The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.
Transgenic Mice Expressing Human Fibroblast Growth Factor-19 Display Increased Metabolic Rate and Decreased Adiposity
Abstract
The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4. Here, we report that FGF19 transgenic mice had a significant and specific reduction in fat mass that resulted from an increase in energy expenditure. Further, the FGF19 transgenic mice did not become obese or diabetic on a high fat diet. The FGF19 transgenic mice had increased brown adipose tissue mass and decreased liver expression of acetyl coenzyme A carboxylase 2, providing two mechanisms by which FGF19 may increase energy expenditure. Consistent with the reduction in expression of acetyl CoA carboxylase 2, liver triglyceride levels were reduced.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Transgenic mice overexpressing FGF-19 have increased BAT mass and reduced susceptibility to diet-induced obesity 105.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [105]
Citations
Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Real time quantitative PCR.Preprint
Heid, C., Stevens, J., Livak, K. J., & Williams, P. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,180
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345
The Spread of the Obesity Epidemic in the United States, 1991-1998
Mokdad, A. H. (1999) · JAMA · doi:10.1001/jama.282.16.1519 · Cited by 2,384
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021
Annual Deaths Attributable to Obesity in the United States
Allison, D. B. (1999) · JAMA · doi:10.1001/jama.282.16.1530 · Cited by 1,863
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630
Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
Shimada, T., Mizutani, S., Muto, T., Yoneya, T., Hino, R., Takeda, S., Takeuchi, Y., Fujita, T., Fukumoto, S., & Yamashita, T. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.101545198 · Cited by 1,391
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379
Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C., & Evans, R. M. (1982) · Nature · doi:10.1038/300611a0 · Cited by 1,341
Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296
Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264
Diet-Induced Type II Diabetes in C57BL/6J Mice
Surwit, R. S., Kuhn, C. M., Cochrane, C., McCubbin, J. A., & Feinglos, M. N. (1988) · Diabetes · doi:10.2337/diab.37.9.1163 · Cited by 1,211
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075
Role of Nonexercise Activity Thermogenesis in Resistance to Fat Gain in Humans
Levine, J. A., Eberhardt, N. L., & Jensen, M. D. (1999) · Science · doi:10.1126/science.283.5399.212 · Cited by 997
The spread of the obesity epidemic in the United States
Mokdad, A. H., Serdula, M. K., & Dietz, W. H. (1999) · Cited by 985
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903
Effects of gender, body composition, and menopause on plasma concentrations of leptin.
Rosenbaum, M., Nicolson, M., Hirsch, J., Heymsfield, S. B., Gallagher, D., Chu, F., & Leibel, R. L. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784109 · Cited by 810
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736
Surwit, R. S., Feinglos, M. N., Rodin, J., Sutherland, A., Petro, A. E., Opara, E. C., Kuhn, C. M., & Rebuffe-Scrive, M. (1995) · Metabolism · doi:10.1016/0026-0495(95)90123-x · Cited by 618
Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
Clapham, J. C., Arch, J. R. S., Chapman, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., et al. (2000) · Nature · doi:10.1038/35019082 · Cited by 604
McGarry, J., Leatherman, G. F., & Foster, D. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34693-8 · Cited by 591
FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
Weinstein, M. B., Xu, X., Ohyama, K., & Deng, C. (1998) · Development · doi:10.1242/dev.125.18.3615 · Cited by 496
Increased feeding in response to decreased glucose utilization in the rat and monkey
Smith, G., & Epstein, A. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.217.4.1083 · Cited by 457
The subcellular localization of acetyl-CoA carboxylase 2
Abu-Elheiga, L. A., Brinkley, W. R., Zhong, L., Chirala, S. S., Woldegiorgis, G., & Wakil, S. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1444 · Cited by 450
Thyroid Hormone Control of Thermogenesis and Energy Balance
Silva, J. E. (1995) · Thyroid · doi:10.1089/thy.1995.5.481 · Cited by 392
Himms‐Hagen, J., Cui, J. Z., Danforth, E., Taatjes, D. J., Lang, S. S., Waters, B. L., & Claus, T. H. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.4.r1371 · Cited by 382
Decreased food intake does not completely account for adiposity reduction after ob protein infusion.
Levin, N. W., Nelson, C., Gurney, A., VANDLEN, R. L., & de Sauvage, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1726 · Cited by 376
Sympathetic and Cardiorenal Actions of Leptin
Haynes, W. G., Sivitz, W. I., Morgan, D. A., Walsh, S. A., & Mark, A. L. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.619 · Cited by 351
Yu, C., Wang, F., Kan, M., Jin, C., Jones, R. B., Weinstein, M. B., Deng, C., & McKeehan, W. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15482 · Cited by 348
FGF-19, A NOVEL FIBROBLAST GROWTH FACTOR WITH UNIQUE SPECIFICITY FOR FGFR4
Xie, M.-H., Holcomb, I. N., Deuel, B., Dowd, P., Huang, A. J. Y., Vagts, A. J., Foster, J., Liang, J., Brush, J., Gu, Q., et al. (1999) · Cytokine · doi:10.1006/cyto.1999.0485 · Cited by 301
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
Li, B., Nolte, L. A., Ju, J.-S., Ho Han, D., Coleman, T., Holloszy, J. O., & Semenkovich, C. F. (2000) · Nature Medicine · doi:10.1038/80450 · Cited by 291
Hughes, S. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704500710 · Cited by 283
Obesity and insulin resistance: Lessons learned from the Pima indians
Lillioja, S., & Bogardus, C. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040508 · Cited by 203
Fibroblast growth factor receptors: lessons from the genes
Burke, D. F., Wilkes, D. C., Blundell, T. L., & Malcolm, S. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01170-5 · Cited by 170
Fritz, I. B., & Marquis, N. R. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.4.1226 · Cited by 161
Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults*
Beshyah, S., Freemantle, C., Thomas, E. L., Rutherford, O. M., Page, B. C., Murphy, M. C., & Johnston, D. G. (1995) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1995.tb01860.x · Cited by 159
Weyer, C., Pratley, R. E., Salbe, A. D., Bogardus, C., Ravussin, E., & Tataranni, P. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6447 · Cited by 158
Yu, S., Gavrilova, O., Chen, H., Lee, R., Liu, J., Pacák, K., Parlow, A. F., Quon, M. J., Reitman, M. L., & Weinstein, L. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8437 · Cited by 151
Practical aspects of indirect calorimetry in laboratory animals
Even, P. C., Mokhtarian, A., & Pele, A. (1994) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(94)90056-6 · Cited by 110
Tissue-specific expression of rat myosin light-chain 2 gene in transgenic mice
Shani, M. (1985) · Nature · doi:10.1038/314283a0 · Cited by 98
Rapid effects of insulin on the hypothalamic satiety center
Debons, A., KRIMSKY, I., From, A., & Cloutier, R. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.217.4.1114 · Cited by 84
Burcelin, R., Muñoz, M. D. C., Guillam, M., & Thorens, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.10930 · Cited by 82
Fibroblast Growth Factor-16 Is a Growth Factor for Embryonic Brown Adipocytes
Konishi, M., Mikami, T., Yamasaki, M., Miyake, A., & Itoh, N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.12119 · Cited by 82
Receptors for fibroblast growth factors
COUTTS, J. C., & Gallagher, J. T. (1995) · Immunology and Cell Biology · doi:10.1038/icb.1995.92 · Cited by 60
Ma, S. W. Y., Nadeau, B. E., & Foster, D. O. (1987) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y87-281 · Cited by 49
Sympathetic and thyroid influences on metabolic rate in fed, fasted, and refed rats
Rothwell, N. J., Saville, M. E., & Stock, M. J. (1982) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1982.243.3.r339 · Cited by 38
Stewart, T. A., Clift, S., Pitts-Meek, S., Martin, L., Terrell, T. G., Liggitt, D., & Oakley, H. (1992) · Endocrinology · doi:10.1210/endo.130.1.1727714 · Cited by 37
Self-citationAmino acid residues which distinguish the mitogenic potentials of two FGF receptors
Wang, J.-K., & Goldfarb, M. P. (1997) · Oncogene · doi:10.1038/sj.onc.1201021 · Cited by 32
Physiological Relationships of Uncoupling Protein-2 Gene Expression in Human Adipose Tissue in Vivo1
Pinkney, J. H., Boss, O., Bray, G. A., Bulmer, K., Coppack, S. W., & Mohamed‐Ali, V. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6622 · Cited by 27
Contribution to the Identification and Analysis of the Mitochondrial Uncoupling Proteins
Ricquier, D., Miroux, B., Cassard, A., Lévi-Meyrueis, C., Gelly, C., Raimbault, S., & Bouillaud, F. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005488105076 · Cited by 12
Effect of Graded Levels of Insulin on Feed Consumption in Normal Female Rats.
Kumaresan, P., & Turner, C. W. (1965) · Experimental Biology and Medicine · doi:10.3181/00379727-120-30667 · Cited by 11
Research works printed but not linked: 1
- Rothwell, 1982, Sympathetic and thryoid influences on metabolic rate in fed, fasted, and refed rats, Am J Physiol, 243, R339
Cited by
Sorted by citations
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
The FGF family: biology, pathophysiology and therapy
Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495
Metadata
- Authors
- Tomlinson, E., Fu, L., John, L., Hultgren, B., Huang, X., Renz, M., Stephan, J. P., Tsai, S. P., Powell-Braxton, L., French, D., & Stewart, T. A.
- Affiliations
- Genentech (US)
- Corresponding author
- Stewart, Timothy A.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2002-05-01
- Volume
- 143
- Issue
- 5
- Pages
- 1741-1747
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2106986971
- Cited by
- 576
- References
- 57
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 29 · 2023: 18 · 2022: 32 · 2021: 37 · 2020: 37 · 2019: 35 · 2018: 35 · 2017: 42 · 2016: 27 · 2015: 43 · 2014: 26 · 2013: 30 · 2012: 31
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Genentech
- Goddard Space Flight Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- FGF19, FGF receptor 4, energy expenditure, adiposity, brown adipose tissue, acetyl-CoA carboxylase 2, hepatic triglycerides, high-fat diet, obesity, diabetes mellitus, metabolic rate
- MeSH terms
- Fibroblast Growth Factor-23, Adipose Tissue, Animals, Body Temperature, Body Weight, Adipose Tissue, Brown, Calorimetry, Indirect, Diabetes Mellitus, Diet, Dietary Fats, Energy Metabolism, Fibroblast Growth Factors, Glucose, Glucose Tolerance Test, Humans, Liver, Mice, Transgenic, Phenotype, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
