The DOI matches its Crossref record; 380 of the 385 references it cites were found in a registry or an index.
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Open accessAbstract
The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. Through the use of advanced mass spectrometry “omics” approaches and detailed experimentation in cells, mice, and humans, we now understand that the liver secretes a wide array of proteins, metabolites, and noncoding RNAs (miRNAs) and that many of these secreted factors exert powerful effects on metabolic processes both in the liver and in peripheral tissues. In this review, we summarize the rapidly evolving field of “hepatokine” biology with a particular focus on delineating previously unappreciated communication between the liver and other tissues in the body. We describe the NAFLD-induced changes in secretion of liver proteins, lipids, other metabolites, and miRNAs, and how these molecules alter metabolism in liver, muscle, adipose tissue, and pancreas to induce insulin resistance. We also synthesize the limited information that indicates that extracellular vesicles, and in particular exosomes, may be an important mechanism for intertissue communication in normal physiology and in promoting metabolic dysregulation in NAFLD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“with ~2,500 liver-secreted proteins identified using modern liquid chromatography and mass spectroscopy technologies39.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [39]
In the citing paper
“These exerkines affect glucose and/or lipid metabolism (for example, angiopoietin-like protein 4 in humans and animal models39,79), browning of WAT (FGF21 in a mouse model106), lipolysis (FGF21 in humans and a mouse model77) and the maintenance of cellular homeostasis (heat shock protein 72 in humans107).”
From Exerkines in health, resilience and disease (2022) · cites this paper as [39]
In the citing paper
“fetuin-A worsens peripheral insulin resistance by reducing insulin signalling and glucose transporter type 4 trafficking39.”
From Exerkines in health, resilience and disease (2022) · cites this paper as [39]
In the citing paper
“Activin-E is elevated in the livers and serum of humans with obesity and NAFLD (Table 1) [29]”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [29]
In the citing paper
“Furthermore, knockdown of FST in mice improved insulin sensitivity [29,196].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [29]
In the citing paper
“Hepassocin has also been implicated in skeletal muscle insulin resistance through an AMPK-dependent mechanism [29] (Figure 3).”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [29]
In the citing paper
“These findings coincide with studies in mice that demonstrate increased hepatic expression of SeP in response to high-fat diet feeding, NAFLD, and type 2 diabetes [29,260,265].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286
Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60460-8 · Cited by 11,952
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781
Abarca-Gómez, L., Abdeen, Z. A., Hamid, Z. A., Abu-Rmeileh, N. M., Acosta-Cazares, B., Acuin, C., Adams, R. J., Aekplakorn, W., Afsana, K., Aguilar-Salinas, C. A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32129-3 · Cited by 7,482
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Drucker, D. J., & Nauck, M. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69705-5 · Cited by 3,896
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Flagged first, then by citations
5 of the 385 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Berglund, 2009, Fibroblast growth fact or 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity, 4084
Cited by
Sorted by citations
Items 101–200 of 620
Miotto, P. M., Yang, C.-H., Keenan, S. N., Nardo, W. D., Beddows, C. A., Fidelito, G., Dodd, G. T., Parker, B. L., Hill, A. F., Burton, P. R., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00971-z · Cited by 45
Self-citationCimini, F. A., Barchetta, I., Ciccarelli, G., Leonetti, F., Silecchia, G., Chiappetta, C., Cristofano, C. D., Capoccia, D., Bertoccini, L., Ceccarelli, V., et al. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3358 · Cited by 39
Huanan, C., Li, S., Amoah, A. N., Yacong, B., Chen, X., Shi, Z., Guodong, W., Jian, H., Shi, S., & Quanjun, L. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-039804 · Cited by 43
Non-alcoholic fatty liver disease in obese children and adolescents: a role for nutrition?
Bonsembiante, L., Targher, G., & Maffeis, C. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00928-z · Cited by 40
Beyond the Liver: Liver-Eye Communication in Clinical and Experimental Aspects
Yuan, T.-H., Yue, Z., Zhang, G.-H., Wang, L., & Dou, G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.823277 · Cited by 39
Metabolic Inflexibility as a Pathogenic Basis for Atrial Fibrillation
Qin, X., Zhang, Y., & Zheng, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158291 · Cited by 38
Organoid-guided precision hepatology for metabolic liver disease
Osonoi, S., & Takebe, T. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.01.002 · Cited by 40
VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway
Li, Y., Li, W., Zhu, X., Xu, N., Meng, Q., Jiang, W., Zhang, L., Yang, M., Xu, F., & Li, Y. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05621-w · Cited by 41
Mechanisms of nonalcoholic fatty liver disease and implications for surgery
Kaufmann, B. K., Reca, A., Wang, B., Friess, H., Feldstein, A. E., & Hartmann, D. (2020) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-020-01965-1 · Cited by 39
Yin, X., Li, M., Wang, Y., Zhao, G., Yang, T., Zhang, Y., Guo, J., Meng, T., Du, R., Li, H., et al. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01573-y · Cited by 37
Dashti, Z. J. S., Yousefi, Z., Kiani, P., Taghizadeh, M., Maleki, M. H., Borji, M., Vakili, O., & Shafiee, S. M. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155811 · Cited by 38
Zakaria, Z., Othman, Z. A., Suleiman, J. B., Jalil, N. A. C., Ghazali, W. S. W., Nna, V. U., & Mohamed, M. (2021) · Antioxidants · doi:10.3390/antiox10122031 · Cited by 37
Impact of NAFLD and its pharmacotherapy on lipid profile and CVD
Wang, Z., Ye, M., Zhang, X., Zhang, P., Cai, J., Li, H., & She, Z. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.07.010 · Cited by 39
Noninvasive scores are poorly predictive of histological fibrosis in paediatric fatty liver disease
Kalveram, L., Baumann, U., Bruyne, R. D., Draijer, L. G., Jańczyk, W., Kelly, D. A., Koot, B. G. P., Lacaille, F., Lefere, S., Moran‐Lev, H., et al. (2023) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12068 · Cited by 36
Acupuncture improved lipid metabolism by regulating intestinal absorption in mice
Han, J., Guo, X., Meng, X., Zhang, J., Yamaguchi, R., Motoo, Y., & Yamada, S. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i34.5118 · Cited by 36
Ji, J., Feng, M., Huang, Y., & Niu, X. (2022) · Bioengineered · doi:10.1080/21655979.2022.2036902 · Cited by 36
Ma, W., Wu, W., Wen, W., Xu, F., Han, D., Lyu, J., & Huang, Y. (2022) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223221122478 · Cited by 39
David-Silva, A., Esteves, J. V. D. C., Morais, M., Freitas, H. S., Zorn, T. M. T., Corrêa‐Giannella, M. L., & Machado, U. F. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s242282 · Cited by 37
Nardo, W. D., Miotto, P. M., Bayliss, J. A., Nie, S., Keenan, S. N., Montgomery, M. K., & Watt, M. J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101491 · Cited by 35
Self-citationMiao, X., Alidadipour, A., Saed, V., Sayyadi, F., Jadidi, Y., Davoudi, M., Amraee, F., Jadidi, N., & Afrisham, R. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02335-9 · Cited by 37
Gao, X., Liu, S., Tan, L., Ding, C., Fan, W., Gao, Z., Li, M., Tang, Z., Wu, Y., Xu, L., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05400 · Cited by 34
Hironori Nakagami, A. (2022) · Hypertension Research · doi:10.1038/s41440-022-01117-6 · Cited by 34
Liu, Z., Huang, H., Zeng, Y., Chen, Y., & Xu, C. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114522003956 · Cited by 32
Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target
Milani, I., Codini, M., Guarisco, G., Chinucci, M., Gaita, C., Leonetti, F., & Capoccia, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910795 · Cited by 40
Lin, J., Jiang, X., Dong, M., Liu, X., Shen, Q., Huang, Y., Zhang, H., Ye, R., Zhou, H., Yan, C., et al. (2021) · Advanced Science · doi:10.1002/advs.202101991 · Cited by 33
Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease
Jung, I., Lee, W., Lee, M. Y., Kwon, H., Rhee, E., Park, C., Oh, K.-W., Lee, W., Park, S., & Park, S. E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.752944 · Cited by 33
Nonalcoholic fatty liver disease and insulin resistance in children
Song, K., Kim, H.-S., & Chae, H. W. (2023) · Korean Journal of Pediatrics · doi:10.3345/cep.2022.01312 · Cited by 39
Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis
García‐Martinez, I., Alén, R., Rada, P., & Valverde, Á. M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00395 · Cited by 32
López-Bermudo, L., Luque‐Sierra, A., Maya‐Miles, D., Gallego‐Durán, R., Ampuero, J., Romero‐Gómez, M., Berná, G., & Martı́n, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.892672 · Cited by 34
Xu, F., Zhang, H., Chen, J., Zhan, J., Liu, P., Liu, W., Qi, S., & Mu, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117514 · Cited by 31
Lin, C., Adhikary, P., & Cheng, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.008 · Cited by 31
Binet, Q., Loumaye, A., Preumont, V., Thissen, J., Hermans, M. P., & Lanthier, N. (2022) · Acta gastro-enterologica belgica · doi:10.51821/85.2.9775 · Cited by 35
A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review
Zhang, S., Liu, H., Du, X., Chen, X., Petlulu, P., Tian, Z., Shi, L., Zhang, B., Yuan, S., Guo, X. H., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158262 · Cited by 31
Mladenović, D. R., Vesković, M. N., Šutulović, N., Hrnčić, D., Stanojlović, O. P., Radić, L., Macut, J. B., & Μacut, D. (2024) · Endocrine · doi:10.1007/s12020-024-03702-w · Cited by 32
Li, Y., Wang, B., Shen, J.-D., Bai, M., & Xu, E. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1756349 · Cited by 32
Tao, L., Guo, X., Xu, M., Wang, Y., Xie, W., Chen, H., Ma, M., & Li, X. (2020) · Pharmacology Research & Perspectives · doi:10.1002/prp2.700 · Cited by 30
Hepatogenous diabetes: Knowledge, evidence, and skepticism
Kumar, R. K., García‐Compeán, D., & Maji, T. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i7.1291 · Cited by 34
Liu, X.-H., Qi, L., Alolga, R. N., & Liu, Q. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.66834 · Cited by 29
Montgomery, M. K., Bayliss, J. A., Nie, S., Nardo, W. D., Keenan, S. N., Miotto, P. M., Karimkhanloo, H., Huang, C., Schittenhelm, R. B., Don, A. S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28889-2 · Cited by 33
Self-citationLiver-derived metabolites as signaling molecules in fatty liver disease
Keles, U., Ow, J. R., Kuentzel, K. B., Zhao, L. N., & Kaldis, P. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04658-8 · Cited by 32
Preventative and Therapeutic Effects of Astaxanthin on NAFLD
Sayuti, N. H., Nawawi, K. N. M., Goon, J. A., Mokhtar, N. M., Makpol, S., & Tan, J. K. (2023) · Antioxidants · doi:10.3390/antiox12081552 · Cited by 29
Iacob, S. A., & Iacob, D. G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.814209 · Cited by 27
Secretory Galectin-3 promotes hepatic steatosis via regulation of the PPARγ/CD36 signaling pathway
Yu, H., Yang, F., Zhong, W., Jiang, X., Zhang, F., Ji, X., Xue, M., Qiu, Y., Yu, J., Hu, X., et al. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110043 · Cited by 29
Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg
Langlois, A., Dumond, A., Vion, J., Pinget, M., & Bouzakri, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.836344 · Cited by 32
Risk factors and prediction model for nonalcoholic fatty liver disease in northwest China
Li, D., Zhang, M., Wu, S., Tan, H., & Li, N. (2022) · Scientific Reports · doi:10.1038/s41598-022-17511-6 · Cited by 29
Kakiyama, G., Rodríguez‐Agudo, D., & Pandak, W. M. (2023) · Cells · doi:10.3390/cells12101434 · Cited by 30
Li, S., Han, B., Li, J., Lv, Z., Jiang, H., Liu, Y., Yang, X., Lu, J., & Zhang, Z. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02349 · Cited by 28
Guo, W., Kim, S. H., Wu, D., Li, L., Ortega, E. F., Thomas, M., Meydani, S. N., & Meydani, M. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa410 · Cited by 29
A Healthful Plant-Based Diet Is Associated with Lower Odds of Nonalcoholic Fatty Liver Disease
Li, X., Peng, Z., Li, M., Zeng, X., Li, H., Zhu, Y., Chen, H., Hu, A., Zhao, Q., Zhang, Z., et al. (2022) · Nutrients · doi:10.3390/nu14194099 · Cited by 27
Exercise, Neuroprotective Exerkines, and Parkinson’s Disease: A Narrative Review
Mitchell, A. K., Bliss, R. R., & Church, F. (2024) · Biomolecules · doi:10.3390/biom14101241 · Cited by 33
Liu, S., Meng, F., Sun, R., Li, Y., Li, H., & Liu, B. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123061 · Cited by 28
Xia, Q., Gao, Y., Wen-bin, W., Wu, F., Dong, H., Xu, L., Fang, K., Hu, M.-L., Fen, Y., Lu, F., et al. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154351 · Cited by 27
Zhang, X., He, Z., Si, Q., Hu, X., Yang, L., Gu, X., Du, L.-J., Wang, L., Pan, L., Li, Y., et al. (2022) · Journal of Diabetes Research · doi:10.1155/2022/2229139 · Cited by 26
Chen, K., Lin, T., Yao, W., Chen, X., Xiong, X., & Huang, Z. (2022) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2022.12.003 · Cited by 26
Khamseh, M. E., Malek, M., Jahangiri, S., Nobarani, S., Hekmatdoost, A., Salavatizadeh, M., Soltanieh, S., Chehrehgosha, H., Taheri, H., Montazeri, Z., et al. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08309-9 · Cited by 26
Epidemiology of NAFLD – Focus on diabetes
Younossi, Z. M., & Henry, L. L. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111648 · Cited by 26
Metabolic dysfunction–associated steatotic liver disease and pregnancy
Sarkar, M., & Kushner, T. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186426 · Cited by 25
Yoshino, S., Iwasaki, Y., Matsumoto, S., Satoh, T., Ozawa, A., Yamada, E., Kakizaki, S., Trejo, J. A. O., Uchiyama, Y., Yamada, M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-70689-5 · Cited by 25
Zhang, N., Zhou, J., Zhao, L., Wang, O., Zhang, L., & Zhou, F. L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.946556 · Cited by 25
Zhang, Y., Fu, Q., Wu, T., Liu, K., Xiao, Y., Liao, Q., Qi, X., Li, Y., & Zhou, L. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.093 · Cited by 26
Wei, L.-M., Cheng, X., Luo, Y., Yang, R., Lei, Z., Jiang, H., & Chen, L. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.08.008 · Cited by 18
Mouchiroud, M., Camiré, É., Aldow, M., Caron, A., Jubinville, É., Turcotte, L., Kaci, I., Beaulieu, M.-J., Roy, C., Labbé, S. M., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.014 · Cited by 24
Lipid Metabolism as a Potential Target of Liver Cancer
Wu, K., & Lin, F. (2024) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s450423 · Cited by 27
Friend or foe for obesity: How hepatokines remodel adipose tissues and translational perspective
Zhang, Y., Wang, Y., & Liu, J. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2021.12.011 · Cited by 26
Cai, X., Gao, J. S., Liu, S., Wang, M., Hu, J., Hong, J., Zhu, Q., Tuerxun, G., Dang, Y., & Li, N. (2022) · Disease Markers · doi:10.1155/2022/3150380 · Cited by 24
Adherence to Mediterranean Diet: Any Association with NAFLD?
Barrea, L., Verde, L., Savastano, S., Colao, A., & Muscogiuri, G. (2023) · Antioxidants · doi:10.3390/antiox12071318 · Cited by 26
Neira, G., Becerril, S., Valentí, V., Moncada, R., Catalán, V., Gómez‐Ambrosi, J., Colina, I., Silva, C., Escalada, J., Frühbeck, G., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.08.007 · Cited by 25
Abassi, W., Ouerghi, N., Hammami, M. B., Jebabli, N., Feki, M., Bouassida, A., Weiss, K., & Knechtle, B. (2025) · Nutrients · doi:10.3390/nu17010164 · Cited by 23
Li, Q., Guo, S., Yang, C., Liu, X., Chen, X., He, J., Tong, C., Ding, Y., Peng, C. X., Geng, Y., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-2027 · Cited by 23
Grossini, E., Garhwal, D. P., Calamita, G., Romito, R., Rigamonti, C., Minisini, R., Smirne, C., Surico, D., Bellan, M., & Pirisi, M. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.693997 · Cited by 23
Feng, Y., Han, L., Chen, C., Lin, H., Xu, G., Li, H., Wang, C., Chen, J., & Sun, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.727636 · Cited by 23
Leven, A., Gieseler, R. K. H., Schlattjan, M., Schreiter, T., Niedergethmann, M., Baars, T., Baba, H. A., Özcürümez, M. K., Sowa, J., & Canbay, A. E. (2021) · Adipocyte · doi:10.1080/21623945.2021.1982164 · Cited by 23
Lu, Y., Hu, L., Song, J., Wan, J., Chen, H., & Yin, J. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00899-z · Cited by 23
Liver Fetuin-A at Initiation of Insulin Resistance
Lanthier, N., Lebrun, V., Molendi‐Coste, O., van Rooijen, N., & Leclercq, I. A. (2022) · Metabolites · doi:10.3390/metabo12111023 · Cited by 23
Roy, J. R., Janaki, C. S., Jayaraman, S., Veeraraghavan, V. P., Vijayalakshmi, P., Balaji, T., Vijayamalathi, M., Ponnusamy, B., & Panneerselvam, S. (2023) · Toxics · doi:10.3390/toxics11030240 · Cited by 23
Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine
Zhang, Y., & Fang, X.-M. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6655335 · Cited by 23
Yang, M., Wei, Y., Liu, J., Wang, Y., & Wang, G. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2024.0537 · Cited by 23
p53: from understanding its structure to advances in therapeutic targeting
Wang, W., Liu, X., Liu, H., Abolhassani, H., Yan, H., Zhang, H., & Wang, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02549-5 · Cited by 29
Liu, J., Nie, C., Xue, L., Yan, Y., Liu, S., Sun, J., Fan, M., Qian, H., Ying, H., Wang, L., et al. (2021) · Theranostics · doi:10.7150/thno.61192 · Cited by 22
The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone
Zi, C., Wang, D., Gao, Y., & He, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1104943 · Cited by 23
Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus
Padda, J., Khalid, K., Khedr, A., Tasnim, F., Al-Ewaidat, O. A., Cooper, A. C., & Jean-Charles, G. (2021) · Cureus · doi:10.7759/cureus.17321 · Cited by 24
Taheri, E., Pourhoseingholi, M. A., Moslem, A., Hassani, A. H., Jarrahi, S. A. M., Aghdaei, H. A., Zali, M. R., & Hatami, B. (2022) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00941-w · Cited by 21
Zhou, Y., Lin, X., Yin, S., Zhu, L., Yang, Y., Li, Y., Wang, B., Jiao, Y., Yu, W., Gao, P., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.933211 · Cited by 21
Wang, S., Zhang, Q., & Qin, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-55282-4 · Cited by 24
Bayliss, J. A., Ooi, G., Nardo, W. D., Johari, Y., Montgomery, M. K., McLean, C., Kemp, W. W., Roberts, S. K., Brown, W. A., Burton, P. R., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.642432 · Cited by 21
Self-citationChu, Y., Yang, S., & Chen, X. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108844 · Cited by 21
Pecani, M., Andreozzi, P., Cangemi, R., Corica, B., Miglionico, M., Romiti, G. F., Stefanini, L., Raparelli, V., & Basili, S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14082750 · Cited by 23
Zhao, E., Wang, R., Chen, Y., Xie, H., Gao, Y., Dong, B., & Zhang, C. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02742-z · Cited by 20
Gravina, A. G., Romeo, M., Pellegrino, R., Tuccillo, C., Federico, A., & Loguercio, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.869446 · Cited by 21
Mei, Y., Hu, H., Deng, L., Sun, X., & Tan, W. (2022) · Scientific Reports · doi:10.1038/s41598-022-16119-0 · Cited by 20
Meda, C., Dolce, A., Vegeto, E., Maggi, A. C., & Torre, S. D. (2022) · Nutrients · doi:10.3390/nu14163262 · Cited by 23
Transcriptomic analysis of the liver in aged laying hens with different eggshell strength
Han, G. P., Kim, J. H., Kim, J., & Kil, D. Y. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102217 · Cited by 21
Nonalcoholic Fatty Liver Disease—A Concise Review of Noninvasive Tests and Biomarkers
Bassal, T., Basheer, M., Boulos, M., & Assy, N. (2022) · Metabolites · doi:10.3390/metabo12111073 · Cited by 25
Montgomery, M. K., Bayliss, J. A., Nie, S., Nardo, W. D., Keenan, S. N., Anari, M., Taddese, A. Z., Williamson, N. A., Ooi, G., Brown, W. A., et al. (2022) · Diabetes · doi:10.2337/db22-0590 · Cited by 22
Self-citationPNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content
Nádasdi, Á., Gál, V., Masszi, T., Somogyi, A., & Firneisz, G. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01792-w · Cited by 22
Zhang, W., Zhang, J., Shi, H., Liu, F., Yu, H., & Shi, H. (2023) · Hepatology International · doi:10.1007/s12072-023-10520-1 · Cited by 20
Metabolic-Associated Fatty Liver Disease and Insulin Resistance: A Review of Complex Interlinks
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2023) · Metabolites · doi:10.3390/metabo13060757 · Cited by 22
The Role of Extracellular Vesicles in Metabolic Diseases
González-Blanco, C., Iglesias-Fortes, S., Lockwood, Á. C., Figaredo, C., Vitulli, D., & Guillén, C. (2024) · Biomedicines · doi:10.3390/biomedicines12050992 · Cited by 20
Zhang, L., Wang, X., He, Y., Cao, J., Wang, K., Lin, H., Qu, C., & Miao, J. (2022) · Marine Drugs · doi:10.3390/md20020091 · Cited by 20
Luo, H., Wang, J., Lin, F., Liu, Y., Wu, X., Gan, L., Su, C., Chen, J., Xiong, F., Mo, J., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.06.024 · Cited by 21
Metadata
- Authors
- Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K.
- Affiliations
- The University of Melbourne (AU)
- Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
- Corresponding author
- Watt, Matthew J
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2019-04-25
- Volume
- 40
- Issue
- 5
- Pages
- 1367-1393
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2942227779
- Cited by
- 615
- References
- 385
- Citations by year
- 2026: 61 · 2025: 98 · 2024: 109 · 2023: 98 · 2022: 128 · 2021: 83 · 2020: 31 · 2019: 7
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (APP1077703, APP1143224, APP1162511, APP1156508)
- Natural Sciences and Engineering Research Council of Canada
- Melbourne Research Scholarship, University of Melbourne (AU)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- non-alcoholic fatty liver disease, insulin resistance, hepatokines, hepatic lipid metabolism, microRNA, extracellular vesicles, exosomes, type 2 diabetes, muscle metabolism, adipose tissue, pancreas
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Endocrine Glands, Humans, Insulin Resistance, Liver, Dyslipidemias, Lipid Metabolism, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
