Cited by 505Circadian rhythm and melatoninSleep and Work-Related FatigueDietary Effects on Health

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Metabolism and Circadian Rhythms—Implications for Obesity

Froy, Oren·2010·Endocrine Reviews

DOI 10.1210/er.2009-0014

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Abstract

Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Human homeostatic systems have adapted to daily changes in light and dark in a way that the body anticipates the sleep and activity periods. Mammals have developed an endogenous circadian clock located in the suprachiasmatic nuclei of the anterior hypothalamus that responds to the environmental light-dark cycle. Similar clocks have been found in peripheral tissues, such as the liver, intestine, and adipose tissue, regulating cellular and physiological functions. The circadian clock has been reported to regulate metabolism and energy homeostasis in the liver and other peripheral tissues. This is achieved by mediating the expression and/or activity of certain metabolic enzymes and transport systems. In return, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism. In addition, the core clock mechanism has been shown to be linked with lipogenic and adipogenic pathways. Animals with mutations in clock genes that disrupt cellular rhythmicity have provided evidence for the relationship between the circadian clock and metabolic homeostasis. In addition, clinical studies in shift workers and obese patients accentuate the link between the circadian clock and metabolism. This review will focus on the interconnection between the circadian clock and metabolism, with implications for obesity and how the circadian clock is influenced by hormones, nutrients, and timed meals.

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Authors: Froy, O.
Affiliations: Hebrew University of Jerusalem (IL)
Corresponding author: Froy, Oren
ORCID: Froy, Oren
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2009-10-23
Volume: 31
Issue: 1
Pages: 1-24
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2009-0014
OpenAlex: W1996003588
Cited by: 505
References: 337
Citations by year: 2026: 19 · 2025: 16 · 2024: 26 · 2023: 23 · 2022: 28 · 2021: 26 · 2020: 19 · 2019: 35 · 2018: 27 · 2017: 34 · 2016: 27 · 2015: 44 · 2014: 44 · 2013: 51 · 2012: 42
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Nutricia Research Foundation
Hebrew University of Jerusalem
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords: circadian clock, obesity, metabolism, energy homeostasis, clock genes, suprachiasmatic nucleus, insulin resistance, hypertension, lipogenesis, adipogenesis, shift work, nutrient regulation, hormonal regulation
MeSH terms: Animals, Biological Clocks, Circadian Rhythm, Energy Metabolism, Female, Homeostasis, Humans, Male, Obesity, Organ Specificity

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Metabolism and Circadian Rhythms—Implications for Obesity

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