Elevated Plasma High-Sensitivity C-Reactive Protein Concentrations in Asian Indians Living in the United States
Abstract
Proinflammatory state may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease observed in populations originating from the Indian subcontinent (Asian Indians). This study was conducted to evaluate whether nondiabetic Asian Indian men living in the United States manifest a proinflammatory state when compared with Caucasians of similar age and body fat content. We also compared the relationships between plasma high-sensitivity C-reactive protein (hs-CRP), a marker of low-grade inflammation, and various parameters of body composition and fat distribution and insulin sensitivity in Asian Indians and Caucasians. For this purpose, plasma hs-CRP, oral glucose tolerance test, and anthropometric measurements were conducted in 82 Asian Indian men and 55 Caucasian men of similar age. The two groups had similar body fat content and truncal skinfolds thickness. Asian Indians had higher insulin areas under the curve during oral glucose tolerance tests, indicating a greater insulin resistance. Asian Indians also manifested a significant elevation of plasma hs-CRP. We conclude that young, overtly healthy Asian Indian men have both greater insulin resistance and higher hs-CRP levels than do Caucasians. This difference cannot be explained by greater adiposity in Asian Indians and suggests that many Asian Indians have an underlying proinflammatory state that may contribute to their increased risk for both type 2 diabetes and cardiovascular disease.
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Insulin-resistant people show evidence of low-grade inflammation even without an increase in total body fat.
“Interestingly, insulin-resistant people manifest evidence of low-grade inflammation even without an increase of total body fat.52”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [52]
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InfluentialSouth Asian ethnicity: What can we do to make this risk enhancer a risk equivalent?
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Serum High Sensitive - C Reactive Protein Levels in Type 2 Diabetes Mellitus -A Case Control Study
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Cardiovascular Disease in Asian Indians Living in the United States
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“High-sensitivity C-reactive protein (hs-CRP) is another such novel risk factor that has been shown to be increased in migrant Asian Indians in the United States compared to whites [39].”
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BackgroundInfluentialC-reactive protein measurement in the patient with vascular disease
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- Authors
- Chandalia, M., Cabo-Chan, A. V., Devaraj, S., Jialal, I., Grundy, S. M., & Abate, N.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- University of California Davis Medical Center (US)
- Corresponding author
- Abate, Nicola
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-08
- Volume
- 88
- Issue
- 8
- Pages
- 3773-3776
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2018418569
- Cited by
- 122
- References
- 30
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 11 · 2012: 4
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k23rr016075-05)
- National Center for Research Resources (M01RR000633, MO-1 RR-00633, K23-RR-16075)
- National Center for Complementary and Integrative Health (K-24AT00596, K24AT000596)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- high-sensitivity C-reactive protein, low-grade inflammation, Asian Indians, insulin resistance, type 2 diabetes risk, cardiovascular risk, body composition, body fat distribution, oral glucose tolerance, ethnic differences, young men
- MeSH terms
- Adipose Tissue, Adult, Anthropometry, Body Composition, Body Height, Body Weight, C-Reactive Protein, Ethnicity, Glucose Tolerance Test, Humans, India, Insulin, Islam, Male, United States, Area Under Curve, White People
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