Cited by 163Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.

Glucocorticoids Down-Regulate Glucose Uptake Capacity and Insulin-Signaling Proteins in Omental But Not Subcutaneous Human Adipocytes

Lundgren, M., Burén, J., Ruge, T., Myrnäs, T., Eriksson, J. W.·2004·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2003-031157

Open this paper in CoChat — free account

Abstract

Visceral adiposity is associated with insulin resistance and type 2 diabetes. This study explores the metabolic differences between s.c. and visceral fat depots with respect to effects in vitro of glucocorticoids and insulin on glucose uptake. Adipocytes from human s.c. and omental fat depots were obtained during abdominal surgery in 18 nondiabetic subjects. Cells were isolated, and metabolic studies were performed directly after the biopsies and after a culture period of 24 h with or without dexamethasone. After washing, basal and insulin-stimulated [14C]glucose uptake as well as cellular content of insulin signaling proteins and glucose transporter 4 (GLUT4) was assessed. Omental adipocytes had an approximately 2-fold higher rate of insulin-stimulated glucose uptake compared with s.c. adipocytes (P < 0.01). Dexamethasone treatment markedly inhibited (by approximately 50%; P < 0.05) both basal and insulin-stimulated glucose uptake in omental adipocytes but had no consistent effect in s.c. adipocytes. The cellular content of insulin receptor substrate 1 and phosphatidylinositol 3-kinase did not differ significantly between the depots, but the expression of protein kinase B (PKB) tended to be increased in omental compared with s.c. adipocytes (P = 0.09). Dexamethasone treatment decreased the expression of insulin receptor substrate 1 (by approximately 40%; P < 0.05) and PKB (by approximately 20%; P < 0.05) in omental but not in s.c. adipocytes. In contrast, dexamethasone pretreatment had no effect on insulin-stimulated Ser473 phosphorylation of PKB. GLUT4 expression was approximately 4-fold higher in omental than s.c. adipocytes (P < 0.05). Dexamethasone treatment did not alter the expression of GLUT4. In conclusion, human omental adipocytes display approximately 2-fold higher glucose uptake rate compared with s.c. adipocytes, and this could be explained by a higher GLUT4 expression. A marked suppression is exerted by glucocorticoids on glucose uptake and on the expression of insulin signaling proteins in omental but not in s.c. adipocytes. These findings may be of relevance for the interaction between endogenous glucocorticoids and visceral fat in the development of insulin resistance.

Integrity signals

Registry

Crossref · 10.1210/jc.2003-031157

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Validation of tetrapolar bioelectrical impedance method to assess human body composition
Lukaski, H. C., Bolonchuk, W. W., Hall, C. B., & Siders, W. A. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.4.1327 · Cited by 1,370
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132
Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance
Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., & Pratley, R. E. (2000) · Diabetologia · doi:10.1007/s001250051560 · Cited by 799
The perils of portliness: causes and consequences of visceral adiposity.
Montague, C. T., & O’Rahilly, S. (2000) · Diabetes · doi:10.2337/diabetes.49.6.883 · Cited by 735
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
Baumann, C. A., Ribon, V., Kanzaki, M., Thurmond, D. C., Mora, S., Shigematsu, S., Bickel, P. E., Pessin, J. E., & Saltiel, A. R. (2000) · Nature · doi:10.1038/35025089 · Cited by 660
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.
Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 520
Visceral fat and insulin resistance — causative or correlative?
Frayn, K. N. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000982 · Cited by 456

Show all 58 references

Research works printed but not linked: 1

Björntorp, 1992, Regional obesity, In: Björntorp P, Brodoff B, eds. Obesity. Philadelphia: JB Lippincott Co.;, 579

Sorted by citations

Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options?
Van Raalte, D. H., Ouwens, D. M., & Diamant, M. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.02067.x · Cited by 439
Mechanisms of Glucocorticoid-Induced Insulin Resistance
Geer, E. B., Islam, J., & Buettner, C. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.10.005 · Cited by 392
Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity
Lee, M., Pramyothin, P., Karastergiou, K., & Fried, S. K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.029 · Cited by 399
Influence of obesity on the risk of developing colon cancer
Frezza, E. E., Wachtel, M. S., & Chiriva‐Internati, M. (2005) · Gut · doi:10.1136/gut.2005.073163 · Cited by 347
IRS1-Independent Defects Define Major Nodes of Insulin Resistance
Hoehn, K. L., Hohnen-Behrens, C., Cederberg, A., Wu, L. E., Turner, N. A., Yuasa, T., Ebina, Y., & James, D. E. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.005 · Cited by 318
Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review
Freedland, E. S. (2004) · Nutrition & Metabolism · doi:10.1186/1743-7075-1-12 · Cited by 303
Fat cell enlargement is an independent marker of insulin resistance and ‘hyperleptinaemia’
Lundgren, M., Svensson, M. K. E., Lindmark, S., Renström, F., Ruge, T., & Eriksson, J. W. (2007) · Diabetologia · doi:10.1007/s00125-006-0572-1 · Cited by 283
Self-citation
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271
Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions
Li, J.-X., & Cummins, C. L. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00683-6 · Cited by 285
Heterogeneity of white adipose tissue: molecular basis and clinical implications
Kwok, K. H. M., Lam, K. S. L., & Xu, A. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.5 · Cited by 264
Effects of Chronic Social Stress on Obesity
Scott, K. A., Melhorn, S. J., & Sakai, R. R. (2012) · Current Obesity Reports · doi:10.1007/s13679-011-0006-3 · Cited by 251
Insulin dysregulation
Frank, N., & Tadros, E. M. (2013) · Equine Veterinary Journal · doi:10.1111/evj.12169 · Cited by 260
Systemic Glucocorticoid Therapy: a Review of its Metabolic and Cardiovascular Adverse Events
Fardet, L., & Fève, B. (2014) · Drugs · doi:10.1007/s40265-014-0282-9 · Cited by 249
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
Giorgino, F., Laviola, L., & Eriksson, J. W. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01385.x · Cited by 230
Self-citation
White adipocyte dysfunction and obesity-associated pathologies in humans
Hagberg, C. E., & Spalding, K. L. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00680-1 · Cited by 236
Adipocyte size predicts incidence of type 2 diabetes in women
Lönn, M., Mehlig, K., Bengtsson, C., & Lissner, L. (2009) · The FASEB Journal · doi:10.1096/fj.09-133058 · Cited by 218
11β-hydroxysteroid dehydrogenase 1: translational and therapeutic aspects
Gathercole, L. L., Lavery, G. G., Morgan, S. A., Cooper, M. S., Sinclair, A. J., Tomlinson, J. W., & Stewart, P. M. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1050 · Cited by 196
Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High‐fat Diet
Starowicz, K., Cristino, L., Matias, I., Capasso, R., Racioppi, A., Izzo, A. A., & Marzo, V. D. (2008) · Obesity · doi:10.1038/oby.2007.106 · Cited by 194
Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer?
Yang, X., & Smith, U. (2007) · Diabetologia · doi:10.1007/s00125-007-0640-1 · Cited by 197
Does altered glucocorticoid homeostasis increase cardiovascular risk?
GIROD, J., & BROTMAN, D. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.07.006 · Cited by 193
Is Metabolic Syndrome A Risk Factor for Colorectal Adenoma?
Kim, J. H., Lim, Y. J., Kim, Y., Sung, I., Shim, S. G., Oh, S.-O., Park, S.-S., Yang, S. Y., Son, H. J., Rhee, P., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0199 · Cited by 174
Abdominal adiposity in rheumatoid arthritis: Association with cardiometabolic risk factors and disease characteristics
Giles, J. T., Allison, M., Blumenthal, R. S., Post, W. S., Gelber, A. C., Petri, M., Tracy, R. P., Szklo, M., & Bathon, J. M. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27629 · Cited by 173
AMP‐activated protein kinase mediates glucocorticoid‐ induced metabolic changes: a novel mechanism in Cushing's syndrome
Christ‐Crain, M., Kola, B., Lolli, F., Fekete, C., Seboek, D., Wittmann, G., Feltrin, D., Igreja, S., Ajodha, S. J., Harvey-White, J. D., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-094144 · Cited by 175
Metabolic stress in insulin's target cells leads to ROS accumulation – A hypothetical common pathway causing insulin resistance
Eriksson, J. W. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.044 · Cited by 176
Self-citation
Polycystic ovary syndrome, adipose tissue and metabolic syndrome
Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4429-2 · Cited by 159
Obesity, Visceral Fat, and NAFLD: Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease
Mirza, M. S. (2011) · ISRN Gastroenterology · doi:10.5402/2011/592404 · Cited by 148
Impact of visceral adipose tissue on liver metabolism
Lafontan, M., & Girard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.04.001 · Cited by 143
Fat depot-related differences in gene expression, adiponectin secretion, and insulin action and signalling in human adipocytes differentiated in vitro from precursor stromal cells
Perrini, S., Laviola, L., Cignarelli, A., Melchiorre, M., Stefano, F. D., Caccioppoli, C., Natalicchio, A., Orlando, M. R., Garruti, G., Fazio, M. D., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0841-7 · Cited by 141
Stress habituation, body shape and cardiovascular mortality
Peters, A., & McEwen, B. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.001 · Cited by 133
Lipid metabolism and secretory function of porcine intramuscular adipocytes compared with subcutaneous and perirenal adipocytes
Gardan, D., Gondret, F., & Louveau, I. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00482.2005 · Cited by 136
Emodin, a natural product, selectively inhibits 11β‐hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet‐induced obese mice
Feng, Y., Huang, S., Dou, W., Zhang, S., Chen, J., Shen, Y., Shen, J., & Leng, Y. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00826.x · Cited by 128
Mitogen-Activated Protein Kinases, Inhibitory-κB Kinase, and Insulin Signaling in Human Omental Versus Subcutaneous Adipose Tissue in Obesity
Bashan, N., Dorfman, K., Tarnovscki, T., Harman‐Boehm, I., Liberty, I. F., Blüher, M., Ovadia, S., Maymon-Zilberstein, T., Potashnik, R., Stümvoll, M., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1369 · Cited by 123
Role of glucocorticoids and the glucocorticoid receptor in metabolism: Insights from genetic manipulations
Rose, A. J., Vegiopoulos, A., & Herzig, S. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.02.010 · Cited by 110
Of mice and men: Pinpointing species differences in adipose tissue biology
Börgeson, E., Boucher, J., & Hagberg, C. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1003118 · Cited by 125
Low-dose glucocorticoid treatment affects multiple aspects of intermediary metabolism in healthy humans: a randomised controlled trial
van Raalte, D. H., Brands, M., van der Zijl, N. J., Muskiet, M. H., Pouwels, P. J. W., Ackermans, M. T., Sauerwein, H. P., Serlie, M. J., & Diamant, M. (2011) · Diabetologia · doi:10.1007/s00125-011-2174-9 · Cited by 109
“GCs were shown to interfere with insulin signalling in vitro and in vivo in rodents in liver [38], adipose tissue [39] and skeletal muscle [40].”
Background
Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition
Zhang, Z. F., Li, Q., Liang, J., Dai, X., Ding, Y., Wang, J. B., & Li, Y. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.09.007 · Cited by 110
The Discovery of New 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors by Common Feature Pharmacophore Modeling and Virtual Screening
Schuster, D., Maurer, E. M., Laggner, C., Nashev, L. G., Wilckens, T., Langer, T., & Odermatt, A. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0600794 · Cited by 110
Insulin Resistance in Rheumatoid Arthritis: Disease‐Related Indicators and Associations With the Presence and Progression of Subclinical Atherosclerosis
Giles, J. T., Danielides, S., Szklo, M., Post, W. S., Blumenthal, R. S., Petri, M., Schreiner, P. J., Budoff, M. J., Detrano, R., & Bathon, J. M. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38986 · Cited by 110
FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance
Pereira, M. J., Palming, J., Svensson, M. K. E., Rizell, M., Dalenbäck, J., Hammar, M., Fall, T., Sidibeh, C. O., Svensson, P., & Eriksson, J. W. (2014) · Metabolism · doi:10.1016/j.metabol.2014.05.015 · Cited by 101
Self-citation
mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
Pereira, M. J., Palming, J., Rizell, M., Aureliano, M., Carvalho, E., Svensson, M. K. E., & Eriksson, J. W. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.01.024 · Cited by 100
Self-citation
Surface protein expression between human adipose tissue-derived stromal cells and mature adipocytes
Festy, F., Hoareau, L., Bès-Houtmann, S., Péquin, A.-M., Gonthier, M., Munstun, A., Hoarau, J., Césari, M., & Roche, R. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0014-z · Cited by 99
Insulin Signaling in Human Visceral and Subcutaneous Adipose Tissue In Vivo
Laviola, L., Perrini, S., Cignarelli, A., Natalicchio, A., Leonardini, A., Stefano, F. D., Cuscito, M., Fazio, M. D., Memeo, V., Neri, V., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1414 · Cited by 95
Effects of decavanadate and insulin enhancing vanadium compounds on glucose uptake in isolated rat adipocytes
Pereira, M. J., Carvalho, E., Eriksson, J. W., Crans, D. C., & Aureliano, M. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.09.015 · Cited by 92
Self-citation
Impact of Glucocorticoid Excess on Glucose Tolerance: Clinical and Preclinical Evidence
Pasieka, A. M., & Rafacho, A. (2016) · Metabolites · doi:10.3390/metabo6030024 · Cited by 91
Unravelling hair follicle–adipocyte communication
Schmidt, B., & Horsley, V. (2012) · Experimental Dermatology · doi:10.1111/exd.12001 · Cited by 88
Glucocorticoid Receptor and Adipocyte Biology
Lee, R. A., Harris, C. A., & Wang, J.-C. (2018) · Nuclear Receptor Research · doi:10.32527/2018/101373 · Cited by 97
Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes
Chan, S. S. Y., Twigg, S. M., Firth, S. M., & Baxter, R. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0595 · Cited by 84
The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer
Holly, J. M. P., Biernacka, K. M., & Perks, C. M. (2019) · Cells · doi:10.3390/cells8101207 · Cited by 83
Visceral adipose tissue in children and adolescents: a review
Suliga, E. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409990096 · Cited by 83
Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes
Gathercole, L., & Stewart, P. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.03.060 · Cited by 82
Is diabetes in Cushing’s syndrome only a consequence of hypercortisolism?
Giordano, C., Guarnotta, V., Pivonello, R., Amato, M. C., Simeoli, C., Ciresi, A., Cozzolino, A., & Colao, A. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0754 · Cited by 79
Glucocorticoid Modulation of Insulin Signaling in Human Subcutaneous Adipose Tissue
Gathercole, L. L., Bujalska, I. J., Stewart, P. M., & Tomlinson, J. W. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1399 · Cited by 73
Differences in the redox status of human visceral and subcutaneous adipose tissues – relationships to obesity and metabolic risk
Janković, A., Korać, A., Srdić, B., Buzadžić, B., Otašević, V., Stančić, A., Vučetić, M., Markelic, M. B., Veličković, K., Golić, I., et al. (2014) · Metabolism · doi:10.1016/j.metabol.2014.01.009 · Cited by 74
Postnatal Testosterone Exposure Results in Insulin Resistance, Enlarged Mesenteric Adipocytes, and an Atherogenic Lipid Profile in Adult Female Rats: Comparisons with Estradiol and Dihydrotestosterone
Alexanderson, C., Eriksson, E., Stener-Victorin, E., Lystig, T., Gabrielsson, B., Lönn, M., & Holmäng, A. (2007) · Endocrinology · doi:10.1210/en.2007-0305 · Cited by 69
Investigation of the Relationship Between Chronic Stress and Insulin Resistance in a Chinese Population
Yan, Y., Xiao, H., Wang, S., Zhao, J., He, Y. L., Wang, W., & Dong, J. (2016) · Journal of Epidemiology · doi:10.2188/jea.je20150183 · Cited by 75
Glucocorticoids Fail to Cause Insulin Resistance in Human Subcutaneous Adipose Tissue In Vivo
Hazlehurst, J. M., Gathercole, L. L., Nasiri, M., Armstrong, M. J., Borrows, S., Yu, J., Wagenmakers, A. J. M., Stewart, P. M., & Tomlinson, J. W. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3523 · Cited by 66
Cyclosporine A and Tacrolimus Reduce the Amount of GLUT4 at the Cell Surface in Human Adipocytes: Increased Endocytosis as a Potential Mechanism for the Diabetogenic Effects of Immunosuppressive Agents
Pereira, M. J., Palming, J., Rizell, M., Aureliano, M., Carvalho, E., Svensson, M. K. E., & Eriksson, J. W. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1266 · Cited by 67
Self-citation
Pan-PPAR agonist beneficial effects in overweight mice fed a high-fat high-sucrose diet
Fernandes‐Santos, C., Carneiro, R. E., Mendonça, L. D. S., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2009) · Nutrition · doi:10.1016/j.nut.2008.12.010 · Cited by 64
Dysmetabolic adipose tissue in obesity: morphological and functional characteristics of adipose stem cells and mature adipocytes in healthy and unhealthy obese subjects
Porro, S., Genchi, V. A., Cignarelli, A., Natalicchio, A., Laviola, L., Giorgino, F., & Perrini, S. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01446-8 · Cited by 64
Differences in Gene Expression and Cytokine Release Profiles Highlight the Heterogeneity of Distinct Subsets of Adipose Tissue-Derived Stem Cells in the Subcutaneous and Visceral Adipose Tissue in Humans
Perrini, S., Ficarella, R., Picardi, E., Cignarelli, A., Barbaro, M. P. F., Nigro, P., Peschechera, A., Palumbo, O., Carella, M., Fazio, M. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057892 · Cited by 60
Kinome Analysis Reveals Nongenomic Glucocorticoid Receptor-Dependent Inhibition of Insulin Signaling
Löwenberg, M., Tuynman, J. B., Scheffer, M., Verhaar, A. P., Vermeulen, L., van Deventer, S. J. H., Hommes, D. W., & Peppelenbosch, M. P. (2006) · Endocrinology · doi:10.1210/en.2005-1602 · Cited by 59
Actions of IGF binding proteins and related proteins in adipose tissue
Baxter, R. C., & Twigg, S. M. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.07.002 · Cited by 57
Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance
Sidibeh, C. O., Pereira, M. J., Lau, J., Kamble, P. G., Skrtic, S., Katsogiannos, P., Sundbom, M., Svensson, M. K. E., & Eriksson, J. W. (2016) · Endocrine · doi:10.1007/s12020-016-1172-6 · Cited by 56
Self-citation
MECHANISMS IN ENDOCRINOLOGY: Local and systemic effects of glucocorticoids on metabolism: new lessons from animal models
Swarbrick, M. M., Zhou, H., & Seibel, M. J. (2021) · European Journal of Endocrinology · doi:10.1530/eje-21-0553 · Cited by 54
Insulin signalling in human adipose tissue
Laviola, L., Perrini, S., Cignarelli, A., & Giorgino, F. (2006) · Archives of Physiology and Biochemistry · doi:10.1080/13813450600736174 · Cited by 56
Biological specificity of visceral adipose tissue and therapeutic intervention
Perrini, S., Leonardini, A., Laviola, L., & Giorgino, F. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802334752 · Cited by 50
Naturally occurring compensated insulin resistance selectively alters glucose transporters in visceral and subcutaneous adipose tissues without change in AS160 activation
Waller, A. P., Köhler, K., Burns, T. A., Mudge, M. C., Belknap, J. K., & Lacombe, V. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.007 · Cited by 49
Visceral adipose tissue: emerging role of gluco‐ and mineralocorticoid hormones in the setting of cardiometabolic alterations
Boscaro, M., Giacchetti, G., & Ronconi, V. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06597.x · Cited by 49
Insulin resistance induced by high glucose and high insulin precedes insulin receptor substrate 1 protein depletion in human adipocytes
Renström, F., Burén, J., Svensson, M. K. E., & Eriksson, J. W. (2007) · Metabolism · doi:10.1016/j.metabol.2006.09.012 · Cited by 46
Self-citation
Ghrelin – Defender of fat
Wells, T. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.04.002 · Cited by 46
Lipocalin 2 produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue
Kamble, P. G., Pereira, M. J., Sidibeh, C. O., Amini, S., Sundbom, M., Lau, J., & Eriksson, J. W. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.03.011 · Cited by 45
Self-citation
Comparison of Gene Transcription between Subcutaneous and Visceral Adipose Tissue in Chinese Adults
Zha, J., Di, W. J., Zhu, T., Xie, Y., Yu, J., Liu, J., Chen, P., & Ding, G. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-091 · Cited by 44
Insulin Sensitization of Human Preadipocytes through Glucocorticoid Hormone Induction of Forkhead Transcription Factors
Tomlinson, J. J., Boudreau, A., Wu, D., Salem, H. A., Carrigan, A., Gagnon, A., Mears, A. J., Sorisky, A., Atlas, E., & Haché, R. J. G. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0091 · Cited by 44
Effects of hyperinsulinemia on lipoprotein lipase, angiopoietin-like protein 4, and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 in subjects with and without type 2 diabetes mellitus
Ruge, T., Sukonina, V., Kroupa, O., Makoveichuk, E., Lundgren, M., Svensson, M. K. E., Olivecrona, G., & Eriksson, J. W. (2011) · Metabolism · doi:10.1016/j.metabol.2011.09.014 · Cited by 42
Self-citation
Winners, losers, and posers: The effect of power poses on testosterone and risk-taking following competition
Smith, K. M., & Apicella, C. L. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.11.003 · Cited by 42
Adipocytokines: a bridge connecting obesity and insulin resistance
Zhuang, X.-F., Zhao, M.-M., Weng, C.-L., & Sun, N.-L. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.05.036 · Cited by 41
Glucose transporter 4 and insulin receptor substrate–1 messenger RNA expression in omental and subcutaneous adipose tissue in women
Veilleux, A., Blouin, K., Rhéaume, C., Daris, M., Marette, A., & Tchernof, A. (2009) · Metabolism · doi:10.1016/j.metabol.2008.12.007 · Cited by 40
Analysis of Insulin Sensitivity in Adipose Tissue of Patients with Primary Aldosteronism
Urbanet, R., Pilon, C., Calcagno, A., Peschechera, A., Hubert, E.-L., Giacchetti, G., Gomez-Sanchez, C., Mulatero, P., Toffanin, M., Sonino, N., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0097 · Cited by 38
Comparison of mitochondrial and macrophage content between subcutaneous and visceral fat in db/db mice.
Okamoto, Y., Higashiyama, H., Rong, J. X., McVey, M. J., Kinoshita, M., Asano, S., & Hansen, M. K. (2007) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2007.02.007 · Cited by 38
Glucocorticoid-induced insulin resistance is related to macrophage visceral adipose tissue infiltration
Do, T. T. H., Garcia, M., Dalle, H., Dorothée, G., Moldes, M., Fève, B., & Buyse, M. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.08.010 · Cited by 36
Neuroendocrine mechanisms in insulin resistance
Sjöstrand, M., & Eriksson, J. G. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.05.010 · Cited by 37
Self-citation
Disturbances of Hormonal Circadian Rhythms by Light Pollution
Zeman, M., Okuliarová, M., & Rumanova, V. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087255 · Cited by 38
Adipose tissue in cortisol excess: What Cushing’s syndrome can teach us?
Bavaresco, A., Mazzeo, P., Lazzara, M., & Barbot, M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116137 · Cited by 41
Expression of adipogenic transcription factors in adipose tissue of fattening Wagyu and Holstein steers
Yamada, T., Kawakami, S.-I., & Nakanishi, N. (2008) · Meat Science · doi:10.1016/j.meatsci.2008.06.022 · Cited by 35
Dexamethasone rapidly inhibits glucose uptake via non-genomic mechanisms in contracting myotubes
Gong, H., Liu, L., Ni, C., Zhang, Y., Su, W., Lian, Y., Wei, P., Zhang, J., & Jiang, C. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.05.020 · Cited by 32
Lipoprotein lipase activity/mass ratio is higher in omental than in subcutaneous adipose tissue
Ruge, T., Sukonina, V., Myrnäs, T., Lundgren, M., Eriksson, J. W., & Olivecrona, G. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01584.x · Cited by 31
Self-citation
Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation
Kazi, T., Nagata, A., Nakagawa, T., Matsuzaki, T., & Inui, S. (2022) · Cells · doi:10.3390/cells11020202 · Cited by 32
Hypoglycemic Properties of the Aqueous Extract from the Stem Bark of Ceiba pentandra in Dexamethasone‐Induced Insulin Resistant Rats
Fofié, C. K., Nguelefack‐Mbuyo, E. P., Tsabang, N., Kamanyi, A., & Nguelefack, T. B. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/4234981 · Cited by 30
The Effects of Glucocorticoids on Fetal and Placental Development
Korgun, E. T., Özmen, A., Ünek, G., & Mendilcioğlu, İ. (2012) · InTech eBooks · doi:10.5772/50103 · Cited by 32
INSIG2 SNPs Associated With Obesity and Glucose Homeostasis Traits in Hispanics: The IRAS Family Study
Talbert, M. E., Langefeld, C. D., Ziegler, J. T., Haffner, S. M., Norris, J. M., & Bowden, D. W. (2009) · Obesity · doi:10.1038/oby.2009.94 · Cited by 27
Association of general and abdominal obesity with age, endocrine and metabolic factors in Asian men
Goh, V. H. H., & Hart, W. G. (2015) · The Aging Male · doi:10.3109/13685538.2015.1088825 · Cited by 25
Effects of Crude Protein Levels in Total Mixed Rations on Growth Performance and Meat Quality in Growing Korean Black Goats
Hwangbo, S., Choi, S. H., Kim, S. W., Son, D. S., Park, H. S., Lee, S. H., & Jo, I.-H. (2009) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2009.80527 · Cited by 25
Steroid Metabolomic Signature of Insulin Resistance in Childhood Obesity
Gawlik, A., Shmoish, M., Hartmann, M. F., Wudy, S. A., & Hochberg, Z. (2019) · Diabetes Care · doi:10.2337/dc19-1189 · Cited by 23
HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
Lichtenstein, K. A., Balasubramanyam, A., Sekhar, R. V., & Freedland, E. S. (2007) · AIDS Research and Therapy · doi:10.1186/1742-6405-4-14 · Cited by 20
Expression of 11β-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity
Mlinar, B., Marc, J., Jensterle, M., Bokal, E. V., Jerin, A., & Pfeifer, M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.002 · Cited by 20
Muscle-specific downregulation of GR levels inhibits adipogenesis in porcine intramuscular adipocyte tissue
Chu, W., Wei, W., Han, H., Gao, Y. H., Liu, K., Tian, Y., Jiang, Z., Zhang, L., & Chen, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00615-9 · Cited by 19
Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells
Sarsenbayeva, A., Pereira, M. J., Jui, B. N., Ahmed, F., Dipta, P., Fanni, G., Almby, K. E., Kristófi, R., Hetty, S., & Eriksson, J. W. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114976 · Cited by 19
Self-citation
Sex Differences in Body Fat Distribution
Veilleux, A., & Tchernof, A. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_5 · Cited by 17
Involvement of glucocorticoid prereceptor metabolism and signaling in rat visceral adipose tissue lipid metabolism after chronic stress combined with high-fructose diet
Bursać, B. N., Djordjevic, A. D., Veličković, N. A., Milutinović, D. V., Petrović, S., Teofilović, A., Gligorovska, L., Preitner, F., Tappy, L., & Matić, G. M. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.04.015 · Cited by 18

Authors: Lundgren, M., Burén, J., Ruge, T., Myrnäs, T., & Eriksson, J. W.
Affiliations: Departments of Medicine (M.L., J.B., T.R., J.W.E.); SE-901 85, Sweden
Surgery (T.M.), Umeå University Hospital, Umeå SE-901 85, Sweden
Corresponding author: Eriksson, J. W.
ORCID: Ruge, T.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2004-06-01
Volume: 89
Issue: 6
Pages: 2989-2997
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2003-031157
OpenAlex: W2015237552
Semantic Scholar: 3ac8ca39fe13f06f9ca60a9ec018ce4f020beaba
Cited by: 163
References: 58
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 13 · 2015: 6 · 2014: 7 · 2013: 11 · 2012: 8
FWCI: 7.43
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: glucocorticoids, dexamethasone, glucose uptake, insulin signaling, omental adipocytes, subcutaneous adipocytes, visceral adipose tissue, GLUT4, IRS-1, phosphatidylinositol 3-kinase, Akt, insulin resistance, type 2 diabetes, adipocyte metabolism, insulin-stimulated glucose uptake
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Biological Transport, Carbon Radioisotopes, Cells, Cultured, Dexamethasone, Female, Glucocorticoids, Glucose, Humans, Insulin, Male, Middle Aged, Monosaccharide Transport Proteins, Muscle Proteins, Omentum, Signal Transduction, Adipocytes, Subcutaneous Tissue, Glucose Transporter Type 4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glucocorticoids Down-Regulate Glucose Uptake Capacity and Insulin-Signaling Proteins in Omental But Not Subcutaneous Human Adipocytes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks