Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress

Gibbs, Daniel M.

doi:10.1016/0024-3205(84)90241-8

Cited by 234Stress Responses and CortisolNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress

Gibbs, Daniel M.·1984·Life Sciences

DOI 10.1016/0024-3205(84)90241-8

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Abstract

Oxytocin (OT), vasopressin (AVP), and corticotropin (ACTH) levels were measured in peripheral plasma of male rats subjected to one of three models of stress: restraint, cold, or ether. ACTH secretion was increased in all three groups compared to unstressed controls. OT secretion was increased in rats subjected to restraint or ether but not cold. AVP secretion was increased only by ether stress. The data suggest that the hypothalamic and neurohypophysial contribution to the control of ACTH secretion may vary in response to different types of stress.

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Socially isolated rats receiving stressors of restraint and ether, but not cold, showed raised plasma oxytocin levels, indicating that some, but not all, non-social stressors precipitate peripheral oxytocin release.
“Socially isolated rats receiving stressors of restraint and ether, but not cold, showed raised plasma oxytocin levels (Gibbs, 1984), indicating that some, but not all, non-social stressors precipitate peripheral oxytocin release.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Gibbs, 1984

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
Stress in Health and Disease
(1976) · Elsevier eBooks · doi:10.1016/c2013-0-06263-9 · Cited by 982 · see citing works
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965 · see citing works
Effects of synthetic ovine corticotropin-releasing factor, glucocorticoids, catecholamines, neurohypophysial peptides, and other substances on cultured corticotropic cells
VALE, W., VAUGHAN, J., SMITH, M., & YAMAMOTO, G. (1983) · Endocrinology · doi:10.1210/endo-113-3-1121 · Cited by 563 · see citing works
Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin
Rivier, C., & Vale, W. (1983) · Nature · doi:10.1038/305325a0 · Cited by 539 · see citing works
Hypothalamic-Pituitary Vasculature: Evidence for Retrograde Blood Flow in the Pituitary Stalk1
Oliver, C., Mical, R. S., & Porter, J. C. (1977) · Endocrinology · doi:10.1210/endo-101-2-598 · Cited by 346 · see citing works
Oxytocin, vasopressin and memory: opposite effects on consolidation and retrieval processes
Bohus, B. ́., Kova´cs, G. L., & de Wied, D. (1978) · Brain Research · doi:10.1016/0006-8993(78)90052-5 · Cited by 312 · see citing works
Oxytocin unlike vasopressin is a stress hormone in the rat.
Lang, R. E., Heil, J. W. E., Ganten, D., Hermann, K., Unger, T., & Rascher, W. (2008) · Neuroendocrinology · doi:10.1159/000123566 · Cited by 304 · see citing works
Inhibition of Adrenocorticotropic Hormone Secretion in the Rat by Immunoneutralization of Corticotropin-Releasing Factor
RIVIER, C. L., Rivier, J., & Vale, W. (1982) · Science · doi:10.1126/science.6289439 · Cited by 273 · see citing works
Hemorrhage-Induced Secretion of Corticotropin-Releasing Factor-Like Immunoreactivity into the Rat Hypophysial Portal Circulation and Its Inhibition by Glucocorticoids*
Plotsky, P. M., & Vale, W. (1984) · Endocrinology · doi:10.1210/endo-114-1-164 · Cited by 259 · see citing works
Vasopressin and Neurophysin: High Concentrations in Monkey Hypophyseal Portal Blood
Zimmerman, E. A., Carmel, P. W., Husain, M., Ferin, M., Tannenbaum, M., FRANTZ, A. G., & ROBINSON, A. G. (1973) · Science · doi:10.1126/science.182.4115.925 · Cited by 208 · see citing works
Effect of the serotonin reuptake inhibitor fluoxetine on corticotropin-releasing factor and vasopressin secretion into hypophysial portal blood
Gibbs, D. M., & Vale, W. (1983) · Brain Research · doi:10.1016/0006-8993(83)91189-7 · Cited by 205 · see citing works
Reduction in Plasma Vasopressin Levels of Dehydrated Rats Following Acute Stress
KEIL, L. C., & Severs, W. B. (1977) · Endocrinology · doi:10.1210/endo-100-1-30 · Cited by 187 · see citing works
Stress in Health and Disease.
(1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-799_1 · Cited by 181 · see citing works
PRESENCE OP CORTICOTROPIN RELEASING FACTOR-LIKE IMMUNOREACTIVITY IN HYPOPHYSIAL PORTAL BLOOD
Gibbs, D. M., & Vale, W. (1982) · Endocrinology · doi:10.1210/endo-111-4-1418 · Cited by 159 · see citing works
Vasopressin Release Due to Manual Restraint in the Rat: Role of Body Compression and Comparison with Other Stressful Stimuli*
Husain, M., Manger, W. M., ROCK, T. W., Weiss, R., & FRANTZ, A. G. (1979) · Endocrinology · doi:10.1210/endo-104-3-641 · Cited by 121 · see citing works
Oxytocin as well as vasopressin potentiate ovine CRF in vitro
Antoni, F. A., Holmes, M. C., & Jones, M. T. (1983) · Peptides · doi:10.1016/0196-9781(83)90041-4 · Cited by 120 · see citing works
Oxytocin potentiates the ACTH-releasing activity of CRF(41) but not vasopressin
Gibbs, D. M., Vale, W., Rivier, J., & Yen, S. S. C. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90212-1 · Cited by 100 · see citing works
High Concentrations of Oxytocin in Hypophysial Portal Plasma*
Gibbs, D. M. (1984) · Endocrinology · doi:10.1210/endo-114-4-1216 · Cited by 96 · see citing works
Neuroendocrinology of vasopressin, corticoliberin and opiomelanocortins
Thomson, A. M. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90156-2 · Cited by 92 · see citing works
In vitro potentiation of the activity of synthetic ovine corticotropin-releasing factor by arginine vasopressin
Turkelson, C. M., Thomas, C. R., Arimura, A., Chang, D.-M., Chang, J. K., & Shimizu, M. (1982) · Peptides · doi:10.1016/0196-9781(82)90037-7 · Cited by 78 · see citing works
Hibernation: Endocrinologic Aspects
Hudson, J. W., & Wang, L. C. H. (1979) · Annual Review of Physiology · doi:10.1146/annurev.ph.41.030179.001443 · Cited by 70 · see citing works
Rat Vasopressin Response to Insulin-Induced Hypoglycemia*
Baylis, P. H., & Robertson, G. L. (1980) · Endocrinology · doi:10.1210/endo-107-6-1975 · Cited by 69 · see citing works
Oxytocin Infusion Increases Plasma Insulin and Glucagon Levels and Glucose Production and Uptake in the Normal Dog
ALTSZULER, N., & Hampshire, J. (1981) · Diabetes · doi:10.2337/diab.30.2.112 · Cited by 66 · see citing works
The vasopressin receptor antagonist dPTyr(Me)AVP does not prevent stress-induced ACTH and corticosterone release
Mormède, P. (1983) · Nature · doi:10.1038/302345a0 · Cited by 65 · see citing works
Functional reinnervation of the denervated neostriatum by nigral transplants
Stenevi, U., Björklund, A., & Dunnett, S. B. (1980) · Peptides · doi:10.1016/0196-9781(80)90108-4 · Cited by 64 · see citing works
Vasopressin secretion induced by hypoxia in sheep: Developmental changes and relationship to β-endorphin release
Stark, R. I., Wardlaw, S. L., Daniel, S. S., Husain, M., Sanocka, U. M., James, L. S., & Wiele, R. L. V. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(82)90656-1 · Cited by 51 · see citing works
Vasopressin Concentrations in Hypophysial Portal Plasma: Insignificant Reduction following Removal of the Posterior Pituitary Gland
Recht, L. D., Hoffman, D. L., Haldar, J., Silverman, A., & Zimmerman, E. A. (2008) · Neuroendocrinology · doi:10.1159/000123208 · Cited by 51 · see citing works
Oxytocin: Major Corticotropin-Releasing Factor Secreted from Diabetes insipidus Rat Posterior Pituitary in vitro
Bény, J., & Baertschi, A. J. (2008) · Neuroendocrinology · doi:10.1159/000123085 · Cited by 40 · see citing works
Characterization of Oxytocin Receptors on Isolated Rat Fat Cells
Bonne, D., & COHEN, P. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb02233.x · Cited by 38 · see citing works
Dissociation of the acute secretions of thyrotropin and adrenocorticotropin
DUCOMMUN, P., Sakiz, E., & Guillemin, R. (1966) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1966.210.6.1257 · Cited by 35 · see citing works
Acute Effects of Oxytocin and Vasopressin on Plasma Levels of Glucagon, Insulin and Glucose in Rabbits
Knudtzon, J. (1983) · Hormone and Metabolic Research · doi:10.1055/s-2007-1018641 · Cited by 34 · see citing works
Effect of Hypothermia on 17-Hydroxycorticosteroid Secretion in Adrenal Venous Blood in the Dog
Egdahl, R. H., Nelson, D. H., & Hume, D. M. (1955) · Science · doi:10.1126/science.121.3145.506 · Cited by 22 · see citing works

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Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
“…of Oxt are increased following physiological and psychological stresses, including forced swim, restraint, cold stress, shaker stress, hyperosmolarity and social stress (Engelmann et al., 1999; Gibbs, 1984; Hashiguchi et al., 1997; Jezova et al., 1995; Lang et al., 1983; Neumann et al., 2000).”
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat
VIAU, V., & MEANEY, M. J. (1991) · Endocrinology · doi:10.1210/endo-129-5-2503 · Cited by 666 · see citing works
Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats<sup>1</sup>
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
Oxytocin — A neuropeptide for affiliation: Evidence from behavioral, receptor autoradiographic, and comparative studies
Insel, T. R. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90073-g · Cited by 487 · see citing works
Oxytocin in general anxiety and social fear: a translational approach
Neumann, I. D., & Slattery, D. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.004 · Cited by 468 · see citing works
The hypothalamic-neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: an old concept revisited
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450 · see citing works
Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
Gjerstad, J. K., Lightman, S. L., & Spiga, F. (2018) · Stress · doi:10.1080/10253890.2018.1470238 · Cited by 437 · see citing works
“In contrast to its inhibitory effect at central level, in vitro studies have shown that oxytocin acts at the level of the pituitary to potentiate the CRH-induced ACTH-secretion (Gibbs, 1984).”
Background
Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression
Purba, J. S. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020055007 · Cited by 433 · see citing works
Oxytocin Attenuates Stress-Induced c-<i>fos</i>mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity
Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408 · see citing works
“In the rat, the release of oxytocin into the peripheral circulation in response to physical and psychological stressors has long been established (Lang et al., 1983; Gibbs, 1984).”
Background
Forebrain Pathways Mediating Stress-Induced Hormone Secretion
de Kar, L. D. V., & Blair, M. L. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0172 · Cited by 380 · see citing works
Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles
Grippo, A. J., Gerena, D., Huang, J., Kumar, N., Shah, M., Ughreja, R., & Sue Carter, C. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.07.004 · Cited by 336 · see citing works
“experiences (Carter, 1998), but also may be increased following stressful events (Lang et al., 1983; Gibbs, 1984; Nishioka et al., 1998; Taylor et al., 2006).”
Background
Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala
Dayas, C. V., Buller, K. M., & Day, T. A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00645.x · Cited by 303 · see citing works
“…this issue in relation to the HPA axis, however, we were also interested to look at the role of the amygdala in the control of oxytocin (OT) secretion, OT having previously been characterized in rodents as a `stress hormone' that may potentiate ACTH release (Gibbs, 1986; Miyata et al., 1995).”
BackgroundInfluential
Local circuit regulation of paraventricular nucleus stress integration
Herman, J. P., Tasker, J. G., Ziegler, D. R., & Cullinan, W. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00681-5 · Cited by 274 · see citing works
An Examination of Changes in Oxytocin Levels in Men and Women Before and After Interaction With a Bonded Dog
Miller, S. C., Kennedy, C., DeVoe, D. C., Hickey, M. S., Nelson, T., & Kogan, L. R. (2009) · Anthrozoös · doi:10.2752/175303708x390455 · Cited by 270 · see citing works
“When released centrally, OT acts as a neuromodulator of maternal and affiliative behavior, social memory, and the stress response (Pedersen and Prange 1979; Gibbs 1984; Carter et al. 1992; Witt, Winslow and Insel 1992; Windle et al. 1997; Ferguson et al. 2000).”
Background
Physiological and Endocrine Effects of Social Contact
Uvnäs‐Moberg, K. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51917.x · Cited by 250 · see citing works
Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation
Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240 · see citing works
“However, increased levels of oxytocin both in the central and peripheral nervous system also have been associated with stressful events in humans and rodents (Gibbs, 1984; Nishioka et al., 1998; Taylor et al., 2006; Grippo et al., 2007b).”
Background
Behaviour and welfare in relation to pathology
Broom, D. (2006) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2005.11.019 · Cited by 215 · see citing works
Endocrine and Behavioural Responses to Noise Stress:Comparison of Virgin and Lactating Female Ratsduring Non‐Disrupted Maternal Activity
Windle, R. J., Wood, S. A., Shanks, N. M., Perks, P., Condé, G. L., Costa, A. P. C., Ingram, C. D., & Lightman, S. L. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00587.x · Cited by 226 · see citing works
Evidence for a Physiological Role for Oxytocin in the Control of Prolactin Secretion*
Samson, W. K., Lumpkin, M. D., & McCann, S. M. (1986) · Endocrinology · doi:10.1210/endo-119-2-554 · Cited by 219 · see citing works
Stress increases oxytocin release within the hypothalamic paraventricular nucleus
Nishioka, T., Anselmo-Franci, J. A., Li, P., Callahan, M. F., & Morris, M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01159-1 · Cited by 214 · see citing works
Low doses of oxytocin facilitate social recognition in rats
Popik, P., Vetulani, J., & van Ree, J. M. (1992) · Psychopharmacology · doi:10.1007/bf02253591 · Cited by 212 · see citing works
“A rise of plasma levels of OXT somewhat above basal values has been reported in rats after restraint and ether anesthesia (Gibbs 1984), in man and various animal species during sexual activity (McNeilly and Ducker 1972; Ogawa et al.”
Background
Structural characterization of a hypothalamic visceromotor pattern generator network
Thompson, R. H. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00232-1 · Cited by 208 · see citing works
Female oxytocin-deficient mice display enhanced anxiety-related behavior
Mantella, R. C., Vollmer, R. R., Li, X., & Amico, J. A. (2003) · Endocrinology · doi:10.1210/en.2002-0197 · Cited by 200 · see citing works
“(9, 10), grooming (11), and the stress response (12, 13).”
The Functional Neuroanatomy of Corticotropin‐Releasing Factor
Sawchenko, P. E., Imaki, T., Potter, E., Kovács, K. J., Imaki, J., & Vale, W. W. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch2 · Cited by 195 · see citing works
Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review
Gibbs, D. M. (1986) · Psychoneuroendocrinology · doi:10.1016/0306-4530(86)90048-x · Cited by 192 · see citing works
Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review
Crockford, C., Deschner, T., Ziegler, T. E., & Wittig, R. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00068 · Cited by 187 · see citing works
Role of the paraventricular nucleus microenvironment in stress integration
Herman, J. P., Cullinan, W. E., Ziegler, D. R., & Tasker, J. G. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02133.x · Cited by 168 · see citing works
“Magnocellular neurohypophysial peptides are released into the portal circulation upon stress exposure (Gibbs, 1984; Plotsky et al., 1985) and appear to modulate ACTH secretion under some circumstances (cf. Dohanics et al., 1991).”
Background
The physiology and mechanisms of the stress-induced changes in prolactin secretion in the rat
Gala, R. R. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90456-2 · Cited by 168 · see citing works
Vasopressin and Oxytocin in Stressa
Ježová, D., Škultétyová, I., Tokarev, D., Bakos, P., & Vigas, M. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44681.x · Cited by 161 · see citing works
Systemic Osmotic Stimulation Increases Vasopressin and Oxytocin Release Within the Supraoptic Nucleus
Ludwig, M., Callahan, M. F., Neumann, I. D., Landgraf, R., & Morris, M. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00595.x · Cited by 155 · see citing works
Stress‐Specific Regulation of Corticotropin Releasing Hormone Receptor Expression in the Paraventricular and Supraoptic Nuclei of the Hypothalamus in the Rat
Luo, X., Kiss, A., Makara, G. B., Lolait, S. J., & Aguilera, G. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00636.x · Cited by 148 · see citing works
Peripheral Administration of an Angiotensin II AT1 Receptor Antagonist Decreases the Hypothalamic-Pituitary-Adrenal Response to Isolation Stress
Armando, I., Carranza, A., Nishimura, Y., Hoe, K.-L., Barontini, M., Terrón, J. A., Falcón-Neri, A., Ito, T., Juorio, A. V., & Saavedra, J. M. (2001) · Endocrinology · doi:10.1210/endo.142.9.8366 · Cited by 148 · see citing works
Studies on the neuroendocrine role of serotonin.
Jørgensen, H. S. (2007) · PubMed · Cited by 144 · see citing works
Anti-Stress Action of a Corticotropin-Releasing Factor Antagonist on Behavioral Reactivity to Stressors of Varying Type and Intensity
Heinrichs, S. C., Menzaghi, F., Pich, E. M., Baldwin, H. A., Rassnick, S., Britton, K. T., & Koob, G. F. (1994) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380104 · Cited by 143 · see citing works
Region-specific reduction in stress-induced c- fos mRNA expression during pregnancy and lactation
Costa, A. P. C., Wood, S. A., Ingram, C. D., & Lightman, S. L. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00962-6 · Cited by 135 · see citing works
The role of central oxytocin in obsessive compulsive disorder and related normal behavior
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., et al. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90021-3 · Cited by 133 · see citing works
The central amygdala modulates hypothalamic–pituitary–adrenal axis responses to systemic interleukin-1β administration
Xu, Y., Day, T. A., & Buller, K. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00311-5 · Cited by 126 · see citing works
Prolactin-Releasing Peptide as a Novel Stress Mediator in the Central Nervous System
Maruyama, M., Matsumoto, H., Fujiwara, K., Noguchi, J., Kitada, C., Fujino, M., & Inoue, K. (2001) · Endocrinology · doi:10.1210/endo.142.5.8118 · Cited by 124 · see citing works
Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion
Amico, J. A., Vollmer, R. R., Cai, H.-M., Miedlar, J. A., & Rinaman, L. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00558.2005 · Cited by 120 · see citing works
“OT neurons are activated by a variety of stressful and anxiogenic stimuli in rats (9, 13, 21, 22, 24, 44, 45) and mice (1, 20, 25).”
Background
Oxytocin and social functioning
Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/cjones · Cited by 132 · see citing works
Effects of developmental stress on animal phenotype and performance: a quantitative review
Eyck, H. J. F., Buchanan, K. L., Crino, O. L., & Jessop, T. S. (2019) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12496 · Cited by 111 · see citing works
The oxytocin antagonist 1-deamino-2-d-Tyr-(Oet)-4-Thr-8-Orn-oxytocin reverses the increase in the withdrawal response latency to thermal, but not mechanical nociceptive stimuli following oxytocin administration or massage-like stroking in rats
Ågren, G., Lundeberg, T., Uvnäs‐Moberg, K., & Sato, A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11335-t · Cited by 114 · see citing works
Nitric oxide synthase-containing magnocellular neurons of the rat hypothalamus synthesize oxytocin and vasopressin and express Fos following stress stimuli
Hatakeyama, S., Kawai, Y., Ueyama, T., & Senba, E. (1996) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(96)00166-4 · Cited by 108 · see citing works
Psychogenic pregnancy disruptions in mammals
de Catanzaro, D., & MacNiven, E. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80050-8 · Cited by 90 · see citing works
Psychological stress of exposure to uncontrollable noise increases plasma oxytocin in high emotionality women
Sanders, G. (1990) · Psychoneuroendocrinology · doi:10.1016/0306-4530(90)90046-c · Cited by 86 · see citing works
“Studies in rats have indicated that OT secretion is s t imulated by emotional , and some types of physical, stress (Lang et al., 1983; Gibbs, 1984), whereas it is thought that AVP secretion responds only to physical stress (Hussain et al.”
Background
Dorsal and Ventral Medullary Catecholamine Cell Groups Contribute Differentially to Systemic Interleukin-1β-Induced Hypothalamic Pituitary Adrenal Axis Responses
Buller, K. M., Xu, Y., Dayas, C. V., & Day, T. A. (2001) · Neuroendocrinology · doi:10.1159/000054629 · Cited by 89 · see citing works
“Moreover it seems likely, at least in the rodent, that the actions of CRH are supplemented by oxytocin (OT) released concurrently from activated magnocellular OT cells of the PVN and supraoptic nucleus (SON) [”
Background
Massage-like stroking of the abdomen lowers blood pressure in anesthetized rats: influence of oxytocin
Kurosawa, M., Lundeberg, T., Ågren, G., Lund, I., & Uvnäs‐Moberg, K. (1995) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(95)00056-7 · Cited by 87 · see citing works
Role of corticotropin-releasing factor, vasopressin and the autonomic nervous system in learning and memory
Croiset, G., Nijsen, M., & Kamphuis, P. J. G. H. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00556-2 · Cited by 84 · see citing works
Social environment regulates corticotropin releasing factor, corticosterone and vasopressin in juvenile prairie voles
Ruscio, M. G., Sweeny, T., Hazelton, J., Suppatkul, P., & Sue Carter, C. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.08.004 · Cited by 81 · see citing works
“social defeat, forced swim, restraint, cold) (Engelmann et al., 2004; Gibbs, 1984; Pacak and Palkovits, 2001).”
Influence of oxytocin on nociception and morphine antinociception
Arletti, R., Benelli, A., & Bertolini, A. (1993) · Neuropeptides · doi:10.1016/0143-4179(93)90075-l · Cited by 81 · see citing works
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1 S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine Hydrochloride (SSR125543A): A Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. I. Biochemical and Pharmacological Characterization
Gully, D., Geslin, M., Serva, L., Fontaine, E., Roger, P., Lair, C., Darre, V., MARCY, C. H., Rouby, P.-E., Simiand, J., et al. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.322 · Cited by 78 · see citing works
“Indeed, ACTH release appears to be a constant feature of the response to most types of stressors (Gibbs, 1984) and changes in pituitaryadrenal tone reflect the intensity of stimulation to which an organism is exposed (Hennessy and Levine, 1978).”
Background
Oxytocin alleviates oxidative renal injury in pyelonephritic rats via a neutrophil-dependent mechanism
Bıyıklı, N., Tuğtepe, H., Şener, G., Velioğlu‐Öğünç, A., Çetınel, Ş., Midillioğlu, Ş., Gedik, N., & Yeğen, B. Ç. (2006) · Peptides · doi:10.1016/j.peptides.2006.03.029 · Cited by 76 · see citing works
Single or repeated mild stress increases synthesis and release of hypothalamic corticotropin-releasing factor
Haas, D. A., & George, S. R. (1988) · Brain Research · doi:10.1016/0006-8993(88)90254-5 · Cited by 76 · see citing works
Glucocorticoids Regulate Ovine Hypophysial Portal Levels of Corticotropin-Releasing Factor and Arginine Vasopressin in a Stress-Specific Manner
Canny, B. J., Funder, J. W., & Clarke, I. J. (1989) · Endocrinology · doi:10.1210/endo-125-5-2532 · Cited by 69 · see citing works
The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat
Hartley, D. E., Edwards, J. E., Spiller, C. E., Alom, N., Tucci, S., Seth, P., Forsling, M. L., & File, S. E. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1369-7 · Cited by 83 · see citing works
The Physiology of Stress and Its Relationship to Mechanisms of Disease and Therapeutics
Breazile, J. E. (1988) · Veterinary Clinics of North America Food Animal Practice · doi:10.1016/s0749-0720(15)31025-2 · Cited by 67 · see citing works
Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis
Rubin, L. H., Carter, C. S., Bishop, J. R., Pournajafi‐Nazarloo, H., Harris, M. S. H., Hill, S. K., Reilly, J. L., & Sweeney, J. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.01.019 · Cited by 65 · see citing works
“It is also important to note that not all stressors stimulate both OT and AVP release in animals or humans (Gibbs, 1984; Altemus et al., 1995, 2001; Jezova et al., 1995).”
Background
Sex differences in hormonal responses to social conflict in the monogamous California mouse
Trainor, B. C., Takahashi, E. Y., Silva, A. L., Crean, K. K., & Hostetler, C. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.04.008 · Cited by 66 · see citing works
“Oxytocin is released peripherally during stress, although this response appears to be more context specific than glucocorticoid release (Gibbs 1984; Carter and Lightman 1987; Sanders et al. 1990), and there is growing evidence the effects of oxytocin may be stronger females versus males (Insel and…”
Background
Serotonergic involvement in stress-induced vasopressin and oxytocin secretion
Jorgensen, H., Knigge, U., Kjær, A., & Warberg, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470815 · Cited by 66 · see citing works
“The pattern emerging from the previous and the present findings indicate that single ultra short-term restraint stress (1 – 2 min) performed by mechanical fixation or restraint in a plastic glass box, does not seem to be sufficient to increase either AVP mRNA in the hypothalamic PVN or AVP in peripheral plasma ( 36 ,…”
Result
Identification and characterization of arginine vasopressin-like substances in the rat testis.
Kasson, B. G., Meidan, R., & Hsueh, A. J. W. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89022-6 · Cited by 65 · see citing works
Expression of Corticotropin-Releasing Hormone Type 1 Receptor in Paraventricular Nucleus after Acute Stress
Imaki, T., Katsumata, H., Miyata, M., Naruse, M., Imaki, J., & Minami, S. (2001) · Neuroendocrinology · doi:10.1159/000054646 · Cited by 64 · see citing works
Oxytocin-induced inhibition of feeding and drinking: No sexual dimorphism in rats
Benelli, A., Bertolini, A., & Arletti, R. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90040-p · Cited by 61 · see citing works
Oxytocin at physiological concentrations evokes adrenocorticotropin (ACTH) release from corticotrophs by increasing intracellular free calcium mobilized mainly from intracellular stores. Oxytocin displays synergistic or additive effects on ACTH-releasing factor or arginine vasopressin-induced ACTH secretion, respectively
Link, H., Dayanithi, G., Föhr, K. J., & Gratzl, M. (1992) · Endocrinology · doi:10.1210/endo.130.4.1312449 · Cited by 61 · see citing works
Temporal changes of c-fos expression in oxytocinergic magnocellular neuroendocrine cells of the rat hypothalamus with restraint stress
Miyata, S., Itoh, T., Lin, S., Ishiyama, M., Nakashima, T., & Kiyohara, T. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)00017-8 · Cited by 62 · see citing works
Inhibition of Corticotropin Release during Hypothermia: The Role of Corticotropin-Releasing Factor, Vasopressin, and Oxytocin*
Gibbs, D. M. (1985) · Endocrinology · doi:10.1210/endo-116-2-723 · Cited by 61 · see citing works
Stress and the pituitary-adrenal axis
Gaillard, R.-C., & Al‐Damluji, S. (1987) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(87)80066-6 · Cited by 59 · see citing works
Oxytocin and love: myths, metaphors and mysteries.
Carter, C. S. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100107 · Cited by 57 · see citing works
Role of the autonomic nervous system and baroreflex in stress-evoked cardiovascular responses in rats
dos Reis, D. G., Fortaleza, E. A. T., Tavares, R. F., & Corrêa, F. M. D. A. (2014) · Stress · doi:10.3109/10253890.2014.930429 · Cited by 58 · see citing works
“In agreement with this, neither was vasopressin release reported during immobilization (Callahan et al., 1992; Gibbs, 1984), nor did intravenous pretreatment with the V1-vasopressin receptor antagonist dTyr-AVP (50 mg/kg) affects RS-evoked hypertension (unpublished data).”
Background
Afferents originating from the dorsal penile nerve excite oxytocin cells in the hypothalamic paraventricular nucleus of the rat
Yanagimoto, M., Honda, K., Goto, Y., & Negoro, H. (1996) · Brain Research · doi:10.1016/0006-8993(96)00800-1 · Cited by 58 · see citing works
Effects of Prenatal Ethanol Exposure on Hypothalamic-Pituitary-Adrenal Responses to Chronic Cold Stress in Rats
Kim, C. K., Giberson, P. K., Yu, W. K., Zoeller, R. T., & Weinberg, J. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04114.x · Cited by 58 · see citing works
Arginine Vasopressin in the Testis: An Intragonadal Peptide Control System*
Kasson, B. G., Adashi, E. Y., & Hsueh, A. J. W. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-2-156 · Cited by 58 · see citing works
Chronic stress increases estrogen and other steroids in inseminated rats
MacNiven, E., deCatanzaro, D., & Younglai, E. V. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90446-9 · Cited by 56 · see citing works
Central and systemic oxytocin release: A study of the paraventricular nucleus by in vivo microdialysis
Hattori, T., Sundberg, D. K., & Morris, M. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90187-3 · Cited by 55 · see citing works
c-Fos expression in hypothalamic neurosecretory and brainstem catecholamine cells following noxious somatic stimuli
Smith, D. W., & Day, T. A. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90453-7 · Cited by 55 · see citing works
Hyponatremia-Induced Inhibition of Magnocellular Neurons Causes Stressor-Selective Impairment of Stimulated Adrenocorticotropin Secretion in Rats*
Dohanics, J., Hoffman, G. E., & Verbalis, J. G. (1991) · Endocrinology · doi:10.1210/endo-128-1-331 · Cited by 54 · see citing works
Atrial natriuretic factor in maternal and fetal sheep
Cheung, C. Y., Gibbs, D. M., & Brace, R. A. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.2.e279 · Cited by 53 · see citing works
Differential effects of emotional and physical stress on the central and peripheral secretion of neurohypophysial hormones in male rats
Iványi, T., Wiegant, V. M., & de Wied, D. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90527-i · Cited by 49 · see citing works
Speculations Concerning the Physiological Significance of Central Oxytocin in Maternal Behavior
McCarthy, M. M., Kow, L., & Pfaff, D. W. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34347.x · Cited by 50 · see citing works
Enhanced corticosterone concentrations and attenuated Fos expression in the medial amygdala of female oxytocin knockout mice exposed to psychogenic stress
Mantella, R. C., Vollmer, R. R., Rinaman, L., Li, X., & Amico, J. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00387.2004 · Cited by 71 · see citing works
“As was the case with group-housed mice, plasma corticosterone concentrations increased in both genotypes 10 minutes after termination of a 10 minute shaker stress compared to mice not receiving this stress (ANOVA, F (1,26) = 8.”
Identification of arginine vasotocin (AVT) neurons activated by acute and chronic restraint stress in the avian septum and anterior diencephalon
Nagarajan, G., Tessaro, B. A., Kang, S. W., & Kuenzel, W. J. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.04.012 · Cited by 50 · see citing works
“Application of restraint stress has been shown to elicit stress levels in both rodents (Gibbs, 1984) and birds (Beuving and Vonder, 1978).”
Background
Vasopressin and oxytocin
Douglas, A. J. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80014-8 · Cited by 48 · see citing works
The role of oxytocin: present concepts
Jenkins, J. S., & Nussey, S. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb00333.x · Cited by 47 · see citing works
“Gibbs (1984a), using body restraint, cold, or ether stress found that all three agents caused an increase in ACTH, while vasopressin responded to ether only, and oxytocin to both restraint and ether but not to cold.”
Background
Arginine Vasopressin as a Thyrotropin-Releasing Hormone
Lumpkin, M. D., Samson, W. K., & McCann, S. M. (1987) · Science · doi:10.1126/science.2881350 · Cited by 48 · see citing works
The medial amygdaloid nucleus modulates cardiovascular responses to acute restraint in rats
Fortaleza, E. A. T., Tavares, R. F., & Corrêa, F. M. D. A. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.003 · Cited by 46 · see citing works
Glucocorticoid modulation of atrial natriuretic peptide, oxytocin, vasopressin and Fos expression in response to osmotic, angiotensinergic and cholinergic stimulation
Lauand, F., Ruginsk, S. G., Rodrigues, H. L. P., Reis, W. L., de Castro, M., Elias, L. L. K., & Antunes‐Rodrigues, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.021 · Cited by 46 · see citing works
Food for thought: a critique on the hypothesis that endogenous cholecystokinin acts as a physiological satiety factor
Baldwin, B. A., Parrott, R. F., & Ebenezer, I. S. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00005-7 · Cited by 46 · see citing works
Osmoreceptor mechanism for oxytocin release in the rat.
Negoro, H., Higuchi, T., Tadokoro, Y., & HONDA, K. (1988) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.38.19 · Cited by 46 · see citing works
Genomic Effects of Cold and Isolation Stress on Magnocellular Vasopressin mRNA‐Containing Cells in the Hypothalamus of the Rat
Angulo, J. A., Ledoux, M., & McEwen, B. S. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb03463.x · Cited by 46 · see citing works
“Increased levels of plasma AVP have been observed in various models of stress: ether (Gibbs, 1984); electric shock (Rosella-Dampman and SummyLong, 1984); hypoglycemia (Plotsky et al.”
Background
Not only osmotic stress but also repeated restraint stress causes structural plasticity in the supraoptic nucleus of the rat hypothalamus
Miyata, S., Itoh, T., Matsushima, O., Nakashima, T., & Kiyohara, T. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90231-3 · Cited by 45 · see citing works
Rapid changes in the content of proenkephalin A and corticotrophin releasing hormone mRNAs in the paraventricular nucleus during morphine withdrawal in urethane-anaesthetized rats
Harbuz, M. S., Russell, J. A., SUMNER, B. E. H., Kawata, M., & Lightman, S. L. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90074-8 · Cited by 44 · see citing works
Expression of α1D adrenergic receptor messenger RNA in oxytocin- and corticotropin-releasing hormone-synthesizing neurons in the rat paraventricular nucleus
Sands, S. A., & Morilak, D. A. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00616-2 · Cited by 43 · see citing works
Arginine Vasopressin as an Intragonadal Hormone in Brattleboro Rats: Presence of a Testicular Vasopressin-Like Peptide and Functional Vasopressin Receptors*
Kasson, B. G., & Hsueh, A. J. W. (1986) · Endocrinology · doi:10.1210/endo-118-1-23 · Cited by 43 · see citing works
Behavioral stress decreases plasma oxytocin concentrations in primates.
Kalin, N., Gibbs, D., Barksdale, C., Shelton, S., & Carnes, M. (1985) · Life Science · doi:10.1016/0024-3205(85)90272-3 · Cited by 50 · see citing works
Oxytocin and Behavior
Kovács, G. L. (1986) · Current topics in neuroendocrinology · doi:10.1007/978-3-642-70414-7_4 · Cited by 43 · see citing works
Immunoneutralization of oxytocin attenuates stress-induced corticotropin secretion in the rat
Gibbs, D. M. (1985) · Regulatory Peptides · doi:10.1016/0167-0115(85)90170-3 · Cited by 41 · see citing works
Surgical Stress and Neuroendocrine Responses in Infants and Children
Rosendahl, W., Schulz, U., Teufel, T. E., von Brenndorff, C. I., & Gupta, D. (1995) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1995.8.3.187 · Cited by 40 · see citing works
Regulation of Oxytocin Release
Forsling, M. L. (1986) · Current topics in neuroendocrinology · doi:10.1007/978-3-642-70414-7_2 · Cited by 40 · see citing works
Vasopressin modulates male squirrel monkeys' behavior during social separation
Winslow, J., & Insel, T. R. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90671-c · Cited by 37 · see citing works
Cortisol and prolactin concentrations during repeated blood sample collection from freely moving, mouse-sized mammals (Phodopus spp.).
Reburn, C. J., & Wynne‐Edwards, K. E. (2000) · PubMed · Cited by 37 · see citing works

Vasopressin and oxytocin: hypothalamic modulators of the stress response: a review
Gibbs, D. M. (1986) · Psychoneuroendocrinology · doi:10.1016/0306-4530(86)90048-x · Cited by 192 · see citing works
Effect of acute ether or restraint stress on plasma corticotropin-releasing hormone, vasopressin and oxytocin levels in the rat.
Hashimoto, K., Murakami, K., Takao, T., Makino, S., Sugawara, M., & Ota, Z. (1989) · PubMed · doi:10.18926/amo/30888 · Cited by 40 · see citing works
EXPERIMENTAL STUDY Serotonergic involvement in stress-induced vasopressin and oxytocin secretion
Jørgensen, H., Knigge, U., Kjær, A., & Warberg, J. (2014)
Serotonergic involvement in stress-induced vasopressin and oxytocin secretion
Jorgensen, H., Knigge, U., Kjær, A., & Warberg, J. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470815 · Cited by 66 · see citing works
Stress-Specific Modulation of ACTH Secretion by Oxytocin
Gibbs, D. M. (2008) · Neuroendocrinology · doi:10.1159/000124487 · Cited by 63 · see citing works

Authors: Gibbs, D. M.
Affiliations: University of California San Diego (US)
Corresponding author: Gibbs, Daniel M.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 1984-07
Volume: 35
Issue: 5
Pages: 487-491
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/0024-3205(84)90241-8
OpenAlex: W2005492092
Cited by: 233
References: 34
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 7 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 8 · 2013: 5 · 2012: 1
FWCI: 5.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, vasopressin, ACTH secretion, stress, restraint stress, cold stress, ether stress, hypothalamic-pituitary-adrenal axis, neurohypophyseal regulation, plasma hormone levels, rats
MeSH terms: Adrenocorticotropic Hormone, Animals, Arginine Vasopressin, Cold Temperature, Ether, Humans, Male, Oxytocin, Restraint, Physical, Stress, Physiological, Stress, Psychological, Rats

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Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress

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