Angiotensin II-induced effects on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects
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The present study was designed to investigate the effects of angiotensin II (Ang II) on adipose and skeletal muscle tissue blood flow and lipolysis in normal-weight and obese subjects using the microdialysis technique. Microdialysis probes were placed in the abdominal sc adipose tissue left and right from the umbilicus and in the gastrocnemius muscle of both legs in eight normal-weight and eight obese men. Probes were consecutively perfused with 1.0 nM Ang II, 1.0 microM Ang II, and 1.0 microM Ang II + 48 microM hydralazine or with Ringer solution (control). Ethanol and glycerol concentrations in the dialysate were measured as an indicator of local blood flow and lipolysis, respectively. Ang II caused an increase in ethanol outflow/inflow ratio, compared with baseline values both in adipose tissue (average of both groups, Ang 1.0 nM: 0.03 +/- 0.01, P = 0.02; Ang 1.0 microM: 0.05 +/- 0.01, P < 0.01) and muscle (average of both groups, Ang 1.0 nM: 0.02 +/- 0.01, P = 0.09; Ang 1.0 microM: 0.04 +/- 0.01, P = 0.01), indicating a decrease in local blood flow. These effects were not significantly different in obese and normal-weight subjects. The decrease in local blood flow was accompanied by unchanged interstitial glycerol concentrations in adipose tissue (except during the supraphysiological dose) and skeletal muscle, suggesting that Ang II inhibits lipolysis in both tissues. Thus, the present data suggest that Ang II decreases local blood flow in a dose-dependent manner and inhibits lipolysis both in adipose and skeletal muscle tissue. These effects were not significantly different in obese and normal-weight subjects in both tissues.
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Stinkens, R., van der Kolk, B. W., Jordan, J., Jax, T. W., Engeli, S., Heise, T., Jocken, J. W. E., May, M., Schindler, C., Havekes, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22194-z · Cited by 12 · see citing works
Self-citationvan der Zijl, N. J., Serné, E. H., Goossens, G. H., Moors, C. C. M., IJzerman, R. G., Blaak, E. E., & Diamant, M. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834a7667 · Cited by 12 · see citing works
Self-citationHemodynamic and metabolic responses to interstitial angiotensin II in normal weight and obese men
Boschmann, M., Adams, F., Schaller, K., Franke, G., Sharma, A. M., Klaus, S., Luft, F. C., & Jordan, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000226207.11184.5f · Cited by 10 · see citing works
Boschmann, M., Kreuzberg, U., Engeli, S., Adams, F., Franke, G., Klaua, S., Scholze, J., Weidinger, G., Luft, F. C., Sharma, A. M., et al. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-925406 · Cited by 10 · see citing works
Involvement of the renin-angiotensin system in obesity: Older and newer pathways
Galletti, F., & Strazzullo, P. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.03.002 · Cited by 9 · see citing works
Adjustment to dietary energy availability: from starvation to overnutrition
Alemany, M. (2012) · RSC Advances · doi:10.1039/c2ra21165c · Cited by 7 · see citing works
Parhofer, K. G., Birkeland, K. I., DeFronzo, R. A., Prato, S. D., Bhaumik, A., & Ptaszynska, A. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02246.x · Cited by 7 · see citing works
Enhanced Metabolic Cycling in Subjects after Colonic Resection for Ulcerative Colitis
Robertson, M. D., Bickerton, A. S. T., Dennis, A., Vidal, H., Jewell, D. P., & Frayn, K. N. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2108 · Cited by 6 · see citing works
The effects of hydralazine on lipolysis in subcutaneous adipose tissue in humans
Boon, N., Goossens, G. H., Blaak, E. E., & Saris, W. H. M. (2007) · Metabolism · doi:10.1016/j.metabol.2007.08.003 · Cited by 6 · see citing works
Self-citationThe mineralocorticoid system, cardiometabolic health and its interplay with adipose tissue
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Sympathetic vascular tone in human obesity
Correia, M. (2007) · doi:10.17077/etd.v54kf0if · Cited by 1 · see citing works
Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans
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Dietary calcium and body weight regulation
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The Skeletal Muscle RAS in Health and Disease
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Study of adipokine secretion and their functions
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Suwannasual, U., & Lund, A. K. (2026) · Toxicology Reports · doi:10.1016/j.toxrep.2026.102304
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- Authors
- Goossens, G. H., Blaak, E. E., Saris, W. H. M., & van Baak, M. A.
- Affiliations
- Maastricht University (NL)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-06
- Volume
- 89
- Issue
- 6
- Pages
- 2690-2696
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1997047615
- Cited by
- 84
- References
- 38
- Citations by year
- 2026: 2 · 2024: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 11
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- angiotensin II, adipose tissue blood flow, skeletal muscle blood flow, lipolysis, obesity, hydralazine, microdialysis, dose-dependent effects, subcutaneous abdominal fat, gastrocnemius
- MeSH terms
- Adipose Tissue, Ethanol, Angiotensin II, Body Weight, Central Nervous System Depressants, Drug Interactions, Glycerol, Humans, Hydralazine, Lipolysis, Male, Middle Aged, Obesity, Regional Blood Flow, Vasoconstrictor Agents, Vasodilator Agents, Microdialysis, Muscle, Skeletal
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