Disrupted fat absorption attenuates obesity induced by a high‐fat diet in Clock mutant mice
Open accessAbstract
The Clock gene is a core component of the circadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an increase in body weight induced by a high-fat diet was attenuated in homozygous Clock mutant mice. We also found that dietary fat absorption was extremely impaired in Clock mutant mice. Circadian expressions of cholecystokinin-A (CCK-A) receptor and lipase mRNAs were damped in the pancreas of Clock mutant mice. We therefore showed that a Clock mutation attenuates obesity induced by a high-fat diet in mice with an ICR background through impaired dietary fat absorption. Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals.
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Other Clock mutant mouse models show different metabolic results, including lack of obesity or weight loss despite lipid imbalance, suggesting the importance of genetic background.
“However, different results have been reported in other Clock mutant mouse models as also lack of obesity or even weight loss, despite lipid imbalance, has been reported suggesting the importance of the genetic background when analyzing the metabolic effects of the Clock gene [13–16].”
From Circadian control of glucose metabolism (2014) · cites this paper as [13]
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Regular Feeding Plays an Important Role in Cholesterol Homeostasis Through the Liver Circadian Clock
Yamajuku, D., Okubo, S., Haruma, T., Inagaki, T., Okuda, Y., Kojima, T., Noutomi, K., Hashimoto, S., & Oda, H. (2009) · Circulation Research · doi:10.1161/circresaha.109.199034 · Cited by 45 · see citing works
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Prospective influences of circadian clocks in adipose tissue and metabolism
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Adiponectin regulates the circadian rhythm of glucose and lipid metabolism
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Gender Disparity of Hepatic Lipid Homoeostasis Regulated by the Circadian Clock
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Daily variation of gene expression in diverse rat tissues
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Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice
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Circadian control of metabolism and pathological consequences of clock perturbations
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Anticipating anticipation: pursuing identification of cardiomyocyte circadian clock function
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Changes in the Daily Rhythm of Lipid Metabolism in the Diabetic Retina
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Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model
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- Authors
- Oishi, K., Atsumi, G.-I., Sugiyama, S., Kodomari, I., Kasamatsu, M., Machida, K., & Ishida, N.
- Affiliations
- National Institute of Advanced Industrial Science and Technology (JP)
- Teikyo University (JP)
- Waseda University (JP)
- University of Tsukuba (JP)
- Corresponding author
- Ishida, Norio
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-12-06
- Volume
- 580
- Issue
- 1
- Pages
- 127-130
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2020273326
- Cited by
- 166
- References
- 17
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 12 · 2012: 7
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Otsuka Pharmaceutical
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- clock genes, circadian clock, obesity, high-fat diet, dietary fat absorption, lipid homeostasis, triglycerides, free fatty acids, CCK-A receptor, lipase, pancreas, ICR mice
- MeSH terms
- Animals, Cholecystokinin, Circadian Rhythm, Dietary Fats, Fatty Acids, Gene Expression Regulation, Homeostasis, Mice, Mutant Strains, Obesity, Triglycerides, Trans-Activators, Receptor, Cholecystokinin A, Mice, CLOCK Proteins
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