Biochemical evidence of metabolic bone disease in women following Roux-Y gastric bypass for morbid obesity

Ott, Michael T.; Fanti, Paolo; Malluche, Hartmut H.; Ryo, U. Yun; Whaley, Fredrich S.; Strodel, William E.; Colacchio, Thomas A.

doi:10.1381/096089292765559936

Cited by 96Bariatric Surgery and OutcomesBone health and osteoporosis researchBone Metabolism and Diseases

Biochemical evidence of metabolic bone disease in women following Roux-Y gastric bypass for morbid obesity

Ott, Michael T., Fanti, Paolo, Malluche, Hartmut H., Ryo, U. Yun, Whaley, Fredrich S., Strodel, William E., Colacchio, Thomas A.·1992·Obesity Surgery

DOI 10.1381/096089292765559936

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Abstract

Twenty-six female patients were recalled for examination 10 years after a Roux-Y gastric bypass (RGB) procedure for morbid obesity, to determine whether there was biochemical and/or bone densitometry evidence of metabolic bone disease. These patients were compared with seven control patients who had achieved weight loss by dietary restriction. The serum calcium (4.3 +/- 0.03 vs 4.6 +/- 0.06 mEq/l; p = 0.002) was decreased in the RGB group. Both the serum alkaline phosphatase level (121.0 +/- 7.6 vs 87.3 +/- 8.3 U/I; p = 0.018) and the serum osteocalcin (12.6 +/- 1.2 vs 9.5 +/- 1.9 µg/ml; p = 0.078) level increased in the RGB group. The 1,25(OH) vitamin D level (50.5 +/- 2.5 vs 40.5 +/- 4.9 pg/ml; p = 0.152) was similar for both groups; the 25(OH) vitamin D level (24.3 +/- 1.6 vs 35.9 +/- 3.4 ng/ml; p = 0.008) was decreased in the RGB group as compared with the control group. Bone mineral density was elevated in three of the lumbar measurement sites, and marginally decreased (0.90 +/- 0.02 g/cm(2) vs 1.03 +/- 0.06 g/cm(2); p = 0.067) in the femoral neck of the RGB group compared with the controls. This biochemical pattern suggests the development of metabolic bone disease following the RGB.

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Authors: Ott, M. T., Fanti, P., Malluche, H. H., Ryo, U. Y., Whaley, F. S., Strodel, W. E., & Colacchio, T. A.
Affiliations: Texas Medical Center (US)
University of Kentucky (US)
Dartmouth College (US)
Dartmouth–Hitchcock Medical Center (US)
ORCID: Fanti, Paolo
Malluche, Hartmut H.
Venue: Obesity Surgery
Publisher: Springer Science and Business Media LLC
Published: 1992-11-01
Volume: 2
Issue: 4
Pages: 341-348
ISSN: 0960-8923 (ISSN-L)
1708-0428
DOI: 10.1381/096089292765559936
OpenAlex: W2082422350
Cited by: 96
References: 26
Citations by year: 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 10 · 2013: 3 · 2012: 6
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Locations: Obesity Surgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: Roux-en-Y gastric bypass, morbid obesity

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Biochemical evidence of metabolic bone disease in women following Roux-Y gastric bypass for morbid obesity

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