Polycystic ovary syndrome, adipose tissue and metabolic syndrome
Abstract
Purpose Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age and is characterized by ovulatory dysfunction and/or androgen excess or polycystic ovaries. Women with PCOS present a number of systemic symptoms in addition to those related to the reproductive system. It has been associated with functional derangements in adipose tissue, metabolic syndrome, type 2 diabetes, and an increased risk of cardiovascular disease (CVD).Methods A detailed literature search on Pubmed was done for articles about PCOS, adipokines, insulin resistance, and metabolic syndrome. Original articles, reviews, and meta-analysis were included.Results PCOS women are prone to visceral fat hypertrophy in the presence of androgen excess and the presence of these conditions is related to insulin resistance and worsens the PCO phenotype. Disturbed secretion of many adipocyte-derived substances (adipokines) is associated with chronic low-grade inflammation and contributes to insulin resistance. Abdominal obesity and insulin resistance stimulate ovarian and adrenal androgen production, and may further increase abdominal obesity and inflammation, thus creating a vicious cycle.Conclusion The high prevalence of metabolic disorders mainly related to insulin resistance and CVD risk factors in women with PCOS highlight the need for early lifestyle changes for reducing metabolic risks in these patients.
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Obesity and insulin resistance are the main components of polycystic ovarian syndrome pathogenesis.
“However, obesity and insulin resistance are the main components of its pathogenesis [71].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [71]
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- Authors
- Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S.
- Affiliations
- Azienda Ospedaliero Universitaria di Sassari (IT)
- University of Sassari (IT)
- Corresponding author
- Delitala, Alessandro P.
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2017-06-22
- Volume
- 296
- Issue
- 3
- Pages
- 405-419
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2651345085
- Cited by
- 159
- References
- 188
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 21 · 2023: 19 · 2022: 20 · 2021: 33 · 2020: 13 · 2019: 17 · 2018: 17 · 2017: 4 · 2012: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, adipose tissue, metabolic syndrome, insulin resistance, adipokines, visceral fat, abdominal obesity, hyperandrogenism, low-grade inflammation, cardiovascular risk, type 2 diabetes, lifestyle intervention
- MeSH terms
- Adipose Tissue, Adult, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Insulin Resistance, Life Style, Polycystic Ovary Syndrome, Metabolic Syndrome, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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