The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation
Abstract
Glycodelin is a glycoprotein that belongs to the lipocalin superfamily. Depending on glycosylation, glycodelin appears in various isoforms. In the uterus, glycodelin-A is the major progesterone-regulated glycoprotein secreted into uterine luminal cavity by secretory/decidualized endometrial glands. The other tissues expressing glycodelin include fallopian tubes, ovary, breast, seminal vesicle, bone marrow, and eccrine glands. Glycodelin-A potently and dose-dependently inhibits human sperm-egg binding, whereas differently glycosylated glycodelin-S from seminal plasma has no such effect. Absence of contraceptive glycodelin-A in the uterus during periovulatory midcycle is consistent with an open "fertile window." Glycodelin induced by local or systemic administration of progestogens may potentially reduce the fertilizing capacity of sperm in any phase of the menstrual cycle. Glycodelin also has immunosuppressive activity. Its high concentration at the fetomaternal interface may contribute to protection of the embryonic semiallograft. Besides being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of glycodelin cDNA into a glycodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers. These various properties, as well as the chemistry, biology, and clinical aspects of glycodelin, continue to be areas of active investigation reviewed in this communication.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The lipocalin protein family: structure and function
FLOWER, D. R. (1996) · Biochemical Journal · doi:10.1042/bj3180001 · Cited by 1,679
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512073332301 · Cited by 1,070
Varki, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7390 · Cited by 946
Pearce, E. J., Caspar, P., Grzych, J. M., Lewis, F. A., & Sher, A. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.1.159 · Cited by 765
A description of 34 human ova within the first 17 days of development
Hertig, A. T., Rock, J., & Adams, E. C. (1956) · American Journal of Anatomy · doi:10.1002/aja.1000980306 · Cited by 648
Deeply infiltrating pelvic endometriosis: histology and clinical significance
Cornillie, F. J., Oosterlynck, D., Lauweryns, J. M., & Koninckx, P. R. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53570-5 · Cited by 594
Glycoprotein Structure Determination by Mass Spectrometry
Dell, A., & Morris, H. R. (2001) · Science · doi:10.1126/science.1058890 · Cited by 577
Wilcox, A. J. (2000) · BMJ · doi:10.1136/bmj.321.7271.1259 · Cited by 452
Burkman, L. J., Coddington, C. C., Franken, D. R., Kruger, T. F., Rosenwaks, Z., & Hodgen, G. D. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59841-0 · Cited by 391
Profile of a mammalian sperm receptor1,2
Wassarman, P. M. (1990) · Development · doi:10.1242/dev.108.1.1 · Cited by 362
Cited by
Kao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696
Self-citationPregnancy complications in women with polycystic ovary syndrome
Palomba, S., de Wilde, M. A., Falbo, A., Koster, M. P. H., La Sala, G. B., & Fauser, B. C. J. M. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv029 · Cited by 691
Endocrine regulation of menstruation
Jabbour, H. N., Kelly, R. W., Fraser, H. M., & Critchley, H. O. D. (2006) · Endocrine Reviews · doi:10.1210/er.2004-0021 · Cited by 588
Campo, S., Campo, V., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.10.003 · Cited by 158
Uchida, H., Maruyama, T., Ono, M., Ohta, K., Kajitani, T., Masuda, H., Nagashima, T., Arase, T., Asada, H., & Yoshimura, Y. (2007) · Endocrinology · doi:10.1210/en.2006-0896 · Cited by 59
Metadata
- Authors
- Seppälä, M., Taylor, R. N., Koistinen, H., Koistinen, R., & Milgrom, E.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2002-08-01
- Volume
- 23
- Issue
- 4
- Pages
- 401-430
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2123266289
- Cited by
- 262
- References
- 148
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation. https://app.cochat.ai/papers/10.1210/er.2001-0026
- The paper
- Seppälä, M., Taylor, R. N., Koistinen, H., Koistinen, R., & Milgrom, E. (2002). Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation. Endocrine Reviews. https://doi.org/10.1210/er.2001-0026
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
