Impact of visceral adipose tissue on liver metabolism

Lafontan, M.; Girard, J.

doi:10.1016/j.diabet.2008.04.001

Cited by 143Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityLiver Disease Diagnosis and Treatment

Impact of visceral adipose tissue on liver metabolism

Lafontan, M., Girard, J.·2008·Diabetes & Metabolism

DOI 10.1016/j.diabet.2008.04.001

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Abstract

Excess visceral adipose tissue is associated with anomalies of blood glucose homoeostasis, elevation of plasma triglycerides and low high-density lipoprotein cholesterol that contribute to the later appearance of type 2 diabetes and cardiovascular syndromes. Visceral adipose tissue releases a large amount of free fatty acids and hormones/cytokines in the portal vein that are delivered to the liver, and interact with hepatocytes and various immune cells in the liver. The functional characteristics of visceral adipose tissue will be compared with subcutaneous adipose tissue to clarify the major mechanisms affecting free fatty acid metabolism and cytokine production.

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Gene expression of angiotensinogen in adipose tissue of obese patients
Giacchetti, G., Faloia, E., Sardu, C., Camilloni, M. A., Mariniello, B., Gatti, C., Garrapa, G., Guerrieri, M., & Mantero, F. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801305 · Cited by 109 · see citing works
Vascular Endothelial Growth Factor Is Induced by the Inflammatory Cytokines Interleukin-6 and Oncostatin M in Human Adipose Tissue In Vitro and in Murine Adipose Tissue In Vivo
Rega‐Kaun, G., Kaun, C., Demyanets, S., Pfaffenberger, S., Rychli, K., Hohensinner, P. J., Kastl, S., Speidl, W. S., Weiss, T. W., Breuss, J. M., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.143081 · Cited by 104 · see citing works
The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans
Andrew, R., Westerbacka, J., Wahren, J., Yki‐Järvinen, H., & Walker, B. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1364 · Cited by 98 · see citing works
Insulin Signaling in Human Visceral and Subcutaneous Adipose Tissue In Vivo
Laviola, L., Perrini, S., Cignarelli, A., Natalicchio, A., Leonardini, A., Stefano, F. D., Cuscito, M., Fazio, M. D., Memeo, V., Neri, V., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1414 · Cited by 95 · see citing works
Inflammatory Cytokines Interleukin-6 and Oncostatin M Induce Plasminogen Activator Inhibitor-1 in Human Adipose Tissue
Rega‐Kaun, G., Kaun, C., Weiss, T. W., Demyanets, S., Zorn, G., Kastl, S., Steiner, S., Seidinger, D., Kopp, C. W., Frey, M., et al. (2005) · Circulation · doi:10.1161/01.cir.0000161823.55935.be · Cited by 91 · see citing works
Activation of α2-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects
Štich, V., de Glisezinski, I., Crampes, F., Hejnová, J., Cottet-Émard, J. M., Galitzky, J., Lafontan, M., Rivière, D., & Berlan, M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.2.r499 · Cited by 88 · see citing works
Self-citation
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity
Guo, W., Pirtskhalava, T., Tchkonia, T., Xie, W., Thomou, T., Han, J., Wang, T., Wong, S., Cartwright, A., Hegardt, F. G., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00557.2006 · Cited by 85 · see citing works
Novel Roles for Acylation Stimulating Protein⧸C3adesArg: A Review of Recent In Vitro and In Vivo Evidence
Maslowska, M., Wang, H., & Cianflone, K. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)70010-8 · Cited by 74 · see citing works
Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals
Fisher, R. M., Eriksson, P. O., Hoffstedt, J., Hotamışlıgil, G. S., Thörne, A., Rydén, M., Hamsten, A., & Arner, P. (2001) · Diabetologia · doi:10.1007/s001250100643 · Cited by 73 · see citing works
-Adrenergic Regulation of IL-6 Release from Adipose Tissue: In Vivo and in Vitro Studies
Mohamed‐Ali, V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5864 · Cited by 69 · see citing works
Millennium Fat-Cell Lipolysis Reveals Unsuspected Novel Tracks
Langin, D., Lucas, S., & Lafontan, M. (2000) · Hormone and Metabolic Research · doi:10.1055/s-2007-978670 · Cited by 63 · see citing works
Self-citation
Regional variation in adipose tissue insulin action and GLUT4 glucose transporter expression in severely obese premenopausal women
Marette, A., Maurie`ge, P., Marcotte, B., Atgié, C., Bouchard, C., Thériault, G., Bukowiecki, L. J., Marceau, P., Biron, S., Nadeau, A., et al. (1997) · Diabetologia · doi:10.1007/s001250050720 · Cited by 53 · see citing works
Adiponectin mRNA levels in the abdominal adipose depots of nondiabetic women
Yang, W.-S., Chen, M.-H., Lee, W.-J., Lee, K.-C., Chao, C.-L., Huang, K.-C., Chen, C., Tai, T.-Y., & Chuang, L.-M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802367 · Cited by 44 · see citing works
Cortisol, 11β-hydroxysteroid dehydrogenase type 1 and central obesity
Stewart, P. M., & Tomlinson, J. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00566-0 · Cited by 42 · see citing works
Human Breast Adipocytes Express Interleukin-6 (IL-6) and Its Receptor System: Increased IL-6 Production by -Adrenergic Activation and Effects of IL-6 on Adipocyte Function
Päth, G. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.5.2281 · Cited by 42 · see citing works
Insulin enhances vascular endothelial growth factor, interleukin-8, and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes
Fain, J. N., & Madan, A. K. (2005) · Metabolism · doi:10.1016/j.metabol.2004.08.016 · Cited by 41 · see citing works
Contribution of CB1 blockade to the management of high-risk abdominal obesity
Despres, J., Lemieux, I., & Alméras, N. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803278 · Cited by 41 · see citing works
The endocrine role of adipose tissue: focus on adiponectin and resistin
Jackson, M. B., Osei, S. Y., & Ahima, R. S. (2005) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000159113.87201.e8 · Cited by 20 · see citing works
Glucose transport is equally sensitive to insulin stimulation, but basal and insulin-stimulated transport is higher, in human omental compared with subcutaneous adipocytes
Westergren, H., Danielsson, A., Nyström, F. H., & Strålfors, P. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.021 · Cited by 18 · see citing works

Flagged first, then by citations

2 of the 100 references couldn’t be matched to a known paper.

Sorted by citations

Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101 · see citing works
“Intra-abdominal (visceral) depots are associated with T2D and cardiovascular disease while subcutaneous depots seem protective against these diseases [99].”
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
“expression of multiple genes, and response to insulin, catecholamines, sex hormones and cortisol((51)).”
Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice
Cho, A.-S., Jeon, S.-M., Kim, M., Yeo, J., Seo, K., Choi, M., & Lee, M. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.003 · Cited by 787 · see citing works
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome
Kahn, C. R., Wang, G., & Lee, K. Y. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129187 · Cited by 656 · see citing works
“Consistent with this, subcutaneous preadipocytes have increased rates of proliferation and lipid accumulation (20, 21), whereas visceral adipocytes have increased rates of lipolysis and increased susceptibility to apoptosis (22, 23).”
Background
Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction
Xu, Y., Nedungadi, T. P., Zhu, L., Sobhani, N., Irani, B. G., Davis, K. E., Zhang, X., Zou, F., Gent, L. M., Hahner, L. D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.009 · Cited by 597 · see citing works
“Given that increased visceral fat is commonly associated with impaired glucose homeostasis (Lafontan and Girard, 2008), we performed glucose tolerance tests and found that ERa/ SF1-Cre females were glucose intolerant (Figure 2L).”
Background
Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?
Bhatia, L. S., Curzen, N. P., Calder, P. C., & Byrne, C. D. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr453 · Cited by 497 · see citing works
Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
Mueller, M., Thorell, A., Claudel, T., Jha, P., Köfeler, H. C., Lackner, C., Hoesel, B., Fauler, G., Stojaković, T., Einarsson, C., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.12.034 · Cited by 314 · see citing works
Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots
Macotela, Y., Emanuelli, B., Mori, M. A., Gesta, S., Schulz, T. J., Tseng, Y., & Kahn, C. R. (2012) · Diabetes · doi:10.2337/db11-1753 · Cited by 300 · see citing works
Interplay Between Human Adipocytes and T Lymphocytes in Obesity
Duffaut, C., Zakaroff‐Girard, A., Bourlier, V., Decaunes, P., Maumus, M., Chiotasso, P., Sengenès, C., Lafontan, M., Galitzky, J., & Bouloumié, A. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.192583 · Cited by 232 · see citing works
Self-citation
Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice
Zhong, W. H., Zhao, Y., Tang, Y., Wei, X., Shi, X., Sun, W., Sun, X., Yin, X., Sun, X., Kim, S., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.017 · Cited by 226 · see citing works
Surgical Removal of Omental Fat Does Not Improve Insulin Sensitivity and Cardiovascular Risk Factors in Obese Adults
Fabbrini, E., Tamboli, R. A., Magkos, F., Marks–Shulman, P. A., Eckhauser, A. W., Richards, W. O., Klein, S., & Abumrad, N. N. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.056 · Cited by 207 · see citing works
Heme Oxygenase-1 Induction Remodels Adipose Tissue and Improves Insulin Sensitivity in Obesity-Induced Diabetic Rats
Nicolai, A., Li, M., Kim, D. H., Peterson, S. J., Vanella, L., Positano, V., Gastaldelli, A., Rezzani, R., Rodella, L. F., Drummond, G., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.124701 · Cited by 170 · see citing works
Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice
Jin, S.-S., Chang, C., Zhang, L., Liu, Y., Huang, X.-R., & Chen, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120842 · Cited by 141 · see citing works
“As we all know the increase in visceral adipose tissue is closely related to diabetes, lipid metabolism disorders and hypertension but negatively correlated with adiponectin secretion [26].”
Background
Omental adipose tissue fibrosis and insulin resistance in severe obesity
Guglielmi, V., Cardellini, M., Cinti, F., Corgosinho, F. C., Cardolini, I., D’Adamo, M., Zingaretti, M. C., Bellia, A., Lauro, D., Gentileschi, P., et al. (2015) · Nutrition and Diabetes · doi:10.1038/nutd.2015.22 · Cited by 122 · see citing works
Is adipose tissue metabolically different at different sites?
Gil, Á., Olza, J., Gil‐Campos, M., Gómez‐Llorente, C., & Aguilera, C. M. (2011) · International Journal of Pediatric Obesity · doi:10.3109/17477166.2011.604326 · Cited by 114 · see citing works
Perspective: Does brown fat protect against diseases of aging?
Mattson, M. P. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.11.004 · Cited by 112 · see citing works
“Most body fat is white/yellow in color, is concentrated in the abdomen and subcutaneous regions, and serves the function of storing energy in the form of fatty acids which can be mobilized under conditions where dietary energy intake and liver glycogen levels are low (Lafontan and Girard, 2008).”
Background
Prevention of Diet-Induced Hyperlipidemia and Obesity by Caffeic Acid in C57BL/6 Mice through Regulation of Hepatic Lipogenesis Gene Expression
Liao, C., Ou, T., Wu, C., & Wang, C. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4026647 · Cited by 104 · see citing works
Deciphering White Adipose Tissue Heterogeneity
Luong, Q. V., Huang, J. R., & Lee, K. Y. (2019) · Biology · doi:10.3390/biology8020023 · Cited by 102 · see citing works
Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans
Huang, C., Chien, Y.-S., Chen, Y.-J., Ajuwon, K. M., Mersmann, H. J., & Ding, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101689 · Cited by 101 · see citing works
Nutrition, the visceral immune system, and the evolutionary origins of pathogenic obesity
West‐Eberhard, M. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809046116 · Cited by 101 · see citing works
Structural and inflammatory heterogeneity in subcutaneous adipose tissue: Relation with liver histopathology in morbid obesity
Tordjman, J., Divoux, A., Prifti, E., Poitou, C., Pelloux, V., Hugol, D., Basdevant, A., Bouillot, J., Chevallier, J., Bédossa, P., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.015 · Cited by 96 · see citing works
“Through the release of pro-inflammatory mediators, macrophages might account, at least in part, for the association between increased VAT mass and co-morbidities associated with central obesity [1].”
Background
In Vivo Adeno-Associated Viral Vector–Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice
Jiménez, V., MUÑOZ, S. A., Casana, E., Mallol, C., Elias, I., Jambrina, C., Ribera, A., Ferré, T., Franckhauser, S., & Bosch, F. (2013) · Diabetes · doi:10.2337/db13-0311 · Cited by 87 · see citing works
“Distinct WAT depots are not equivalent, because developmental, morphological, molecular, and functional differences among them have been reported for mice and humans (44,45).”
Background
Visceral adipose tissue mass in nonlactating dairy cows fed diets differing in energy density1
Drackley, J. K., Wallace, R. L., Graugnard, D. E., Vasquez, J. A., Richards, B. F., & Loor, J. J. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-8014 · Cited by 86 · see citing works
“Differences in gene expression may contribute to differences in physiological function among depots, such as the greater catecholamine-stimulated lipolysis in visceral adipocytes compared with external adipocytes of humans and rodents (Van Harmelen et al., 1997; Lafontan and Girard, 2008).”
Background
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration
Gesta, S., Bézy, O., Mori, M. A., Macotela, Y., Lee, K. Y., & Kahn, C. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019704108 · Cited by 83 · see citing works
Adipogenesis: A Necessary but Harmful Strategy
Hafidi, M. E., Buelna‐Chontal, M., Sánchez‐Muñoz, F., & Carbó, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153657 · Cited by 80 · see citing works
Activation of peroxisome proliferator-activated receptor-γ by rosiglitazone improves lipid homeostasis at the adipose tissue-liver axis in ethanol-fed mice
Sun, X., Tang, Y., Tan, X., Li, Q., Zhong, W., Sun, X., Jia, W. P., McClain, C. J., & Zhou, Z. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00342.2011 · Cited by 81 · see citing works
“Disorder in adipose fat storage function may cause excess fatty acid influx into the liver, leading to steatosis (8, 23, 42).”
Background
Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels
Rydén, M., & Arner, P. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309759 · Cited by 75 · see citing works
An Atypical Form of Diabetes Among Individuals With Low BMI
Lontchi‐Yimagou, E., Dasgupta, R., Shajith Anoop, S., Kehlenbrink, S., Koppaka, S., Goyal, A., Venkatesan, P., Livingstone, R. S., Ye, K. Q., Chapla, A., et al. (2022) · Diabetes Care · doi:10.2337/dc21-1957 · Cited by 73 · see citing works
“A striking feature described in these studies is the complete absence of ketosis or ketonuria (44), which has been attributed to delayed mobilization of FFAs from adipose tissue and suppressed postprandial glucagon regardless of peripheral insulinopenia (45).”
Background
The Impact of Adipose Tissue on Insulin Resistance in Acromegaly
Olarescu, N. C., & Bollerslev, J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.02.005 · Cited by 72 · see citing works
“Second, VAT produces more proinflammatory cytokines and less anti-inflammatory adiponectin, thus contributing to systemic low-grade inflammation [33].”
Background
Sesamol ameliorates diet‐induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3‐L1 cells via regulating mitochondria‐lipid metabolism
Liu, Z., Qiao, Q., Sun, Y., Chen, Y., Ren, B., & Liu, X. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600717 · Cited by 70 · see citing works
Adipose tissue inflammation and liver pathology in human obesity
Tordjman, J., Guerre-Millo, M., & Clément, K. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)74601-9 · Cited by 69 · see citing works
“phase of infl ammation (IL-6, plasminogen activator inhibitor-1), haptoglobin, serum amyloid A (SAA), chemokines (monocyte chemoattractant proteins; MCP-1, -3, -4), angiopoietins, metallothioneins, macrophage infl ammatory protein-1α (MIP-1α), complement factors and retinol-binding protein-4 (RBP4) [16-19].”
BackgroundInfluential
Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue
Zhao, W., Li, A., Feng, X., Hou, T., Liu, K., Liu, B., & Zhang, N. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.06.018 · Cited by 68 · see citing works
Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data
Kim, M. T., Huang, R., Sedykh, A., Wang, W., Xia, M., & Zhu, H. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509763 · Cited by 67 · see citing works
“Adipose tissue, in particular visceral adipose tissue, releases fatty acids directly into the liver via the hepatic portal vein (Lafontan and Girard 2008).”
Background
Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans.
Lefebvre, B., Benomar, Y., Guédin, A., Langlois, A., Hennuyer, N., Dumont, J., Bouchaert, E., Dacquet, C., Pénicaud, L., Casteilla, L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38606 · Cited by 56 · see citing works
“Indeed, while subcutaneous WAT (scWAT) is predominantly, but not exclusively, a lipid storage tissue exhibiting a high adipocyte plasticity, visWAT also triggers complex endocrine regulations by releasing free fatty acids (FFA), hormones and cytokines which reach the liver through the portal vein [reviewed in (4)].”
Mapping body fat distribution: A key step towards the identification of the vulnerable patient?
Arsenault, B. J., Pelletier-Beaumont, É., Després, J., & Larose, É. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.605387 · Cited by 56 · see citing works
MR Imaging Evaluation of Cardiovascular Risk in Metabolic Syndrome
van der Meer, R. W., Lamb, H. J., Smit, J. W. A., & Roos, A. (2012) · Radiology · doi:10.1148/radiol.12110772 · Cited by 57 · see citing works
DPP4Gene DNA Methylation in the Omentum is Associated With Its Gene Expression and Plasma Lipid Profile in Severe Obesity
Turcot, V., Bouchard, L., Faucher, G., Tchernof, A., Deshaies, Y., Përusse, L., Bélisle, A., Marceau, S., Biron, S., Lescelleur, O., et al. (2010) · Obesity · doi:10.1038/oby.2010.198 · Cited by 54 · see citing works
Association of lung function measurements and visceral fat in men with metabolic syndrome
Thijs, W., Dehnavi, R. A., Hiemstra, P. S., Roos, A., Melissant, C. F., Janssen, K., Tamsma, J. T., & Rabe, K. F. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.10.003 · Cited by 50 · see citing works
Effect of alcohol on adipose tissue: a review on ethanol mediated adipose tissue injury
Kema, V. H., Mojerla, N. R., Khan, I., & Mandal, P. (2015) · Adipocyte · doi:10.1080/21623945.2015.1017170 · Cited by 49 · see citing works
Link between Adipose Tissue Angiogenesis and Fat Accumulation in Severely Obese Subjects
Lemoine, A. Y., Ledoux, S., Quéguiner, I., Caldérari, S., Mechler, C., Msika, S., Corvol, P. L., & Larger, É. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2649 · Cited by 47 · see citing works
Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins
da Silva, I. V., Rodrigues, J. S., Rebelo, I., Miranda, J., & Soveral, G. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2781-4 · Cited by 42 · see citing works
Polysaccharides from Cyclocarya paliurus: Chemical composition and lipid-lowering effect on rats challenged with high-fat diet
Hu, W.-B., Zhao, J., Chen, H., Xiong, L., & Wang, W. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.07.020 · Cited by 46 · see citing works
Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances
Guénard, F., Tchernof, A., Deshaies, Y., Përusse, L., Biron, S., Lescelleur, O., Biertho, L. D., Marceau, S., & Vohl, M. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00160.2013 · Cited by 45 · see citing works
The hepatoprotective effect of aqueous extracts of Penthorum chinense Pursh against acute alcohol-induced liver injury is associated with ameliorating hepatic steatosis and reducing oxidative stress
Cao, Y., Jiang, Y., Zhang, D.-Y., Zhang, X., Yuanjia, H., Li, P., Su, H., & Wan, J. (2015) · Food & Function · doi:10.1039/c5fo00098j · Cited by 45 · see citing works
Estrogens Prevent Metabolic Dysfunctions Induced by Circadian Disruptions in Female Mice
Zhu, L., Zou, F., Yang, Y., Xu, P., Saito, K., Hinton, A. O., Jr., Yan, X., Ding, H., Wu, Q., Fukuda, M., et al. (2015) · Endocrinology · doi:10.1210/en.2014-1922 · Cited by 44 · see citing works
“Given that increased visceral fat is commonly associated with insulin resistance and glucose intolerance (36), one possibility is that insulin/glucose phenotypes observed in JL OVX V mice may be attributed to the increased visceral fat accumulation.”
Background
Preparation and characterization of soybean insoluble dietary fiber and its prebiotic effect on dyslipidemia and hepatic steatosis in high fat-fed C57BL/6J mice
Wang, S., Sun, W., Swallah, M. S., Amin, K., Lyu, B., Fan, H., Zhang, Z., & Yu, H. (2021) · Food & Function · doi:10.1039/d1fo01050f · Cited by 42 · see citing works
Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications
Burgess, A., Vanella, L., Bellner, L., Schwartzman, M. L., & Abraham, N. G. (2011) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2011.10.002 · Cited by 41 · see citing works
“Additionally, subcutaneous fat tissue which is considered a more healthy fat tissue differs from visceral adipose tissue in three main ways (1) expression of specific receptors; (2) secretion of a specific adipokine pattern; and (3) location [136–138].”
Background
Characteristics of Abdominal Visceral Adipose Tissue, Metabolic Health and the Gut Microbiome in Adults
U-Din, M., Ahmed, B. A., Syed, S. A., Ong, F. J., Oreskovich, S. M., Gunn, E., Surette, M. G., Punthakee, Z., Steinberg, G. R., & Morrison, K. M. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad604 · Cited by 37 · see citing works
Reduction in Inflammatory Gene Expression in Skeletal Muscle from Roux-en-Y Gastric Bypass Patients Randomized to Omentectomy
Tamboli, R. A., Hajri, T., Jiang, A., Marks–Shulman, P. A., Williams, D. B., Clements, R. H., Melvin, W. V., Bowen, B. P., Shyr, Y., Abumrad, N. N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028577 · Cited by 37 · see citing works
“Expanded visceral fat, as opposed to subcutaneous fat, is more strongly associated with insulin resistance and various comorbidities, especially cardiovascular disease, hypertension and hyperlipidemia [6,7,8,9,10]; it is also considered an important source of systemic free fatty acid (FFA) overload and inflammation du…”
Background
Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study
Kang, M., Lee, A., Yoo, H. J., Kim, M., Kim, M., Shin, D. Y., & Lee, J. H. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0642-z · Cited by 37 · see citing works
“These features are similar to those that can be observed in individuals with excess visceral fat area [18, 19].”
Background
The longitudinal association between changes in lung function and changes in abdominal visceral obesity in Korean non-smokers
Choe, E. K., Kang, H. Y., Lee, Y., Choi, S. H., Kim, H. J., & Kim, J. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193516 · Cited by 37 · see citing works
Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole
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The newly proposed Metabolic Score for Visceral Fat is a reliable tool for identifying non-alcoholic fatty liver disease, requiring attention to age-specific effects in both sexes
Kuang, M., Qiu, J., Li, D., Hu, C., Zhang, S., Sheng, G., & Zou, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1281524 · Cited by 31 · see citing works
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Intestinal and Hepatic Cholesterol Carriers in Diabetic Psammomys obesus
Levy, E. H., Lalonde, G., DELVIN, E. E., Elchebly, M., Précourt, L. P., Seidah, N. G., Spahis, S., RABASA-LHORET, R. P. R., & Ziv, E. (2010) · Endocrinology · doi:10.1210/en.2009-0866 · Cited by 30 · see citing works
“In the context of obesity, inflammatory adipokines directly target the liver through the portal vein (58) and bring out the pathogenesis of obesity-related disorders, including derangements in CHOL homeostasis (59–61).”
Background
The lipidomic and inflammatory profiles of visceral and subcutaneous adipose tissues are distinctly regulated by the SGLT2 inhibitor empagliflozin in Zucker diabetic fatty rats
Aragón‐Herrera, A., Moraña‐Fernández, S., Otero-Santiago, M., Anido‐Varela, L., Campos‐Toimil, M., García‐Seara, J., Roman, A. V., Seijas‐Amigo, J., García‐Caballero, L., Rodríguez, J., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114535 · Cited by 27 · see citing works
The role of obesity on chronic kidney disease development, progression, and cardiovascular complications
Than, W. H., Chan, G. C., Ng, J. K., & Szeto, C. (2020) · Advances in Biomarker Sciences and Technology · doi:10.1016/j.abst.2020.09.001 · Cited by 24 · see citing works
The metabolic and neuroinflammatory changes induced by consuming a cafeteria diet are age-dependent
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Type 2 Innate Lymphoid Cells: Protectors in Type 2 Diabetes
Painter, J. D., & Akbari, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.727008 · Cited by 20 · see citing works
Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice
Lin, Y., Pan, Y., Jiang, T., Chen, Y., Shang, T., Xu, M., Feng, H.-B., Ma, Y., Tan, Y., Wang, H., et al. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01124-y · Cited by 19 · see citing works
“Consistent with this, previous studies have showed that visceral adipocytes have enhanced lipolysis rate and susceptibility to cell apoptosis [73], while sub-cutaneous preadipocytes have enhanced lipid accumulation and proliferation rate [74].”
DNA 5-Hydroxymethylation in Human Adipose Tissue Differs Between Subcutaneous and Visceral Adipose Tissue Depots
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Protective Effects of Korean Red Ginseng against Alcohol-Induced Fatty Liver in Rats
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Herring Milt and Herring Milt Protein Hydrolysate Are Equally Effective in Improving Insulin Sensitivity and Pancreatic Beta-Cell Function in Diet-Induced Obese- and Insulin-Resistant Mice
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Herring Milt Protein Hydrolysate Improves Insulin Resistance in High-Fat-Diet-Induced Obese Male C57BL/6J Mice
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The cholecystokinin receptor agonist, CCK‐8, induces adiponectin production in rat white adipose tissue
Plaza, A., Merino, B., Olmo, N. D., & Ruiz‐Gayo, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14690 · Cited by 17 · see citing works
“This topic has been reviewed by Lafontan and Girard (2008).”
Background
Intrahepatic lipid content is linked to insulin resistance in obese subjects
Sada, Y., Katabami, T., Asai, S., Sato, T., Furukawa, K., Ishii, S., Kato, H., KOBAYASHI, H., Kondo, A., Ohta, A., et al. (2011) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2010.12.007 · Cited by 16 · see citing works
Procyanidins target mesenteric adipose tissue in Wistar lean rats and subcutaneous adipose tissue in Zucker obese rat
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Evaluation of Visceral Fat in Massive Obesity
Vatier, C., Poitou, C., & Clément, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407869-7.00006-4 · Cited by 16 · see citing works
Interplay between Heart Disease and Metabolic Steatosis: A Contemporary Perspective
Ramadan, M. S., Russo, V., Nigro, G., Durante‐Mangoni, E., & Zampino, R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081569 · Cited by 14 · see citing works
“It also generates and interacts with various inflammatory hormones/cytokines secreted from places like visceral adipose tissue, macrophages, and endothelial cells, which are associated with CVD initiation and progression [109,110].”
Background
Visceral Adiposity, Insulin Resistance, and Type 2 Diabetes
Griffith, M. L., Younk, L. M., & Davis, S. N. (2010) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609360959 · Cited by 14 · see citing works
“VAT comprises 10% to 20% of total body fat in men and 5% to 10% of total body fat in women and primarily consists of omental and mesenteric fat depots.(30) Growing evidence suggests that increased amounts of abdominal VAT may pose an increased risk of cardiometabolic disease compared with SCAT.”
Background
Chronic low-grade inflammation
Margioris, A. N., Dermitzaki, E., Venihaki, M., & Tsatsanis, C. (2013) · Elsevier eBooks · doi:10.1533/9780857095749.1.105 · Cited by 13 · see citing works
Increasing serum pre-adipocyte factor-1 (Pref-1) correlates with decreased body fat, increased free fatty acids, and level of recent alcohol consumption in excessive alcohol drinkers
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“Decreasing body fat and its storage in adipose tissue may cause excess fatty acid influx into the liver, leading to hepatic steatosis (Cusi, 2010; Lafontan & Girard, 2008; Wree, Kahraman, Gerken, & Canbay, 2011).”
Background
Associations Between Sensitivity to Thyroid Hormones and Visceral Adiposity in Euthyroid Adults
Wei, Y., Yang, M., Liu, J., Wang, Y., & Wang, G. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae806 · Cited by 11 · see citing works
White Adipose Tissue
Gesta, S., & Kahn, C. R. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_4 · Cited by 12 · see citing works
Perinephric and Epididymal Fat Affect Hepatic Metabolism in Rats
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F4/80hiCCR2hi macrophage infiltration into the intra-abdominal fat worsens the severity of experimental IBD in obese mice with DSS colitis
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DUSP1Gene Polymorphisms Are Associated with Obesity-Related Metabolic Complications among Severely Obese Patients and Impact on Gene Methylation and Expression
Guénard, F., Bouchard, L., Tchernof, A., Deshaies, Y., Hould, F. S., Lebel, S., Marceau, P., Përusse, L., & Vohl, M. (2013) · International Journal of Genomics · doi:10.1155/2013/609748 · Cited by 11 · see citing works
“Excess accumulation of fat inside the abdominal cavity (visceral adipose tissue: VAT) is associated with altered insulin sensitivity, bloodpressure (BP), andplasma lipid profile [3, 4].”
Background
Decreased levels and activity of Sirt1 are modulated by increased miR-34a expression in adipose tissue mononuclear cells from subjects with overweight and obesity: A pilot study
Briones-Espinoza, M., Cortés-García, J. D., Vega‐Cárdenas, M., Uresti‐Rivera, E. E., Gómez-Otero, A., López‐López, N., Mejía-Torres, M., & Portales‐Pérez, D. P. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.07.014 · Cited by 11 · see citing works
Er-Miao-Fang Extracts Inhibits Adipose Lipolysis and Reduces Hepatic Gluconeogenesis via Suppression of Inflammation
Zhao, W., Feng, X., Liu, B., Xian, J.-C., & Zhang, N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01041 · Cited by 8 · see citing works
Adipose Tissue Inflammation and Metabolic Disorders
Henriques, F. D. S., Bedard, A. H., & Júnior, M. L. B. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88631 · Cited by 8 · see citing works
Comparison of the Lipid Composition of Three Adipose Tissue Types of Male and Female Wild Nile Crocodiles (Crocodylus niloticus)
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“In general, the adipose fats of different body compartments of mammals differ in fatty acid composition (Lafontan and Girard, 2008).”
Background
Evaluating the effect of diallyl sulfide on regulation of inflammatory mRNA expression in 3T3L1 adipocytes and RAW 264.7 macrophages during ethanol treatment
Kema, V. H., Khan, I., Kapur, S., & Mandal, P. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2017.1405969 · Cited by 7 · see citing works
“Also, chronic ethanol feeding has been shown to increase the production and activity of the CYP2E1 enzyme in adipose tissue (Lafontan and Girard 2008, Song et al. 2008).”
Background
Impaired metabolic and hepatic functions following subcutaneous lipectomy in adult obese rats
El-Kafoury, B. M. A., Bahgat, N. M., Abdel‐Hady, E. A., Samad, A. A. A. E., Shawky, M., & Mohamed, F. A. (2019) · Experimental Physiology · doi:10.1113/ep087670 · Cited by 7 · see citing works
“…Chen, Reitman, & Shulman, 2000), and also that VAT, which contains a large number of inflammatory and immune cells, drains its metabolites and its secretions through the portal system to the liver where they interact with hepatocytes and affecting their functions (Lafontan & Girard, 2008).”
Background
White Adipose Tissue
Gesta, S., & Kahn, C. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-52031-5_5 · Cited by 7 · see citing works
Effect of one session of aerobic exercise associated with abdominal laser therapy in lipolytic activity, lipid profile, and inflammatory markers
Barbosa, P. F. T., Coimbra, C., Noites, A., Vilarinho, R., Carvalho, P. J., Amorim, M., Moreira, T., & de Melo, C. A. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13781 · Cited by 6 · see citing works
Comparative three-dimensional genome architectures of adipose tissues provide insight into human-specific regulation of metabolic homeostasis
Liu, P., Li, D., Zhang, J., He, M., Gao, D., Wang, Y., Lin, Y., Pan, D., Li, P., Wang, T., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104757 · Cited by 5 · see citing works
“The human VAT drains into the portal vein, therefore the free fatty acids and adipokines released from them can be delivered to the liver and influence liver metabolism (8).”
Background
Short-Term Effects of Early Menopause on Adiposity, Fatty Acids Profile and Insulin Sensitivity of a Swine Model of Female Obesity
Heras-Molina, A., Pacheco, J. L. P., Vázquez-Gómez, M., García-Contreras, C., Astiz, S., Isabel, B., & Gonzalez‐Bulnes, A. (2020) · Biology · doi:10.3390/biology9090284 · Cited by 5 · see citing works
Circulating Plasma Free Fatty Acids, Insulin Resistance and Metabolic Markers in Obese Women
Zaki, M. E., Hussein, J., Ibrahim, A. M. M., & Youness, E. R. (2020) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2034 · Cited by 5 · see citing works
Liver Fat Storage Is a Better Predictor of Coronary Artery Disease than Visceral Fat
Basheer, M., Saad, E., Jeries, H., & Assy, N. (2023) · Metabolites · doi:10.3390/metabo13080896 · Cited by 5 · see citing works
“In fasting states, lipolysis performed in adipose tissue results in the release of nonesterified fatty acids [41].”
Background
The Heterogeneity of White Adipose Tissue
Luong, Q. V., & Lee, K. Y. (2018) · InTech eBooks · doi:10.5772/intechopen.76898 · Cited by 4 · see citing works
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FDA regulation of adipose cell use in clinical trials and clinical translation
Chirba, M. A., Jones, V. M., Simon, P., & Katz, A. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819376-1.00003-2 · Cited by 4 · see citing works
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Adipose tissue distribution in metabolic disease: depot-specific biology, clinical assessment, and therapeutic remodeling
Liuli, A., Zhang, T., & Feng, Z. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1822659 · Cited by 3 · see citing works
Les actions physiologiques de l’insuline
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Self-citation
Role of -675 4G/5G in the Plasminogen Activator Inhibitor-1 Gene and -308G/A Tumor Necrosis Factor-α Gene Polymorphisms in Obese Argentinean Patients
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“Adipose tissue actively participates in hormonal and inflammatory systems (Lafontan and Girard, 2008; Gustafson 2010).”

Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism
Girard, J. R., & Lafontan, M. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.04.002 · Cited by 79 · see citing works
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Authors: Lafontan, M., & Girard, J.
Affiliations: Université Toulouse III - Paul Sabatier (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Lafontan, M.
Venue: Diabetes & Metabolism
Publisher: Elsevier BV
Published: 2008-09
Volume: 34
Issue: 4
Pages: 317-327
ISSN: 1262-3636 (ISSN-L)
DOI: 10.1016/j.diabet.2008.04.001
OpenAlex: W1980825557
Cited by: 143
References: 100
Citations by year: 2026: 6 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 12
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Diabetes & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords: visceral adipose tissue, hepatic metabolism, free fatty acid metabolism, cytokines, adipokines, portal vein, subcutaneous adipose tissue, glucose homeostasis, hypertriglyceridemia, low HDL cholesterol, type 2 diabetes, cardiovascular risk, hepatocytes
MeSH terms: Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Humans, Insulin Resistance, Liver, Male, Obesity, Adipocytes, Glucose Intolerance, Intra-Abdominal Fat, Abdominal Fat, Subcutaneous Fat, Abdominal, Adipokines

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Impact of visceral adipose tissue on liver metabolism

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