Cited by 84Renin-Angiotensin System StudiesAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Angiotensin II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects

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Goossens, G. H., Blaak, E. E., Saris, W. H. M., van Baak, M. A.·2004·The Journal of Clinical Endocrinology & Metabolism

Abstract

The present study was designed to investigate the effects of angiotensin II (Ang II) on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects using the microdialysis technique. Microdialysis probes were placed in the abdominal sc adipose tissue left and right from the umbilicus and in the gastrocnemius muscle of both legs in eight normal-weight and eight obese men. Probes were consecutively perfused with 1.0 nM Ang II, 1.0 microM Ang II, and 1.0 microM Ang II + 48 microM hydralazine or with Ringer solution (control). Ethanol and glycerol concentrations in the dialysate were measured as an indicator of local blood flow and lipolysis, respectively. Ang II caused an increase in ethanol outflow/inflow ratio, compared with baseline values both in adipose tissue (average of both groups, Ang 1.0 nM: 0.03 +/- 0.01, P = 0.02; Ang 1.0 microM: 0.05 +/- 0.01, P < 0.01) and muscle (average of both groups, Ang 1.0 nM: 0.02 +/- 0.01, P = 0.09; Ang 1.0 microM: 0.04 +/- 0.01, P = 0.01), indicating a decrease in local blood flow. These effects were not significantly different in obese and normal-weight subjects. The decrease in local blood flow was accompanied by unchanged interstitial glycerol concentrations in adipose tissue (except during the supraphysiological dose) and skeletal muscle, suggesting that Ang II inhibits lipolysis in both tissues. Thus, the present data suggest that Ang II decreases local blood flow in a dose-dependent manner and inhibits lipolysis both in adipose and skeletal muscle tissue. These effects were not significantly different in obese and normal-weight subjects in both tissues.

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Crossref · 10.1210/jc.2003-032053

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Authors
Goossens, G. H., Blaak, E. E., Saris, W. H. M., & van Baak, M. A.
Affiliations
Maastricht University (NL)
Venue
The Journal of Clinical Endocrinology & Metabolism
Published
2004-06
Volume
89
Issue
6
Pages
2690-2696
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
OpenAlex
W1997047615
Cited by
84
References
38
Citations by year
2026: 2 · 2024: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 11
FWCI
6.10
Type
journal article
Language
en
Licence
other-oa
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
angiotensin II, adipose tissue blood flow, skeletal muscle blood flow, lipolysis, obesity, hydralazine, microdialysis, dose-dependent effects, subcutaneous abdominal fat, gastrocnemius
MeSH terms
Adipose Tissue, Ethanol, Angiotensin II, Body Weight, Central Nervous System Depressants, Drug Interactions, Glycerol, Humans, Hydralazine, Lipolysis, Male, Middle Aged, Obesity, Regional Blood Flow, Vasoconstrictor Agents, Vasodilator Agents, Microdialysis, Muscle, Skeletal

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