining the consequences of androgen ablation and androgen deprivation therapy on bone (210 -212).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [212]
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PARFITT, A. M., Drezner, M. K., Glorieux, F. H., Kanis, J. А., Malluche, H. H., Meunier, P. J., Ott, S. M., & Recker, R. R. (1987) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650020617 · Cited by 5,344
Self-citationManolagas, S. C., & Jilka, R. L. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320506 · Cited by 1,670
Self-citationIncreased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6
Jilka, R. L., Hangoc, G., Girasole, G., Passeri, G., Williams, D. C., Abrams, J. S., Boyce, B. F., Broxmeyer, H. E., & Manolagas, S. C. (1992) · Science · doi:10.1126/science.1621100 · Cited by 1,440
Self-citationEstrogen promotes apoptosis of murine osteoclasts mediated by TGF–β
Hughes, D. E., Dai, A., Tiffee, J. C., Li, H. H., Mundy, G. R., & Boyce, B. F. (1996) · Nature Medicine · doi:10.1038/nm1096-1132 · Cited by 813 · cited 1×
“Alternatively, sex steroid deficiency, which is known to delay apoptosis of osteoclasts (44), may not have such an antiapoptotic effect on osteoblasts, thereby creating an imbalance in bone turnover.”
Girasole, G., Jilka, R. L., Passeri, G., Boswell, S. H., Boder, G. B., Williams, D. C., & Manolagas, S. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115668 · Cited by 677
Self-citationTemporal relationship between bone loss and increased bone turnover in ovariectomized rats
Wronski, T. J., Cintrón, M., & Dann, L. M. (1988) · Calcified Tissue International · doi:10.1007/bf02571317 · Cited by 501
Bellido, T., Jilka, R. L., Boyce, B. F., Girasole, G., Broxmeyer, H. E., Dalrymple, S. A., Murray, R., & Manolagas, S. C. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117995 · Cited by 429
Self-citationIsolation and characterization of osteoblast precursor cells from human bone marrow
Rickard, D. J., Kassem, M. S., Hefferan, T. E., Sarkar, G., Spelsberg, T. C., & Riggs, B. L. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110305 · Cited by 397
Bellows, C. G., Aubin, J. E., & Heersche, J. N. M. (1991) · Bone and Mineral · doi:10.1016/0169-6009(91)90100-e · Cited by 396
Ernst, M., Heath, J. K., & Rodan, G. A. (1989) · Endocrinology · doi:10.1210/endo-125-2-825 · Cited by 362
Research works printed but not linked: 7
- Manolagas, 1996, Interleukin-6-type cytokines and their receptors, In: Bilezikian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic Press, San Diego, pp, 701
- Reis, 1995, A strategy for chromosome mapping of osteoporosis-associated genes in the senescence accelerated mouse (SAM): use of high-resolution dual-energy x-ray absorptiometry, J Bone Miner Res, 10, S161
- Benes, 1996, Polymorphic microsatellite markers distinguish three AKR mouse substrains that exhibit different levels of bone mineral density, J Bone Miner Res, 11, S331
- Halstead, 1996, Comparison of the effects of 22-oxacalcitriol and calcitriol on bone metabolism in young X-linked hypophosphatemic (HYP) mice, Am J Physiol, 270, E141
- Owen, 1985, Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA (ed) Bone and Mineral Research., Elsevier, Amsterdam, vol, 3, 1
- 1995, Stata Statistical Software Release 4 0, Stata Corp., College Station, pp, 1
- Parfitt, 1988, Bone remodeling: relationship to the amount and structure of bone and the pathogenesis and prevention of fractures In: Riggs BL, Melton LJ (eds) Osteoporosis: Etiology, Diagnosis, and Management, Raven Press, New York, pp, 45
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Self-citationWeinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753
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Aguirre, J. I., Plotkin, L. I., Stewart, S. A., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C., & Bellido, T. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060107 · Cited by 494
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Self-citationGori, F., Hofbauer, L. C., Dunstan, C. R., Spelsberg, T. C., Khosla, S., & Riggs, B. L. (2000) · Endocrinology · doi:10.1210/endo.141.12.7840 · Cited by 309
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Self-citationWeinstein, R. S., & Manolagas, S. C. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00420-9 · Cited by 250
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Kajkenova, O., Lecka‐Czernik, B., Gubrij, I. B., Hauser, S. P., Takahashi, K., PARFITT, A. M., Jilka, R. L., Manolagas, S. C., & Lipschitz, D. A. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1772 · Cited by 226
Self-citationJilka, R. L., Takahashi, K., Munshi, M., Williams, D. C., Roberson, P. K., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1039 · Cited by 213
Self-citationQuantitative Trait Loci Affecting Peak Bone Mineral Density in Mice
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Bellido, T., Borba, V. Z. C., Roberson, P. K., & Manolagas, S. C. (1997) · Endocrinology · doi:10.1210/endo.138.9.5364 · Cited by 212
Self-citationKawaguchi, H., Manabe, N., Miyaura, C., Chikuda, H., Nakamura, K., & Kuro‐o, M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5705 · Cited by 204
Mishina, Y. M., Starbuck, M. W., Gentile, M. A., Fukuda, T., Kasparcova, V., Seedor, J. G., Hanks, M. C., Amling, M., Pinero, G. J., Harada, S.-I., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404222200 · Cited by 198
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Gregorio, G. B. D., Yamamoto, M., Ali, A., Abe, E., Roberson, P. K., Manolagas, S. C., & Jilka, R. L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11653 · Cited by 127
Self-citationChen, J., Lin, P., Tsai, Y.-R., Yang, Y.-C., & Kang, H. (2019) · Cells · doi:10.3390/cells8111318 · Cited by 129
McLaughlin, F., Mackintosh, J., Hayes, B., McLaren, A., Uings, I., Salmon, P., Humphreys, J., Meldrum, E., & Farrow, S. N. (2002) · Bone · doi:10.1016/s8756-3282(02)00737-8 · Cited by 117
Grey, A. B., Chen, Q., Callon, K. E., Xu, X., Reid, I. R., & Cornish, J. (2002) · Endocrinology · doi:10.1210/en.2002-220347 · Cited by 114
Danilovic, D. L. S., Corrêa, P. H. S., Costa, E. M. F., Melo, K., Mendonca, B. B., & Arnhold, I. J. P. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0243-6 · Cited by 110
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Shimizu, M., Higuchi, K., Bennett, B., Chen, X., Tsuboyama, T., Kasai, S., Chiba, T., Fujisawa, H., Kogishi, K., Kitado, H., et al. (1999) · Mammalian Genome · doi:10.1007/s003359900949 · Cited by 107
M-CSF neutralization and Egr-1 deficiency prevent ovariectomy-induced bone loss
Cenci, S., Weitzmann, M. N., Gentile, M. A., Aisa, M. C., & Pacifici, R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8672 · Cited by 103
Beneš, H., Weinstein, R. S., Zheng, W., Thaden, J. J., Jilka, R. L., Manolagas, S. C., & Reis, R. J. S. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.4.626 · Cited by 99
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Kiernan, J., Davies, J. E., & Stanford, W. L. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0054 · Cited by 74
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Gupta, A., Tenenhouse, H. S., Hoag, H. M., Wang, D., Khadeer, M., Namba, N., Feng, X., & Hruska, K. A. (2001) · Bone · doi:10.1016/s8756-3282(01)00601-9 · Cited by 69
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Oxidation-specific epitopes restrain bone formation
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Self-citationFritton, J. C., Myers, E. R., Wright, T. M., & van der Meulen, M. C. H. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080104 · Cited by 63
Reim, N. S., Breig, B., Stähr, K., Eberle, J., Hoeflich, A., Wolf, E., & Erben, R. G. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080202 · Cited by 59
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Self-citationEyre, L. J., Bland, R., Bujalska, I. J., Sheppard, M. C., Stewart, P. M., & Hewison, M. (1998) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1998.13.6.996 · Cited by 52
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Androgen exposure and the maintenance of skeletal integrity in aging men
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Androgens, Estrogens, and Bone in Men
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Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice
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Peptidomimetic inhibitor of L-plastin reduces osteoclastic bone resorption in aging female mice
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Glucocorticoid-Induced Osteoporosis
Adler, R. A., Weinstein, R. S., & Saag, K. G. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-415853-5.00049-2 · Cited by 6
Self-citationCellular and Molecular Mechanisms of Postmenopausal Osteoporosis
Manolagas, S. C. (2000) · Springer eBooks · doi:10.1007/978-0-387-21628-7_13 · Cited by 6
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Testosterone therapy in children and adolescents: to whom, how, when?
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Quantitative trait locus on chromosome X affects bone loss after maturation in mice
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Human and Animal Studies of the Genetics of Osteoporosis
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Metadata
- Authors
- Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1997-09-01
- Volume
- 138
- Issue
- 9
- Pages
- 4013-4021
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1972472172
- Cited by
- 126
- References
- 39
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Aging (P01-AG-13918-01, P01AG013918)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- androgen deficiency, bone remodeling, bone mineral density, osteoblast lineage, osteoblastogenesis, osteoclastogenesis, orchiectomy, sex hormone deficiency, bone loss, trabecular bone, bone formation
- MeSH terms
- Androgens, Animals, Body Weight, Bone Marrow Cells, Cell Count, Male, Mice, Mutant Strains, Orchiectomy, Osteoblasts, Stem Cells, Bone Density, Bone Remodeling, Mice
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