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Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
Abstract
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver and muscle and impaired insulin secretion. Considerable evidence also implicates deranged adipocyte metabolism and altered fat topography in the pathogenesis of glucose intolerance in T2DM. 1) Fat cells are resistant to insulin’s antilipolytic effect, leading to day-long elevated plasma FFA levels. Chronically increased plasma FFA stimulates gluconeogenesis, induces hepatic/muscle insulin resistance, and impairs insulin secretion in genetically predisposed individuals. These FFA-induced disturbances are referred to as lipotoxicity. 2) Dysfunctional fat cells produce excessive amounts of insulin resistance-inducing, inflammatory, and atherosclerotic-provoking cytokines and fail to secrete normal amounts of insulin-sensitizing adipocytokines. 3) Enlarged fat cells are insulin resistant and have diminished capacity to store fat. When adipocyte storage capacity is exceeded, lipid “overflows” into muscle, liver, and perhaps β-cells, causing muscle/hepatic insulin resistance and impaired insulin secretion. Thiazolidinediones enhance adipocyte insulin sensitivity, inhibit lipolysis, reduce plasma FFA, and favorably influence the production of adipocytokines. Thiazolidinediones also redistribute fat within the body (decreased visceral and hepatic fat; increased sc fat) and decrease intracellular concentrations of triglyceride metabolites in muscle, liver, and β-cells, contributing to improvements in muscle/hepatic insulin sensitivity and pancreatic function in type 2 diabetics.
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In the citing paper
“an increased intramyocellar fat content and fatty acid metabolites have been shown to play a pivotal role in the development of insulin resistance in skeletal muscle [11–15].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“Dysregulation of fatty acid metabolism plays a pivotal role in the pathogenesis of insulin resistance in skeletal muscle.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“Considerable data implicate a causative role for elevated plasma FFA level in insulin resistance in skeletal muscle.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“It is well established that chronically elevated plasma FFA levels cause insulin resistance in skeletal muscle [1, 12, 14, 62–65].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“The important role of elevated plasma FFA in the pathogenesis of insulin resistance is now well established [12, 14, 57].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [14]
In the citing paper
“Insulin resistance, in combination with b cell dysfunction, contributes to the development of type 2 diabetes (T2D) 4 (1).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [1]
In the citing paper
“Obesity, particularly visceral and ectopic adiposity, increases the risk of type 2 diabetes.”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [1]
Citations
Cites
1 retracted
Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding
Defronzo, R. A., Soman, V., Sherwin, R. S., Hendler, R., & Felig, P. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109108 · Cited by 252
Self-citationRetractedPositional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Self-citationWeight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Research works printed but not linked: 16
- Kelley, 1995, Effects of weight loss on glucose homeostasis in NIDDM., Diabetes Rev, 3, 366
- Schneider, 1995, Effects of fitness and physical training on carbohydrate metabolism and associated cardiovascular risk factors in patients with diabetes., Diabetes Rev, 3, 378
- Kashyap, 2002, Chronic elevation in plasma free fatty acids impairs insulin secretion in non-diabetic offspring with a strong family history of T2DM, Diabetes, 51, A12
- Miyazaki, 2002, Effect of pioglitazone on liver fat content, abdominal fat distribution, and insulin sensitivity in patients with type 2 diabetes mellitus, Diabetes, 51, A69
- Kashyap, 2002, A chronic physiologic increase in FFA in healthy subjects causes insulin signaling defects similar to those of insulin-resistant non-diabetic subjects with a strong family history of T2DM, Diabetes, 51, A24
- Seppala-Lindroos, 2002, Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men., J Clin Endocrinol Metab, 87, 3023, 10.1210/jcem.87.7.8638 · DOI · Paper page
- McTernan, 2002, Depot-specific expression of resistin in human adipose tissue and regulation of resistin secretion by insulin and rosiglitazone in human subcutaneous adipocytes in vitro, Diabetologia, 45, A66
- Groop, 1992, Effect of insulin on oxidative and non-oxidative pathways of glucose and free fatty acid metabolism in human obesity, Am J Physiol, 263, E79
- Krssak, 1999, Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study., Diabetologia, 42, 113, 10.1007/s001250051123 · DOI · Paper page
- Stein, 1999, Increasing intramyocellular triglyceride stores are associated with impaired glucose tolerance and NIDDM, Diabetes, 48, A287
- Greco, 2002, Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion., Diabetes, 51, 144, 10.2337/diabetes.51.1.144 · DOI · Paper page
- Kahsyap, 2003, Effect of sustained reduction in plasma FFA concentration on insulin secretion in non-diabetic subjects with a strong family history of T2DM, Diabetes, 52, A336
- Chilcott, 2001, A systematic review of the effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus., Clin Ther, 23, 1792, 10.1016/S0149-2918(00)80078-8 · DOI
- Finegood, 2001, β-Cell mass dynamics in Zucker diabetic fatty rats: rosiglitazone prevents the rise in net cell death., Diabetes, 50, 1021, 10.2337/diabetes.50.5.1021 · DOI
- Lupi, 2002, PPARγ ligand-specificity in the modulation of insulin release from isolated human islets in response to fatty acid incubation, Diabetologia, 45, A161
- Marselli, 2002, Rosiglitazone partially prevents free fatty acid-induced cytotoxicity of human pancreatic islet cells, Diabetologia, 45, A161
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Self-citationPathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
Self-citationAMP-activated protein kinase signaling in metabolic regulation
Long, Y. C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29044 · Cited by 1,125
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Michalik, L., Auwerx, J. H., Berger, J. P., Chatterjee, K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O’Rahilly, S., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.5 · Cited by 1,022
Insulin resistance: a metabolic pathway to chronic liver disease
Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900
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Self-citationSGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control
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Berger, J. P., Akiyama, T. E., & Meinke, P. T. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.03.003 · Cited by 716
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Lu, X., Xie, Q., Pan, X., Zhang, R., Zhang, X., Peng, G., Zhang, Y., Shen, S., & Tong, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01951-9 · Cited by 895
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Self-citationObesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association
Bays, H. E., Toth, P. P., Kris-Etherton, P. M., Abate, N., Aronne, L. J., Brown, W. V., Gonzalez-Campoy, J. M., Jones, S. R., Kumar, R., La Forge, R., et al. (2013) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2013.04.001 · Cited by 521
Self-citationBays, H. E., González-Campoy, J. M., Bray, G. A., Kitabchi, A. E., Bergman, D. A., Schorr, A. B., Rodbard, H. W., & Henry, R. R. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.343 · Cited by 543
Self-citationBays, H. E., Chapman, R. H., Grandy, S., & the SHIELD Investigators’ Group (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01336.x · Cited by 510
Self-citationChristensen (2008) · doi:10.1016/s1043-4526(08)00401-4 · Cited by 504
Insulin Resistance, Obesity and Lipotoxicity
Yazıcı, D., & Sezer, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_12 · Cited by 525
Bays, H. E. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.038 · Cited by 431
Self-citationNguyen, M. T. A., Satoh, H., Favelyukis, S., Babendure, J. L., Imamura, T., Sbodio, J. I., Zalevsky, J., Dahiyat, B. I., Chi, N.-W., & Olefsky, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504611200 · Cited by 411
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Belfort, R., Mandarino, L., Kashyap, S., Wirfel, K., Pratipanawatr, T., Berria, R., DeFronzo, R. A., & Cusi, K. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1640 · Cited by 404
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Norton, L., Shannon, C. E., Gastaldelli, A., & DeFronzo, R. A. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155142 · Cited by 367
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Sharabi, K., Tavares, C. D. J., Rines, A. K., & Puigserver, P. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.09.003 · Cited by 344
DeFronzo, R. A., & Abdul‐Ghani, M. A. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.03.013 · Cited by 324
Self-citationPathophysiologic Approach to Therapy in Patients With Newly Diagnosed Type 2 Diabetes
DeFronzo, R. A., Eldor, R., & Abdul‐Ghani, M. A. (2013) · Diabetes Care · doi:10.2337/dcs13-2011 · Cited by 323
Self-citationInflammatory Process in Type 2 Diabetes: The Role of Cytokines
ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309
Angiotensin II-induced NADPH Oxidase Activation Impairs Insulin Signaling in Skeletal Muscle Cells
Wei, Y., Sowers, J. R., Nistala, R., Gong, H., Uptergrove, G. M., Clark, S. E., Morris, E. M., Szary, N. M., Manrique, C. M., & Stump, C. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601320200 · Cited by 302
Srivastava, R. A. K., Pinkosky, S. L., Filippov, S. I., Hanselman, J. C., Cramer, C. T., & Newton, R. S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r025882 · Cited by 308
Gastaldelli, A., Harrison, S. A., Belfort-Aguilar, R., Hardies, L. J., Balas, B., Schenker, S., & Cusi, K. (2009) · Hepatology · doi:10.1002/hep.23116 · Cited by 285
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Chiquette, E., Ramı́rez, G., & DeFronzo, R. A. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.19.2097 · Cited by 291
Self-citationHOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 295
Bays, H. E., Tighe, A. P., D, R. S. M., & Davidson, M. H. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.3.391 · Cited by 267
Self-citationImpact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
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Ke, C., Narayan, K. M. V., Chan, J. C. N., Jha, P., & Shah, B. R. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00669-4 · Cited by 263
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Self-citationControl of lipolysis by natriuretic peptides and cyclic GMP
Lafontan, M., Moro, C., Berlan, M., Crampes, F., Sengenès, C., & Galitzky, J. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.11.006 · Cited by 230
Current and investigational antiobesity agents and obesity therapeutic treatment targets
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Self-citationAMP‐activated protein kinase: role in metabolism and therapeutic implications
Schimmack, G., DeFronzo, R. A., & Musi, N. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00561.x · Cited by 231
Self-citationPioglitazone: the forgotten, cost-effective cardioprotective drug for type 2 diabetes
DeFronzo, R. A., Inzucchi, S., Abdul-Ghani, M., & Nissen, S. E. (2019) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118825376 · Cited by 223
Self-citationTannic Acid Stimulates Glucose Transport and Inhibits Adipocyte Differentiation in 3T3-L1 Cells
Liu, X., Kim, J. K., Li, Y., Li, J., Liu, F., & Chen, X. (2005) · Journal of Nutrition · doi:10.1093/jn/135.2.165 · Cited by 219
Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes
Schmid, A. I., Szendroedi, J., Chmelik, M., Krššák, M., Moser, E., & Roden, M. (2011) · Diabetes Care · doi:10.2337/dc10-1076 · Cited by 212
Wu, J., Flach, R. J. R., Anderson, E. J., Hong, E., Lee, M., Choi, C. S., Neufer, P. D., Shulman, G. I., Kim, J. K., & Bennett, A. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.010 · Cited by 215
PPARγ regulates adipose triglyceride lipase in adipocytes in vitro and in vivo
Kershaw, E. E., Schupp, M., Guan, H.-P., Gardner, N. P., Lazar, M. A., & Flier, J. S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00122.2007 · Cited by 210
Curtis, J., Grimsrud, P. A., Hahn, W. S., Xu, X. M., Foncea, R. E., Graham, D. W., Brestoff, J. R., Wiczer, B. M., Ilkayeva, O., Cianflone, K., et al. (2010) · Diabetes · doi:10.2337/db09-1105 · Cited by 211
Demerath, E. W., Reed, D., Rogers, N. L., Sun, S. S., Lee, M., Choh, A. C., Couch, W. P., Czerwinski, S. A., Chumlea, W. C., Siervogel, R. M., et al. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26546 · Cited by 206
Ectopic lipids and organ function.
Szendroedi, J., & Roden, M. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328321b3a8 · Cited by 200
Thiazolidinediones improve β-cell function in type 2 diabetic patients
Gastaldelli, A., Ferrannini, E., Miyazaki, Y., Matsuda, M., Mari, A., & DeFronzo, R. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00551.2006 · Cited by 200
Self-citationPilz, S., Scharnagl, H., Tiran, B., Seelhorst, U., Wellnitz, B., Boehm, B. O., Schaefer, J. R., & März, W. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0195 · Cited by 199
Wei, Y., Sowers, J. R., Clark, S. E., Li, W., Ferrario, C. M., & Stump, C. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00456.2007 · Cited by 197
Excess body fat in obese and normal-weight subjects
Thomas, E. L., Frost, G. S., Taylor-Robinson, S. D., & Bell, J. D. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422412000054 · Cited by 203
Musso, G., Gambino, R., Biroli, G., Carello, M., Fagà, E., Pacini, G., Michieli, F. D., Cassader, M., Durazzo, M., Rizzetto, M., et al. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00297.x · Cited by 191
Haddad, P. S., Eid, H., Nachar, A., Thong, F. S. L., & Sweeney, G. (2015) · Pharmacognosy Magazine · doi:10.4103/0973-1296.149708 · Cited by 189
Abdul‐Ghani, M. A., Puckett, C., Triplitt, C., Maggs, D., Adams, J., Cersosimo, E., & DeFronzo, R. A. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12417 · Cited by 208
Self-citationBajaj, M., Suraamornkul, S., Romanelli, A., Cline, G. W., Mandarino, L. J., Shulman, G. I., & DeFronzo, R. A. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3148 · Cited by 181
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Mattiasson, G., & Sullivan, P. G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1 · Cited by 181
Bradford, P. G. (2013) · BioFactors · doi:10.1002/biof.1074 · Cited by 178
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Self-citationMelatonin improves glucose homeostasis in young Zucker diabetic fatty rats
Agil, A., Rosado, I., Ruiz, R., Figueroa, A., Zen, N., & Fernández‐Vázquez, G. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00928.x · Cited by 169
Sahebkar, A. (2012) · BioFactors · doi:10.1002/biof.1062 · Cited by 171
Marzio, D. D. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s993 · Cited by 169
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QUINN, C. E., Hamilton, P., Lockhart, C., & McVeigh, G. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707452 · Cited by 168
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Walaszczyk, E., Luijten, M., Spijkerman, A. M. W., Bonder, M. J., Lutgers, H. L., Snieder, H., Wolffenbuttel, B. H. R., & van Vliet‐Ostaptchouk, J. V. (2017) · Diabetologia · doi:10.1007/s00125-017-4497-7 · Cited by 165
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Vertino, A. M., Taylor-Jones, J. M., Longo, K. A., Bearden, E. D., Lane, T. F., McGehee, R. E., MacDougald, O. A., & Peterson, C. A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0720 · Cited by 158
Huh, J. Y., Kim, Y., Jeong, J., Park, J., Kim, I., Huh, K. H., Kim, Y. S., Woo, H. A., Rhee, S. G., Lee, K., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3766 · Cited by 158
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Metadata
- Authors
- Bays, H., Mandarino, L., & DeFronzo, R. A.
- Affiliations
- Louisville Metabolic and Atherosclerosis Research Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-02-01
- Volume
- 89
- Issue
- 2
- Pages
- 463-478
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2151025367
- Cited by
- 664
- References
- 328
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 20 · 2023: 13 · 2022: 27 · 2021: 12 · 2020: 14 · 2019: 22 · 2018: 24 · 2017: 20 · 2016: 24 · 2015: 31 · 2014: 42 · 2013: 48 · 2012: 28
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- type 2 diabetes, free fatty acids, lipotoxicity, ectopic fat, thiazolidinediones, adipokines, insulin secretion, hepatic insulin resistance, muscle insulin resistance, adipocyte lipolysis, fat redistribution, impaired glucose tolerance
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Humans, Obesity, Transcription Factors, Adipocytes, Receptors, Cytoplasmic and Nuclear, Lipid Metabolism
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