Cited by 576Fibroblast Growth Factor ResearchAdipose Tissue and MetabolismRegulation of Appetite and Obesity

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Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

Tomlinson, Elizabeth, Fu, Ling, John, Linu, Hultgren, Bruce, Huang, Xiaojian, Renz, Mark, Stephan, Jean Philippe, Tsai, Saio Ping, Powell-Braxton, Lyn, French, Dorothy, Stewart, Timothy A.·2002·Endocrinology

DOI 10.1210/endo.143.5.8850

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Abstract

The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4. Here, we report that FGF19 transgenic mice had a significant and specific reduction in fat mass that resulted from an increase in energy expenditure. Further, the FGF19 transgenic mice did not become obese or diabetic on a high fat diet. The FGF19 transgenic mice had increased brown adipose tissue mass and decreased liver expression of acetyl coenzyme A carboxylase 2, providing two mechanisms by which FGF19 may increase energy expenditure. Consistent with the reduction in expression of acetyl CoA carboxylase 2, liver triglyceride levels were reduced.

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Authors: Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., & Stewart, T. A.
Affiliations: Genentech (US)
Corresponding author: Stewart, Timothy A.
ORCID: John, Linu
Huang, Xiaojian
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2002-05-01
Volume: 143
Issue: 5
Pages: 1741-1747
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.143.5.8850
OpenAlex: W2106986971
Cited by: 576
References: 57
Citations by year: 2026: 11 · 2025: 20 · 2024: 29 · 2023: 18 · 2022: 32 · 2021: 37 · 2020: 37 · 2019: 35 · 2018: 35 · 2017: 42 · 2016: 27 · 2015: 43 · 2014: 26 · 2013: 30 · 2012: 31
FWCI: 1.97
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Genentech
Goddard Space Flight Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: FGF19, FGF receptor 4, energy expenditure, adiposity, brown adipose tissue, acetyl-CoA carboxylase 2, hepatic triglycerides, high-fat diet, obesity, diabetes mellitus, metabolic rate
MeSH terms: Fibroblast Growth Factor-23, Adipose Tissue, Animals, Body Temperature, Body Weight, Adipose Tissue, Brown, Calorimetry, Indirect, Diabetes Mellitus, Diet, Dietary Fats, Energy Metabolism, Fibroblast Growth Factors, Glucose, Glucose Tolerance Test, Humans, Liver, Mice, Transgenic, Phenotype, Mice

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Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity

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