A Mutation in the KCNE3 Potassium Channel Gene Is Associated with Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis
Open accessAbstract
Hypokalemic Periodic Paralyses comprise diverse diseases characterized by acute and reversible attacks of severe muscle weakness, associated with low serum potassium. The most common causes are Familial Hypokalemic Periodic Paralysis (FHypoKPP), an autosomal dominant disease, and Thyrotoxic Hypokalemic Periodic Paralysis (THypoKPP), secondary to thyrotoxicosis. Symptoms of paralysis are similar in both diseases, distinguished by thyrotoxicosis present in THypoKPP. FHypoKPP is caused by mutations in ionic channel genes calcium (CACN1AS), sodium (SCN4A) and potassium (KCNE3). Since both diseases are similar, we tested the hypothesis that THypoKPP could carry the same mutations described in FHypoKPP, being the paralysis a genetically conditioned complication of thyrotoxicosis. In 15 patients with THypoKPP, using target-exon PCR, CSGE screening, and direct sequencing, we excluded known mutations in CACN1AS and SCN4A genes. On the other hand, we were able to identify the R83H mutation in the KCNE3 gene in one sporadic case of THypoKPP, a man who had been asymptomatic until developing thyrotoxicosis caused by Graves’ disease; we confirmed the disease-causing mutation in 2 of 3 descendants. R83H was recently found in two FHypoKPP unrelated families, in which the mutant decreased outward potassium flux, resulting in a more positive resting membrane potential. We, therefore, identified the first genetic defect in THypoKPP, a mutation in the KCNE3 gene.
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A mutation in the KCNE3 gene has been linked to THPP susceptibility.
“A mutation in the Kv3.4 gene potassium voltage-gated channel, Isk-related family, member 3 (KCNE3) has been linked to THPP susceptibility [18].”
From Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms (2025) · cites this paper as [18]
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- [4]4. Ptáček LJ, Bendahhou S. 2001 Ion channel disorders of muscle. In: G Karpati, D Hilton-Jones, RC Griggs, eds. Disorders of Voluntary Muscle. 7th ed. Cambridge: Cambridge Univ. Press;604-635.
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Cooper, D. S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14073-1 · Cited by 377 · see citing works
Thyrotoxic Periodic Paralysis: A Diagnostic Challenge
Kung, A. W. C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0356 · Cited by 371 · see citing works
The primary periodic paralyses: diagnosis, pathogenesis and treatment
Venance, S. L., Cannon, S. C., Fialho, D., Fontaine, B., Hanna, M. G., Ptacek, L. J., Tristani-Firouzi, M., Tawil, R., & Griggs, R. C. (2006) · Brain · doi:10.1093/brain/awh639 · Cited by 370 · see citing works
Correlating phenotype and genotype in the periodic paralyses
Miller, T. M., Dias-da-Silva, M. R., Miller, H. A., Kwieciński, H., Mendell, J. R., Tawil, R., McManis, P. G., Griggs, R. C., Angelini, C. I., Servidei, S., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000143383.91137.00 · Cited by 259 · see citing works
Self-citationMcCrossan, Z. A., & Abbott, G. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.018 · Cited by 254 · see citing works
The genetic basis of Brugada syndrome: A mutation update
Hedley, P., Jørgensen, P., Schlamowitz, S., Moolman-Smook, J., Kanters, J. K., Corfield, V., & Christiansen, M. (2009) · Human Mutation · doi:10.1002/humu.21066 · Cited by 184 · see citing works
In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart
Bendahhou, S., Marionneau, C., HAUROGNE, K., Larroque, M. M., Dérand, R., Szüts, V., Escande, D., Demolombe, S., & Barhanin, J. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.014 · Cited by 150 · see citing works
Expression of multiple KCNE genes in human heart may enable variable modulation of
Lundquist, A. L., Manderfield, L. J., Vanoye, C. G., ROGERS, C., Donahue, B. S., CHANG, P., Drinkwater, D. C., Murray, K. J., & George, A. L. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.012 · Cited by 141 · see citing works
Potassium channels: New targets in cancer therapy
Felipe, A., Vicente, R., Villalonga, N., Roura‐Ferrer, M., Martínez‐Mármol, R., Solé, L., Ferreres, J. C., & Condom, E. (2006) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2006.06.002 · Cited by 136 · see citing works
Preston‐Ferrer, P., Wartosch, L., Günzel, D., Fromm, M., Kongsuphol, P., Ousingsawat, J., Kunzelmann, K., Barhanin, J., Warth, R., & Jentsch, T. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047829 · Cited by 107 · see citing works
Fontaine, B. (2008) · Advances in genetics · doi:10.1016/s0065-2660(08)01001-8 · Cited by 103 · see citing works
When calcium goes wrong: genetic alterations of a ubiquitous signaling route
Rizzuto, R., & Pozzan, T. (2003) · Nature Genetics · doi:10.1038/ng0603-135 · Cited by 98 · see citing works
Voltage-Gated Potassium Channels: Regulation by Accessory Subunits
Li, Y., Um, S. Y., & McDonald, T. V. (2006) · The Neuroscientist · doi:10.1177/1073858406287717 · Cited by 91 · see citing works
Novel etiopathophysiological aspects of thyrotoxic periodic paralysis
Maciel, R. M. B., Lindsey, S. C., & Dias da Silva, M. R. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.58 · Cited by 86 · see citing works
Self-citationKCNE1 and KCNE3: The yin and yang of voltage-gated K+ channel regulation
Abbott, G. W. (2015) · Gene · doi:10.1016/j.gene.2015.09.059 · Cited by 84 · see citing works
Analytic review: thyrotoxic periodic paralysis: a review
Pothiwala, P., & Levine, S. N. (2010) · Journal of Intensive Care Medicine · doi:10.1177/0885066609358849 · Cited by 80 · see citing works
Kung, A. W. C., Lau, K. S., Fong, G. C. Y., & Chan, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030924 · Cited by 77 · see citing works
Thyrotoxic periodic paralysis: clinical and molecular aspects
Falhammar, H., Thorén, M., & Calissendorff, J. (2012) · Endocrine · doi:10.1007/s12020-012-9777-x · Cited by 74 · see citing works
Schalin‐Jäntti, C., Laine, T., Valli‐Jaakola, K., Lönnqvist, T. R. I., Kontula, K., & Välimäki, M. J. (2005) · Hormone Research in Paediatrics · doi:10.1159/000084689 · Cited by 61 · see citing works
Absence of Ion Channels CACN1AS and SCN4A Mutations in Thyrotoxic Hypokalemic Periodic Paralysis
Ng, W. Y., Lui, K. F., Thai, A. C., & Cheah, J. S. (2004) · Thyroid · doi:10.1089/105072504773297858 · Cited by 57 · see citing works
KCNE Beta Subunits Determine pH Sensitivity of KCNQ1 Potassium Channels
Heitzmann, D., Koren, V., Wagner, M., Sterner, C. W., Reichold, M., Tegtmeier, I., Volk, T., & Warth, R. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000099189 · Cited by 53 · see citing works
Maggi, L., Bonanno, S., Altamura, C., & Desaphy, J.-F. (2021) · Cells · doi:10.3390/cells10061521 · Cited by 51 · see citing works
Marchant, C. L., ELLIS, F. R., Halsall, P. J., Hopkins, P. M., & Robinson, R. L. (2004) · Muscle & Nerve · doi:10.1002/mus.20068 · Cited by 49 · see citing works
Neuromuscular complications of thyrotoxicosis
Kung, A. W. C. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02909.x · Cited by 46 · see citing works
Insulin resistance in subjects with a history of thyrotoxic periodic paralysis (TPP)
Soonthornpun, S., Setasuban, W., & Thamprasit, A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03395.x · Cited by 47 · see citing works
Sternberg, D., Tabti, N., Fournier, E., Hainque, B., & Fontaine, B. (2003) · Neurology · doi:10.1212/01.wnl.0000082392.66713.e3 · Cited by 43 · see citing works
Periodic paralysis mutation MiRP2-R83H in controls
Jurkat‐Rott, K., & Lehmann‐Horn, F. (2004) · Neurology · doi:10.1212/01.wnl.0000119392.29624.88 · Cited by 43 · see citing works
Dias-da-Silva, M. R., Chiamolera, M. I., Kasamatsu, T. S., Cerutti, J. M., & Maciel, R. M. B. (2004) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302004000100022 · Cited by 39 · see citing works
Self-citationThyrotoxic hypokalemic periodic paralysis: An overlooked pathology in western countries
Pompeo, A., Nepa, A., Maddestra, M., Feliziani, V., & Genovesi, N. (2007) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2007.03.003 · Cited by 40 · see citing works
Thyrotoxic periodic paralysis in a Hispanic man after the administration of prednisone
Liu, Z., Braverman, L. E., & Malabanan, A. (2006) · Endocrine Practice · doi:10.4158/ep.12.4.427 · Cited by 38 · see citing works
Mutation screening in Chinese hypokalemic periodic paralysis patients
Wang, W., Jiang, L., Ye, L., Zhu, N., Su, T., Guan, L., Li, X., & Ning, G. (2006) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.10.020 · Cited by 35 · see citing works
Thyrotoxic, hypokalaemic periodic paralysis: Polynesians, an ethnic group at risk
Elston, M. S., Orr‐Walker, B., Dissanayake, A. M., & Conaglen, J. V. (2007) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2007.01313.x · Cited by 34 · see citing works
Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel
Horn, W. D. V., Vanoye, C. G., & Sanders, C. R. (2011) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2011.01.001 · Cited by 32 · see citing works
Hypokalemic Periodic Paralysis: A Model for a Clinical and Research Approach to a Rare Disorder
Fontaine, B., Fournier, E., Sternberg, D., Vicart, S., & Tabti, N. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.01.002 · Cited by 32 · see citing works
Thyrotoxic periodic paralysis: an overview
Hsieh, C., Kuo, S., Pei, D., Hung, Y.-J., Fan, S. C., Wu, L.-I., He, C., Yang, T., Lian, W., & Lee, C.-H. (2004) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2004.418 · Cited by 31 · see citing works
Davies, T. F., Laurberg, P., & Bahn, R. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00012-5 · Cited by 32 · see citing works
Miyashita, Y., Monden, T., Yamamoto, K., Matsumura, M., Kawagoe, N., Iwata, C., Banba, N., Hattori, Y., & Kasai, K. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1495 · Cited by 29 · see citing works
Arimura, K., Arimura, Y., Ng, A. R., Sakoda, S., & Higuchi, I. (2007) · Muscle & Nerve · doi:10.1002/mus.20865 · Cited by 29 · see citing works
Kim, M., Lee, S., Park, M., Kim, B. C., Cho, K.-H., Lee, M.-C., Kim, J., & Kim, S. M. (2004) · Neuromuscular Disorders · doi:10.1016/j.nmd.2004.07.005 · Cited by 28 · see citing works
Tang, N. L. S., Chow, C. C., Ko, G. T. C., Tai, M. H. L., Kwok, R., Yao, X., & Cockram, C. S. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02079.x · Cited by 26 · see citing works
Thyrotoxic Periodic Paralysis Associated with a Mutation in the Sodium Channel Gene SCN4A
Lane, A., Markarian, K., & Braziunene, I. (2004) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2004.17.12.1679 · Cited by 27 · see citing works
Ion channelopathies in endocrinology: recent genetic findings and pathophysiological insights
Rolim, A. L., Lindsey, S. C., Kunii, I. S., Fujikawa, A. M., Soares, F. A., Chiamolera, M. I., Maciel, R. M. B., & Dias-da-Silva, M. R. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000800002 · Cited by 26 · see citing works
Self-citationWu, C., Wu, Y., Lin, J., & Kuo, S. (2008) · Thyroid · doi:10.1089/thy.2008.0232 · Cited by 26 · see citing works
The role of clinical, genetic and segregation evaluation in sudden infant death
Campuzano, Ó., Allegue, C., Sarquella‐Brugada, G., et al. (2014) · Forensic Science International · doi:10.1016/j.forsciint.2014.06.007 · Cited by 23 · see citing works
Deep resequencing of the voltage-gated potassium channel subunit KCNE3 gene in chronic tinnitus
Sand, P. G., Langguth, B., & Kleinjung, T. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-39 · Cited by 22 · see citing works
Extrarenal Potassium Metabolism
Sahni, V., Gmurczyk, A., & Rosa, R. M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00048-3 · Cited by 19 · see citing works
Diagnosis and Management of Thyroid Disease and the Critically Ill Patient
Young, R., & Worthley, L. I. G. (2004) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01699-x · Cited by 18 · see citing works
Mandel, S. J., Larsen, P. R., & Davies, T. F. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00012-2 · Cited by 30 · see citing works
Does thyrotoxic periodic paralysis have a genetic predisposition? A case report
Rasheed, E., Seheult, J. N., Gibney, J., & Boran, G. P. (2018) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/0004563218785395 · Cited by 16 · see citing works
Mutation analysis of CACNA1S and SCN4A in patients with hypokalemic periodic paralysis
Wang, X., REN, B.-W., YONG, Z.-H., XU, H.-Y., Fu, Q., & Yao, H. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4201 · Cited by 14 · see citing works
Thyrotoxic periodic paralysis and anesthesia report of a case and literature review
Diedrich, D. A., & Wedel, D. J. (2006) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2005.08.016 · Cited by 14 · see citing works
The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study
Hedley, P. L., Haundrup, O., Andersen, P. S., Aidt, F., Jensen, M. K., Moolman‐Smook, J. C., Bundgaard, H., & Christiansen, M. (2011) · Journal of Negative Results in BioMedicine · doi:10.1186/1477-5751-10-12 · Cited by 13 · see citing works
Jongjaroenprasert, W., Chanprasertyotin, S., Butadej, S., Nakasatien, S., Charatcharoenwitthaya, N., Himathongkam, T., & Ongphiphadhanakul, B. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03083.x · Cited by 13 · see citing works
Hypokalaemic thyrotoxic periodic paralysis in an Asian man in the United Kingdom
Sinharay, R. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2003.006684 · Cited by 13 · see citing works
Kim, T. Y., Song, J. Y., Kim, W. B., & Shong, Y. K. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02264.x · Cited by 13 · see citing works
Extrarenal Potassium Metabolism
Rosa, R. M., & Epstein, F. H. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50049-8 · Cited by 12 · see citing works
Imashuku, S., Teramura-Ikeda, T., Kudo, N., et al. (2012) · Pediatric Reports · doi:10.4081/pr.2012.e18 · Cited by 10 · see citing works
Donovan, L., Parkins, V. M., & Mahalingham, A. (2007) · Thyroid · doi:10.1089/thy.2006.0288 · Cited by 10 · see citing works
À propos de deux cas de paralysie périodique hypokaliémique
Burtey, S., Vacher-Coponat, H., Berland, Y., & Dussol, B. (2006) · Néphrologie & Thérapeutique · doi:10.1016/j.nephro.2006.07.012 · Cited by 9 · see citing works
Autonomously Functioning Thyroid Nodule Associated with Thyrotoxic Periodic Paralysis
Ozaki, H., Mori, K., Nakagawa, Y., Hoshikawa, S., Ito, S., & Yoshida, K. (2008) · Endocrine Journal · doi:10.1507/endocrj.k07e-017 · Cited by 8 · see citing works
Fialho, D., & Hanna, M. G. (2007) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)86004-0 · Cited by 8 · see citing works
Thyrotoxic Periodic Paralysis: An Under-Recognized Cause of Paralysis in Young Hispanic Men
Gulde, A., Zhang, S., & Hussain, I. (2023) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2022.10.023 · Cited by 7 · see citing works
Tang, N. L. S., Chow, C. C., Ko, G. T. C., Tai, M. H. L., Kwok, R., Yao, X., & Cockram, C. S. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02713.x · Cited by 7 · see citing works
Molecular biology of channelopathies: impact on diagnosis and treatment
AVANZINI, G., Franceschetti, S., Avoni, P., & Liguori, R. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.3.519 · Cited by 7 · see citing works
Park, S., Kim, T. Y., Sim, S., Lim, S., Kim, M., Kwon, H., Jeon, M. J., Kim, W. G., Shong, Y. K., & Kim, W. B. (2016) · Endocrinology and Metabolism · doi:10.3803/enm.2016.31.1.142 · Cited by 7 · see citing works
Thyrotoxic Hypokalemic Periodic Paralysis: Pathophysiological Mechanisms
Qing, G., Zakaria, W. N. A., Rom, F. Z. M., Nik, W. N. F. H. W., Zulkeflee, H. A., & Rahim, S. N. A. (2025) · Endocrinology and Metabolism · doi:10.3803/enm.2025.2554 · Cited by 5 · see citing works
“4 gene potassium voltage-gated channel, Isk-related family, member 3 ( KCNE3 ) has been linked to THPP susceptibility [18].”
A Rare Case of Thyrotoxic Periodic Paralysis Presenting to the Medical Examiner
Thompson, M. P., & Pinckard, J. K. (2011) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e318219ca5b · Cited by 5 · see citing works
Clinical study of cases with hyperthyroidism in Erbil Governorate, Kurdistan Region-Iraq
Albustany, D. A. (2011) · Zanco Journal of Medical Sciences · doi:10.15218/zjms.2011.0002 · Cited by 5 · see citing works
Thyrotoxic periodic paralysis in an Italian man: clinical manifestation and genetic analysis
Vendrame, F., Verrienti, A., Parlapiano, C., Filetti, S., Dotta, F., & Morano, S. (2008) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2007.007117 · Cited by 5 · see citing works
Thyrotoxic Periodic Paralysis Induced by Dexamethasone
Lee, E. J., Kim, T. K., Kwon, M. J., Lee, S. H., & Park, J. H. (2012) · Endocrinology and Metabolism · doi:10.3803/enm.2012.27.4.299 · Cited by 4 · see citing works
Periodic Paralysis and Encephalopathy as Initial Manifestations of Graves’ Disease
Tsironis, T., Tychalas, A., Kiourtidis, D., Kountouras, J., Xiromerisiou, G., Rudolf, J., & Deretzi, G. (2017) · The Neurologist · doi:10.1097/nrl.0000000000000125 · Cited by 4 · see citing works
Sequence CLCN1 and SCN4A genes in patients with nondystrophic myotonia in Chinese people
Meng, Y., Yu, M., Liu, C., et al. (2022) · Medicine · doi:10.1097/md.0000000000029591 · Cited by 4 · see citing works
Heydorn, A., Bertelsen, B., Nolsöe, R. L. M., Eiken, P., & Kristensen, P. L. (2023) · Thyroid Research · doi:10.1186/s13044-023-00152-w · Cited by 4 · see citing works
Goncharuk, S. A., Shulga, A. A., Ermolyuk, Y. S., Kuzmichev, P. K., Sobol, V. A., Bocharov, E. V., Chupin, V., Arseniev, A. S., & Kirpichnikov, M. P. (2009) · Biochemistry (Moscow) · doi:10.1134/s0006297909120074 · Cited by 4 · see citing works
Hypokalaemic thyrotoxic periodic paralysis in the UK
Sinharay, R. (2003) · QJM · doi:10.1093/qjmed/hcg105 · Cited by 4 · see citing works
Ptáček, L. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021458 · Cited by 4 · see citing works
Kim, W. G., Kim, T. Y., Kim, J. M., Rhee, Y. S., Choi, H. J., Kim, W. B., & Shong, Y. K. (2008) · Journal of Korean Endocrine Society · doi:10.3803/jkes.2008.23.2.117 · Cited by 3 · see citing works
A young man presenting with paralysis after vigorous exercise
Gubran, C., Narain, R., Malik, L., & Saeed, S. A. (2012) · BMJ Case Reports · doi:10.1136/bcr-02-2012-5931 · Cited by 3 · see citing works
Wémeau, J.-L., Cardot-Bauters, C., d'Herbomez-Boidein, M., Perimenis, P., & Cephise-Velayoudom, F. L. (2006) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(06)41940-5 · Cited by 3 · see citing works
Thyrotoxic hypokalemic periodic paralysis as a rare manifestation of Graves disease
Гостимский, А. В., Матвеева, З. С., Af, R., et al. (2019) · Grekov s Bulletin of Surgery · doi:10.24884/0042-4625-2019-178-2-62-64 · Cited by 2 · see citing works
Muscle channelopathies: periodic paralyses and nondystrophic myotonias
Ralph, J. W., & Ptáček, L. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813866-3.00031-x · Cited by 2 · see citing works
Sinharay, R. (2009) · QJM · doi:10.1093/qjmed/hcn166 · Cited by 2 · see citing works
Tran, H. A. (2005) · Endocrine Journal · doi:10.1507/endocrj.52.651 · Cited by 2 · see citing works
Description of muscle disease – specific diseases
Karpati, G. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511674747.014 · Cited by 2 · see citing works
Montoya, M. Z., Kunii, I. S., Paninka, R. M., Simões, D. M. N., Castillo, V. A., Reche, A., Maciel, R. M. B., & Dias-da-Silva, M. R. (2014) · Biology Open · doi:10.1242/bio.20148003 · Cited by 2 · see citing works
Self-citationParálisis periódica hipokalémica tirotóxica: reporte de un caso y revisión del tema
Rueda, S. M. A., & Albarrán, L. Á. R. (2013) · Medunab · doi:10.29375/01237047.1763 · Cited by 1 · see citing works
Iodine, Thyroid Diseases and Neuromuscular Dysfunction
Tran, H. A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374135-6.00072-8 · Cited by 1 · see citing works
Marinò, M., Chiovato, L., & Pinchera, A. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00080-0 · Cited by 1 · see citing works
Handy, J. M. (2009) · Elsevier eBooks · doi:10.1016/b978-0-7020-3096-3.00052-x · Cited by 1 · see citing works
Muscle ion channelopathies and related disorders
Fontaine, B., & Hanna, M. G. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511674747.025 · Cited by 1 · see citing works
Thyrotoxic Periodic Paralysis – Clinical Diagnosis and Management
Rolim, A. L., & Dias-da-Silva, M. R. (2014) · InTech eBooks · doi:10.5772/58475 · Cited by 1 · see citing works
Self-citationHypokalemic periodic paralysis: an unusual presentation
Ramineni, H. B., Chandini, M., Sri, M., et al. (2015) · International Journal of Advances in Medicine · doi:10.5455/2349-3933.ijam20150523 · Cited by 1 · see citing works
Hypokalemia and Thyrotoxicosis in a Patient with Quadriplegia
Elmahi, N., Noor, M., & Mehra, S. (2007) · Cited by 1 · see citing works
Utilizing C. elegans as a neurological model to characterize KCNL-2, an SK channel homologue
Chotoo, C. K. (2013) · D-Scholarship@Pitt (University of Pittsburgh)
Paralisia periódica tireotóxica.
Vale, J., Canas, N., Leal, A., et al. (2012) · Acta Médica Portuguesa · doi:10.20344/amp.1056
Paralisi periodiche e miopatia da deplezione potassica
Fiacchino, F. (2009) · Springer eBooks · doi:10.1007/978-88-470-1120-5_19
Woke up paralysed—without injury or stroke
Bawaskar, H. S., & Bawaskar, P. H. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60385-2
An unusual cause of muscle weakness: a diagnostic challenge for clinicians
Ray, S., Kundu, S., Goswami, M., Maitra, S., Talukdar, A., & Maiti, A. (2012) · BMJ Case Reports · doi:10.1136/bcr.01.2012.5625
Potassium Channels: Evaluating Alternative Cancer Therapies
Felipe, A., Solé, L., Bielaska, J., et al. (2007)
Hypokalemic thyrotoxic periodic paralysis in a young Serbian male
Ristić, P., Dragovic, T., Kikovic, S., Ristić, D., Zdravkovic, M. D., Hinić, S., Durmić, T., & Hajdukovic, Z. (2018) · Vojnosanitetski pregled · doi:10.2298/vsp161130064r
- Authors
- Dias Da Silva, M. R., Cerutti, J. M., Arnaldi, L. A. T., & Maciel, R. M. B.
- Affiliations
- Laboratory of Molecular Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil
- Universidade Federal de São Paulo (BR)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-11-01
- Volume
- 87
- Issue
- 11
- Pages
- 4881-4884
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2067200379
- Cited by
- 113
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 8
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
- Keywords
- thyrotoxic hypokalemic periodic paralysis, KCNE3, potassium channels, thyrotoxicosis, Graves' disease, familial hypokalemic periodic paralysis, SCN4A, genetic susceptibility, muscle weakness, resting membrane potential
- MeSH terms
- Adult, Humans, Iodine Radioisotopes, Male, Membrane Potentials, Methimazole, Mutation, Pedigree, Potassium Chloride, Antithyroid Agents, Thyrotoxicosis, Potassium Channels, Polymerase Chain Reaction, Genetic Predisposition to Disease, Hypokalemic Periodic Paralysis, Potassium Channels, Voltage-Gated
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