The DOI matches its Crossref record; 323 of the 328 references it cites were found in a registry or an index.
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
Abstract
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat cells are resistant to insulin’s antilipolytic effect, leading to day-long elevated plasma FFA levels. Chronically increased plasma FFA stimulates gluconeogenesis, induces hepatic/muscle insulin resistance, and impairs insulin secretion in genetically predisposed individuals. These FFA-induced disturbances are referred to as lipotoxicity. 2) Dysfunctional fat cells produce excessive amounts of insulin resistance-inducing, inflammatory, and atherosclerotic-provoking cytokines and fail to secrete normal amounts of insulin-sensitizing adipocytokines. 3) Enlarged fat cells are insulin resistant and have diminished capacity to store fat. When adipocyte storage capacity is exceeded, lipid “overflows” into muscle, liver, and perhaps β-cells, causing muscle/hepatic insulin resistance and impaired insulin secretion. Thiazolidinediones enhance adipocyte insulin sensitivity, inhibit lipolysis, reduce plasma FFA, and favorably influence the production of adipocytokines. Thiazolidinediones also redistribute fat within the body (decreased visceral and hepatic fat; increased sc fat) and decrease intracellular concentrations of triglyceride metabolites in muscle, liver, and β-cells, contributing to improvements in muscle/hepatic insulin sensitivity and pancreatic function in type 2 diabetics.
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“an increased intramyocellar fat content and fatty acid metabolites have been shown to play a pivotal role in the development of insulin resistance in skeletal muscle [11–15].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“Dysregulation of fatty acid metabolism plays a pivotal role in the pathogenesis of insulin resistance in skeletal muscle.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“Considerable data implicate a causative role for elevated plasma FFA level in insulin resistance in skeletal muscle.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“It is well established that chronically elevated plasma FFA levels cause insulin resistance in skeletal muscle [1, 12, 14, 62–65].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“The important role of elevated plasma FFA in the pathogenesis of insulin resistance is now well established [12, 14, 57].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“Insulin resistance, in combination with b cell dysfunction, contributes to the development of type 2 diabetes (T2D) 4 (1).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [1]
In the citing paper
“Obesity, particularly visceral and ectopic adiposity, increases the risk of type 2 diabetes.”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [1]
Citations
Cites
1 retracted
Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding
Defronzo, R. A., Soman, V., Sherwin, R. S., Hendler, R., & Felig, P. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109108 · Cited by 252
Self-citationRetractedPositional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Self-citationWeight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
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5 of the 328 references couldn’t be matched to a known paper.
Research works printed but not linked: 16
- Kelley, 1995, Effects of weight loss on glucose homeostasis in NIDDM., Diabetes Rev, 3, 366
- Schneider, 1995, Effects of fitness and physical training on carbohydrate metabolism and associated cardiovascular risk factors in patients with diabetes., Diabetes Rev, 3, 378
- Kashyap, 2002, Chronic elevation in plasma free fatty acids impairs insulin secretion in non-diabetic offspring with a strong family history of T2DM, Diabetes, 51, A12
- Miyazaki, 2002, Effect of pioglitazone on liver fat content, abdominal fat distribution, and insulin sensitivity in patients with type 2 diabetes mellitus, Diabetes, 51, A69
- Kashyap, 2002, A chronic physiologic increase in FFA in healthy subjects causes insulin signaling defects similar to those of insulin-resistant non-diabetic subjects with a strong family history of T2DM, Diabetes, 51, A24
- Seppala-Lindroos, 2002, Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men., J Clin Endocrinol Metab, 87, 3023, 10.1210/jcem.87.7.8638 · DOI · Paper page
- McTernan, 2002, Depot-specific expression of resistin in human adipose tissue and regulation of resistin secretion by insulin and rosiglitazone in human subcutaneous adipocytes in vitro, Diabetologia, 45, A66
- Groop, 1992, Effect of insulin on oxidative and non-oxidative pathways of glucose and free fatty acid metabolism in human obesity, Am J Physiol, 263, E79
- Krssak, 1999, Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study., Diabetologia, 42, 113, 10.1007/s001250051123 · DOI · Paper page
- Stein, 1999, Increasing intramyocellular triglyceride stores are associated with impaired glucose tolerance and NIDDM, Diabetes, 48, A287
- Greco, 2002, Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion., Diabetes, 51, 144, 10.2337/diabetes.51.1.144 · DOI · Paper page
- Kahsyap, 2003, Effect of sustained reduction in plasma FFA concentration on insulin secretion in non-diabetic subjects with a strong family history of T2DM, Diabetes, 52, A336
- Chilcott, 2001, A systematic review of the effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus., Clin Ther, 23, 1792, 10.1016/S0149-2918(00)80078-8 · DOI
- Finegood, 2001, β-Cell mass dynamics in Zucker diabetic fatty rats: rosiglitazone prevents the rise in net cell death., Diabetes, 50, 1021, 10.2337/diabetes.50.5.1021 · DOI
- Lupi, 2002, PPARγ ligand-specificity in the modulation of insulin release from isolated human islets in response to fatty acid incubation, Diabetologia, 45, A161
- Marselli, 2002, Rosiglitazone partially prevents free fatty acid-induced cytotoxicity of human pancreatic islet cells, Diabetologia, 45, A161
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Mitochondrial Dysfunction in Type 2 Diabetes—An Update
Abdul‐Ghani, M. A., DeFronzo, R. A., & Medicine, A. P. O. (2009) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2009.05.00.28 · Cited by 4
Self-citationPathophysiology of Diabetes in Obesity
Soodini, G. R., & Hamdy, O. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-985-1_7 · Cited by 4
Lipoprotein Subfraction Analysis Using Nuclear Magnetic Resonance Spectroscopy
Cromwell, W. C., Bays, H. E., & Toth, P. P. (2007) · doi:10.1002/9780470691984.ch19 · Cited by 4
Self-citationLin, J., Guo, X., Sun, M., Zhang, Y., & Lu, J. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01581 · Cited by 3
Larsen, A. T., Melander, S. A., Mohamed, K. E., Petersen, E. A., Benmarce, M., Karsdal, M. A., & Henriksen, K. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118388 · Cited by 3
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Hiriart, M., Velasco, M., Díaz‐García, C. M., Larqué, C., Sánchez-Soto, C., Albarado-Ibáñez, A., Chávez‐Maldonado, J. P., Toledo, A., & García-Delgado, N. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_27 · Cited by 3
Overview Of Embedded Dsp Design
Hunter, I. (2009) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.41824 · Cited by 3
Metabolic effects of bariatric surgery on type 2 diabetes mellitus
Özmen, M. M. (2017) · Laparoscopic Endoscopic Surgical Science · doi:10.14744/less.2014.77486 · Cited by 3
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Siroha, A. K., Bangar, S. P., & Suri, S. (2023) · Royal Society of Chemistry eBooks · doi:10.1039/9781837670291-00027 · Cited by 3
Unveiling the Significance of Surrogate Markers of Insulin Resistance in Metabolic Health Assessment
Prashant, A., Nataraj, S. M., Swetha, N., Gowda, J., Najmunnissa, F., & Guruswamy, K. M. (2024) · Indian Journal of Medical Biochemistry · doi:10.5005/jp-journals-10054-0227 · Cited by 3
Peart, L. A., Draper, M., & Tarasov, A. I. (2024) · Peptides · doi:10.1016/j.peptides.2024.171243 · Cited by 3
STOLAR, M. W. (2009) · Clinical Medicine Therapeutics · doi:10.4137/cmt.s2370 · Cited by 3
Xu, W., Huang, Y., Wang, L., Yang, Q., Xiao, H., & Zhang, D. (2010) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2010.00547 · Cited by 3
Jensen, C., Storgaard, H., Holst, J., Dela, F., Madsbad, S., & Vaag, A. (2005) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2005.05.005 · Cited by 3
Shinoki, A., & Hara, H. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90817 · Cited by 3
Chu, J. J., & Mehrzad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90960-0.00003-5 · Cited by 5
Eshiet, E. R. (2010) · ThinkTech (Texas Tech University) · Cited by 3
New approach to optimize therapy in type 2 diabetes mellitus: the importance of subclassification
Reyes-Medina, M. J., Cantón-Habas, V., Sánchez-Jiménez, F. J., Molina-Hurtado, E., & Carrera-González, M. P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1710511 · Cited by 2
Wu, E., Qian, W., Zhang, X., 顾立立, Guo, Z., Yu, Z., Li, Y., & Zhu, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1754302 · Cited by 2
Pokoly, B., & Somogyi, A. (2023) · Orvosi Hetilap · doi:10.1556/650.2023.32783 · Cited by 3
Almutairi, S. M. (2024) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3252 · Cited by 3
Ngan, J., O'Neal, D. N., Lee, M. H., Kong, Y. W., & MacIsaac, R. J. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112284 · Cited by 2
Triplitt, C. L., Cersósimo, E., Alatrach, M., Adams, J. M., HANSIS-DIARTE, A. A., Baskoy, G., Gastaldelli, A., Chavez-Velazquez, A., & DeFronzo, R. A. (2025) · Diabetes Care · doi:10.2337/dc25-0490 · Cited by 2
Self-citationDietary fat and insulin resistance: a connection through leptin and PPARγ activation
Al-Jada, D. N., & Ahmad, M. N. (2016) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v6i6.249 · Cited by 3
Fatouros, I. G., & Mitrakou, A. (2012) · CRC Press eBooks · doi:10.1201/b12085-16 · Cited by 2
Moderate aerobic exercise-induced cytokines changes are disturbed in PPARα knockout mice
Cabral‐Santos, C., Silveira, L. S., Chimin, P., Neto, J. C. R., & Lira, F. S. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155207 · Cited by 2
Lastra, G., Manrique, C. M., & Sowers, J. R. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6372-5_5 · Cited by 2
Gil, J. E. C., & Spinedi, E. (2017) · Revista Argentina de Endocrinología y Metabolismo · doi:10.1016/j.raem.2017.06.001 · Cited by 6
Ethnic Differences in Insulin Resistance as a Mediator of Cancer Disparities
Hasson, R. E., & Goran, M. I. (2014) · Springer eBooks · doi:10.1007/978-3-319-06103-0_8 · Cited by 2
Lafontan, M., Berlan, M., Sengenès, C., Moro, C., Crampes, F., & Galitzky, J. (2006) · Springer eBooks · doi:10.1007/3-540-34447-0_4 · Cited by 2
Combination therapy in type 2 diabetes mellitus
Abdul‐Ghani, M. A., DeFronzo, R. A., & Eldor, R. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch46 · Cited by 2
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Elte, J. W. F., & Blickle, J. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.08.002 · Cited by 2
RetractedObesity, inflammation, and aging
Chu, J. J., & Mehrzad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90960-0.00001-1 · Cited by 1
O’Connor, E., Kiely, C., Gildea, N., O'Shea, D. B., Green, S., & Egaña, M. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16648 · Cited by 1
Neshat, S., Moradi, H., Bidares, M., Heidari, A., Marvast, A. F., Ortega, R., & Heshmat, K. (2025) · Cureus · doi:10.7759/cureus.99752 · Cited by 2
Albumin-Bound Fatty Acids Modulate Endogenous Angiotensin-Converting Enzyme (ACE) Inhibition
Enyedi, E. E., Szabó, A. Á., Pintér, T. B., Mányiné, I. S., Anna, P., Váradi, C., Bányai, E., Tóth, A., Papp, Z., & Fagyas, M. (2026) · Biomedicines · doi:10.3390/biomedicines14010103 · Cited by 1
Xuan, Y., Wu, D., & Yao, Q. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1818931 · Cited by 1
Sailis, A. B. (2026) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2026.2658739 · Cited by 1
Molecular Aspects of Obesity and Insulin Resistance in Metabolic Syndrome and Neurological Disorders
Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_5 · Cited by 1
Osman, M. M., Osman, K. A., & Ahmed, M. H. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000212651.05656.5b · Cited by 1
Treatment of the Metabolic Syndrome by Bariatric Surgery
Madsbad, S. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1331-8_14 · Cited by 1
Araia, M. H., Roxas, R. C. D., Abou‐Samra, A., & Seyoum, B. (2015) · Journal of the National Medical Association · doi:10.1016/s0027-9684(15)30004-3 · Cited by 1
Diabetes and Health Care: An Overview
Abhilash, M., & Augustine, R. (2014) · Apple Academic Press eBooks · doi:10.1201/b16415-6 · Cited by 2
Metabolism Analysis in Mice with Reduced Citrate Synthase Activity
Fokin, A., Minderis, P., Žūkienė, R., & Ratkevičius, A. (2017) · Baltic Journal of Sport and Health Sciences · doi:10.33607/bjshs.v2i105.20 · Cited by 1
Subclinical inflammation and redox status in untreated patients with type 2 diabetes mellitus
Kobalava, Z. D., Вадимовна, В. С., Isikova, H. V., & Гудгалис, Н. И. (2008) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2008-14-2-151-161 · Cited by 1
Venditti, E. M., Emery, R. L., & Kolko, R. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-33286-0_19 · Cited by 1
Gil, J. E. C., & Spinedi, E. (2017) · Revista Argentina de Endocrinología y Metabolismo · doi:10.1016/j.raem.2017.06.002 · Cited by 1
Abhilash, M., & Augustine, R. (2014) · Apple Academic Press eBooks · doi:10.1201/b16415-2 · Cited by 1
Pancreatic Beta Cells in Metabolic Syndrome
Hiriart, M., Velasco, M., Díaz‐García, C. M., Larqué, C., Sánchez-Soto, C., Albarado-Ibáñez, A., Chávez‐Maldonado, J. P., Toledo, A., & García-Delgado, N. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_27-2 · Cited by 1
Stracquadanio, M., & Ciotta, L. (2015) · Springer eBooks · doi:10.1007/978-3-319-16760-2_3 · Cited by 1
Obesity, Dysmetabolic and Proinflammatory Milieu of Polycystic Ovary Syndrome
Morong, J. J., & González, F. (2022) · Springer eBooks · doi:10.1007/978-3-030-92589-5_9 · Cited by 1
Yilmaz, B. A., & Törüner, F. B. (2013) · CRC Press eBooks · doi:10.1201/b14907-9 · Cited by 1
Chuks, A. A. N., Amarachi, C.-N. P., Ijioma, S. N., Uroko, R. I., & Gideon, M. K. (2022) · Majalah Obat Tradisional · doi:10.22146/mot.69945 · Cited by 1
Physiology of obesity and metabolism
Chu, J. J., & Mehrzad, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90965-5.00004-0 · Cited by 1
Adiponectin, Diabetes, and the Cardiovascular System
Gasbarrino, K., Boutari, C., Filippaios, A., Gianopoulos, I., Daskalopoulou, S. S., & Mantzoros, C. S. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6_8 · Cited by 1
INFLAMMATION IN NEWLY DIAGNOSED DIABETES PATIENTS
SARIÇAM, O. (2023) · Acta Medica Nicomedia · doi:10.53446/actamednicomedia.1211545 · Cited by 1
Central obesity and the cardiometabolic syndrome in Hispanics
Lastra‐González, G., Manrique‐Acevedo, C., & Lastra‐Lastra, G. (2007) · Therapy · doi:10.2217/14750708.4.5.609 · Cited by 1
Adiposopathy and Obesity Paradox
Sukmawati, I. R., & Wijaya, A. (2013) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v5i1.45 · Cited by 1
The Lipogenic Effect of Insulin Revisited
Najjar, S. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-25065-6_14 · Cited by 1
Effects of MGB on Type 2 Diabetes in Morbid Obesity, and Comparison with Other Operations
Forieg, A. M. (2018) · Springer eBooks · doi:10.1007/978-3-319-76177-0_13 · Cited by 1
Loh, K. W., Shaz, N., Singh, S., Raman, M. M., Raghavendran, H. R. B., & Kamarul, T. (2021) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2020-0320 · Cited by 1
Bourey, R. E., Kaw, M., Lester, S. G., Ghanem, S. S., & Najjar, S. M. (2014) · CRC Press eBooks · doi:10.1201/b16783-4 · Cited by 1
Journal, B. S. (2016) · Baghdad Science Journal · doi:10.21123/bsj.13.2.383-391 · Cited by 1
Guido Lastra, G., Manrique, C. M., & Guido Lastra, L. (2005) · Cited by 1
Metabolic Syndrome, Diabetes and Nonalcoholic Steatohepatitis
Kyrou, I., Haukeland, J. W., Bhala, N. B., & Kumar, S. (2009) · Wiley eBooks · doi:10.1002/9781444307627.ch16 · Cited by 1
Martín, C. S. (2011) · Gredos (University of Salamanca) · doi:10.14201/gredos.110568 · Cited by 1
Two-year effect of rosiglitazone in chinese poorly controlled type 2 diabetic patients.
Lee, J., Chu, C.-H., Chuang, M.-J., Lin, S.-C., Wang, M.-C., Lu, C.-C., Sun, C.-C., & Lam, H. (2006) · PubMed · Cited by 1
Gao, C. (2011) · Louisiana State University · doi:10.31390/gradschool_theses.1569 · Cited by 1
The 6th Annual World Congress on the Insulin Resistance Syndrome
Bloomgarden, Z. T. (2009) · Diabetes Care · doi:10.2337/dc09-zb10 · Cited by 1
Defining the metabolic effect of peroxisome proliferator-activated receptor δ activation
Roberts, L. D. (2010) · Apollo (University of Cambridge) · doi:10.17863/cam.16521 · Cited by 2
Insulin Resistance in States of Energy Excess: Underlying Pathophysiological Concepts
Blüher, S., & Mantzoros, C. S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-453-1_5 · Cited by 1
Causes and consequences of lipid overload in skeletal muscle, liver and heart
Bilet, L. (2015) · Research Publications (Maastricht University) · doi:10.26481/dis.20150702lb
Obesity, Diabetes, and Dental Health: Relationship and Management
Chauhan, R. (2013) · Springer eBooks · doi:10.1007/978-1-4471-2834-2_20
Patel, N. N. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)
FATTY ACIDS INDUCE POTENTIALLY ATHEROGENIC CHANGES IN EXTRACELLULAR MATRIX PROTEOGLYCANS
Rodrı́guez-Lee, M. (2007) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Curtis, J. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)
Paulino, E. C. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2009.tde-08032010-154558
Mitchell, C. S., & Gurnell, M. (2006) · Advances in molecular and cellular endocrinology · doi:10.1016/s1569-2566(06)05002-2
Pintér, Z. (2013) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.1918
Juurinen, L. (2014) · Työväentutkimus Vuosikirja
The role of adipocyte CREB in insulin resistance
van Eeuwijk, J. M. M. (2011) · Utrecht University Repository (Utrecht University)
Shepherd, S. O. (2013) · University of Birmingham Institutional Research Archive (University of Birmingham)
Genetic analyses of type 2 diabetes related metabolic risk factors : a twin study
Souren, N. Y. (2009) · Research Publications (Maastricht University) · doi:10.26481/dis.20090123ns
Cardiovascular Complications of Obesity
Ashen, M. D., & Blumenthal, R. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0548-5_13
Pilz, S., & März, W. (2007) · Journal of Laboratory Medicine · doi:10.1515/jlm.2007.022
An Approach to Obesity as a Cardiometabolic Disease: Potential Implications for Clinical Practice
(2014) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781608059140114020003
Genetic Association of the Tenomodulin Gene (TNMD) with
Tolppanen, A. (2009)
The Problems of Childhood Obesity and the Metabolic Syndrome
Caprio, S., & Weiss, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-32164-6_9
Odegaard, A. (2009) · University of Minnesota Digital Conservancy (University of Minnesota)
Forero, M., & Antonio, S. (2006) · TDX (Tesis Doctorals en Xarxa)
ROLE OF INFLAMMATION IN OBESITY RELATED METABOLIC DISORDERS.
Rajarajeswari, D. (2014) · International Journal of Pharma and Bio Sciences
ASSOCIATION OF DYSLIPIDEMIA AND INFLAMMATORY MARKERS IN TYPE 2 DIABETES MELLITUS
Rajarajeswari, D., Naidu, J. N., & Sowjanya, B. (2014)
PPAR-γ: A Master Metabolic Nuclear Receptor
Onteru, S. K., & Singh, D. (2013) · Journal of Endocrinology & Reproduction · doi:10.18519/jer/2013/v17/75785
Nitta, C. F. (2013) · UNM’s Digital Repository (University of New Mexico)
Pioglitazone: lessons and learnings 15 years since launch and beyond
Stempa, O. (2015) · Diabetes Management · doi:10.2217/dmt.15.38
Treatment with Thiazolidinediones
Suvag, S., Utzschneider, K. M., & Kahn, S. E. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1331-8_9
CMS and Type 2 Diabetes Mellitus: Bound Together by the Renin Angiotensin Aldosterone System
Gupta, D., Lastra, G., Manrique, C. M., & Sowers, J. R. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-186-8_13
Metadata
- Authors
- Bays, H., Mandarino, L., & DeFronzo, R. A.
- Affiliations
- Louisville Metabolic and Atherosclerosis Research Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-02-01
- Volume
- 89
- Issue
- 2
- Pages
- 463-478
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2151025367
- Cited by
- 664
- References
- 328
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 20 · 2023: 13 · 2022: 27 · 2021: 12 · 2020: 14 · 2019: 22 · 2018: 24 · 2017: 20 · 2016: 24 · 2015: 31 · 2014: 42 · 2013: 48 · 2012: 28
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- type 2 diabetes, free fatty acids, lipotoxicity, ectopic fat, thiazolidinediones, adipokines, insulin secretion, hepatic insulin resistance, muscle insulin resistance, adipocyte lipolysis, fat redistribution, impaired glucose tolerance
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Humans, Obesity, Transcription Factors, Adipocytes, Receptors, Cytoplasmic and Nuclear, Lipid Metabolism
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