The DOI matches its Crossref record; 337 of the 337 references it cites were found in a registry or an index.
Metabolism and Circadian Rhythms—Implications for Obesity
Abstract
Obesity has become a serious public health problem and a major risk factor for the development of illnesses, such as insulin resistance and hypertension. Human homeostatic systems have adapted to daily changes in light and dark in a way that the body anticipates the sleep and activity periods. Mammals have developed an endogenous circadian clock located in the suprachiasmatic nuclei of the anterior hypothalamus that responds to the environmental light-dark cycle. Similar clocks have been found in peripheral tissues, such as the liver, intestine, and adipose tissue, regulating cellular and physiological functions. The circadian clock has been reported to regulate metabolism and energy homeostasis in the liver and other peripheral tissues. This is achieved by mediating the expression and/or activity of certain metabolic enzymes and transport systems. In return, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism. In addition, the core clock mechanism has been shown to be linked with lipogenic and adipogenic pathways. Animals with mutations in clock genes that disrupt cellular rhythmicity have provided evidence for the relationship between the circadian clock and metabolic homeostasis. In addition, clinical studies in shift workers and obese patients accentuate the link between the circadian clock and metabolism. This review will focus on the interconnection between the circadian clock and metabolism, with implications for obesity and how the circadian clock is influenced by hormones, nutrients, and timed meals.
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“Current evidence indicates that meal timing may have important effects on body weight, appetite and glucose and lipid metabolism (7 -11) .”
From Effects of consuming later evening meal v. earlier evening meal on weight loss during a weight loss diet: a randomised clinical trial (2021) · cites this paper as [10]
In the citing paper
“A role for circadian rhythms, including the circadian clock within the adipocytes, in the development of obesity was described 17, 71, 72, 73.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [72]
Citations
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Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
Timing of food intake predicts weight loss effectiveness
Garaulet, M., Gómez-Abellán, P., Alburquerque-Béjar, J. J., Lee, Y.-C., Ordovás, J. M., & Scheer, F. A. J. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.229 · Cited by 639
Jakubowicz, D., Barnea, M., Wainstein, J., & Froy, O. (2013) · Obesity · doi:10.1002/oby.20460 · Cited by 593
Self-citationCircadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410
The Circadian Syndrome: is the Metabolic Syndrome and much more!
Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387
Metadata
- Authors
- Froy, O.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Froy, Oren
- ORCID
- Froy, Oren
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2009-10-23
- Volume
- 31
- Issue
- 1
- Pages
- 1-24
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W1996003588
- Cited by
- 505
- References
- 337
- Citations by year
- 2026: 19 · 2025: 16 · 2024: 26 · 2023: 23 · 2022: 28 · 2021: 26 · 2020: 19 · 2019: 35 · 2018: 27 · 2017: 34 · 2016: 27 · 2015: 44 · 2014: 44 · 2013: 51 · 2012: 42
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Nutricia Research Foundation
- Hebrew University of Jerusalem
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian clock, obesity, metabolism, energy homeostasis, clock genes, suprachiasmatic nucleus, insulin resistance, hypertension, lipogenesis, adipogenesis, shift work, nutrient regulation, hormonal regulation
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Energy Metabolism, Female, Homeostasis, Humans, Male, Obesity, Organ Specificity
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