Thyrotoxic periodic paralysis in a Hispanic man after the administration of prednisone

Liu, Zhao; Braverman, Lewis E.; Malabanan, Alan

doi:10.4158/ep.12.4.427

Cited by 38Thyroid Disorders and TreatmentsPotassium and Related DisordersOphthalmology and Eye Disorders

Thyrotoxic periodic paralysis in a Hispanic man after the administration of prednisone

Liu, Zhao, Braverman, Lewis E., Malabanan, Alan·2006·Endocrine Practice

DOI 10.4158/ep.12.4.427

Open this paper in CoChat — free account

Abstract

Objective To present a case of thyrotoxic periodic paralysis (TPP) in a Hispanic man and to discuss the potential precipitating mechanisms.Methods We review the clinical and laboratory findings relative to the occurrence of TPP in a 34-year-old Hispanic man, who had been diagnosed as having Graves' disease.Results TPP is a rare complication of thyrotoxicosis. The two known triggers of TPP are high carbohydrate intake and rest after strenuous physical activity. Other precipitating factors include ingestion of alcohol, infection, trauma, emotional stress, and exposure to cold. Nonselective beta-adrenergic blocking agents are used as prophylaxis for the paralytic attacks. Glucocorticoids have been used to treat nonresponsive and recurrent episodes. Nevertheless, our patient, a 34-year-old Hispanic man, had received propranolol for 7 days and one single dose of prednisone 2 hours before the onset of the paralysis. In patients with TPP, the Na+/K+-adenosinetriphosphatase (ATPase) pump activity is considerably increased by excess thyroid hormones, resulting in an increased intracellular potassium shift. Insulin activates the Na+/K+-ATPase pump as well; thus, the precipitating effect of a high carbohydrate diet is explained. Glucocorticoids have been shown to increase the number of Na+/K+-ATPase molecules in skeletal muscle. They also increase insulin secretion in the basal state and the first-phase insulin release after a glucose load.Conclusion In our patient with TPP, the onset of the attack was not prevented by the use of propranolol and was likely triggered by the administration of prednisone.

Integrity signals

Registry

Crossref · 10.4158/ep.12.4.427

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Corticosteroids are an important but often overlooked trigger for TPP.
“Corticosteroids are an important but often overlooked trigger [5].”
From Iatrogenic Thyrotoxicosis and Corticosteroid-Triggered Hypokalemic Periodic Paralysis in a Patient With Treated Hypothyroidism (2026) · cites this paper as [5]
In susceptible individuals, infection, carbohydrate loading, alcohol, and medications can precipitate an acute attack of TPP.
“In susceptible individuals, several factors can precipitate an acute attack, including infection, carbohydrate loading, alcohol, and medications [5].”
From Iatrogenic Thyrotoxicosis and Corticosteroid-Triggered Hypokalemic Periodic Paralysis in a Patient With Treated Hypothyroidism (2026) · cites this paper as [5]

Na + -K + Pump Regulation and Skeletal Muscle Contractility
Clausen, T. (2003) · Physiological Reviews · doi:10.1152/physrev.00011.2003 · Cited by 582 · see citing works
Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets.
Lambillotte, C., Gilon, P., & Henquin, J. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119175 · Cited by 419 · see citing works
Periodic paralysis complicating thyrotoxicosis in Chinese.
McFadzean, A. J., & Yeung, R. (1967) · BMJ · doi:10.1136/bmj.1.5538.451 · Cited by 303 · see citing works
Thyrotoxic Periodic Paralysis in the United States Report of 7 Cases and Review of the Literature
OBER, K. P. (1992) · Medicine · doi:10.1097/00005792-199205000-00001 · Cited by 289 · see citing works
Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.
Hundal, H. S., Marette, A., Mitsumoto, Y., Ramlal, T., Blostein, R., & Klip, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42725-1 · Cited by 257 · see citing works
Clinical and Metabolic Features of Thyrotoxic Periodic Paralysis in 24 Episodes
Manoukian, M. A., Foote, J. A., & Crapo, L. M. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.6.601 · Cited by 255 · see citing works
Thyrotoxic periodic paralysis
Lin, S.-H. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.1.99 · Cited by 254 · see citing works
Regulation of the Na, K-pump in skeletal muscle
Clausen, T., & Everts, M. E. (1989) · Kidney International · doi:10.1038/ki.1989.1 · Cited by 237 · see citing works
Thyrotoxic Periodic Paralysis
Kelley, D. E. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.11.2597 · Cited by 227 · see citing works
THE ASSOCIATION OF PERIODIC PARALYSIS AND HYPERTHYROIDISM IN JAPAN
OKINAKA, S., SHIZUME, K., UNO, S., WATANABE, A., IRIE, M., NOGUCHI, A., KUMA, S., KUMA, K., & ITO, T. (1957) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-17-12-1454 · Cited by 206 · see citing works
Association of Hypertension and Hypokalemia with Cushing's Syndrome Caused by Ectopic ACTH Secretion
Torpy, D. J., Mullen, N., Ilias, Ι., & Nieman, L. K. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04419.x · Cited by 173 · see citing works
Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes.
Ogawa, A., Johnson, J. H., Ohneda, M., McAllister, C. T., Inman, L., Alam, T., & Unger, R. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115886 · Cited by 159 · see citing works
Thyrotoxic Periodic Paralysis: Report of 10 Cases and Review of Electromyographic Findings
Kelley, D. E. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390110139031 · Cited by 158 · see citing works
Cortisol inactivation overload: a mechanism of mineralocorticoid hypertension in the ectopic adrenocorticotropin syndrome
Ulick, S., Wang, J. Z., Blumenfeld, J. D., & Pickering, T. G. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.5.1569172 · Cited by 135 · see citing works
Periodic paralysis and the sodium‐potassium pump
Layzer, R. B. (1982) · Annals of Neurology · doi:10.1002/ana.410110602 · Cited by 122 · see citing works
Thyrotoxic periodic paralysis
Yeung, R. T. T., & Tse, T. F. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90010-2 · Cited by 115 · see citing works
A Mutation in the KCNE3 Potassium Channel Gene Is Associated with Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis
Dias Da Silva, M. R., Cerutti, J. M., Arnaldi, L. A. T., & Maciel, R. M. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020698 · Cited by 113 · see citing works
Islet Amyloid Polypeptide and Insulin Secretion From Isolated Perfused Pancreas of Fed, Fasted, Glucose-Treated, and Dexamethasone-Treated Rats
O'Brien, T. D., Westermark, P., & Johnson, K. H. (1991) · Diabetes · doi:10.2337/diab.40.12.1701 · Cited by 108 · see citing works
The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature
Tassone, H., Moulin, A., & Henderson, S. O. (2004) · The Journal of Emergency Medicine · doi:10.1016/j.jemermed.2003.05.004 · Cited by 93 · see citing works
Thyrotoxicosis and Periodic Paralysis: Improvement with Beta Blockade
Conway, M. J., SEIBEL, J. A., & EATON, R. P. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-81-3-332 · Cited by 86 · see citing works
Cardiovascular Safety of High Doses of Inhaled Fenoterol and Albuterol in Acute Severe Asthma
Newhouse, M. T., Chapman, K. R., McCallum, A. L., Abboud, R. T., BOWIE, D. M., Hodder, R. V., Paré, P. D., Mesic-Fuchs, H., & Molfino, N. A. (1996) · CHEST Journal · doi:10.1378/chest.110.3.595 · Cited by 84 · see citing works
Thyrotoxic Periodic Paralysis With Ventricular Fibrillation
Fisher, J. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340200130024 · Cited by 79 · see citing works
Thyrotoxic Periodic Paralysis
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6003 · Cited by 78 · see citing works
Association of Novel Single Nucleotide Polymorphisms in the Calcium Channel α1 Subunit Gene (Ca<sub>v</sub>1.1) and Thyrotoxic Periodic Paralysis
Kung, A. W. C., Lau, K. S., Fong, G. C. Y., & Chan, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030924 · Cited by 77 · see citing works
Insulin increases the Na(+)-K(+)-ATPase alpha 2-subunit in the surface of rat skeletal muscle: morphological evidence
Marette, A., Krischer, J. P., Lavoie, L., Ackerley, C., Carpentier, J. L., & Klip, A. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.6.c1716 · Cited by 75 · see citing works
Thyrotoxic Periodic Paralysis Terminated With Intravenous Propranolol
Shayne, P. H., & Hart, A. (1994) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(94)70286-1 · Cited by 73 · see citing works
The effects of dexamethasone on insulin release and biosynthesis are dependent on the dose and duration of treatment
Jeong, I.-K., Oh, S.-H., Kim, B.-J., Chung, J.-H., Min, Y.-K., Lee, M.-S., Lee, M.-K., & Kim, K.-W. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00229-1 · Cited by 71 · see citing works
Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans
Hollingdal, M., Juhl, C. B., Dall, R., Sturis, J., Veldhuis, J. D., Schmitz, O., & Pørksen, N. (2002) · Diabetologia · doi:10.1007/s125-002-8244-y · Cited by 67 · see citing works
Thyrotoxic periodic paralysis and intravenous propranolol in the emergency setting
Birkhahn, R., Gaeta, T. J., & Melniker, L. A. (2000) · Journal of Emergency Medicine · doi:10.1016/s0736-4679(99)00194-8 · Cited by 66 · see citing works
Na+,K+‐ATPase trafficking in skeletal muscle: insulin stimulates translocation of both α1‐ and α2‐subunit isoforms
Al‐Khalili, L., Yu, M., & CHIBALIN, A. V. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00047-4 · Cited by 62 · see citing works
Manifestation, Management and Molecular Analysis of Candidate Genes in Two Rare Cases of Thyrotoxic Hypokalemic Periodic Paralysis
Schalin‐Jäntti, C., Laine, T., Valli‐Jaakola, K., Lönnqvist, T. R. I., Kontula, K., & Välimäki, M. J. (2005) · Hormone Research in Paediatrics · doi:10.1159/000084689 · Cited by 61 · see citing works
Absence of Ion Channels CACN1AS and SCN4A Mutations in Thyrotoxic Hypokalemic Periodic Paralysis
Ng, W. Y., Lui, K. F., Thai, A. C., & Cheah, J. S. (2004) · Thyroid · doi:10.1089/105072504773297858 · Cited by 57 · see citing works
Dexamethasone-induced insulin resistance shows no gender difference in healthy humans
Binnert, C., Ruchat, S.-M., Nicod, N. M., & Tappy, L. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70123-4 · Cited by 56 · see citing works
Increased glucocorticoid sensitivity in islet beta-cells: effects on glucose 6-phosphatase, glucose cycling and insulin release
Ling, Z.-C., Khan, A. W., Delauny, F., Davani, B., Östenson, C., Gustafsson, J.-Α., Okret, S., Landau, B. R., & Efendić, S. (1998) · Diabetologia · doi:10.1007/s001250050961 · Cited by 52 · see citing works
Mutations linked to familial hypokalaemic periodic paralysis in the calcium channel α1 subunit gene (Ca<sub>v</sub>1·1) are not associated with thyrotoxic hypokalaemic periodic paralysis
Dias da Silva, M. R., Cerutti, J. M., Tengan, C. H., Furuzawa, G. K., Vieira, T. C. A., Gabbai, A. A., & Maciel, R. M. B. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01481.x · Cited by 50 · see citing works
Glucocorticoids increase sodium pump α2- and β1-subunit abundance and mRNA in rat skeletal muscle
Thompson, C. B., Dørup, I., Ahn, J. J., Leong, P. K. K., & McDonough, A. A. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.3.c509 · Cited by 50 · see citing works
Glucocorticoids antagonize insulin's antiproteolytic action on skeletal muscle in humans
Louard, R. J., Bhushan, R., Gelfand, R., Barrett, E. J., & Sherwin, R. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.1.8027242 · Cited by 45 · see citing works
Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans
Ludvik, B. H., Clodi, M., Kautzky‐Willer, A., Capek, M., Hartter, E., Pacini, G., & Prager, R. (1993) · Diabetologia · doi:10.1007/bf00399099 · Cited by 44 · see citing works
On the Role of Glucocorticoid in Glucose-Induced Insulin Secretion
Kawai, A., & Kuzuya, N. (1977) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093528 · Cited by 35 · see citing works
β-cell activity and hepatic insulin extraction following dexamethasone administration in healthy subjects
Kautzky-Willer, A., Thomaseth, K., Clodi, M., Ludvik, B., Waldhäusl, W., Prager, R., & Pacini, G. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90224-3 · Cited by 35 · see citing works
The administration of ??2-agonists for paediatric asthma and its adverse reaction in Australian and New Zealand emergency departments: a cross-sectional survey
Habashy, D., Lam, L. T.-M., & Browne, G. J. (2003) · European Journal of Emergency Medicine · doi:10.1097/00063110-200309000-00012 · Cited by 34 · see citing works
Skeletal Muscle Dihydropyridine-Sensitive Calcium Channel (CACNA1S) Gene Mutations in Chinese Patients with Hypokalemic Periodic Paralysis
Lin, S., Cheng, N.-L., Hsu, Y., & Kao, M. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200502000-00003 · Cited by 29 · see citing works
Steroid-Induced Myopathy in the ICU
Polsonetti, B. W., Joy, S., & Laos, L. F. (2002) · Annals of Pharmacotherapy · doi:10.1345/aph.1c095 · Cited by 28 · see citing works
Thyrotoxic Periodic Paralysis Associated with a Mutation in the Sodium Channel Gene SCN4A
Lane, A., Markarian, K., & Braziunene, I. (2004) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2004.17.12.1679 · Cited by 27 · see citing works
The concentration of sodium,potassium pumps in chronic obstructive lung disease (COLD) patients: the impact of magnesium depletion and steroid treatment
Ravn, H. B., & Dørup, I. (1997) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1997.69891000.x · Cited by 26 · see citing works
No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients
Tang, N. L. S., Chow, C. C., Ko, G. T. C., Tai, M. H. L., Kwok, R., Yao, X., & Cockram, C. S. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02079.x · Cited by 26 · see citing works
Potassium shift in thyrotoxic periodic paralysis
Feely, J. (1981) · Postgraduate Medical Journal · doi:10.1136/pgmj.57.666.238 · Cited by 25 · see citing works
Normokalemic Thyrotoxic Periodic Paralysis: A New Therapeutic Strategy
González-Treviño, O., & Rosas-Guzmán, J. (1999) · Thyroid · doi:10.1089/thy.1999.9.61 · Cited by 22 · see citing works
Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler
Rakhmanina, N. Y., Kearns, G. L., & Farrar, H. C. (1998) · Pediatric Emergency Care · doi:10.1097/00006565-199804000-00015 · Cited by 16 · see citing works
Magnesium, sodium, and potassium content and [3H]ouabain binding capacity of skeletal muscle in relatives of patients with type 2 diabetes: Effect of dexamethasone
Djurhuus, M. S., Henriksen, J. E., & Klitgaard, N. A. (2002) · Metabolism · doi:10.1053/meta.2002.35199 · Cited by 13 · see citing works
Hypokalaemic thyrotoxic periodic paralysis: case report and review of an Oriental syndrome
VanDam, G., Reisman, Y., & VANWIERINGEN, K. (1996) · The Netherlands Journal of Medicine · doi:10.1016/0300-2977(96)00014-9 · Cited by 13 · see citing works
Dexamethasone stimulates transcription of the Na+-K+-ATPase β1gene in adult rat lung epithelial cells
Hao, H., Wendt, C. H., Sandhu, G., & Ingbar, D. H. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00037.2003 · Cited by 13 · see citing works
Thyrotoxic hypokalemic periodic paralysis: report of four cases and review of the literature (1).
Td, T., & Jb, V. (1987) · PubMed · Cited by 13 · see citing works
Prednisolone enhances β-cell function independently of ambient glycemic levels in type II diabetes
Hosker, J. P., Burnett, M. A., Matthews, D. R., & Turner, R. C. (1993) · Metabolism · doi:10.1016/0026-0495(93)90268-s · Cited by 9 · see citing works
Predictors of Change in Insulin Sensitivity During Glucocorticoid Treatment
Meacham, L. R., Abdullatif, H., Sullivan, K. M., & Culler, F. L. (1997) · Hormone and Metabolic Research · doi:10.1055/s-2007-979015 · Cited by 5 · see citing works

Flagged first, then by citations

Sorted by citations

A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants
Chang, C.-C., Cheng, C.-J., Sung, C.-C., Chiueh, T.-S., Lee, C.-H., Chau, T., & Lin, S.-H. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0381 · Cited by 114 · see citing works
Novel etiopathophysiological aspects of thyrotoxic periodic paralysis
Maciel, R. M. B., Lindsey, S. C., & Dias da Silva, M. R. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.58 · Cited by 86 · see citing works
Practical aspects in the management of hypokalemic periodic paralysis
Levitt, J. O. (2008) · Journal of Translational Medicine · doi:10.1186/1479-5876-6-18 · Cited by 75 · see citing works
Thyrotoxic periodic paralysis: clinical and molecular aspects
Falhammar, H., Thorén, M., & Calissendorff, J. (2012) · Endocrine · doi:10.1007/s12020-012-9777-x · Cited by 74 · see citing works
Primary periodic paralyses
Finsterer, J. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00963.x · Cited by 73 · see citing works
Insulin resistance in subjects with a history of thyrotoxic periodic paralysis (TPP)
Soonthornpun, S., Setasuban, W., & Thamprasit, A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03395.x · Cited by 47 · see citing works
Thyrotoxic hypokalaemic periodic paralysis in a Turkish population: three new case reports and analysis of the case series
Cesur, M., Bayram, F., Temel, M. A., Ozkaya, M., Kocer, A., Ertorer, M. E., Koc, F., Kaya, A., & Gullu, S. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03014.x · Cited by 45 · see citing works
Case 4-2012
Rhee, E. P., Scott, J. A., & Dighe, A. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmcpc1110051 · Cited by 43 · see citing works
Thyrotoxic hypokalemic periodic paralysis: An overlooked pathology in western countries
Pompeo, A., Nepa, A., Maddestra, M., Feliziani, V., & Genovesi, N. (2007) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2007.03.003 · Cited by 40 · see citing works
Thyrotoxic Periodic Paralysis Induced by Pulse Methylprednisolone
Wongraoprasert, S., Buranasupkajorn, P., Sridama, V., & Snabboon, T. (2007) · Internal Medicine · doi:10.2169/internalmedicine.46.0044 · Cited by 37 · see citing works
Corticosteroid-exacerbated symptoms in an Andersen's syndrome kindred
Bendahhou, S., Fournier, E., Gallet, S., Ménard, D., Larroque, M. M., & Barhanin, J. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm034 · Cited by 23 · see citing works
Hypokalemic paralysis following administration of intravenous methylprednisolone in a patient with Graves’ thyrotoxicosis and ophthalmopathy
Tigas, S. K., Papachilleos, P., Ligkros, N., Andrikoula, M., & Tsatsoulis, A. A. (2011) · HORMONES · doi:10.14310/horm.2002.1323 · Cited by 20 · see citing works
Thyrotoxic Periodic Paralysis (TPP) in a 28-Year-Old Sudanese Man Started on Prednisone
Tessier, J. J., Neu, S., & Horning, K. K. (2010) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2010.04.090220 · Cited by 19 · see citing works
Thyrotoxic Periodic Paralysis
Siddamreddy, S., & Dandu, V. (2021) · StatPearls · Cited by 18 · see citing works
Thyrotoxic Periodic Paralysis: A Review of Cases in the Last Decade
Clarine, L., & Hosein, N. (2015) · AACE Clinical Case Reports · doi:10.4158/ep14304.cr · Cited by 11 · see citing works
Thyrotoxic periodic paralysis triggered by β2- adrenergic bronchodilators
Yeh, F., Chiang, W., Wang, C.-C., & Lin, S. (2014) · Canadian Journal of Emergency Medicine · doi:10.2310/8000.2013.130867 · Cited by 10 · see citing works
Hepatitis C Infection and Thyrotoxic Periodic Paralysis—A Novel Use of an Old Drug
Tran, H. A., & Reeves, G. E. M. (2008) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181643e3d · Cited by 9 · see citing works
Chest pain and paralysis after pulse prednisolone therapy an unusual case presentation of thyrotoxic periodic paralysis: a case report
Hagel, S., Elznerova, T., Dietrich, W., Schrauzer, T., & John, S. (2009) · Cases Journal · doi:10.4076/1757-1626-2-7501 · Cited by 9 · see citing works
Thyrotoxic, hypokalemic periodic paralysis (THPP) in adolescents
Al-Zubeidi, H., Demeterco, C., & Jones, K. L. (2014) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2014-0016 · Cited by 9 · see citing works
Steroids and thyrotoxicosis precipitate periodic paralysis
Ahamed, R., McCalley, S., & Sule, A. A. (2018) · Cureus · doi:10.7759/cureus.2106 · Cited by 7 · see citing works
“There have been three case reports of prednisone [4-6], two of methylprednisolone [7-8], and one of hydrocortisone [9] precipitating TPP.”
Background
Muscle weakness in a girl with autoimmune hepatitis and Graves’ disease
Sarkhy, A. A. A., Persad, R., & Tarnopolsky, M. A. (2008) · European Journal of Pediatrics · doi:10.1007/s00431-008-0738-6 · Cited by 7 · see citing works
Intravenous methylprednisolone-induced hypokalaemic periodic paralysis in a thyrotoxic patient: a case report and literature review
Wanas, A. M., Giacuzzo, C., Ghazi-Nouri, S., & Tan, L. T. (2025) · Orbit · doi:10.1080/01676830.2023.2296553 · Cited by 6 · see citing works
A rare case of thyrotoxic periodic paralysis precipitated by hydrocortisone
Chakrabarti, S. (2015) · Journal of Natural Science Biology and Medicine · doi:10.4103/0976-9668.149236 · Cited by 6 · see citing works
A Rare Case of Thyrotoxic Periodic Paralysis Presenting to the Medical Examiner
Thompson, M. P., & Pinckard, J. K. (2011) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e318219ca5b · Cited by 5 · see citing works
Levothyroxine and Prednisone Causing Generalized Weakness in a Middle-Aged Man
Word, A. P., Davidson, K. R., & Elsayed, E. F. (2012) · Case Reports in Endocrinology · doi:10.1155/2012/616930 · Cited by 5 · see citing works
Steroid-induced thyrotoxic periodic paralysis during Graves' ophthalmopathy treatment
Sayıner, Z. A., Eraydın, A., & Akarsu, E. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2016-134292 · Cited by 5 · see citing works
Pathologies endocriniennes et muscles
Berthelot, J. (2008) · Revue du Rhumatisme · doi:10.1016/j.rhum.2007.11.004 · Cited by 3 · see citing works
A Case of Thyrotoxic Periodic Paralysis With Respiratory Failure in an African American Woman
Shields, D. L. (2015) · American Journal of Critical Care · doi:10.4037/ajcc2015910 · Cited by 3 · see citing works
A young man presenting with paralysis after vigorous exercise
Gubran, C., Narain, R., Malik, L., & Saeed, S. A. (2012) · BMJ Case Reports · doi:10.1136/bcr-02-2012-5931 · Cited by 3 · see citing works
Features of approaches to the treatment of secondary hypokalemic paralysis in emergency neurology. Review
Саковец, Т. Г. (2019) · Annals of critical care · doi:10.21320/1818-474x-2019-4-113-122 · Cited by 2 · see citing works
Glucocorticoid-induced Thyrotoxic Periodic Paralysis Following Lumbar Nerve Root Block
Uda, S., Shimizu, H., & Nishioka, H. (2025) · Internal Medicine · doi:10.2169/internalmedicine.5987-25 · Cited by 1 · see citing works
A Thyrotoxic Periodic Paralysis Case Study: From Weakness to Wellness
Hussain, S. H. Z., Al-Alousi, S., Keshav, L. B., Hussain, A. T. Z., & Seenithamby, K. (2023) · Cureus · doi:10.7759/cureus.47820 · Cited by 1 · see citing works
Thyrotoxic Periodic Paralysis: Case Presentation With Tetraparesis and Cardiac Dysrhythmia
Dosu, A., Gupta, M., Walsh, O., & Makan, J. (2022) · Cureus · doi:10.7759/cureus.29759 · Cited by 1 · see citing works
Iatrogenic Thyrotoxicosis and Corticosteroid-Triggered Hypokalemic Periodic Paralysis in a Patient With Treated Hypothyroidism
Brini, G., Sharron, K., Ahmad, Z., & Madu, C. (2026) · Cureus · doi:10.7759/cureus.109603
“Corticosteroids are an important but often overlooked trigger [5].”
Kortikosteroid ile indüklenen hipokalemik periyodik paralizi: İki olgu sunumu
MUT, S. F. (2016) · Ankara Üniversitesi Tıp Fakültesi Mecmuası · doi:10.1501/tipfak_0000000947
Thyrotoxic Periodic Paralysis: A Review and Suggestions for Treatment
Krasnova, S. L., Topilow, A. A., Calissendorff, J., & Falhammar, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-76097-3.00006-5
Diagnóstico de parálisis periódica tirotóxica posterior a la administración de corticosteroide sistémico: presentación de un caso
Contreras-García, C., Salgado-Gómez, E., & Ochoa-Magdaleno, J. (2023) · Revista Mexicana de Endocrinología Metabolismo y Nutrición · doi:10.24875/rme.23000014
Thyrotoxic Hypokalemic Periodic Paralysis in Colombia: From a Single Case to a Review of the National Experience
Nati-Castillo, H. A., Abreu-Lomba, A., Ospina, J. D. U., Saavedra-Torres, J. S., Ciro, S. L., Paz, J. V., Alvis-Linero, N. J., & Izquierdo‐Condoy, J. S. (2026) · Diseases · doi:10.3390/diseases14090345

A rare case of thyrotoxic periodic paralysis precipitated by hydrocortisone
Chakrabarti, S. (2015) · Journal of Natural Science Biology and Medicine · doi:10.4103/0976-9668.149236 · Cited by 6 · see citing works
Thyrotoxic periodic paralysis after administration of methyl prednisolone
Sabeer, T., & Sudheeran (2007) · Thyroid Research and Practice
Thyrotoxic Periodic Paralysis Induced by Dexamethasone
Lee, E. J., Kim, T. K., Kwon, M. J., Lee, S. H., & Park, J. H. (2012) · Endocrinology and Metabolism · doi:10.3803/enm.2012.27.4.299 · Cited by 4 · see citing works
Steroids and thyrotoxicosis precipitate periodic paralysis
Ahamed, R., McCalley, S., & Sule, A. A. (2018) · Cureus · doi:10.7759/cureus.2106 · Cited by 7 · see citing works
SAT-602 Thyrotoxic Periodic Paralysis Precipitated by Glucocorticoid Injection
Carlson, S., Force, B. K., & Ram, N. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-sat-602 · Cited by 2 · see citing works

Authors: Liu, Z., Braverman, L. E., & Malabanan, A.
Affiliations: Boston Medical Center (US)
Corresponding author: Braverman, Lewis E.
ORCID: Braverman, Lewis E.
Malabanan, Alan
Venue: Endocrine Practice
Publisher: Elsevier BV
Published: 2006-07
Volume: 12
Issue: 4
Pages: 427-431
ISSN: 1530-891X (ISSN-L)
DOI: 10.4158/ep.12.4.427
OpenAlex: W1990287622
Cited by: 38
References: 55
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
FWCI: 2.44
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrine Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords: thyrotoxic periodic paralysis, Graves' disease, thyrotoxicosis, prednisone, Na+/K+-ATPase, propranolol, beta-adrenergic blockade, precipitating factors, high-carbohydrate diet, insulin secretion, Hispanic patients
MeSH terms: Adult, Graves Disease, Humans, Male, Prednisone, Propranolol, Thyrotoxicosis, Hypokalemic Periodic Paralysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Thyrotoxic periodic paralysis in a Hispanic man after the administration of prednisone

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks