The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Obesity and Risk of Type 2 Diabetes and Cardiovascular Disease in Children and Adolescents
Abstract
Overweight/obesity continues to increase in children and adolescents, and annual obesity-related hospital costs in 6-17 yr olds have reached 127 million dollars per year. Overweight children and adolescents are now being diagnosed with impaired glucose tolerance and type 2 diabetes, and they show early signs of the insulin resistance syndrome and cardiovascular risk. Several risk factors have been identified as contributors to the development of type 2 diabetes and cardiovascular risk in youth. These factors include increased body fat and abdominal fat, insulin resistance, ethnicity (with greater risk in African-American, Hispanic, and Native American children), and onset of puberty. There is no clear explanation of how these factors increase risk, but they appear to act in an additive fashion. We hypothesize that the constellation of these risk factors may be especially problematic during the critical period of adolescent development, especially in individuals who may have compromised beta-cell function and an inability to compensate for severe insulin resistance. Therefore, the purpose of this paper is to review the pathophysiology of type 2 diabetes and cardiovascular risk in obese children and adolescents.
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Cites
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Cited by
Rapid growth in infancy and childhood and obesity in later life – a systematic review
Monteiro, P. O. A., & Victora, C. G. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00183.x · Cited by 909
Chanoine, J.-P., Hampl, S., Jensen, C., Boldrin, M., & Hauptman, J. (2005) · JAMA · doi:10.1001/jama.293.23.2873 · Cited by 624
Eyre, H., Kahn, R., Robertson, R. M., the ACS/ADA/AHA Collaborative Writing Committee, ACS/ADA/AHA Collaborative Writing Committee Members, Clark, N. G., Doyle, C., Hong, Y., Gansler, T., Glynn, T., et al. (2004) · Circulation · doi:10.1161/01.cir.0000133321.00456.00 · Cited by 542
Interventions to prevent global childhood overweight and obesity: a systematic review
Bleich, S. N., Vercammen, K. A., Zatz, L. Y., Frelier, J. M., Ebbeling, C. B., & Peeters, A. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30358-3 · Cited by 420
Endothelial Dysfunction in Obesity and Insulin Resistance: A Road to Diabetes and Heart Disease
Caballero, A. E. (2003) · Obesity Research · doi:10.1038/oby.2003.174 · Cited by 416
Metadata
- Authors
- Goran, M. I., Ball, G. D. C., & Cruz, M. L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-04
- Volume
- 88
- Issue
- 4
- Pages
- 1417-1427
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2164529668
- Cited by
- 735
- References
- 15
- FWCI
- 22.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goran, M. I., Ball, G. D. C., & Cruz, M. L. (2003). Obesity and Risk of Type 2 Diabetes and Cardiovascular Disease in Children and Adolescents. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2002-021442
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
