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Cited by 47Thyroid Disorders and TreatmentsDiabetes, Cardiovascular Risks, and LipoproteinsPotassium and Related Disorders

Insulin resistance in subjects with a history of thyrotoxic periodic paralysis (TPP)

Soonthornpun, Supamai, Setasuban, Worawong, Thamprasit, Atchara·2009·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2008.03395.x
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Abstract

Summary: Background Hyperinsulinaemia has been suggested as an important factor for developing hypokalaemic paralysis in patients with thyrotoxic periodic paralysis (TPP). Since hyperinsulinaemia is a common feature of insulin resistance, there may be a causal relationship between insulin resistance and TPP. Objective To compare insulin sensitivity between subjects with a history of TPP and others with a history of thyrotoxicosis without periodic paralysis. Methods Insulin sensitivity measured by euglycaemic hyperinsulinaemic clamp and 75‐g oral glucose tolerance test (OGTT) were performed nonselectively in 10 subjects with a history of TPP (TPP group) and 10 age‐ and sex‐matched subjects with a history of simple thyrotoxicosis (control group). All participants had euthyroidism and fasting plasma glucose of < 5·55 mmol/l at the time of the study. Results Body mass index and waist circumference of the TPP group were higher than that of the control group. One of 10 (10%) subjects in the TPP group and 6 of 10 (60%) in the control group had BMI of < 23 kg/m 2. Areas under the curve (AUC) of plasma glucose after OGTT were comparable, while the AUC of serum insulin of the TPP group was higher than in the control group. The TPP group had lower insulin sensitivity than the control group. Conclusion The subjects with a history of TPP were more obese and had lower insulin sensitivity than those with a history of simple thyrotoxicosis. Insulin resistance with compensatory hyperinsulinaemia may be a key feature of the pathogenesis of TPP.

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Crossref · 10.1111/j.1365-2265.2008.03395.x

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  • Insulin participates in the pathogenesis of hypokalemia in TPP.

    “Hyperinsulinemia is also observed in acute attack of TPP, and the release of insulin in response to oral glucose challenge is exaggerated in TPP patients, supporting the idea that insulin participates in the pathogenesis of hypokalemia in TPP [9].”

    From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [9]

  • Hyperinsulinemia is observed in acute attack of TPP, and the release of insulin in response to oral glucose challenge is exaggerated in TPP patients.

    “Hyperinsulinemia is also observed in acute attack of TPP, and the release of insulin in response to oral glucose challenge is exaggerated in TPP patients, supporting the idea that insulin participates in the pathogenesis of hypokalemia in TPP [9].”

    From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [9]

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Authors
Soonthornpun, S., Setasuban, W., & Thamprasit, A.
Affiliations
Prince of Songkla University (TH)
Corresponding author
Soonthornpun, Supamai
ORCID
Soonthornpun, Supamai
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2009-03-31
Volume
70
Issue
5
Pages
794-797
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2008.03395.x
OpenAlex
W2133917516
Cited by
47
References
28
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2018: 4 · 2017: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 6
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Thailand Research Fund
  • Prince of Songkla University
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
Keywords
thyrotoxic periodic paralysis, insulin resistance, insulin sensitivity, hyperinsulinemia, thyrotoxicosis, hypokalaemic paralysis, obesity, body mass index, waist circumference, hyperinsulinemic-euglycemic clamp, oral glucose tolerance test
MeSH terms
Sodium-Potassium-Exchanging ATPase, Adult, Blood Glucose, Glucose Tolerance Test, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Thyrotoxicosis, Glucose Clamp Technique, Body Mass Index, Case-Control Studies, Hypokalemic Periodic Paralysis, Waist Circumference

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