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Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity
Abstract
The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4. Here, we report that FGF19 transgenic mice had a significant and specific reduction in fat mass that resulted from an increase in energy expenditure. Further, the FGF19 transgenic mice did not become obese or diabetic on a high fat diet. The FGF19 transgenic mice had increased brown adipose tissue mass and decreased liver expression of acetyl coenzyme A carboxylase 2, providing two mechanisms by which FGF19 may increase energy expenditure. Consistent with the reduction in expression of acetyl CoA carboxylase 2, liver triglyceride levels were reduced.
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“Transgenic mice overexpressing FGF-19 have increased BAT mass and reduced susceptibility to diet-induced obesity 105.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [105]
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Metadata
- Authors
- Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., & Stewart, T. A.
- Affiliations
- Genentech (US)
- Corresponding author
- Stewart, Timothy A.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2002-05-01
- Volume
- 143
- Issue
- 5
- Pages
- 1741-1747
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2106986971
- Cited by
- 576
- References
- 57
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 29 · 2023: 18 · 2022: 32 · 2021: 37 · 2020: 37 · 2019: 35 · 2018: 35 · 2017: 42 · 2016: 27 · 2015: 43 · 2014: 26 · 2013: 30 · 2012: 31
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Genentech
- Goddard Space Flight Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- FGF19, FGF receptor 4, energy expenditure, adiposity, brown adipose tissue, acetyl-CoA carboxylase 2, hepatic triglycerides, high-fat diet, obesity, diabetes mellitus, metabolic rate
- MeSH terms
- Fibroblast Growth Factor-23, Adipose Tissue, Animals, Body Temperature, Body Weight, Adipose Tissue, Brown, Calorimetry, Indirect, Diabetes Mellitus, Diet, Dietary Fats, Energy Metabolism, Fibroblast Growth Factors, Glucose, Glucose Tolerance Test, Humans, Liver, Mice, Transgenic, Phenotype, Mice
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