The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
The Effects of Light at Night on Circadian Clocks and Metabolism
Abstract
Most organisms display endogenously produced ∼ 24-hour fluctuations in physiology and behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throughout the brain and body, with the suprachiasmatic nucleus of the hypothalamus serving as the master circadian oscillator at the top of the hierarchy. Appropriate circadian regulation is important for many homeostatic functions including energy regulation. Multiple genes involved in nutrient metabolism display rhythmic oscillations, and metabolically related hormones such as glucagon, insulin, ghrelin, leptin, and corticosterone are released in a circadian fashion. Mice harboring mutations in circadian clock genes alter feeding behavior, endocrine signaling, and dietary fat absorption. Moreover, misalignment between behavioral and molecular circadian clocks can result in obesity in both rodents and humans. Importantly, circadian rhythms are most potently synchronized to the external environment by light information and exposure to light at night potentially disrupts circadian system function. Since the advent of electric lights around the turn of the 20th century, exposure to artificial and irregular light schedules has become commonplace. The increase in exposure to light at night parallels the global increase in the prevalence of obesity and metabolic disorders. In this review, we propose that exposure to light at night alters metabolic function through disruption of the circadian system. We first provide an introduction to the circadian system, with a specific emphasis on the effects of light on circadian rhythms. Next we address interactions between the circadian system and metabolism. Finally, we review current experimental and epidemiological work directly associating exposure to light at night and metabolism.
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Citations
Cites
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Cited by
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733
Meta-analysis on shift work and risks of specific obesity types
Sun, M., Feng, W., Wang, F., Li, P., Li, Z., Li, M., Tse, G., Vlaanderen, J., Vermeulen, R., & Tse, L. A. (2018) · Obesity Reviews · doi:10.1111/obr.12621 · Cited by 391
Circadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 365
Microglia inflammatory responses are controlled by an intrinsic circadian clock
Fonken, L. K., Frank, M. G., Kitt, M. M., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.11.009 · Cited by 281
Self-citationMelatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders
Ahmad, S. B., Ali, A., Bilal, M., Rashid, S. M., Wani, A. B., Bhat, R. R., & Rehman, M. U. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01324-w · Cited by 267
Metadata
- Authors
- Fonken, L. K., & Nelson, R. J.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2014-03-27
- Volume
- 35
- Issue
- 4
- Pages
- 648-670
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2154741089
- Cited by
- 460
- References
- 67
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
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