Cited by 159Ovarian function and disordersAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Polycystic ovary syndrome, adipose tissue and metabolic syndrome

Delitala, Alessandro P., Capobianco, Giampiero, Delitala, Giuseppe, Cherchi, Pier Luigi, Dessole, Salvatore·2017·Archives of Gynecology and Obstetrics

Abstract

Purpose Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD).Methods A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome. Original articles, reviews, and meta-analysis were included.Results PCOS women are prone to visceral fat hypertrophy in the presence of androgen excess and the presence of these conditions is related to insulin resistance and worsens the PCO phenotype. Disturbed secretion of many adipocyte-derived substances (adipokines) is associated with chronic low-grade inflammation and contributes to insulin resistance. Abdominal obesity and insulin resistance stimulate ovarian and adrenal androgen production, and may further increase abdominal obesity and inflammation, thus creating a vicious cycle.Conclusion The high prevalence of metabolic disorders mainly related to insulin resistance and CVD risk factors in women with PCOS highlight the need for early lifestyle changes for reducing metabolic risks in these patients.

Integrity signals

Registry

Crossref · 10.1007/s00404-017-4429-2

Cites

187 of 187 references verified0 citation errors · 0 not checkable

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Authors
Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S.
Affiliations
  • Azienda Ospedaliero Universitaria di Sassari (IT)
  • University of Sassari (IT)
Corresponding author
Delitala, Alessandro P.
Venue
Archives of Gynecology and Obstetrics
Published
2017-06-22
Volume
296
Issue
3
Pages
405-419
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
OpenAlex
W2651345085
Cited by
159
References
188
Citations by year
2026: 8 · 2025: 6 · 2024: 21 · 2023: 19 · 2022: 20 · 2021: 33 · 2020: 13 · 2019: 17 · 2018: 17 · 2017: 4 · 2012: 1
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
  • UnissResearch (Università degli Studi di Sassari) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, adipose tissue, metabolic syndrome, insulin resistance, adipokines, visceral fat, abdominal obesity, hyperandrogenism, low-grade inflammation, cardiovascular risk, type 2 diabetes, lifestyle intervention
MeSH terms
Adipose Tissue, Adult, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Life Style, Polycystic Ovary Syndrome, Metabolic Syndrome, Adipokines

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