The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity
Abstract
Leptin deficiency causes obesity in rodents and humans, but circulating levels of leptin are paradoxically elevated in obesity. The mechanisms underlying this leptin resistance are unknown, but may involve reduced leptin transport across the blood-brain barrier via short isoforms of the leptin receptor (Ob-R). Here, we first quantified short Ob-R mRNA expression in isolated rat cerebral microvessels constituting the blood-brain barrier and found that Ob-Ra and Ob-Rc mRNA were abundantly expressed in similar amounts. Second, brain uptake of leptin was reduced in mice lacking Ob-R. Third, brain uptake of leptin in New Zealand Obese mice, a strain that responds to central, but not peripheral, leptin, was reduced, suggesting that their obesity is at least partly due to deficient leptin transport into the brain. Fourth, brain uptake of leptin was significantly reduced in diet-induced obese mice. Neither New Zealand Obese mice nor diet-induced obese mice exhibited significant decreases in Ob-R mRNA expression in isolated cerebral microvessels. These data support the ideas that short isoforms of Ob-R are involved in brain uptake of leptin and that impaired blood-brain barrier function contributes to the pathogenesis of obesity. However, the mechanisms by which obesity-related deficits in brain uptake of leptin occur remain to be defined.
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Cites
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Self-citationAdipose Tissue as an Endocrine Organ
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Self-citationDivergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
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Self-citationTwo defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
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Self-citationLeptin Regulation of Neuroendocrine Systems
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Cited by
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
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Self-citationLeptin in Human Physiology and Pathophysiology
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Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later
Izquierdo, A. G., Crujeiras, A. B., Casanueva, F. F., & Carreira, M. C. (2019) · Nutrients · doi:10.3390/nu11112704 · Cited by 525
The source of cerebral insulin
Banks, W. A. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.040 · Cited by 489
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Metadata
- Authors
- Hileman, S. M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2002-03-01
- Volume
- 143
- Issue
- 3
- Pages
- 775-783
- ISSN
- 0013-7227 (ISSN-L)
- OpenAlex
- W2136556119
- Cited by
- 267
- References
- 9
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hileman, S. M. (2002). Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity. Endocrinology. https://doi.org/10.1210/en.143.3.775
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