Glucocorticoids and the regulation of memory consolidation

Roozendaal, Benno

doi:10.1016/s0306-4530(99)00058-x

Cited by 665Memory and Neural MechanismsStress Responses and CortisolMemory Processes and Influences

Glucocorticoids and the regulation of memory consolidation

Roozendaal, Benno·2000·Psychoneuroendocrinology

DOI 10.1016/s0306-4530(99)00058-x

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Abstract

This paper summarizes recent findings on the amygdala's role in mediating acute effects of glucocorticoids on memory consolidation in rats. Posttraining activation of glucocorticoid-sensitive pathways involving glucocorticoid receptors (GRs or type II) enhances memory consolidation in a dose-dependent inverted-U fashion. Selective lesions of the basolateral nucleus of the amygdala (BLA) or infusions of beta-adrenoceptor antagonists into the BLA block the memory-modulatory effects of systemic injections of glucocorticoids. Additionally, posttraining infusions of a specific GR agonist administered directly into the BLA enhance memory consolidation, whereas those of a GR antagonist impair. These findings indicate that glucocorticoid effects on memory consolidation are mediated, in part, by an activation of GRs in the BLA and that the effects require beta-adrenergic activity in the BLA. Other findings indicate that the BLA interacts with the hippocampus in mediating glucocorticoid-induced modulatory influences on memory consolidation. Lesions of the BLA or inactivation of beta-adrenoceptors within the BLA also block the memory-modulatory effects of intrahippocampal administration of a GR agonist or antagonist. These findings are in agreement with the general hypothesis that the BLA integrates hormonal and neuromodulatory influences on memory consolidation. However, the BLA is not a permanent locus of storage for this information, but modulates consolidation processes for explicit/associative memories in other brain regions, including the hippocampus.

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A highly responsive stress response system facilitates social learning, enhances mental activities in localized domains, focuses attention, and primes memory storage, improving cognitive processes for dealing with environmental opportunities and threats.
“a highly responsive system facilitates social learning, enhances mental activities in localized domains, focuses attention, and primes memory storage, thus improving cognitive processes for dealing with environmental opportunities and threats (Barsegyan et al., 2010; Flinn, 2006; Roozendaal, 2000; van Marle et al., 2009)”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Roozendaal, 2000

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NMDA receptor antagonism in the lateral/basolateral but not central nucleus of the amygdala prevents the induction of facilitated learning in response to stress.Preprint
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Blockade of isoproterenol-induced synaptic potentiation by tetra-9-aminoacridine in the rat amygdala
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Merchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2
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Finch (1996) · doi:10.1002/(sici)1098-1063(1996)6:5

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Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256 · see citing works
The concept of allostasis in biology and biomedicine
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Immune modulation of learning, memory, neural plasticity and neurogenesis
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The Adaptive Calibration Model of stress responsivity
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The role of sleep in learning and memory
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Mood disorders and allostatic load
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The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease
Korte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097 · see citing works
Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval
Roozendaal, B. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4080 · Cited by 838 · see citing works
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Enhanced memory for emotional material following stress-level cortisol treatment in humans
Buchanan, T. W., & Lovallo, W. R. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00058-5 · Cited by 762 · see citing works
The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law
Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“This component of the temporal dynamics hypothesis is consistent with a vast literature which has demonstrated that epinephrine-or corticosteroids-(Gold and Van Buskirk [272]; Sandi et al. [79]; McGaugh and Roozendaal [273]; Cahill and Alkire [274]; Sandi [275]; Mc-Gaugh [88]; Akirav et al. [276]; Hui et al. [85]; Roo…”
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Sex, stress and the hippocampus: allostasis, allostatic load and the aging process
MCEWEN, B. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00027-1 · Cited by 753 · see citing works
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Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease
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Emotional memory formation is enhanced across sleep intervals with high amounts of rapid eye movement sleep
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Stress and memory in humans: twelve years of progress?
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Glucocorticoid effects on object recognition memory require training-associated emotional arousal
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Peripheral and central effects of circulating catecholamines
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Psychosocial stress impairs working memory at high loads: an association with cortisol levels and memory retrieval
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Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD
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Glucocorticoid Effects on Memory Retrieval Require Concurrent Noradrenergic Activity in the Hippocampus and Basolateral Amygdala
Roozendaal, B., Hahn, E. L., Nathan, S. V., de Quervain, D. J.-F., & McGaugh, J. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2574-04.2004 · Cited by 301 · see citing works
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Learning under stress impairs memory formation
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Authors: Roozendaal, B.
Affiliations: University of California, Irvine (US)
Corresponding author: Roozendaal, Benno
ORCID: Roozendaal, Benno
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2000-04
Volume: 25
Issue: 3
Pages: 213-238
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/s0306-4530(99)00058-x
OpenAlex: W2076241195
Cited by: 665
References: 154
Citations by year: 2026: 1 · 2025: 5 · 2024: 9 · 2023: 7 · 2022: 9 · 2021: 15 · 2020: 30 · 2019: 13 · 2018: 21 · 2017: 22 · 2016: 25 · 2015: 28 · 2014: 39 · 2013: 26 · 2012: 27
FWCI: 2.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH12526)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: glucocorticoids, memory consolidation, amygdala, basolateral amygdala, glucocorticoid receptor, beta-adrenergic receptors, hippocampus, stress hormones, memory modulation
MeSH terms: Amygdala, Animals, Awards and Prizes, Dose-Response Relationship, Drug, Glucocorticoids, Hippocampus, Memory, Neural Pathways, Synaptic Transmission, Neurobiology, Norepinephrine, Reaction Time, Receptors, Glucocorticoid, Stress, Physiological, History, 20th Century, Rats

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Glucocorticoids and the regulation of memory consolidation

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