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Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a Decrease in Bone Mass
Abstract
Little is known about the effects on the skeleton of laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity and subsequent weight loss. We compared 25 patients who had undergone LRGB 11 ± 3 months previously with 30 obese controls matched for age, gender, and menopausal status. Compared with obese controls, patients post LRGB had significantly lower weight (92 ± 16 vs. 133 ± 20 kg; P < 0.001) and body mass index (31 ± 5 vs. 48 ± 7 kg/m2; P < 0.001). Markers of bone turnover were significantly elevated in patients post LRGB compared with controls (urinary N-telopeptide cross-linked collagen type 1, 93 ± 38 vs. 24 ± 11 nmol bone collagen equivalents per mmol creatinine; and osteocalcin, 11.6 ± 3.4 vs. 7.6 ± 3.6 ng/ml; both P < 0.001). Fifteen patients were studied prospectively for an average of 9 months after LRGB. They lost 37 ± 9 kg and had a 29 ± 8% fall in body mass index (both P < 0.001). Urinary N-telopeptide cross-linked collagen type 1 increased by 174 ± 168% at 3 months (P < 0.01) and 319 ± 187% at 9 months (P < 0.01). Bone mineral density decreased significantly at the total hip (7.8 ± 4.8%; P < 0.001), trochanter (9.3 ± 5.7%; P < 0.001), and total body (1.6 ± 2.0%; P < 0.05), with significant decreases in bone mineral content at these sites. In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term.
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“Vitamin D deficiency is widespread9, 10”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [10]
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Cites
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,827
Pories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00011 · Cited by 2,293
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
Evidence for alteration of the vitamin D-endocrine system in obese subjects.
Bell, N. H., Epstein, S., Greene, A. S., Shary, J., Oexmann, M. J., & Shaw, S. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111971 · Cited by 685
Prentice, A., Parsons, T., & Cole, T. J. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.6.837 · Cited by 578
Bariatric surgery and long-term control of morbid obesity
Brolin, R. E. (2002) · JAMA · doi:10.1001/jama.288.22.2793 · Cited by 474
Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans
Holdstock, C., Engström, B. E., Öhrvall, M., Lind, L., Sundbom, M., & Karlsson, F. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021734 · Cited by 318
Pi-Sunyer, F. X. (1996) · Clinical Therapeutics · doi:10.1016/s0149-2918(96)80057-9 · Cited by 224
National Trends in Utilization and In-Hospital Outcomes of Bariatric Surgery
Pope, G. D., Birkmeyer, J. D., & Finlayson, S. R. G. (2002) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(02)00085-9 · Cited by 204
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Bone Loss in Adolescents After Bariatric Surgery
Kaulfers, A.-M. D., Bean, J. A., Inge, T. H., Dolan, L. M., & Kalkwarf, H. J. (2011) · PEDIATRICS · doi:10.1542/peds.2010-0785 · Cited by 77
Alterations in Gastrointestinal Physiology after Roux-En-Y Gastric Bypass
Ponsky, T. A., Brody, F. J., & Pucci, E. (2005) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2005.03.021 · Cited by 75
Gil, S., Kirwan, J. P., Murai, I. H., Dantas, W. S., Merege‐Filho, C. A. A., Ghosh, S., Shinjo, S. K., Pereira, R. M. R., Teodoro, W. R., Felau, S. M., et al. (2021) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12815 · Cited by 72
Vitamin D absorption: consequences of gastric bypass surgery
Aarts, E. O., van Groningen, L. F. J., Horst, R. L., Telting, D., van Sorge, A., Janssen, I. M. C., & de Boer, H. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-1126 · Cited by 72
Inge, T. H., Zeller, M. H., Lawson, M. L., & Daniels, S. R. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2005.03.021 · Cited by 71
Karefylakis, C., Näslund, I., Edholm, D., Sundbom, M., Karlsson, F. A., & Rask, E. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1104-y · Cited by 71
“The current literature suggests that vitamin D deficiency and secondary hyperparathyroidism are common even after RYGB [1, 11, 13, 22].”
BackgroundDigiorgi, M. F., Daud, A., Inabnet, W. B., Schrope, B., Urban‐Skuro, M., Restuccia, N. L., & Bessler, M. (2008) · Obesity Surgery · doi:10.1007/s11695-007-9408-4 · Cited by 70
Ahlin, S., Peltonen, M., Sjöholm, K., Anveden, Å., Jacobson, P., Andersson‐Assarsson, J. C., Taube, M., Larsson, I., Lohmander, S. L., Näslund, I., et al. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13020 · Cited by 72
Effect of gastric bypass surgery on vitamin D nutritional status
Carlin, A. M., Rao, D. S., Yager, K. M., Genaw, J. A., Parikh, N. J., & Szymanski, W. (2006) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2006.09.003 · Cited by 69
Bone marrow fat changes after gastric bypass surgery are associated with loss of bone mass
Kim, T. Y., Schwartz, A., Li, X.-J., Xu, K.-P., Black, D. M., Petrenko, D., Stewart, L., Rogers, S. J., Posselt, A., Carter, J. T., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3212 · Cited by 67
Thin bones: Vitamin D and calcium handling after bariatric surgery
Corbeels, K., Verlinden, L., Lannoo, M., Simoens, C., Matthys, C., Verstuyf, A., Meulemans, A., Carmeliet, G., & der Schueren, B. V. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.02.002 · Cited by 67
“For RYGB, numerous clinical studies showed major increases in bone resorption markers such as CTX and TRACP 5b, but only small increases in bone formation markers P1NP and OC (Obinwanne et al., 2014; Casagrande et al., 2012; Shanbhogue et al., 2017; Yu et al., 2015; Muschitz et al., 2015; Bredella et al., 2017; Elias…”
BackgroundGonnelli, S., Caffarelli, C., Santo, K. D., Cadirni, A., Guerriero, C., Lucani, B., Franci, B., & Nuti, R. (2008) · Calcified Tissue International · doi:10.1007/s00223-008-9149-y · Cited by 66
“In humans, after laparoscopic gastric bypass surgery for morbid obesity, a decrease in serum ghrelin levels and an increase in bone resorption, with a subsequent reduction in bone mass, have been detected [31].”
BackgroundPluskiewicz, W., Bužga, M., Holéczy, P., Bortlík, L., Šmajstrla, V., & Adamczyk, P. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0654-8 · Cited by 67
“Some authors presented weight loss after 6 months, and their results of 13 % [4] and 16 % [13, 25] were smaller than noted in the reported study.”
ResultRiedl, M., Vila, G., Maier, C., Handisurya, A., Shakeri-Manesch, S., Prager, G., Wagner, O. F., Kautzky‐Willer, A., Ludvik, B. H., Clodi, M., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2383 · Cited by 67
Stemmer, K., Bielohuby, M., Grayson, B. E., Begg, D. P., Chambers, A. P., Neff, C., Woods, S. C., Erben, R. G., Tschöp, M. H., Bidlingmaier, M., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2130 · Cited by 66
Wucher, H., Ciangura, C., Poitou, C., & Czernichow, S. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9258-0 · Cited by 62
“Contrary to what was found in these two studies [25, 27], others [ 24 , 26, 28, 29] did not mention secondary hyperparathyroidism or a decrease in serum calcium among their study population.”
BackgroundResultInfluentialVitamin D and intestinal calcium transport after bariatric surgery
Schafer, A. L. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.12.012 · Cited by 63
“Bone mineral density (BMD) decreases after RYGB, with one-year declines of 5% to 11% consistently reported at the proximal femur by dual-energy X-ray absorptiometry (DXA), and declines of 3% to 7% reported at the spine by DXA and quantitative computed tomography (QCT) in some—although not all—studies [11-15].”
Impact of marked weight loss induced by bariatric surgery on bone mineral density and remodeling
Pereira, F. A., Castro, J. A. S. D., Santos, J. E. D., Foss, M. C., & Paula, F. J. A. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2007000400009 · Cited by 61
Impact of marked weight loss induced by bariatric surgery on bone mineral density and remodeling
Pereira, F. A. C., de Castro, J. A. S., dos Santos, J. E., Foss, M. C., & de Paula, F. J. A. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006005000074 · Cited by 61
“calcium loss has been observed in other studies (9,12) and is probably due to limited absorption and/or ingestion of calcium.”
BackgroundResultTsiftsis, D. D. A., Mylonas, P., Mead, N., Kalfarentzos, F., & Alexandrides, T. K. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9938-z · Cited by 60
“Some studies report elevated baseline PTH levels [8, 24 , 25] while others do not confirm this finding [26, 27].”
BackgroundResultScibora, L. M. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12363 · Cited by 63
“Reduced ghrelin could explain bone loss, but ambiguities regarding the direction or magnitude of post-bariatric surgery ghrelin change [80] also exist in bone density studies [8].”
BackgroundElevated Serum Parathormone after Roux-en-Y Gastric Bypass
Diniz, M. D. F. H. S., Diniz, M. T. C., Sanches, S. R. D. A., Salgado, P. P. C. D. A., Valadão, M. M. A., Araújo, F. C., Martins, D. S., & Rocha, A. L. S. (2004) · Obesity Surgery · doi:10.1381/0960892042386959 · Cited by 59
Carences nutritionnelles liées à la chirurgie de l’obésité
Folope, V., Coëffier, M., & Déchelotte, P. (2007) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(07)89395-x · Cited by 57
“Des anomalies de la masse osseuse ont été décrites chez les malades ayant maigri suite à une chirurgie bariatrique, qu’il s’agisse de la pose d’un anneau gastrique [24], de la réalisation d’un bypass gastrique [65, 66], d’une dérivation biliopancréatique [67] ou d’une gastroplastie verticale [68].”
BackgroundCirurgia bariátrica: como e por que suplementar
Bordalo, L. A., Teixeira, T. F. S., Bressan, J., & Mourão, D. M. (2011) · Revista da Associação Médica Brasileira · doi:10.1590/s0104-42302011000100025 · Cited by 55
Bariatric Surgery for Type 2 Diabetes Reversal: The Risks
Keidar, A. (2011) · Diabetes Care · doi:10.2337/dc11-s254 · Cited by 57
“Iron deficiency is especially a problem because the majority of patients are menstruating women, in whom iron deficiency is more significant (42,43).”
BackgroundMetabolic bone changes after bariatric surgery
Kim, J. J., & Brethauer, S. A. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.03.010 · Cited by 54
“[35] Coates PS, Fernstrom JD, Fernstrom MH, et al.”
BackgroundUnderweight, Overweight, and Pediatric Bone Fragility: Impact and Management
Bialo, S. R., & Gordon, C. M. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0226-z · Cited by 53
Balsa, J. A., Botella-Carretero, J. I., Peromingo, R., Caballero, C., Muñoz-Malo, T., Villafruela, J. J., Arrieta, F., Zamarrón, I., & Vázquez, C. (2009) · Obesity Surgery · doi:10.1007/s11695-009-0028-z · Cited by 53
“Immediately after a bariatric surgery intervention, there is an increase in markers of bone turnover [5, 6 , 20, 21], which is not related to the levels of 25-hydroxyvitamin D and PTH [6].”
BackgroundInfluentialBen‐Porat, T., Elazary, R., Dagan, S. S., Goldenshluger, A., Brodie, R., Mintz, Y., & Weiss, R. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx024 · Cited by 54
“Studies on the effect of RYGB on bone indicated a significant reduction in BMD at several sites during the first postoperative year (87, 108–110), with an increase in bone turnover markers from 3 mo postoperatively (85, 108, 111, 112).”
BackgroundMahlay, N. F., Verka, L. G., Thomsen, K., Merugu, S., & Salomone, M. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9698-1 · Cited by 52
“Also, an increase in intraluminal fat and steatorrhea may further impair calcium absorption [4, 5]. Coates and colleagues [ 25 ] found evidence of bone resorption”
BackgroundHsin, M.-C., Huang, C., Tai, C., Yeh, L., Kuo, H., & Garg, A. K. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.07.008 · Cited by 52
“LRYGB, which involves both restrictive and malabsorptive procedures, has shown a 70% decrease in excess weight within 1 year, with a significant increase in the levels of markers of bone formation and resorption [4].”
BackgroundAfter bariatric surgery, what vitamins should be measured and what supplements should be given?
Pournaras, D. J., & le Roux, C. W. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03564.x · Cited by 50
Metabolic Bone Disease in the Bariatric Surgery Patient
Williams, S. E. I. (2010) · Journal of Obesity · doi:10.1155/2011/634614 · Cited by 50
Calcium Intake and Metabolic Bone Disease after Eight Years of Roux-en-Y Gastric Bypass
de Campos, C. D., Dalcanale, L., Pajecki, D., Junior, A. B. G., & Halpern, A. (2008) · Obesity Surgery · doi:10.1007/s11695-007-9393-7 · Cited by 48
“Some studies demonstrate low vitamin D and elevated PTH levels in patients after RYGBP [6, 20–23].”
BackgroundResultChanges in Bone Metabolism After Sleeve Gastrectomy Versus Gastric Bypass: a Meta-Analysis
Tian, Z., Fan, X.-T., Shizhen, L., Zhai, T., & Dong, J. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04119-5 · Cited by 49
“Several studies reported that the association between GB and bone loss was partly caused by malabsorption of calcium, phosphate, and vitamin D [52, 53].”
BackgroundIncidence of bone loss, falls, and fractures after Roux-en-Y gastric bypass for morbid obesity
Berarducci, A., Haines, K., & Murr, M. M. (2009) · Applied Nursing Research · doi:10.1016/j.apnr.2007.03.004 · Cited by 45
“Although previous studies had evaluated physiological changes in bone parameters after bariatric surgery (Coates et al., 2004; Guney et al., 2003; Pugnale et al., 2003; von Mach et al., 2004), no study has addressed functional risks for falls and fractures.”
BackgroundResultPerioperative management of bariatric surgery patients: Focus on metabolic bone disease
Williams, S. E. I., Cooper, K., Richmond, B. J., & Schauer, P. R. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.5.333 · Cited by 46
Self-citationBody composition and bone health in adolescents after Roux‐en‐Y gastric bypass for severe obesity
Beamish, A. J., Gronowitz, E., Olbers, T., Flodmark, C., Marcus, C., & Dahlgren, J. (2016) · Pediatric Obesity · doi:10.1111/ijpo.12134 · Cited by 48
“In adults, loss of bone mass and increased bone turnover after RYGB have been described for over a decade (13,14).”
BackgroundRaoof, M., Näslund, I., Rask, E., & Szabó, É. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2114-3 · Cited by 45
Short-term changes in bone and mineral metabolism following gastrectomy in gastric cancer patients
Baek, K. H., Jeon, H. M., Lee, S. S., Lim, D. J., Oh, K. W., Lee, W., Rhee, E., Han, J. H., Cha, B. Y., Lee, K. W., et al. (2007) · Bone · doi:10.1016/j.bone.2007.08.027 · Cited by 45
“8% at the total hip after 9 months following surgery [23], a result similar to this report.”
BackgroundResultMicronutrient deficiencies and bariatric surgery
Kushner, R. F. (2006) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000244220.53163.85 · Cited by 45
Balsa, J. A., Botella-Carretero, J. I., Peromingo, R., Zamarrón, I., Arrieta, F., Muñoz-Malo, T., & Vázquez, C. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03346429 · Cited by 44
Obesity, Bariatric Surgery, and Fractures
Lespessailles, É., Paccou, J., Javier, R., Thomas, T., & Cortet, B. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02084 · Cited by 44
Effect of ghrelin on bone mass density: The InChianti study
Napoli, N., Pedone, C., Pozzilli, P., Lauretani, F., Bandinelli, S., Ferrucci, L., & Incalzi, R. A. (2011) · Bone · doi:10.1016/j.bone.2011.03.772 · Cited by 43
“Similarly, obese patients receiving laparoscopic gastric bypass surgery have low serum Ghrelin levels that cause an increase in bone resorption and reduction in bone mass [34–36].”
BackgroundNutritional deficiencies after gastric bypass surgery.
John, S., & Hoegerl, C. (2009) · PubMed · Cited by 43
Three-month weight reduction does not compromise bone strength in obese premenopausal women
Uusi‐Rasi, K., Rauhio, A., Kannus, P., Pasanen, M. E., Kukkonen-Harjula, K. T., Fogelholm, M., & Sievänen, H. T. (2009) · Bone · doi:10.1016/j.bone.2009.10.013 · Cited by 42
“However, there is no consensus whether the changes in body weight would ensue changes in bone mass [5-9].”
BackgroundBone Health Following Bariatric Surgery: An Update
Saad, R. K., Habli, D., Sabbagh, R. E., & Chakhtoura, M. (2019) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2019.08.002 · Cited by 42
Nutritional and psychological considerations after bariatric surgery
SONG, A., & Fernstrom, M. H. (2008) · Aesthetic Surgery Journal · doi:10.1016/j.asj.2008.01.005 · Cited by 42
Self-citationMineral Metabolism in Obese Patients Following Vertical Banded Gastroplasty
Olmos, J. M., Vázquez, L. A., Amado, J., Hernández, J. L., & Macías, J. G. (2008) · Obesity Surgery · doi:10.1007/s11695-007-9307-8 · Cited by 41
Moreiro, J., Ruiz, O., Perez, G., Salinas, R., Urgeles, J. R., Riesco, M., & García-Sanz, M. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9063-9 · Cited by 40
Metabolic Management following Bariatric Surgery
Strohmayer, E., Via, M. A., & Yanagisawa, R. T. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20211 · Cited by 41
Follow-Up Strategy After Curative Resection of Gastric Cancer: A Nationwide Survey in Korea
Hur, H., Song, K. Y., Park, C. H., & Jeon, H. M. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0676-1 · Cited by 40
Pacifico, L., Anania, C., Poggiogalle, E., Osborn, J. F., Prossomariti, G., Martino, F., & Chiesa, C. (2009) · Bone · doi:10.1016/j.bone.2009.04.204 · Cited by 39
“Recent studies indicate that ghrelin is involved in the regulation of bone growth and metabolism [25–35].”
BackgroundVitamin D and Visceral Obesity in Humans: What Should Clinicians Know?
Shantavasinkul, P. C., & Nimitphong, H. (2022) · Nutrients · doi:10.3390/nu14153075 · Cited by 40
The Effects of Bariatric Surgery on Bone Metabolism
Gregory, N. S. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.09.011 · Cited by 38
Bariatric surgery for adolescents
Stefater, M., Jenkins, T. M., & Inge, T. H. (2012) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2012.00899.x · Cited by 37
Stenström, B., Furnes, M. W., Tømmerås, K. A., Syversen, U., Zhao, C., & Chen, D. (2006) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2006.07.005 · Cited by 36
Bariatric surgery in adolescents: an update.
Xanthakos, S. A., Daniels, S. R., & Inge, T. H. (2006) · PubMed · doi:10.1016/j.admecli.2006.06.001 · Cited by 35
“This possibility needs to be tracked in prospective long-term studies in adolescents and adults [84].”
Vitamin D Metabolism in Bariatric Surgery
Chakhtoura, M., Rahme, M., & Fuleihan, G. E. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.07.006 · Cited by 36
“Downlo tomography at the lumbar spine,(64) and ultrasonography measurements of the peripheral skeleton.(62)”
BackgroundIs Lean Body Mass Decreased after Obesity Treatment by Adjustable Gastric Banding?
Coupaye, M., Bouillot, J., Poitou, C., Schütz, Y., Basdevant, A., & Oppert, J. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9072-8 · Cited by 35
Mineral Metabolism and Bone Disease after Bariatric Surgery and Ways to Optimize Bone Health
Schweitzer, D. H. (2007) · Obesity Surgery · doi:10.1007/s11695-008-9431-0 · Cited by 35
Metabolic Consequences of Bariatric Surgery
Lynch, R., Eisenberg, D., & Bell, R. L. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200609000-00001 · Cited by 35
“Postoperative patients may have metabolic and radiographic evidence of increased bone resorption despite normal serum calcium, vitamin D, and parathyroid hormone levels.(46) Postmenopausal women who have undergone gastric bypass have been found to be at increased risk of developing secondary hyperparathyroidism and ac…”
BackgroundBariatric surgery: how and why to supplement
Bordalo, L. A., Teixeira, T. F. S., Bressan, J., & Mourão, D. M. (2011) · Revista da Associação Médica Brasileira (English Edition) · doi:10.1016/s2255-4823(11)70025-x · Cited by 34
Avgerinos, D. V., Leitman, I. M., Martinez, R. E., & Liao, P. E. (2007) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2007.02.078 · Cited by 34
Vitamin Deficiency After Gastric Bypass Surgery: A Review
Matrana, M. R., & Davis, W. E. (2009) · Southern Medical Journal · doi:10.1097/smj.0b013e3181b62614 · Cited by 32
The Skeletal Consequences of Bariatric Surgery
Krez, A. N., & Stein, E. M. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00579-2 · Cited by 35
Abbasi, A. A., Amin, M., Smiertka, J. K., Grunberger, G., MacPherson, B. H., Hares, M., Lutrzykowski, M., & Najar, A. (2007) · Endocrine Practice · doi:10.4158/ep.13.2.131 · Cited by 32
Canales, B. K., Schafer, A. L., Shoback, D., & Carpenter, T. O. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.01.021 · Cited by 31
“For instance, 3 small prospective bone mineral density (BMD) studies in RYGB patients reported femoral neck, spine, and hip BMD losses of 7–10% from baseline within the first year of RYGB [4–6].”
BackgroundAdamczyk, P., Bužga, M., Holéczy, P., Švagera, Z., Šmajstrla, V., Zonča, P., & Pluskiewicz, W. (2015) · International Journal of Surgery · doi:10.1016/j.ijsu.2015.09.048 · Cited by 30
“[2] W-16, M-9 LRGB Nine months 3.”
BackgroundInfluentialBeavers, K. M., Greene, K. A., & Yu, E. W.-Y. (2020) · European Journal of Endocrinology · doi:10.1530/eje-20-0548 · Cited by 30
Jensen, V. F. H., Mølck, A., Dalgaard, M., McGuigan, F. E., & Åkesson, K. (2020) · Bone · doi:10.1016/j.bone.2020.115781 · Cited by 33
Sakhaee, K., & Pak, C. Y. C. (2011) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2011.11.011 · Cited by 29
Bariatric Surgery for Adolescents with Type 2 Diabetes: an Emerging Therapeutic Strategy
Stefater, M. A., & Inge, T. H. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0887-y · Cited by 30
Bone Response to Weight Loss Following Bariatric Surgery
Mele, C., Caputo, M., Ferrero, A., Daffara, T., Cavigiolo, B., Spadaccini, D., Nardone, A., Prodam, F., Aimaretti, G., & Marzullo, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.921353 · Cited by 37
“At the lumbar spine, some authors did not observe significant variations in BMD at 6-12 month after RYGB (34, 129, 135), whereas others showed a significant reduction in BMD equivalent to -2 to -6% at 6 months and -3 to -7% at 9-12 months (33, 133, 134, 138).”
BackgroundNutritional Challenges and Treatment After Bariatric Surgery
Moize, V. L., Laferrère, B., & Shapses, S. A. (2024) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-061121-101547 · Cited by 33
“Deterioration progresses over time (26, 45, 158).”
Bariatric surgery in adolescents: what do we know so far?
Beamish, A. J., Johansson, S., & Olbers, T. (2014) · Scandinavian Journal of Surgery · doi:10.1177/1457496914553150 · Cited by 31
“there is objective evidence of reduced bone mineral density and bone mineral content within a year following gastric bypass surgery (61), requiring counseling, monitoring, and nutrient and mineral supplementation.”
BackgroundNeurologic Complications of Bariatric Surgery
Kumar, N. (2014) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000450967.76452.f2 · Cited by 28
“’’ Bone mineral density may be significantly decreased 3 to 9 months after Roux-en-Y gastric bypass.(50) Physiologic role of vitamin D.”
BackgroundUnrecognized and Unappreciated Secondary Causes of Osteoporosis
Miller, P. D. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.05.005 · Cited by 28
Breznikar, B., & Dinevski, D. (2009) · Journal of International Medical Research · doi:10.1177/147323000903700543 · Cited by 28
Correction of preoperative vitamin D deficiency after Roux-en-Y gastric bypass surgery
Nelson, M. L., Bolduc, L., Toder, M., Clough, D. M., & Sullivan, S. S. (2007) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2007.02.007 · Cited by 28
Time-Course Changes in Bone Turnover Markers and Fat-Soluble Vitamins After Obesity Surgery
Granado‐Lorencio, F., Simal-Antón, A., Mosteiro, J. S., Herrero-Barbudo, C., Donoso-Navarro, E., Blanco-Navarro, I., & Pérez-Sacristán, B. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0257-1 · Cited by 27
“Obesity is associated with a reduced risk of osteoporosis while, overall, bariatric surgery procedures are complicated by gastrointestinal complaints, bone resorption, and bone loss [5, 6].”
BackgroundBlood lead levels and bone turnover with weight reduction in women
Riedt, C. S., Buckley, B., Brolin, R. E., Ambia‐Sobhan, H., Rhoads, G. G., & Shapses, S. A. (2008) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2008.5 · Cited by 27
“, 2004), especially so in women who undergo severe weight loss due to surgery (Coates et al., 2004; Riedt et al., 2006).”
BackgroundInfluentialWakolbinger, M., Kruschitz, R., Langer, F. B., Prager, G., Walker, M., Marculescu, R., Hoppichler, F., Schindler, K., & Ludvik, B. H. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1492-7 · Cited by 27
“Our findings suggest that both, bone resorption and formation, changed over the time period, which was previously reported by others [20, 36, 37].”
ResultThe effects of bariatric surgery on bone and nephrolithiasis
Sakhaee, K., POINDEXTER, J. R., & Aguirre, C. (2015) · Bone · doi:10.1016/j.bone.2015.12.001 · Cited by 27
Cadart, O., Degrandi, O., Barnetche, T., Mehsen-Cêtre, N., Monsaingeon, M., Pupier, É., Bosc, L., Collet, D., Gronnier, C., Trémollières, F., et al. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04568-3 · Cited by 26
Metabolic, Renal, and Nutritional Consequences of Bariatric Surgery: Implications for the Clinician
Chauhan, V., Vaid, M., Gupta, M., Kalanuria, A. A., & Parashar, A. (2010) · Southern Medical Journal · doi:10.1097/smj.0b013e3181e6cc3f · Cited by 27
“Since the ingested food will not pass through the duodenum after a bypass procedure, calcium levels in the blood may decrease, causing secondary hyperparathyroidism, increase in bone turnover, and a decrease in bone mass.(51,52) This might be further exacerbated by low intake of dietary vitamin D.”
BackgroundImplicaciones nutricionales de la cirugía bariátrica sobre el tracto gastrointestinal
Rubio, M. Á., & Moreno, C. (2007) · Hispana · Cited by 26
Fui, M. N. T., Hoermann, R., Nolan, B. J., Clarke, M., Zajac, J. D., & Grossmann, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-27481-3 · Cited by 26
Bone Density and Trabecular Morphology at Least 10 Years After Gastric Bypass and Gastric Banding
Lindeman, K. G., Rushin, C. C., Cheney, M. C., Bouxsein, M., Hutter, M. M., & Yu, E. W.-Y. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4112 · Cited by 26
Vitamin D Status After Gastric Bypass or Sleeve Gastrectomy over 4 Years of Follow-up
Fox, A., Slater, C., Ahmed, B., Ammori, B. J., Senapati, S., Akhtar, K., Ellison, J., Summers, L. K. M., Robinson, A., New, J. P., et al. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04318-0 · Cited by 25
Advances in the surgical treatment of morbid obesity.
Stefater, M., Kohli, R., & Inge, T. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.10.006 · Cited by 27
Wakolbinger, M., Kruschitz, R., Winzer, E., Schindler, K., Grabovac, I., Kainberger, F. M., Krebs, M., Hoppichler, F., Langer, F. B., Prager, G., et al. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3353-2 · Cited by 27
Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass
Yu, E. W.-Y., Carmody, J. S., Brooks, D. J., Lajoie, S., Kaplan, L. M., & Bouxsein, M. (2016) · Bone · doi:10.1016/j.bone.2016.01.017 · Cited by 25
de Vasconcelos, R. S., Viégas, M., Marques, T. F., Diniz, E. T., Lucena, C. S., Neto, J. B. C., & Bandeira, F. A. F. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000200021 · Cited by 23
“The patient from the non-surgery group presented low LS BMD and normal serum 25OHD and PTH.”
BackgroundInfluentialOsteocalcin increase after bariatric surgery predicts androgen recovery in hypogonadal obese males
Samavat, J., Facchiano, E., Cantini, G., Franco, A. D., Alpigiano, G., Poli, G., Seghieri, G., Lucchese, M., Forti, G., & Luconi, M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.228 · Cited by 24
Gastric bypass for severe obesity: Approaches and outcomes
Schauer, P. R. (2005) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2005.03.214 · Cited by 24
Self-citationMarengo, A. P., Pérez, F. G., Martín, L. S., Monseny, R., Casajoana, A., Valera, R., Virgili, N. M., Simó-Servat, A., Prats‐Galino, A., Gómez‐Vaquero, C., et al. (2017) · Nutrients · doi:10.3390/nu9121314 · Cited by 23
Gómez‐Martín, J. M., Balsa, J. A., Aracil, E., Ayuso, M. C., Rosillo, M., la Peña, G. D., Lasunción, M. A., Escobar-Morreale, H. F., & Botella-Carretero, J. I. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0794-5 · Cited by 24
Bone Loss and Gastric Bypass Surgery for Morbid Obesity
Bell, N. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032162 · Cited by 23
“(18) describe the development of marked bone resorption and loss of bone mass in patients who had undergone Roux-Y gastric bypass for morbid obesity.”
BackgroundSevere Hypocalcemia following Total Thyroidectomy after Biliopancreatic Diversion
Rojas‐Marcos, P. M., Rubio, M. Á., Kreskshi, W. I., Cabrerizo, L., & Sánchez-Pernaute, A. (2005) · Obesity Surgery · doi:10.1381/0960892053576712 · Cited by 23
Metadata
- Authors
- Coates, P. S., Fernstrom, J. D., Fernstrom, M. H., Schauer, P. R., & Greenspan, S. L.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Schauer, Philip R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-03-01
- Volume
- 89
- Issue
- 3
- Pages
- 1061-1065
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2116196260
- Cited by
- 423
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 1 · 2022: 10 · 2021: 14 · 2020: 25 · 2019: 9 · 2018: 16 · 2017: 23 · 2016: 21 · 2015: 20 · 2014: 33 · 2013: 23 · 2012: 20
- FWCI
- 29.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR000056, M01-RR00056-39)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- laparoscopic Roux-en-Y gastric bypass, morbid obesity, bone turnover, bone mineral density, bone mineral content, bone resorption, osteocalcin, N-telopeptide, weight loss, bariatric surgery
- MeSH terms
- Adult, Bone and Bones, Calcium, Dietary, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Vitamin D, Gastric Bypass, Weight Loss, Bone Density, Bone Remodeling
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